S. R. Chhabra

发表

The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasR

S. Diggle, K. Winzer, P. Williams, 2003, Molecular microbiology.

Quinolones: from Antibiotics to Autoinducers

S. Diggle, P. Williams, S. Heeb, 2022 .

Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole–linear ion trap mass spectrometry

P. Williams, D. Barrett, C. Ortori, 2007, Analytical and bioanalytical chemistry.

Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

J H Lamb, M K Winson, M. Cámara, 1997, Microbiology.

Versatile Dde-based primary amine linkers for solid phase synthesis

S. R. Chhabra, B. Bycroft, Azra N Khan, 1998 .

Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules

M K Winson, S. Swift, M. Winson, 1997, Journal of bacteriology.

Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.

M K Winson, S. Swift, M. Winson, 1998, FEMS microbiology letters.

A novel amino protection–deprotection procedure and its application in solid phase peptide synthesis

P. Teesdale-Spittle, W. Chan, S. R. Chhabra, 1993 .

Biosynthesis of Carbapenem Antibiotics: New Carbapenam Substrates for Carbapenem Synthase (CarC)

Christopher J Schofield, Barrie Kellam, C. Schofield, 2004, Chembiochem : a European journal of chemical biology.

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.

D. Pritchard, P. Fischer, S. R. Chhabra, 2011, Journal of medicinal chemistry.

Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

S. Fetzner, M. Cámara, P. Williams, 2009, Chemistry & biology.

The immunomodulatory Pseudomonas aeruginosa signalling molecule N‐(3‐oxododecanoyl)‐l‐homoserine lactone enters mammalian cells in an unregulated fashion

D. Pritchard, S. R. Chhabra, A. Ritchie, 2007, Immunology and cell biology.

Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3

D. Pritchard, P. Shaw, S. R. Chhabra, 2004, Oncogene.

Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with downmodulation of STAT3

D. Pritchard, P. Shaw, S. R. Chhabra, 2004, Oncogene.

A Dde-based carboxy linker for solid-phase synthesis

H. Parekh, S. R. Chhabra, B. Bycroft, 2001 .

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

S. Fetzner, R. Kappl, S. R. Chhabra, 2014, Chemistry & biology.

Solid phase strategies: Applications of 2-acetyl-4-nitroindane-1,3-dione as a selective protecting group for primary amines

W. Chan, S. R. Chhabra, B. Bycroft, 1998 .

Solid phase applications of Dde and the analogue Nde: Synthesis of trypanothione disulphide

S. R. Chhabra, B. Bycroft, B. Kellam, 1997 .

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

Kok-Gan Chan, S. Fetzner, S. Heeb, 2015, Environmental microbiology.

Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440

P. Williams, S. Fetzner, S. R. Chhabra, 2011, Applied Microbiology and Biotechnology.

Genome-Wide Transposon Mutagenesis Identifies a Role for Host Neuroendocrine Stress Hormones in Regulating the Expression of Virulence Genes in Salmonella

K. Winzer, P. Williams, S. R. Chhabra, 2009, Journal of bacteriology.

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

P. Williams, J. Emsley, S. Heeb, 2013, PLoS pathogens.

Quorum sensing and Chrornobacteriurn violaceurn : exploitation of violacein production and inhibition for the detection of N-acyl homoserine lactones

McClean, Michael, M. Cámara, 2008 .

RESIN-BOUND DENDRIMERS AS HIGH LOADING SUPPORTS FOR SOLID PHASE CHEMISTRY

W. Chan, S. R. Chhabra, A. Mahajan, 1999 .

Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies.

R. W. Baldwin, M. Garnett, S. R. Chhabra, 1993, Journal of medicinal chemistry.

Convenient syntheses of (3S,5S)-carbapenam-3-carboxylates and their biosynthetic relevance

Barrie W. Bycroft, Barrie Kellam, Paul A. Smith, 2003 .

Reissert compound studies. LXV: Preparation of Reissert compounds derived from α,β-unsaturated acid chlorides

S. R. Chhabra, J. Kant, F. Popp, 1992 .

raiIR Genes Are Part of a Quorum-Sensing Network Controlled by cinI and cinR in Rhizobium leguminosarum

F. Wisniewski-Dyé, J. Downie, J. Jones, 2002, Journal of bacteriology.

Reissert compound chemistry. Part IV. N-acyl pseudo-base formation and stereochemistry

S. R. Chhabra, B. Uff, J. R. Kershaw, 1974 .

Reissert compound chemistry. Part III. Some rearrangement and substitution reactions

S. R. Chhabra, B. Uff, J. R. Kershaw, 1972 .

Reissert compound chemistry: formation of a stable N-acyl pseudo-base

S. R. Chhabra, B. Uff, J. R. Kershaw, 1969 .

Homochiral 4-azalysine building blocks: syntheses and applications in solid-phase chemistry.

W. Chan, S. R. Chhabra, A. Mahajan, 2002, The Journal of organic chemistry.

A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules.

S. Diggle, P. Williams, M. Cámara, 2007, Environmental microbiology.

2-Alkyl-4(1 H )-Quinolone Signalling in Pseudomonas aeruginosa

S. Diggle, P. Williams, S. Heeb, 2010 .

The chemistry of methotrexate and its analogues

S. R. Chhabra, L. K. A. Rahman, 1988, Medicinal research reviews.

Quinolones: from antibiotics to autoinducers

S. Diggle, P. Williams, S. Heeb, 2010, FEMS microbiology reviews.

Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: Co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia

Kok-Gan Chan, Kalai Mathee, Miguel Cámara, 2011, BMC Microbiology.

N-Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus

Philip Hill, P. Williams, M. Cámara, 2006, Infection and Immunity.

Functional genetic analysis reveals a 2-Alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria.

S. Diggle, K. Winzer, P. Williams, 2006, Chemistry & biology.

Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone.

G. Salmond, P. Williams, S. R. Chhabra, 1993, The Journal of antibiotics.

Synthesis of novel, orthogonally protected multifunctional amino acids

W. Chan, S. R. Chhabra, A. Mahajan, 1999 .

A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin

J. Dubern, W. Chan, Ewan Murray, 2022, Cell chemical biology.

The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse

P. Usherwood, T. King, S. R. Chhabra, 1986, Brain Research.

N-Acylhomoserine Lactones Undergo Lactonolysis in a pH-, Temperature-, and Acyl Chain Length-Dependent Manner during Growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

Steve Atkinson, Edwin A. Yates, P. Williams, 2002, Infection and Immunity.

A novel strategy for the isolation of luxl homologues: evidence for the widespread distribution of a LuxR:Luxl superfamily in enteric bacteria

G. Salmond, P. Reeves, S. Swift, 1993, Molecular microbiology.

Theluxautoinducer regulates theproduction of exoenzyme virulence determinants inErwinia carotovora andPseudomonas aeruginosa

G. Salmond, P. Reeves, M. Winson, 1993 .

Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS

Miguel Cámara, David A Barrett, K. Hardie, 2011, Analytical and bioanalytical chemistry.

The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.

Miguel Cámara, S. Diggle, P. Williams, 2007, Chemistry & biology.

Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa.

G. Salmond, M. Bally, M. Cámara, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N‐acylhomoserine lactone signal molecules

M. Cámara, M. Winson, S. R. Chhabra, 1995, Molecular microbiology.

Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors

W. Chan, P. O'shea, Ewan Murray, 2014, Journal of medicinal chemistry.

The Growth Response of Escherichia coli to Neurotransmitters and Related Catecholamine Drugs Requires a Functional Enterobactin Biosynthesis and Uptake System

C. L. Burton, S. Hill, S. Swift, 2002, Infection and Immunity.

The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase.

F. O'Gara, J. Downie, P. Williams, 2000, Microbiology.

Cell density-regulated recovery of starved biofilm populations of ammonia-oxidizing bacteria

J. Prosser, L. A. Glover, P. Williams, 1997, Applied and environmental microbiology.

Differential Immune Modulatory Activity of Pseudomonas aeruginosa Quorum-Sensing Signal Molecules

D. Pritchard, S. R. Chhabra, B. Bycroft, 2004, Infection and Immunity.

N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities.

P. Williams, M. Cámara, P. Oger, 2005, Microbiology.

Extracellular communication in bacteria

Miguel Cámara, Leo Eberl, Paul Williams, 2005 .

Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

D. Pritchard, S. R. Chhabra, M. Daykin, 2003, Journal of medicinal chemistry.

Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics.

M K Winson, G. Salmond, S. Swift, 1992, FEMS microbiology letters.

Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone

M. Cámara, D. Milton, P. Williams, 1997, Journal of bacteriology.

Involvement of N‐acyl‐l‐homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens

S. Molin, L. Eberl, C. Sternberg, 1996, Molecular microbiology.

Solid-phase synthesis of polyamines using a Dde-linker: philanthotoxin-4.3.3 via an on-resin Mitsunobu reaction

S. R. Chhabra, B. Bycroft, Azra N Khan, 2000 .

Novel Nε-lysine protection for the continuous flow SPPS of branched peptides

W. Chan, S. R. Chhabra, B. Bycroft, 1993 .

A novel lysine-protecting procedure for continuous flow solid phase synthesis of branched peptides

W. Chan, S. R. Chhabra, B. Bycroft, 1993 .

A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Erwinia.

G. Salmond, M. Winson, S. R. Chhabra, 1992, Gene.

Expedient synthesis of a novel class of pseudoaromatic amino acids: tetrahydroindazol-3-yl- and tetrahydrobenzisoxazol-3-ylalanine derivatives

W. Chan, S. R. Chhabra, B. Bycroft, 2004 .

The Pseudomonas aeruginosa quorum‐sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, inhibits porcine arterial smooth muscle contraction

M. Cámara, P. Williams, S. R. Chhabra, 1999, British journal of pharmacology.

Solid-phase synthesis of symmetrical and unsymmetrical polyamine analogues of philanthotoxins using a Dde-linker

S. R. Chhabra, B. Bycroft, Azra N Khan, 2000 .

An appraisal of new variants of Dde amine protecting group for solid phase peptide synthesis

Barrie W. Bycroft, W. Chan, P. White, 1998 .

Bacterial Evasion of Host Immune Responses: Bacterial quorum sensing signalling molecules as immune modulators

S. Diggle, D. Pritchard, M. Cámara, 2003 .

In vitro biosynthesis of the Pseudomonas aeruginosa quorum‐sensing signal molecule N‐butanoyl‐L‐homoserine lactone

G. Salmond, K. Hardie, M. Cámara, 1998, Molecular microbiology.

N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity.

P. Williams, S. R. Chhabra, M. Cooley, 2008, Chemistry & biology.

N-(3-oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora.

G. Salmond, P. Williams, S. R. Chhabra, 1992, The Biochemical journal.

Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone

D. Pritchard, I. Todd, P. Williams, 2005, Acta Diabetologica.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus

W. Chan, J. O’Gara, Ewan Murray, 2016, The Journal of antimicrobial chemotherapy.

Nα-Dmc protected amino acid aglycones: versatile hydrogenolysis stable acceptors for O-glycosylation

S. R. Chhabra, B. Kellam, A. Rahim, 2005 .

Recent progress in the design of selectin inhibitors.

S. R. Chhabra, B. Kellam, A. Rahim, 2003, Mini reviews in medicinal chemistry.

The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa.

P. Reeves, S. R. Chhabra, B. Bycroft, 1993, The EMBO journal.

N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1

P. Williams, M. Cámara, P. Oger, 2007, Archives of Microbiology.

6.12 Detection, Purification, and Synthesis of n-acylhomoserine Lactone Quorum Sensing Signal Molecules

M. Cámara, S. R. Chhabra, M. Daykin, 1998 .

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

Kok-Gan Chan, S. Fetzner, S. Heeb, 2015, Environmental microbiology.

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.

D. Pritchard, P. Fischer, S. R. Chhabra, 2011, Journal of medicinal chemistry.

A CONVENIENT SYNTHESIS OF THE NEUROEXCITATORY AMINO ACID QUISQUALIC ACID AND ITS ANALOGS

S. R. Chhabra, B. Bycroft, P. Crowley, 1985 .

A convenient synthesis of the neuroexcitatory amino acid quisqalic acid and its analogues

S. R. Chhabra, B. Bycroft, P. Crowley, 1984 .

N-Acylhomoserine Lactones Undergo Lactonolysis in a pH-, Temperature-, and Acyl Chain Length-Dependent Manner during Growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

P. Williams, M. Cámara, S. Atkinson, 2002, Infection and Immunity.

Haemodynamic effects of the bacterial quorum sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, in conscious, normal and endotoxaemic rats

D. Pritchard, S. Gardiner, T. Bennett, 2001, British journal of pharmacology.