C. Kalle

发表

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Gary D Bader, David T. W. Jones, R. Eils, 2014, Nature.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

David T. W. Jones, R. Eils, G. Reifenberger, 2014, Nature.

An unbiased genome-wide analysis of zinc-finger nuclease specificity

Jeffrey C. Miller, P. Gregory, L. Naldini, 2011, Nature Biotechnology.

The German Corona Consensus Dataset (GECCO): a standardized dataset for COVID-19 research in university medicine and beyond

C. von Kalle, K. Heitmann, S. Thun, 2020, BMC Medical Informatics and Decision Making.

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing

Stephan Wolf, Wei Wang, Richard Gabriel, 2010, Nature Protocols.

Molecular Evolution of Ear ly-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories Graphical

Takafumi N. Yamaguchi, R. Eils, J. Korbel, 2018 .

Dissecting the genomic complexity underlying medulloblastoma

Matthew J. Betts, Robert B. Russell, Roland Eils, 2012, Nature.

Lenti in red: progress in gene therapy for human hemoglobinopathies

David A. Williams, C. Baum, C. Kalle, 2004 .

Overdiagnosis of melanoma – causes, consequences and solutions

Roman C. Maron, R. Maron, A. Hekler, 2020, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

Structural requirements of research tissue banks derived from standardized project surveillance

P. Schirmacher, E. Herpel, C. Kalle, 2012, Virchows Archiv.

Gene therapy: Therapeutic gene causing lymphoma

I. Verma, V. Bottero, Manfred Schmidt, 2006, Nature.

Stem Cell Collection and Gene Transfer in Fanconi Anemia.

David A. Williams, J. Cancelas, A. Auerbach, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β‐thalassemia patient

C. Eaves, A. Cheung, S. Fucharoen, 2013, Stem Cells.

Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-identification in Genomic Research

D. Ose, E. Winkler, Sebastian Schleidgen, 2019 .

Gene therapy for Wiskott-Aldrich syndrome-long - Term efficacy and genotoxicity (Science Translational Medicine)

D. Steinemann, A. Schambach, W. Al-Herz, 2014 .

Synergizing genome editing and cancer immunotherapy

R. Gabriel, C. Kalle, Friederike Knipping, 2017 .

706. Retrovirus integration site distribution in long-term gene-corrected hematopoiesis of the SCID-X1 gene therapy clinical trial

A. Fischer, F. Ledeist, M. Cavazzana‐Calvo, 2004 .

Propagation of Hodgkin and Reed-Sternberg Cells

V. Diehl, C. Kalle, U. Kapp, 1995 .

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model

C. Dunbar, P. Hematti, C. Kalle, 2002, Oncogene.

HMGI-C, a member of the high mobility group family of proteins, is expressed in hematopoietic stem cells and in leukemic cells.

P. Rogalla, J. Bullerdiek, C. Kalle, 1997, Leukemia & lymphoma.

Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver.

Manfred Schmidt, M. Penaud-Budloo, C. Kalle, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle (cid:1)

F. Rolling, Manfred Schmidt, M. Penaud-Budloo, 2008 .

Pioneer Vector Integration and Tumorigenesis

Manfred Schmidt, C. Kalle, A. Deichmann, 2014 .

10-Year stability of clinical-grade serum-free γ-retroviral vector-containing medium

H. Glimm, H. Veelken, C. Kalle, 2011, Gene Therapy.

A Model for the Detection of Clonality in Marked Hematopoietic Stem Cells

H. Glimm, Manfred Schmidt, C. Kalle, 2001, Annals of the New York Academy of Sciences.

Hematopoietic Ex Vivo Gene Transfer

R. Mertelsmann, R. Henschler, H. Glimm, 1998 .

Hot spots of retroviral integration in human CD34 (cid:1) hematopoietic cells

Claudia Cattoglio, A. Thrasher, Manfred Schmidt, 2007 .

Analysis of the clonal repertoire of gene-corrected cells in gene therapy.

H. Glimm, Manfred Schmidt, C. Kalle, 2012, Methods in enzymology.

Retrovirus-Mediated Gene Transduction Into Canine Peripheral Blood Repopulating Cells

H. Deeg, R. Storb, F. Appelbaum, 1994 .

rosette-inhibiting factor L428 cells derived from Hodgkin's disease produce E

V. Diehl, U. Wirnitzer, C. Kalle, 2011 .

Position paper: Cornerstones for an ethically and legally informed practice of whole genome sequencing

R. Eils, P. Kirchhof, P. Schirmacher, 2015 .

Initial Results from Study Hgb-206: A Phase 1 Study Evaluating Gene Therapy By Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the Lentiglobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease

J. Tisdale, L. Krishnamurti, A. Thompson, 2015 .

Outcomes of Gene Therapy for Severe Sickle Disease and Beta-Thalassemia Major Via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral Beta AT87Q-Globin Vector

F. Monpoux, B. Neven, Manfred Schmidt, 2015 .

Fragile sites are preferential targets for integrations of MLV vectors in gene therapy

B. Kerem, M. Cavazzana‐Calvo, A. Bester, 2006, Gene Therapy.

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

Clelia Di Serio, Alessandro Ambrosi, Luigi Naldini, 2006, Nature Biotechnology.

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

Yang Du, Manuel Grez, Hanno Glimm, 2006, Nature Medicine.

Efficient Characterization of Retro‐, Lenti‐, and Foamyvector‐Transduced Cell Populations by High‐Accuracy Insertion Site Sequencing

S. Karlsson, H. Glimm, M. Wissler, 2003, Annals of the New York Academy of Sciences.

Mutations in TNFRSF13B Encoding TACI Are Associated With Common Variable Immunodeficiency in Humans

Christine Kinnon, Manfred Schmidt, R. Levinsky, 2006, Pediatrics.

Biffi Metachromatic Leukodystrophy Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits

Gianluigi Zanetti, Luca Biasco, Alessandro Aiuti, 2013 .

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

Hans Martin, Barbara Burwinkel, Rongxi Yang, 2010, Nature Medicine.

Comprehensive genomic access to vector integration in clinical gene therapy

Luca Biasco, Alessandro Aiuti, Richard Gabriel, 2009, Nature Medicine.

High-resolution insertion-site analysis by linear amplification–mediated PCR (LAM-PCR)

Hanno Glimm, Manfred Schmidt, Kerstin Schwarzwaelder, 2007, Nature Methods.

Hot spots of retroviral integration in human CD 34

Claudia Cattoglio, A. Thrasher, Manfred Schmidt, 2007 .

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

B. Aronow, M. Wissler, D. Kohn, 2003, Nature Medicine.

Effective gene therapy with nonintegrating lentiviral vectors

S. E. Barker, Rafael J. Yáñez-Muñoz, J. Heckenlively, 2006, Nature Medicine.

Clinical Outcomes up to 3 Years Following Lentiglobin Gene Therapy for Transfusion-Dependent β-Thalassemia in the Northstar Hgb-204 Study

J. Rasko, E. Vichinsky, G. Schiller, 2017 .

Interim Results from a Phase 1/2 Clinical Study of Lentiglobin Gene Therapy for Severe Sickle Cell Disease

J. Tisdale, L. Krishnamurti, A. Thompson, 2016 .

Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus

K. Zaoui, P. Plinkert, G. Ungerechts, 2011, Cancer Gene Therapy.

Single-Agent Plerixafor Mobilization to Collect Autologous Stem Cells for Use in Gene Therapy for Severe Sickle Cell Disease

Weiliang Shi, J. Tisdale, L. Krishnamurti, 2018 .

MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus

D. Jäger, C. E. Engeland, G. Ungerechts, 2014, Cancer Gene Therapy.

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

Roland Eils, Thomas Zichner, Hans Lehrach, 2013, Nature Genetics.

Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling

S. Fröhling, A. Rosenwald, D. Jäger, 2016, Leukemia.

Copy number determination of genetically-modified hematopoietic stem cells.

E. Grassman, C. Kalle, L. Reeves, 2009, Methods in molecular biology.

A largely random AAV integration profile after LPLD gene therapy

Stephan Wolf, Raffaele Fronza, Hanno Glimm, 2013, Nature Medicine.

Armed and targeted measles virus for chemovirotherapy of pancreatic cancer

E. Rieber, A. Temme, R. Cattaneo, 2011, Cancer Gene Therapy.

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia

A. Jauch, A. Ho, H. Glimm, 2013, British journal of haematology.

The influence of low molecular weight heparin medication on plasma DNA in pregnant women

C. Kalle, E. Prott, M. Stumm, 2015, Prenatal diagnosis.

therapy trial differentiation potential and self-renewal capacity in the SCID-X1 gene Clonal evidence for the transduction of CD34+ cells with lymphomyeloid

A. Fischer, F. Deist, M. Cavazzana‐Calvo, 2013 .

Studying the pathophysiology of coronavirus disease 2019 - a protocol for the Berlin prospective COVID-19 patient cohort (Pa- COVID-19)

F. Tacke, M. Endres, B. Pieske, 2020, medRxiv.

Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors

Raffaele Fronza, Manfred Schmidt, Hanno Glimm, 2014, Nature Medicine.

Tracking Genetically Engineered Lymphocytes Long-Term Reveals the Dynamics of T-Cell Immunological Memory

L. Biasco, R. Fronza, C. Bordignon, 2015 .

Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome.

C. Klein, K. Welte, C. Kalle, 2007 .

Mapping the precision of genome editing

Manfred Schmidt, R. Gabriel, C. Kalle, 2015, Nature Biotechnology.

In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early post-transplant and steady-state reconstitution phases

Samantha, Serio, Victor Neduva, 2018 .

University of Groningen In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases Biasco,

Victor Neduva, E. Wit, L. Biasco, 2022 .

Immunologic, functional and moleculargenetic properties of Hodgkin-derived cell lines

V. Diehl, H. Tesch, C. Kalle, 1988 .

A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging

C. Lilley, M. Weitzman, M. Ozawa, 2006, Cell.

Erratum: Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory (Science Translational Medicine (2015) 7:319 (319er9))

L. Biasco, R. Fronza, C. Bordignon, 2015 .

Lentiglobin Gene Therapy for Transfusion-Dependent β-Thalassemia: Update from the Northstar Hgb-204 Phase 1/2 Clinical Study

J. Rasko, M. Cavazzana‐Calvo, E. Vichinsky, 2016, Blood.

Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy.

A. Fischer, M. Cavazzana‐Calvo, P. Bougnères, 2012, Methods in Enzymology.

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

W. Al-Herz, C. Klein, A. Schwarzer, 2011 .

Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice

Simon N. Waddington, Michael Themis, Manfred Schmidt, 2005 .

Systematic comparative study of computational methods for T‐cell receptor sequencing data analysis

Raffaele Fronza, Manfred Schmidt, Richard Gabriel, 2019, Briefings Bioinform..

Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib® versus TACE plus placebo in patients with hepatocellular cancer before liver transplantation – HeiLivCa [ISRCTN24081794]

C. von Kalle, C. Heining, H. Glimm, 2008, BMC Cancer.

LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Cameron S. Osborne, A. Fischer, C. von Kalle, 2003, Science.

Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.

C. von Kalle, V. Diehl, C. Schoch, 1996, Blood.

hematopoietic progenitor cells in a rhesus macaque Acute myeloid leukemia is associated with retroviral gene transfer to

Young, S. Pittaluga, B. Ryu, 2014 .

Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib versus TACE plus placebo in patients with hepatocellular cancer before liver transplantation - HeiLivCa [ISRCTN24081794].

C. Heining, H. Glimm, P. Schemmer, 2008 .

Lentivirus-induced ‘Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma

C. von Kalle, R. Gutzmer, F. Farzaneh, 2015, Gene Therapy.

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy.

C. von Kalle, H. Allgayer, I. Roeder, 2011, Human gene therapy.

Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma

C. von Kalle, S. Fröhling, R. Eils, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

Kathryn L. Parsley, R. Levinsky, R. Ali, 2004, The Lancet.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

C. von Kalle, A. Fischer, Claudia Cattoglio, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

DRUG PERTURBATION BASED STRATIFICATION OF LYMPHOPROLIFERATIVE DISORDERS

C. Plass, S. Anders, D. Rossi, 2017 .

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.

C. von Kalle, A. Nienhuis, C. A. Blau, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Preliminary report: growth of Hodgkin's lymphoma derived cells in immune compromised mice.

C. von Kalle, V. Diehl, C. Fonatsch, 1992, Annals of oncology : official journal of the European Society for Medical Oncology.

Reactogenicity of homologous and heterologous prime-boost immunization with BNT162b2 and ChAdOx1-nCoV19: a prospective cohort study

N. Suttorp, D. Treue, V. Corman, 2021, medRxiv.

Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

C. von Kalle, C. Eaves, T. Holyoake, 2001, The Journal of clinical investigation.

and insertional genotoxicity Cell culture assays reveal the importance of retroviral vector design for

Christof von Kalle, Christopher Baum, Ute Modlich, 2006 .

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.

Christine Kinnon, Christof von Kalle, Dick de Ridder, 2007, The Journal of clinical investigation.

Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples.

C. von Kalle, D. Williams, S. Ragg, 2001, Human gene therapy.

Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency

Rafael J. Yáñez-Muñoz, C. von Kalle, P. Gregory, 2018, Scientific Reports.

345. Sensitive Molecular Detection of Various Stable Episomal Concatemeric and Integrated Forms of rAAV2 after Long-Term Expression In Vivo

H. Glimm, K. Zaoui, K. High, 2004 .

Modeling and Increasing the Genome Accessibility of Viral Integration Sites

Alessandro Aiuti, Steven J. Howe, Robin R. Ali, 2009 .

Still a long way to go to achieve multidisciplinarity for the benefit of patients: commentary on the ESMO position paper (Annals of Oncology 25(1): 9-15, 2014).

A. Torresin, A. Chiti, T. Saarto, 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

Thymus-autonomous T cell development in the absence of progenitor import

Susan M. Schlenner, C. Kalle, Vera C. Martins, 2012 .

Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease.

C. von Kalle, M. Jücker, H. Merz, 1991, Blood.

Integration Frequency and Intermolecular Recombination of rAAV Vectors in Non-human Primate Skeletal Muscle and Liver.

Christof von Kalle, Manfred Schmidt, C. von Kalle, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

The cell of origin in Hodgkin's disease.

C. von Kalle, V. Diehl, H. Tesch, 1990, Seminars in oncology.

L428 cells derived from Hodgkin's disease produce E rosette-inhibiting factor.

C. von Kalle, V. Diehl, U. Wirnitzer, 1990, Blood.

Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs.

C. von Kalle, C. A. Blau, H. Kiem, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

LYMPHOID NEOPLASIA Recurrent CDKN1B (p27) mutations in hairy cell leukemia

A. Jauch, B. Hutter, B. Brors, 2022 .

Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy.

A. Fischer, M. Cavazzana‐Calvo, P. Bougnères, 2012, Methods in enzymology.

Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells.

C. von Kalle, H. Deeg, F. Appelbaum, 1994, Blood.