T. Sunyer

发表

Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins.

R. Iyengar, M. Caron, R. Lefkowitz, 1985, Recent progress in hormone research.

Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorption.

T. Sunyer, P. Collin‐Osdoby, P. Osdoby, 1997, Endocrinology.

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

A. Benko, Y. Kawasawa, N. Olsen, 2018, Clinical and experimental immunology.

Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro.

A. Benko, Y. Kawasawa, N. Olsen, 2019, Clinical immunology.

Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene.

T. Sunyer, N. Sahyoun, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells.

J. Lewis, T. Sunyer, P. Collin‐Osdoby, 1999, The Journal of clinical investigation.

Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells

T. Sunyer, P. Collin‐Osdoby, Jennifer J Lewis, 1999 .

T. Sunyer, P. Collin‐Osdoby, P. Osdoby, 1997, Endocrinology.

STRUCTURAL AND FUNCTIONAL PROPERTIES OF NS AND Ni, THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES*

L. Birnbaumer, W. Rosenthal, J. Codina, 1985 .

Structural and regulatory properties of nucleotide binding regulatory N proteins of adenylate cyclase and their effects on hormone receptors

L. Birnbaumer, W. Rosenthal, R. Mattera, 1984 .

Proinflammatory agents, IL‐8 and IL‐10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast‐like cells

T. Sunyer, P. Collin‐Osdoby, P. Osdoby, 1996, Journal of cellular biochemistry.

GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.

L. Birnbaumer, J. Codina, T. Sunyer, 1984, The Journal of biological chemistry.

Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8.

L. Chaudhary, L. Avioli, S. Goldring, 1998, Endocrinology.

Studies on nucleotide and receptor regulation of Gi proteins: effects of pertussis toxin.

L. Birnbaumer, J. Codina, T. Sunyer, 1989, Molecular endocrinology.

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.

O. Nemirovskiy, T. Sunyer, T. P. Misko, 2009, Nitric oxide : biology and chemistry.

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.

Dean M. Messing, A. Bendele, O. Nemirovskiy, 2010, Arthritis and rheumatism.

Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis.

M. Hellio le Graverand, O. Nemirovskiy, T. Sunyer, 2008, Osteoarthritis and cartilage.

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

R. Gay, S. Gay, C. Flory, 2009, Annals of the rheumatic diseases.

Extended Report

R. Gay, S. Gay, C. Flory, 2022 .

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.

O. Nemirovskiy, T. Sunyer, D. Dufield, 2007, Analytical biochemistry.

Pituitary neuropeptides and B lymphocyte function

A. Benko, N. Olsen, T. Sunyer, 2021, Scandinavian journal of immunology.

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Ying Yu, Gary A Decrescenzo, James R Kiefer, 2010, Journal of medicinal chemistry.

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

R. D. Dyer, Adam R. Johnson, K. Aston, 2010, Bioorganic & medicinal chemistry letters.

Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.

Dean M. Messing, J. Collins, Michelle A. Schmidt, 2016, Journal of medicinal chemistry.

Cell type‐ and differentiation‐dependent expression from the mouse acetylcholine receptor ϵ‐subunit promoter

J. Merlie, T. Sunyer, J. Merlie, 1993 .

Mechanisms in the vectorial receptor-adenylate cyclase signal transduction.

R. Iyengar, L. Birnbaumer, J. Codina, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis.

R. Buck, K. Brandt, S. Mazzuca, 2006, Osteoarthritis and cartilage.

Pharmacokinetic/pharmacodynamic (PK/PD) differentiation of native and PEGylated recombinant human growth hormone (rhGH and PEG-rhGH) in the rat model of osteoarthritis

O. Nemirovskiy, T. Sunyer, D. Aguiar, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis

H C Charles, F Eckstein, D J Hunter, 2011, Annals of the rheumatic diseases.

Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar®) on human B cells in vitro

A. Benko, N. Olsen, T. Sunyer, 2021, Journal of Neuroimmunology.

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.

O. Nemirovskiy, T. Sunyer, T. P. Misko, 2009, Nitric oxide : biology and chemistry.

Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain

T. Sunyer, J. Connor, P. Manning, 2012 .