A. Steinbach

发表

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Michael P. Storz, R. Hartmann, J. D. de Jong, 2012, Journal of the American Chemical Society.

Interfering with Bacterial Quorum Sensing

V. Helms, A. Steinbach, K. Reuter, 2016, Perspectives in medicinal chemistry.

The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography.

A. Scheidig, A. Steinbach, C. Klein, 2008, Journal of medicinal chemistry.

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

M. Negri, R. Hartmann, Christine K. Maurer, 2013, BMC biophysics.

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing.

R. Hartmann, Christine K. Maurer, A. Steinbach, 2014, Angewandte Chemie.

Catalytic enzyme activity on a biosensor chip: combination of surface plasmon resonance and mass spectrometry.

R. Hartmann, A. Steinbach, S. Boettcher, 2012, Analytical biochemistry.

Development and validation of a UHPLC-MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors.

R. Hartmann, Christine K. Maurer, A. Steinbach, 2013, Journal of pharmaceutical and biomedical analysis.

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.

Michael P. Storz, M. Negri, R. Hartmann, 2013, Journal of medicinal chemistry.

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.

R. Hartmann, O. Dolezal, C. Ritter, 2013, Journal of medicinal chemistry.

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis

M. Negri, R. Hartmann, Christina Zimmer, 2014, Journal of Molecular Modeling.

Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.

R. Hartmann, C. Lehr, Marc Schneider, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

R. Hartmann, J. D. de Jong, Mathias Müsken, 2012, Chemistry & biology.

Structure–Activity Relationships of 2‐Sufonylpyrimidines as Quorum‐Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa

R. Hartmann, A. Thomann, Christian Brengel, 2016, ChemMedChem.

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures.

Michael P. Storz, R. Hartmann, R. Müller, 2013, ACS chemical biology.

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

R. Hartmann, J. D. de Jong, R. Müller, 2012, ACS chemical biology.

Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure-activity relationships.

R. Hartmann, J. D. de Jong, A. Steinbach, 2014, European journal of medicinal chemistry.

Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa

Volkhard Helms, Rolf W. Hartmann, Nadine S. Schaadt, 2013, BMC Systems Biology.

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.

Michael P. Storz, M. Negri, R. Hartmann, 2013, Journal of medicinal chemistry.

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Christina Zimmer, A. Steinbach, C. Henn, 2012, ACS chemical biology.