J. Hildebrandt

发表

Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins.

R. Iyengar, M. Caron, R. Lefkowitz, 1985, Recent progress in hormone research.

Receptor Docking Sites for G-protein βγ Subunits

J. Benovic, Guangyu Wu, J. Hildebrandt, 1998, The Journal of Biological Chemistry.

Analysis of signal transfer from receptor to Go/Gi in different membrane environments and receptor-independent activators of brain G protein.

J. Hildebrandt, C. Ribas, S. Lanier, 2002, Methods in enzymology.

Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly.

J. Hildebrandt, C. A. Wells, J. Dingus, 2006, The Journal of biological chemistry.

Identification of Gβγ Binding Sites in the Third Intracellular Loop of the M3-muscarinic Receptor and Their Role in Receptor Regulation*

J. Benovic, Guangyu Wu, J. Hildebrandt, 2000, The Journal of Biological Chemistry.

Aquaporin 0-calmodulin interaction and the effect of aquaporin 0 phosphorylation.

K. Schey, E. Hazard, Zhen Wang, 2008, Biochemistry.

The Relationship of Goα Subunit Deamidation to the Tissue Distribution, Nucleotide Binding Properties, and βγ Dimer Interactions of Goα Subunit Isoforms

J. Hildebrandt, W. McIntire, J. Dingus, 1999 .

A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor.

Roneka L Ravenell, J. Cleator, J. Hildebrandt, 2004, The Journal of biological chemistry.

Effect of ras-gene transformation on the inhibition of NIH3T3 cell growth by pertussis toxin.

J. Hildebrandt, L. Lederman, D. Steffen, 1991, Molecular endocrinology.

Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase.

L. Birnbaumer, J. Hildebrandt, 1983, The Journal of biological chemistry.

Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins

R. Iyengar, L. Birnbaumer, J. Codina, 1983, Nature.

A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors

L. Feig, J. Hildebrandt, C. Farnsworth, 1991, Molecular and cellular biology.

Alterations in macrophage G proteins are associated with endotoxin tolerance.

M. Makhlouf, P. Halushka, J. Cook, 1996, Biochimica et biophysica acta.

Factors Determining Specificity of Signal Transduction by G-protein-coupled Receptors

J. Hildebrandt, S. Lanier, M. Sato, 1995, The Journal of Biological Chemistry.

Characterization of a G-protein Activator in the Neuroblastoma-Glioma Cell Hybrid NG108-15*

J. Hildebrandt, C. Ribas, S. Lanier, 1996, The Journal of Biological Chemistry.

Hormonal Regulation of Adenylyl Cyclase Activity

R. Iyengar, L. Birnbaumer, M. Hunzicker-Dunn, 1984 .

The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor.

J. Hildebrandt, M. Castresana, W. Newman, 1994, Endocrinology.

STRUCTURAL AND FUNCTIONAL PROPERTIES OF NS AND Ni, THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES*

L. Birnbaumer, W. Rosenthal, J. Codina, 1985 .

Structural and regulatory properties of nucleotide binding regulatory N proteins of adenylate cyclase and their effects on hormone receptors

L. Birnbaumer, W. Rosenthal, R. Mattera, 1984 .

Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.

J. Hanoune, L. Birnbaumer, J. Hildebrandt, 1982, The Journal of biological chemistry.

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.

R. Iyengar, L. Birnbaumer, J. Codina, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Hormonal Inhibition of Adenylyl Cyclase by αi and βγ, αi orβγ, αi and/or βγ

J. Hildebrandt, 1993 .

Model of Signal Transduction by G Proteins

R. Iyengar, A. Brown, L. Birnbaumer, 1990 .

Pertussis toxin alters the growth characteristics of Swiss 3T3 cells

J. Hildebrandt, E. Stolzenberg, Jeanine Graves, 1986, FEBS letters.

Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.

R. Risinger, L. Birnbaumer, J. Codina, 1984, The Journal of biological chemistry.

The N54 mutant of Gαs has a conditional dominant negative phenotype which suppresses hormone‐stimulated but not basal cAMP levels

J. Cleator, J. Hildebrandt, D. T. Kurtz, 1999, FEBS letters.

Separation and analysis of G protein gamma subunits.

K. Schey, J. Hildebrandt, J. Dingus, 2002, Methods in enzymology.

Bovine Brain GO Isoforms Have Distinct γ Subunit Compositions (*)

K. Schey, J. Hildebrandt, W. McIntire, 1995, The Journal of Biological Chemistry.

Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands.

L. Birnbaumer, W. Rosenthal, J. Codina, 1985, Methods in enzymology.

Updated protocols and comments on the purification without use of activating ligands of the coupling proteins Ns and Ni of the hormone sensitive adenylyl cyclase.

L. Birnbaumer, W. Rosenthal, J. Codina, 1984, Journal of receptor research.

Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos.

J. Hildebrandt, C. Ziomek, A. Allworth, 1990, Developmental biology.

Sequence Dependence and Differential Expression of Gγ5 Subunit Isoforms of the Heterotrimeric G Proteins Variably Processed after Prenylation in Mammalian Cells*

E. Kilpatrick, J. Hildebrandt, 2007, Journal of Biological Chemistry.

G protein subunit interactions. Studies with biotinylated G protein subunits.

J. Hildebrandt, R. Kohnken, 1989, The Journal of biological chemistry.

A Mutation in the Putative Mg2"-Binding Site of Gs (x Prevents Its Activation by Receptors

L. Feig, J. Hildebrandt, C. Farnsworth, 2022 .

Bring Your Own G Protein

J. Hildebrandt, 2006, Molecular Pharmacology.

Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.

J. Hildebrandt, R. Kohnken, 1990, The Journal of biological chemistry.

Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni).

R. Iyengar, J. Codina, J. Hildebrandt, 1984, The Journal of biological chemistry.

G-proteins | Gq Family

Wanling Yang, J. Hildebrandt, J. Schaffer, 2021, Encyclopedia of Biological Chemistry III.

G q Family

J. Hildebrandt, W. Yang, W. Yang, 2013 .

Intrathyroidally generated iodide: its measurement and origins.

N. Halmi, J. Hildebrandt, J. Scranton, 1979, Endocrinology.

Interaction of the stimulatory and inhibitory regulatory proteins of the adenylyl cyclase system with the catalytic component of cyc-S49 cell membranes.

L. Birnbaumer, J. Codina, J. Hildebrandt, 1984, The Journal of biological chemistry.

Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry.

M. Busman, K. Schey, J. Hildebrandt, 1995, Biochemical and biophysical research communications.

Analysis of G protein gamma subunit heterogeneity using mass spectrometry.

J. W. Finch, M. Halushka, K. Schey, 1994, Journal of Biological Chemistry.

Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties.

R. Iyengar, E. Landau, J. Hildebrandt, 1991, The Journal of biological chemistry.

Preparation and antibacterial activities of new 1,2,3-diazaborine derivatives and analogues.

J. Hildebrandt, M A Grassberger, F Turnowsky, 1984, Journal of medicinal chemistry.

Immunostimulatory, but not antiendotoxin, activity of lipid X is due to small amounts of contaminating N,O-acylated disaccharide-1-phosphate: in vitro and in vivo reevaluation of the biological activity of synthetic lipid X

B. Rosenwirth, P. Stütz, R. Proctor, 1991, Infection and immunity.

Heterogeneous Prenyl Processing of the Heterotrimeric G protein Gamma Subunits

J. Hildebrandt, 2011 .

Identification of a region in G protein γ subunits conserved across species but hypervariable among subunit isoforms

K. Schey, J. Cleator, J. Hildebrandt, 2001, Protein science : a publication of the Protein Society.

Role of subunit diversity in signaling by heterotrimeric G proteins.

J. Hildebrandt, John D. Hildebrandt, 1997, Biochemical pharmacology.

Membrane-disorganizing property of polymyxin B nonapeptide.

J. Hildebrandt, A. Wenzel, C. Lam, 1986, The Journal of antimicrobial chemotherapy.

Syntheses and biological activities of new penem derivatives with side chains derived from 4-hydroxyproline.

P. Stütz, J. Hildebrandt, A. Wenzel, 1985, The Journal of antibiotics.

The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases.

L. Birnbaumer, J. Tash, J. Codina, 1985, Endocrinology.

Prediction of the role of granulocyte-macrophage colony-stimulating factor in animals and man from in vitro results

J. Hildebrandt, E. Liehl, C. Lam, 2005, European Journal of Clinical Microbiology and Infectious Diseases.

Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies.

Wanling Yang, J. Hildebrandt, E. Spicer, 2004, Pharmacogenetics.

SDZ MRL 953, a novel immunostimulatory monosaccharidic lipid A analog with an improved therapeutic window in experimental sepsis

P. Stütz, J. Hildebrandt, I. Macher, 1991, Antimicrobial Agents and Chemotherapy.

Induction of early gene expression in murine macrophages by synthetic lipid A analogs with differing endotoxic potentials

C. Manthey, S. Vogel, P. Stütz, 1993, Infection and immunity.

Highly purified lipid X is devoid of immunostimulatory activity. Isolation and characterization of immunostimulating contaminants in a batch of synthetic lipid X.

J. Hildebrandt, H. Aschauer, E. Schuetze, 1990, The Journal of biological chemistry.

ADP-ribosylation of membrane components by pertussis and cholera toxin.

L. Birnbaumer, R. Mattera, J. Codina, 1985, Methods in enzymology.

Synthesis and assembly of G protein βγ dimers: comparison of in vitro and in vivo studies.

J. Hildebrandt, Jane Dingus, John D Hildebrandt, 2012, Sub-cellular biochemistry.

Structural characterization of intact G protein gamma subunits by mass spectrometry.

H. Hamm, M. Busman, K. Schey, 2002, Methods in enzymology.

Ion trap tandem mass spectrometry of intact GTP-binding protein γ-subunits

K. Schey, J. Hildebrandt, L. A. Cook, 2001 .

Mechanisms in the vectorial receptor-adenylate cyclase signal transduction.

R. Iyengar, L. Birnbaumer, J. Codina, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

Intrathyroidally generated iodide: the role of transport in its utilization.

N. Halmi, J. Hildebrandt, 1981, Endocrinology.

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

R. Iyengar, J. Bryan, L. Birnbaumer, 1984, The Journal of biological chemistry.

Characterization of the major bovine brain Go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions.

K. Schey, J. Hildebrandt, W. McIntire, 1998, The Journal of biological chemistry.

Distinct guanine nucleotide binding and release properties of the three Gi proteins.

R. Iyengar, L. Birnbaumer, J. Codina, 1990, The Journal of biological chemistry.

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

E. Neer, L. Birnbaumer, M. Bitensky, 1985, The Journal of biological chemistry.

The N54-αs Mutant Has Decreased Affinity for βγ and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation

J. Cleator, J. Hildebrandt, D. T. Kurtz, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Proteomic Analysis of Bovine Brain G Protein γ Subunit Processing Heterogeneity*S

K. Schey, D. Knapp, J. Hildebrandt, 2006, Molecular & Cellular Proteomics.

Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

L. Birnbaumer, J. Codina, J. Hildebrandt, 1984, The Journal of biological chemistry.

Role of the Chaperonin CCT/TRiC Complex in G Protein βγ-Dimer Assembly*

J. Hildebrandt, J. Dingus, Christopher A. Wells, 2006, Journal of Biological Chemistry.

Genomic analysis of G protein γ subunits in human and mouse - The relationship between conserved gene structure and G protein βγ dimer formation

Wanling Yang, J. Hildebrandt, 2006 .

Genomic analysis of G protein gamma subunits in human and mouse - the relationship between conserved gene structure and G protein betagamma dimer formation.

Wanling Yang, J. Hildebrandt, 2006, Cellular signalling.

γ2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate

Theodore R. McRackan, K. Schey, J. Hildebrandt, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Pertussis Toxin-insensitive Activation of the Heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein Activator*

J. Hildebrandt, A. Takesono, C. Ribas, 2002, The Journal of Biological Chemistry.

Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells.

S. Treistman, J. Hildebrandt, N. Mehta, 1995, Molecular pharmacology.

G Protein βγ Dimer Formation: Gβ and Gγ Differentially Determine Efficiency of in Vitro Dimer Formation†

J. Cleator, J. Hildebrandt, K. Robinson, 2005 .

Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation.

J. Benovic, J. Hildebrandt, G. Bogatkevich, 2000, The Journal of biological chemistry.

Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation.

J. Benovic, J. Hildebrandt, S. Lanier, 1998, Journal of Biological Chemistry.

Intrathyroidally generated iodide: the role of propylthiouracil-sensitive processes in its production.

N. Halmi, J. Hildebrandt, 1980, Endocrinology.

Synthesis and use of biotinylated beta gamma complexes prepared from bovine brain G proteins.

J. Hildebrandt, J. Dingus, M. Wilcox, 1994, Methods in Enzymology.

Gβ Subunit Interacts with a Peptide Encoding Region 956-982 of Adenylyl Cyclase 2

R. Iyengar, H. Weinstein, J. Hildebrandt, 1996, The Journal of Biological Chemistry.

A major G protein alpha O isoform in bovine brain is deamidated at Asn346 and Asn347, residues involved in receptor coupling.

K. Schey, D. Knapp, J. Hildebrandt, 1998, Biochemistry.

A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases.

R. Iyengar, H. Weinstein, F. Guarnieri, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Proteomic analysis of bovine brain G protein gamma subunit processing heterogeneity.

K. Schey, D. Knapp, J. Hildebrandt, 2006, Molecular & Cellular Proteomics.

A Dominant Negative Gαs Mutant That Prevents Thyroid-stimulating Hormone Receptor Activation of cAMP Production and Inositol 1,4,5-Trisphosphate Turnover

J. Cleator, J. Hildebrandt, D. T. Kurtz, 2004, Journal of Biological Chemistry.

Bovine brain GO isoforms have distinct gamma subunit compositions.

K. Schey, J. Hildebrandt, W. McIntire, 1995, Journal of Biological Chemistry.

Characterization of deamidated G protein subunits.

K. Schey, D. Knapp, J. Hildebrandt, 2002, Methods in enzymology.