B. Friedrich

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Positive Transcriptional Feedback Controls Hydrogenase Expression in Alcaligenes eutrophusH16

T. Buhrke, E. Schwartz, U. Gerischer, 1999, Journal of bacteriology.

A hydrogen-sensing multiprotein complex controls aerobic hydrogen metabolism in Ralstonia eutropha.

O. Lenz, T. Buhrke, B. Friedrich, 2005, Biochemical Society transactions.

The complex structure of polyhydroxybutyrate (PHB) granules: four orthologous and paralogous phasins occur in Ralstonia eutropha.

A. Steinbüchel, F. Reinecke, Markus Pötter, 2004, Microbiology.

Oxygen Tolerance of the H2-sensing [NiFe] Hydrogenase from Ralstonia eutropha H16 Is Based on Limited Access of Oxygen to the Active Site*

O. Lenz, N. Krauß, T. Buhrke, 2005, Journal of Biological Chemistry.

The Soluble NAD+-Reducing [NiFe]-Hydrogenase from Ralstonia eutropha H16 Consists of Six Subunits and Can Be Specifically Activated by NADPH

C. D. de Koster, A. Muijsers, J. Back, 2005, Journal of bacteriology.

Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels.

F. Armstrong, O. Lenz, K. Vincent, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen sensing by enzyme-catalyzed electrochemical detection.

B. Friedrich, T. Burgdorf, Bärbel Friedrich, 2005, Analytical chemistry.

The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli

B. Friedrich, T. Eitinger, L. Wolfram, 1995, Journal of bacteriology.

Expression of bacterial mercuric ion reductase in Saccharomyces cerevisiae

U. Stahl, C. Rensing, U. Kües, 1992, Journal of bacteriology.

H2 conversion in the presence of O2 as performed by the membrane-bound [NiFe]-hydrogenase of Ralstonia eutropha.

O. Lenz, M. Ludwig, Tobias Goris, 2010, Chemphyschem : a European journal of chemical physics and physical chemistry.

Impact of amino acid substitutions near the catalytic site on the spectral properties of an O2-tolerant membrane-bound [NiFe] hydrogenase.

O. Lenz, P. Hildebrandt, M. Ludwig, 2010, Chemphyschem : a European journal of chemical physics and physical chemistry.

Characterization of the active site of a hydrogen sensor from Alcaligenes eutrophus

O. Lenz, B. Friedrich, S. Albracht, 1998, FEBS letters.

The H2 Sensor of Ralstonia eutropha Is a Member of the Subclass of Regulatory [NiFe] Hydrogenases

O. Lenz, T. Buhrke, B. Friedrich, 2000, Journal of bacteriology.

The hydrogen-sensing apparatus in Ralstonia eutropha.

O. Lenz, T. Buhrke, E. Schwartz, 2002, Journal of molecular microbiology and biotechnology.

A hydrogen-sensing system in transcriptional regulation of hydrogenase gene expression in Alcaligenes species

O. Lenz, B. Friedrich, A. Strack, 1997, Journal of bacteriology.

Monitoring catalysis of the membrane-bound hydrogenase from Ralstonia eutropha H16 by surface-enhanced IR absorption spectroscopy.

O. Lenz, P. Hildebrandt, M. Ludwig, 2009, Angewandte Chemie.

Spectroscopic Insights into the Oxygen-tolerant Membrane-associated [NiFe] Hydrogenase of Ralstonia eutropha H16*

O. Lenz, P. Hildebrandt, M. Ludwig, 2009, The Journal of Biological Chemistry.

Histidine utilization by Alcaligenes eutrophus: Regulation of histidase formation under heterotrophic conditions of growth

B. Friedrich, M. Schlesier, 1982, Archives of Microbiology.

Effect of molecular hydrogen on histidine utilization by Alcaligenes eutrophus

B. Friedrich, M. Schlesier, 1982, Archives of Microbiology.

Hydrogen production under aerobic conditions by membrane-bound hydrogenases from Ralstonia species.

F. Armstrong, O. Lenz, M. Ludwig, 2008, Journal of the American Chemical Society.

Microbial Sensor Systems for Dihydrogen, Nitric Oxide, and Carbon Monoxide

B. Friedrich, R. Cramm, 2009 .

Transcriptional Regulation of Alcaligenes eutrophus Hydrogenase Genes

E. Schwartz, U. Gerischer, B. Friedrich, 1998, Journal of bacteriology.

Formation of Enzymes of Autotrophic Metabolism During Heterotrophic Growth of Alcaligenes eutrophus

C. Friedrich, B. Friedrich, B. Bowien, 1981 .

A physical map of the megaplasmid pHG1, one of three genomic replicons in Ralstonia eutropha H16.

E. Schwartz, B. Friedrich, 2001, FEMS microbiology letters.

Naturally occurring genetic transfer of hydrogen-oxidizing ability between strains of Alcaligenes eutrophus

B. Friedrich, H. Schlegel, C. Hogrefe, 1981, Journal of bacteriology.

An improved purification procedure for the soluble [NiFe]-hydrogenase of Ralstonia eutropha: new insights into its (in)stability and spectroscopic properties

A. L. Lacey, V. Fernández, T. Buhrke, 2006, JBIC Journal of Biological Inorganic Chemistry.

Selective release and function of one of the two FMN groups in the cytoplasmic NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha.

B. Friedrich, T. Burgdorf, E. van der Linden, 2004, European journal of biochemistry.

Requirements for Heterologous Production of a Complex Metalloenzyme: the Membrane-Bound [NiFe] Hydrogenase

O. Lenz, B. Friedrich, A. Strack, 2005, Journal of bacteriology.

A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase.

F. Armstrong, O. Lenz, I. Zebger, 2011, Nature chemical biology.

Nickel requirement for active hydrogenase formation in Alcaligenes eutrophus

C. Friedrich, B. Friedrich, E. Heine, 1981, Journal of bacteriology.

O. Lenz, E. Siebert, I. Zebger, 2014, The Journal of Biological Chemistry.

Hydrogenases in Lithoautotrophic Bacteria

C. Friedrich, B. Friedrich, 1990 .

Transcriptional regulation of nitric oxide reduction in Ralstonia eutropha H16.

B. Friedrich, R. Cramm, K. Strube, 2005, Biochemical Society transactions.

Light-driven Hydrogen Production by a Hybrid Complex of a [NiFe]-Hydrogenase and the Cyanobacterial Photosystem I

O. Lenz, K. Yoon, Hitoshi Nakamoto, 2006, Photochemistry and photobiology.

Reduction of Unusual Iron-Sulfur Clusters in the H2-sensing Regulatory Ni-Fe Hydrogenase from Ralstonia eutropha H16*

L. K. Andersen, O. Lenz, E. Schlodder, 2005, Journal of Biological Chemistry.

Comparison of the membrane-bound [NiFe] hydrogenases from R. eutropha H16 and D. vulgaris Miyazaki F in the oxidized ready state by pulsed EPR.

W. Lubitz, O. Lenz, P. Hildebrandt, 2010, Physical chemistry chemical physics : PCCP.

The Soluble NAD (cid:1) -Reducing [NiFe]-Hydrogenase from Ralstonia eutropha H16 Consists of Six Subunits and Can Be Speciﬁcally Activated by NADPH

C. G. Koster, A. Muijsers, J. Back, 2005 .

Functional Analysis by Site-Directed Mutagenesis of the NAD+-Reducing Hydrogenase from Ralstonia eutropha

B. Friedrich, T. Burgdorf, A. L. De Lacey, 2002, Journal of bacteriology.

Unusual FTIR and EPR properties of the H2‐activating site of the cytoplasmic NAD‐reducing hydrogenase from Ralstonia eutropha

C. Friedrich, B. Friedrich, S. Albracht, 2000, FEBS letters.

Structure, function and biosynthesis of O2-tolerant hydrogenases

O. Lenz, B. Friedrich, J. Fritsch, 2013, Nature Reviews Microbiology.

Reversible [4Fe-3S] cluster morphing in an O(2)-tolerant [NiFe] hydrogenase.

A. Schmidt, S. Frielingsdorf, O. Lenz, 2014, Nature chemical biology.

Nickel in the catalytically active hydrogenase of Alcaligenes eutrophus

K. Schneider, C. Friedrich, B. Friedrich, 1982, Journal of bacteriology.

A DNA Region Recognized by the Nitric Oxide-Responsive Transcriptional Activator NorR Is Conserved in (cid:2) - and (cid:3) -Proteobacteria

B. Friedrich, R. Cramm, A. Pohlmann, 2004 .

Genetic transfer of lithoautotrophy mediated by a plasmid-cointegrate from Pseudomonas facilis

B. Friedrich, J. Warrelmann, 1989, Archives of Microbiology.

Genes of lithoautotrophic metabolism are clustered on the megaplasmid pHG1 in Alcaligenes eutrophus

A. Pühler, B. Friedrich, G. Eberz, 1987, Molecular and General Genetics MGG.

CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase

S. Frielingsdorf, O. Lenz, E. Siebert, 2016, Proceedings of the National Academy of Sciences.

Crystallization and preliminary X-ray crystallographic analysis of the [NiFe]-hydrogenase maturation factor HypF1 from Ralstonia eutropha H16.

P. Scheerer, N. Krauß, W. Höhne, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Concerted Action of Two Novel Auxiliary Proteins in Assembly of the Active Site in a Membrane-bound [NiFe] Hydrogenase*

O. Lenz, P. Hildebrandt, M. Ludwig, 2009, Journal of Biological Chemistry.

Carbamoylphosphate serves as the source of CN−, but not of the intrinsic CO in the active site of the regulatory [NiFe]‐hydrogenase from Ralstonia eutropha

O. Lenz, P. Hildebrandt, I. Zebger, 2007, FEBS letters.

A model system for [NiFe] hydrogenase maturation studies: Purification of an active site‐containing hydrogenase large subunit without small subunit

O. Lenz, T. Buhrke, Michael Forgber, 2005, FEBS letters.

The soluble [NiFe]-hydrogenase from Ralstonia eutropha contains four cyanides in its active site, one of which is responsible for the insensitivity towards oxygen

B. Friedrich, T. Burgdorf, M. Bernhard, 2004, JBIC Journal of Biological Inorganic Chemistry.

Mutagenesis of Alcaligenes eutrophus by insertion of the drug-resistance transposon Tn5

S. Srivastava, B. Friedrich, Marlies Urban, 1982, Archives of Microbiology.

Three nitrate reductase activities in Alcaligenes eutrophus

B. Friedrich, U. Warnecke-Eberz, Ute Warnecke-Eberz, 1993, Archives of Microbiology.

Carboxyl-terminal processing of the cytoplasmic NAD-reducing hydrogenase of Alcaligenes eutrophus requires the hoxW gene product

J. Dernedde, B. Friedrich, M. Bernhard, 1996, Journal of bacteriology.

Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus.

B. Friedrich, T. Eitinger, 1991, The Journal of biological chemistry.

Construction and properties of a triprotein containing the high‐affinity nickel transporter of Alcaligenes eutrophus

B. Friedrich, T. Eitinger, L. Wolfram, 1991, FEBS letters.

Genetic determinants of a nickel-specific transport system are part of the plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus

B. Friedrich, G. Eberz, T. Eitinger, 1989, Journal of bacteriology.

investigated by X-ray absorption spectroscopy: insights into O2-tolerant H2-cleavage

A. L. Lacey, O. Lenz, E. Siebert, 2011 .

The Alcaligenes eutrophus H16 hoxX gene participates in hydrogenase regulation

O. Lenz, J. Dernedde, E. Schwartz, 1994, Journal of bacteriology.

Cloning of plasmid genes encoding resistance to cadmium, zinc, and cobalt in Alcaligenes eutrophus CH34

M. Mergeay, D. Nies, B. Friedrich, 1987, Journal of bacteriology.

Determinants Encoding Resistance to Several Heavy Metals in Newly Isolated Copper-Resistant Bacteria

U. Kües, D. Nies, C. Dressler, 1991, Applied and environmental microbiology.

Characterization of the membranous denitrification enzymes nitrite reductase (cytochrome cd1) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans

P. Kroneck, W. Zumft, B. Friedrich, 1996, Archives of Microbiology.

Structural gene (nirS) for the cytochrome cd1 nitrite reductase of Alcaligenes eutrophus H16

B. Friedrich, B. Schneider, R. A. Siddiqui, 1997, Applied and environmental microbiology.

Transfer and Expression of Lithoautotrophy and Denitrification in a Host Lacking These Metabolic Activities

B. Friedrich, B. Schneider, A. Nies, 1988, Applied and environmental microbiology.

Purification and characterization of the single‐component nitric oxide reductase from Ralstonia eutropha H16

B. Friedrich, R. Cramm, A. Pohlmann, 1999, FEBS letters.

Molecular cloning of structural and regulatory hydrogenase (hox) genes of Alcaligenes eutrophus H16

B. Friedrich, G. Eberz, C. Hogrefe, 1986, Journal of bacteriology.

The formation of an oxygen-binding flavohemoprotein in Alcaligenes eutrophus is plasmid-determined

K. Schmidt, B. Friedrich, V. Weihs, 1989, Archives of Microbiology.

A kinetic and thermodynamic understanding of O2 tolerance in [NiFe]-hydrogenases

F. Armstrong, O. Lenz, B. Friedrich, 2009, Proceedings of the National Academy of Sciences.

Protein-protein complex formation affects the Ni-Fe and Fe-S centers in the H2-sensing regulatory hydrogenase from Ralstonia eutropha H16.

O. Lenz, T. Buhrke, M. Haumann, 2010, Chemphyschem : a European journal of chemical physics and physical chemistry.

Impact of alterations near the [NiFe] active site on the function of the H2 sensor from Ralstonia eutropha

O. Lenz, A. Martínez-Arias, B. Friedrich, 2007, The FEBS journal.

Cofactor composition and function of a H2-sensing regulatory hydrogenase as revealed by Mössbauer and EPR spectroscopy† †Electronic supplementary information (ESI) available: Tables with the simulation parameters and details of the Mössbauer, and EPR spectra (Tables S1–S4). additional EPR and Mössba

W. Lubitz, O. Lenz, F. Roncaroli, 2015, Chemical science.

Isolation and characterization of megaplasmid DNA from lithoautotrophic bacteria.

B. Friedrich, C. Hogrefe, Christine Hogrefe, 1984, Plasmid.

Pleotropic mutants from Alcaligenes eutrophus defective in the metabolism of hydrogen, nitrate, urea, and fumarate

C. Friedrich, B. Friedrich, M. Lohmeyer, 1988, Archives of Microbiology.

Expression of a functional NAD-reducing [NiFe] hydrogenase from the gram-positive Rhodococcus opacus in the gram-negative Ralstonia eutropha

B. Friedrich, M. Bernhard, Antje Porthun, 2002, Archives of Microbiology.

Subforms and In Vitro Reconstitution of the NAD-Reducing Hydrogenase of Alcaligenes eutrophus

S. Schmidt, B. Friedrich, C. Massanz, 1998, Journal of bacteriology.

C-terminal extension of the H2-activating subunit, HoxH, directs maturation of the NAD-reducing hydrogenase in Alcaligenes eutrophus.

B. Friedrich, V. Fernández, C. Massanz, 1997, European journal of biochemistry.

The plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus

B. Friedrich, 1990 .

Identification of distinct NAD-linked hydrogenase protein species in mutants and nickel-deficient wild-type cells of Alcaligenes eutrophus H16.

K. Schneider, B. Friedrich, H. Schlegel, 1990, European journal of biochemistry.

Genetics of hydrogenase from aerobic lithoautotrophic bacteria.

B. Friedrich, J. Warrelmann, G. Eberz, 1986, Biochimie.

Formate and Oxalate Metabolism in Alcaligenes eutrophus

C. Friedrich, B. Friedrich, B. Bowien, 1979 .

Chaperones specific for the membrane‐bound [NiFe]‐hydrogenase interact with the Tat signal peptide of the small subunit precursor in Ralstonia eutropha H16

R. Volkmer, O. Lenz, E. Krause, 2007, Molecular microbiology.

Hydrogenase mutants of Alcaligenes eutrophus H16 show alterations in the electron transport system.

K. Schmidt, B. Friedrich, R. Kömen, 1992, FEMS microbiology letters.

Electrochemical definitions of O2 sensitivity and oxidative inactivation in hydrogenases.

F. Armstrong, J. Fontecilla-Camps, O. Lenz, 2005, Journal of the American Chemical Society.

Characterization of the norB Gene, Encoding Nitric Oxide Reductase, in the Nondenitrifying Cyanobacterium Synechocystis sp. Strain PCC6803

B. Friedrich, R. Cramm, A. Büsch, 2002, Applied and Environmental Microbiology.

Non-standard structures of the Ni-Fe cofactor in the regulatory and the NAD-reducing hydrogenases from Ralstonia eutropha.

T. Buhrke, M. Haumann, H. Dau, 2005, Biochemical Society transactions.

The role of the active site-coordinating cysteine residues in the maturation of the H2-sensing [NiFe] hydrogenase from Ralstonia eutropha H16

T. Buhrke, B. Friedrich, A. Jones, 2004, Archives of Microbiology.

EPR and theoretical investigations of [NiFe] hydrogenase: Insight into the mechanism of biological hydrogen conversion

W. Lubitz, Y. Higuchi, T. Buhrke, 2002 .

Hydrogen Oxidation by Alcaligenes

O. Lenz, J. Dernedde, E. Schwartz, 1996 .

Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes

B. Magasanik, B. Friedrich, 1979, Journal of bacteriology.

Catabolic N2-acetylornithine 5-aminotransferase of Klebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase

B. Magasanik, C. Friedrich, B. Friedrich, 1978, Journal of bacteriology.

Complete Genome Sequence of the Type Strain Cupriavidus necator N-1

R. Daniel, Anja Poehlein, B. Friedrich, 2011, Journal of bacteriology.

Direct detection of a hydrogen ligand in the [NiFe] center of the regulatory H2-sensing hydrogenase from Ralstonia eutropha in its reduced state by HYSCORE and ENDOR spectroscopy.

W. Lubitz, T. Buhrke, M. Brecht, 2003, Journal of the American Chemical Society.

Detrimental and Beneficial Effects of Oxygen Exerted on Hydrogen-Oxidizing Bacteria

K. Schneider, K. A. Malik, B. Friedrich, 1981 .

Transfer and expression of the herbicide-degrading plasmid pJP4 in aerobic autotrophic bacteria

B. Friedrich, H. Schlegel, M. Meyer, 1983, Archives of Microbiology.

Expression of hydrogenase in Alcaligenes spp. is altered by interspecific plasmid exchange

C. Friedrich, B. Friedrich, H. Schlegel, 1984, Journal of bacteriology.

Regulation of hydrogenase formation is temperature sensitive and plasmid coded in Alcaligenes eutrophus

C. Friedrich, B. Friedrich, 1983, Journal of bacteriology.

Utilization of arginine by Klebsiella aerogenes

B. Magasanik, B. Friedrich, 1978, Journal of bacteriology.

A physical map of the megaplasmid pHG1, one of three genomic replicons in Ralstonia eutropha H16.

E. Schwartz, B. Friedrich, 2001, FEMS microbiology letters.

Novel methodology for topological studies of photosynthetic membrane protein complexes

B. Thiede, K. Irrgang, J. Vater, 1996 .

Purification of the F420-reducing hydrogenase from Methanosarcina barkeri (strain Fusaro).

K. Fiebig, B. Friedrich, 1989, European journal of biochemistry.

The H2 sensor of Ralstoniaeutropha: biochemical and spectroscopic analysis of mutant proteins modified at a conserved glutamine residue close to the [NiFe] active site

W. Lubitz, T. Buhrke, M. Brecht, 2002, JBIC Journal of Biological Inorganic Chemistry.

Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy.

M. Haumann, H. Dau, B. Friedrich, 2005, Journal of the American Chemical Society.

Cloning and nucleotide sequences of the genes for the subunits of NAD-reducing hydrogenase of Alcaligenes eutrophus H16

B. Friedrich, C. Zaborosch, A. Tran-Betcke, 1990, Journal of bacteriology.

Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution.

U. Ermler, B. Friedrich, R Cramm, 1995, The EMBO journal.

H2-Metabolizing Prokaryotes

E. Schwartz, B. Friedrich, J. Fritsch, 2013 .

The H2-Metabolizing Prokaryotes

E. Schwartz, B. Friedrich, 2006 .

Complete Nucleotide Sequence of pHG1: A Ralstonia eutropha H16 Megaplasmid Encoding Key Enzymes of H2-based Lithoautotrophy and Anaerobiosis

G. Gottschalk, A. Henne, E. Schwartz, 2003 .

The H2 Sensor of Ralstonia eutropha

T. Buhrke, B. Friedrich, M. Bernhard, 2001, The Journal of Biological Chemistry.

Involvement of hyp Gene Products in Maturation of the H2-Sensing [NiFe] Hydrogenase ofRalstonia eutropha

T. Buhrke, B. Friedrich, S. Albracht, 2001, Journal of bacteriology.

A proteomic view of the facultatively chemolithoautotrophic lifestyle of Ralstonia eutropha H16

Anne Pohlmann, Cornelia Krause, Michael Hecker, 2009, Proteomics.

Climate change and infectious diseases--impact of global warming and climate change on infectious diseases: myth or reality?

J. Hacker, U. Dobrindt, T. Mettenleiter, 2012, International journal of medical microbiology : IJMM.

Ralstonia eutropha H16 Flagellation Changes According to Nutrient Supply and State of Poly(3-Hydroxybutyrate) Accumulation

M. Hecker, W. F. Fricke, A. Steinbüchel, 2008, Applied and Environmental Microbiology.

A DNA Region Recognized by the Nitric Oxide-Responsive Transcriptional Activator NorR Is Conserved in β- and γ-Proteobacteria

Anne Pohlmann, B. Friedrich, Rainer Cramm, 2004 .

Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16

Anne Pohlmann, Frank Reinecke, Alexander Steinbüchel, 2006, Nature Biotechnology.

Analyses of soluble and membrane proteomes of Ralstonia eutropha H16 reveal major changes in the protein complement in adaptation to lithoautotrophy.

M. Hecker, A. Otto, D. Becher, 2011, Journal of proteome research.

[NiFe]-Hydrogenases of Ralstonia eutropha H16: Modular Enzymes for Oxygen-Tolerant Biological Hydrogen Oxidation

O. Lenz, T. Buhrke, B. Friedrich, 2006, Journal of Molecular Microbiology and Biotechnology.

Temperature tolerance of hydrogenase expression in Alcaligenes eutrophus is conferred by a single amino acid exchange in the transcriptional activator HoxA

E. Schwartz, B. Friedrich, A. Tran-Betcke, 1995, Journal of bacteriology.

Derived amino acid sequences of the nosZ gene (respiratory N2O reductase) from Alcaligenes eutrophus, Pseudomonas aeruginosa and Pseudomonas stutzeri reveal potential copper-binding residues. Implications for the CuA site of N2O reductase and cytochrome-c oxidase.

H. Cuypers, W. Zumft, B. Friedrich, 1992, European journal of biochemistry.

The Maturation Factors HoxR and HoxT Contribute to Oxygen Tolerance of Membrane-Bound [NiFe] Hydrogenase in Ralstonia eutropha H16

O. Lenz, B. Friedrich, J. Fritsch, 2011, Journal of bacteriology.

Regulation of assimilatory nitrate reductase formation in Klebsiella aerogenes W70

R. Bender, B. Friedrich, 1990, Journal of bacteriology.

The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre

C. Spahn, S. Frielingsdorf, O. Lenz, 2011, Nature.

Urease of Klebsiella aerogenes: control of its synthesis by glutamine synthetase

B. Magasanik, B. Friedrich, '. Barbelfriedrich, 1977, Journal of bacteriology.

Nucleotide sequence of the rpoN (hno) gene region of Alcaligenes eutrophus: evidence for a conserved gene cluster

E. Schwartz, B. Friedrich, J. Warrelmann, 1992, Archives of Microbiology.

The Alcaligenes eutrophus membrane-bound hydrogenase gene locus encodes functions involved in maturation and electron transport coupling

J. Rietdorf, E. Schwartz, B. Friedrich, 1996, Journal of bacteriology.

hyp gene products in Alcaligenes eutrophus are part of a hydrogenase-maturation system.

J. Dernedde, N. Patenge, B. Friedrich, 1996, European journal of biochemistry.

A novel multicomponent regulatory system mediates H2 sensing in Alcaligenes eutrophus.

O. Lenz, B. Friedrich, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Duplication of hyp genes involved in maturation of [NiFe] hydrogenases in Alcaligenes eutrophus H16

T. Buhrke, J. Dernedde, B. Friedrich, 1998, Archives of Microbiology.

Crystallization and preliminary X‐ray diffraction studies of a bacterial flavohemoglobin protein

U. Ermler, B. Friedrich, R. Cramm, 1995, Proteins.

An rpoN-like gene of Alcaligenes eutrophus and Pseudomonas facilis controls expression of diverse metabolic pathways, including hydrogen oxidation

R. Bender, B. Friedrich, J. Warrelmann, 1989, Journal of bacteriology.

Coping with anoxia: a comprehensive proteomic and transcriptomic survey of denitrification.

D. Zühlke, M. Hecker, A. Otto, 2014, Journal of proteome research.

Three trans-acting regulatory functions control hydrogenase synthesis in Alcaligenes eutrophus

B. Friedrich, G. Eberz, 1991, Journal of bacteriology.

The Alcaligenes eutrophus hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth

D. Jahn, B. Friedrich, R. A. Siddiqui, 1997, Archives of Microbiology.

Photosynthetic hydrogen production by a hybrid complex of photosystem I and [NiFe]-hydrogenase.

O. Lenz, B. Friedrich, J. Heberle, 2009, ACS nano.

Autotrophic Production of Stable-Isotope-Labeled Arginine in Ralstonia eutropha Strain H16

Anne Pohlmann, H. Heumann, E. Zaychikov, 2012, Applied and Environmental Microbiology.

A Megaplasmid-Borne Anaerobic Ribonucleotide Reductase in Alcaligenes eutrophus H16

B. Friedrich, R. Cramm, R. A. Siddiqui, 1999, Journal of bacteriology.

Molecular biology of hydrogen utilization in aerobic chemolithotrophs.

E. Schwartz, B. Friedrich, 1993, Annual review of microbiology.

Physical evidence for plasmids in autotrophic, especially hydrogen-oxidizing bacteria

B. Friedrich, H. Schlegel, Christine Gerstenberg, 1982, Archives of Microbiology.

Involvement of megaplasmids in heterotrophic derepression of the carbon-dioxide assimilating enzyme system in Alcaligenes spp.

C. Friedrich, B. Friedrich, B. Bowien, 1984, Archives of Microbiology.

Maturation of membrane-bound hydrogenase of Alcaligenes eutrophus H16

B. Friedrich, C. Kortlüke, 1992, Journal of bacteriology.

Genetics of Aerobic Lithoautotrophs

B. Friedrich, 1987 .

Mutants of Pseudomonas facilis Defective in Lithoautotrophy

B. Friedrich, J. Warrelmann, 1986 .

Denitrification by Alcaligenes eutrophus is plasmid dependent

B. Friedrich, D. Römermann, 1985, Journal of bacteriology.

Novel, Oxygen-Insensitive Group 5 [NiFe]-Hydrogenase in Ralstonia eutropha

O. Lenz, B. Friedrich, Oliver Lenz, 2013, Applied and Environmental Microbiology.

Oxygen-tolerant hydrogenases in hydrogen-based technologies.

O. Lenz, B. Friedrich, J. Fritsch, 2011, Current opinion in biotechnology.

Corrigendum: Genome sequence of the bioplastic-producing “Knallgas” bacterium Ralstonia eutropha H16

W. F. Fricke, G. Gottschalk, H. Liesegang, 2007, Nature Biotechnology.

A novel NO‐responding regulator controls the reduction of nitric oxide in Ralstonia eutropha

B. Friedrich, R Cramm, B Friedrich, 2000, Molecular microbiology.

[Hydroxylation of phenylalanine by Hydrogenomonas eutropha H 16].

B. Friedrich, H. Schlegel, 1972, Archiv fur Mikrobiologie.

[NiFe] and [FeS] cofactors in the membrane-bound hydrogenase of Ralstonia eutropha investigated by X-ray absorption spectroscopy: insights into O(2)-tolerant H(2) cleavage.

O. Lenz, E. Siebert, M. Ludwig, 2011, Biochemistry.

MOLECULAR BIOLOGY OF HYD1ROGEN UTILIZATION IN AEROBIC CHEv10LITHOTROPH S

E. Schwartz, B. Friedrich, 1993 .

Analysis of a pleiotropic gene region involved in formation of catalytically active hydrogenases in Alcaligenes eutrophus H16

J. Dernedde, B. Friedrich, M. Eitinger, 1993, Archives of Microbiology.

Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based ithoautotrophy and anaerobiosis.

G. Gottschalk, A. Henne, E. Schwartz, 2003, Journal of molecular biology.

The Auxiliary Protein HypX Provides Oxygen Tolerance to the Soluble [NiFe]-Hydrogenase of Ralstonia eutropha H16 by Way of a Cyanide Ligand to Nickel*

Boris Bleijlevens, T. Buhrke, B. Friedrich, 2004, Journal of Biological Chemistry.

Role of the HoxZ subunit in the electron transfer pathway of the membrane-bound [NiFe]-hydrogenase from Ralstonia eutropha immobilized on electrodes.

S. Frielingsdorf, P. Hildebrandt, I. Zebger, 2011, The journal of physical chemistry. B.

A trimeric supercomplex of the oxygen-tolerant membrane-bound [NiFe]-hydrogenase from Ralstonia eutropha H16.

S. Frielingsdorf, O. Lenz, B. Friedrich, 2011, Biochemistry.

Enzymatic oxidation of H2 in atmospheric O2: the electrochemistry of energy generation from trace H2 by aerobic microorganisms.

Marcus Ludwig, F. Armstrong, O. Lenz, 2008, Journal of the American Chemical Society.

4 Oxygen-tolerant hydrogenases and their biotechnological potential

S. Frielingsdorf, O. Lenz, B. Friedrich, 2015 .

The H2‐sensing complex of Ralstonia eutropha: interaction between a regulatory [NiFe] hydrogenase and a histidine protein kinase

O. Lenz, T. Buhrke, B. Friedrich, 2004, Molecular microbiology.

Probing the Origin of the Metabolic Precursor of the CO Ligand in the Catalytic Center of [NiFe] Hydrogenase*

O. Lenz, E. Siebert, I. Zebger, 2011, The Journal of Biological Chemistry.

Gas pressure effects on the rates of catalytic H(2) oxidation by hydrogenases.

F. Armstrong, B. Friedrich, J. Cracknell, 2010, Chemical communications.

Electricity from low-level H2 in still air--an ultimate test for an oxygen tolerant hydrogenase.

Marcus Ludwig, F. Armstrong, O. Lenz, 2006, Chemical communications.

Two isofunctional nitric oxide reductases in Alcaligenes eutrophus H16

B. Friedrich, R. Cramm, R. A. Siddiqui, 1997, Journal of bacteriology.

Primary sequence and evidence for a physiological function of the flavohemoprotein of Alcaligenes eutrophus.

B. Friedrich, R Cramm, R A Siddiqui, 1994, The Journal of biological chemistry.

NiFe hydrogenase active site biosynthesis: identification of Hyp protein complexes in Ralstonia eutropha.

O. Lenz, T. Buhrke, B. Friedrich, 2004, Biochemistry.

Ralstonia eutropha TF93 Is Blocked in Tat-Mediated Protein Export

B. Friedrich, M. Bernhard, R. A. Siddiqui, 2000, Journal of bacteriology.

Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16.

A. Hochkoeppler, D. Zannoni, B. Friedrich, 1997, European journal of biochemistry.

A gene complex coding for the membrane-bound hydrogenase of Alcaligenes eutrophus H16

M. Rohde, E. Schwartz, B. Friedrich, 1992, Journal of bacteriology.

Analysis of the Molecular Species of Hydrogenase in the Cells of an Obligately Chemolithoautotrophic, Marine Hydrogen-Oxidizing Bacterium, Hydrogenovibrio marinus

B. Friedrich, M. Bernhard, Y. Miyata, 2001, Bioscience, biotechnology, and biochemistry.

A topological model for the high‐affinity nickel transporter of Alcaligenes eutrophus

B. Friedrich, T. Eitinger, 1994, Molecular microbiology.

Climate change and infectious diseases--impact of global warming and climate change on infectious diseases: myth or reality?

S. Hasnain, J. Hacker, U. Dobrindt, 2012, International journal of medical microbiology : IJMM.

In vivo inactivation of soluble hydrogenase of Alcaligenes eutrophus

B. Friedrich, M. Schlesier, 1981, Archives of Microbiology.

Bias from H2 cleavage to production and coordination changes at the Ni-Fe active site in the NAD+-reducing hydrogenase from Ralstonia eutropha.

P. Hildebrandt, M. Haumann, H. Dau, 2006, Biochemistry.

Hydrogen-induced structural changes at the nickel site of the regulatory [NiFe] hydrogenase from Ralstonia eutropha detected by X-ray absorption spectroscopy.

T. Buhrke, M. Haumann, H. Dau, 2003, Biochemistry.

Amino acid replacements at the H2-activating site of the NAD-reducing hydrogenase from Alcaligenes eutrophus.

B. Friedrich, C. Massanz, 1999, Biochemistry.

A Universal Scaffold for Synthesis of the Fe(CN)2(CO) Moiety of [NiFe] Hydrogenase*

O. Lenz, E. Siebert, I. Zebger, 2012, The Journal of Biological Chemistry.

Aromatic amino acid biosynthesis in Alcaligenes eutrophus H16

B. Friedrich, H. Schlegel, 1975, Archives of Microbiology.

Regulation of assimilatory nitrate reductase formation in Klebsiella aerogenes W70

B. Friedrich, R A Bender, 1990, Journal of bacteriology.

Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus

C. Friedrich, B. Friedrich, H. Schlegel, 1976, Journal of bacteriology.

Regulation of Chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from alcaligenes eutrophus

C. Friedrich, B. Friedrich, H. Schlegel, 1976, Journal of bacteriology.

hoxX (hypX) is a functional member of the Alcaligenes eutrophus hyp gene cluster

T. Buhrke, B. Friedrich, 1998, Archives of Microbiology.

Coping with anoxia: a comprehensive proteomic and transcriptomic survey of denitrification.

D. Zühlke, M. Hecker, A. Otto, 2014, Journal of proteome research.