Christina Zimmer

发表

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Michael P. Storz, R. Hartmann, J. D. de Jong, 2012, Journal of the American Chemical Society.

1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.

Qingzhong Hu, R. Hartmann, S. Rau, 2015, European journal of medicinal chemistry.

Design, synthesis and evaluation of novel 16-imidazolyl substituted steroidal derivatives possessing potent diversified pharmacological properties

R. Hartmann, A. Harvey, Christina Zimmer, 2012, Steroids.

Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.

Silvia Gobbi, Maurizio Recanatini, Christina Zimmer, 2010, Journal of medicinal chemistry.

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis

M. Negri, R. Hartmann, Christina Zimmer, 2014, Journal of Molecular Modeling.

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.

Angelo Carotti, Francesco Leonetti, Orazio Nicolotti, 2011, Journal of medicinal chemistry.

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.

F. Belluti, A. Bisi, S. Gobbi, 2016, Journal of medicinal chemistry.

Synthesis of some novel androstanes as potential aromatase inhibitors

R. Hartmann, R. Giridhar, M. Yadav, 2011, Steroids.

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).

Carsten A. Vock, R. Hartmann, Christina Zimmer, 2011, Bioorganic & medicinal chemistry letters.

Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.

M. Negri, R. Hartmann, Christina Zimmer, 2011, Journal of medicinal chemistry.

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.

Ulrike E. Hille, Carsten A. Vock, R. Hartmann, 2011, ACS medicinal chemistry letters.

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

R. Hartmann, J. D. de Jong, Mathias Müsken, 2012, Chemistry & biology.

Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy

R. Hartmann, Christina Zimmer, R. Bansal, 2011, Medicinal Chemistry Research.

Steroidal carbonitriles as potential aromatase inhibitors

R. Hartmann, R. Giridhar, M. Yadav, 2012, Steroids.

Synthesis and Preliminary Screening of Novel A- and D-Ring Modified Steroids as Aromatase Inhibitors

R. Hartmann, R. Giridhar, M. Yadav, 2011 .

Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate

P. Wutzler, A. Henke, Christina Zimmer, 2011, Medical Microbiology and Immunology.

Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.

Qingzhong Hu, R. Hartmann, S. Rau, 2015, European journal of medicinal chemistry.

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

R. Hartmann, J. D. de Jong, R. Müller, 2012, ACS chemical biology.

Targeting Steroidogenic Cytochromes P450 (CYPs) with 6‐Substituted 1‐Imidazolylmethylxanthones

F. Belluti, A. Bisi, S. Gobbi, 2016, ChemMedChem.

Synthesis and biological evaluation of 16E-arylidenosteroids as cytotoxic and anti-aromatase agents.

R. Hartmann, Christina Zimmer, R. Bansal, 2011, Chemical & pharmaceutical bulletin.

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.

R. Hartmann, U. Laufs, M. Böhm, 2015, Journal of molecular and cellular cardiology.

Synthesis of imidazole-derived steroidal hybrids as potent aromatase inhibitors

R. Hartmann, Christina Zimmer, R. Bansal, 2013, Medicinal Chemistry Research.

Synthesis and aromatase inhibitory activity of some new 16E-arylidenosteroids.

R. Hartmann, Christina Zimmer, R. Bansal, 2012, Bioorganic chemistry.

Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.

F. Belluti, A. Bisi, S. Gobbi, 2017, European journal of medicinal chemistry.

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.

Ulrike E. Hille, R. Hartmann, Christina Zimmer, 2011, ACS medicinal chemistry letters.

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Christina Zimmer, A. Steinbach, C. Henn, 2012, ACS chemical biology.