A. Agrawal

发表

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

C. Will, R. Lührmann, Peter G. Smith, 2018, Molecular cell.

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.

M. Warmuth, Shouyong Peng, K. Kunii, 2015, Cell reports.

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Arun K. Ghosh, M. Jurica, N. Larsen, 2021, Nature Communications.

Structural Basis of Splicin g Modulation by Antitumor Macrolide Compounds Graphical Abstract Highlights

C. Will, Peter G. Smith, N. Larsen, 2022 .

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

M. Warmuth, Shouyong Peng, O. Abdel-Wahab, 2018, Nature Medicine.

Targeting splicing abnormalities in cancer.

Peter G. Smith, Lihua Yu, S. Buonamici, 2018, Current opinion in genetics & development.

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Qiang Zhou, Peter G. Smith, P. Zhu, 2018, Genes & development.

Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients.

J. Byrd, M. Warmuth, A. Johnson, 2017, Blood advances.

The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease.

A. Agrawal, A. Goyal, A. Verma, 2022, Experimental and molecular pathology.

Syntheses, crystal structures, topology and dual electronic behaviors of a family of amine-templated three- dimensional zinc-organophosphonate hybrid solids

A. Gaur, A. Agrawal, Tanmay Rom, 2022, Journal of Molecular Structure.

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Ping Zhu, Michael Seiler, Lihua Yu, 2018, Cell reports.

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

D. Kent, E. Papaemmanuil, N. Bolli, 2016, Leukemia.

Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA

A. Agrawal, J. Jenkins, C. Kielkopf, 2014, Proceedings of the National Academy of Sciences.

Escholarship@umms Program in Gene Function and Expression Publications and Presentations Program in Gene Function and Expression U2af65 Adapts to Diverse Pre-mrna Splice Sites through Conformational Selection of Specific and Promiscuous Rna Recognition Motifs Repository Citation U2af65 Adapts to Div

Michael R. Green, Ankit Gupta, A. Agrawal, 2022 .

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

Michael R. Green, Ankit Gupta, A. Agrawal, 2013, Nucleic acids research.

Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.

Shouyong Peng, P. Zhu, Lihua Yu, 2020, Cell chemical biology.

An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

Michael R. Green, A. Agrawal, J. Jenkins, 2016, Nature Communications.

Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.

Eliezra Glasser, A. Agrawal, J. Jenkins, 2017, Biochemistry.

Reprogramming RNA processing: an emerging therapeutic landscape.

M. Seiler, A. Agrawal, D. Reynolds, 2022, TIPS - Trends in Pharmacological Sciences.