Xin Lin

发表

Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.

Jiang Bian, Yi-Qi Liu, Jie He, 2021, European journal of medicinal chemistry.

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site*

Li Lei, Bin Zhao, S. Kelly, 2009, The Journal of Biological Chemistry.

CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.

Xin Lin, S. Queener, A. Gangjee, 2010, Bioorganic & medicinal chemistry.

Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation.

Guoshun Luo, H. Xiang, Xin Lin, 2021, Journal of medicinal chemistry.

Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance.

Guoshun Luo, H. Xiang, Xin Lin, 2020, European journal of medicinal chemistry.

Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia.

J. Bian, Chao Peng, Jie He, 2021, Journal of medicinal chemistry.

Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.

Shuangjie Wu, Shengnan Ren, Guoshun Luo, 2021, European journal of medicinal chemistry.

Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation.

Guoshun Luo, H. Xiang, Xin Lin, 2021, Bioorganic chemistry.

Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.

Guoshun Luo, H. Xiang, Xin Lin, 2020, European journal of medicinal chemistry.

Novel 11β-substituted estradiol conjugates: Transition from ERα agonizts to effective PROTAC degraders

Guoshun Luo, H. Xiang, Xin Lin, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.

D. Cane, Chieh-Mei Wang, Xin Lin, 2009, Journal of the American Chemical Society.

Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

Xiaohong Song, Xin Lin, A. Gangjee, 2006, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Xin Lin, S. Queener, A. Gangjee, 2004, Journal of medicinal chemistry.

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as

Xin Lin, A. Gangjee, J. McGuire, 2005, Journal of medicinal chemistry.

CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.

Xin Lin, A. Gangjee, Aleem Gangjee, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2.

Q. You, Guoshun Luo, H. Xiang, 2019, European journal of medicinal chemistry.

Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer.

Chengfeng Bai, Guoshun Luo, H. Xiang, 2020, Bioorganic & medicinal chemistry.

Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.

Tiangang Liu, Zixin Deng, Z. Deng, 2008, Chemistry & biology.

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules.

Guoshun Luo, H. Xiang, Xin Lin, 2019, European journal of medicinal chemistry.

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.

V. Cody, Xin Lin, S. Queener, 2018, Bioorganic & medicinal chemistry.

Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.

D. Cane, Xin Lin, Russell Hopson, 2006, Journal of the American Chemical Society.

Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi‐isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi‐isozizaene metabolite

M. Komatsu, H. Ikeda, D. Cane, 2011, Microbial biotechnology.

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone

Xin Lin, 2009 .

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)*

S. Kelly, D. Lamb, D. Cane, 2008, Journal of Biological Chemistry.

Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates.

D. Cane, D. Christianson, Xin Lin, 2010, Biochemistry.

Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor. Mechanism and stereochemistry of the enzymatic formation of epi-isozizaene.

D. Cane, Xin Lin, 2009, Journal of the American Chemical Society.

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Guoshun Luo, H. Xiang, Xin Lin, 2020, Acta pharmaceutica Sinica. B.

Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system.

J. Bian, Xin Lin, Wen-Bo Yu, 2020, Bioorganic & medicinal chemistry.

RNA-binding protein RBM28 can translocate from the nucleolus to the nucleoplasm to inhibit the transcriptional activity of p53

Yuanzhong Wu, Ruhua Zhang, T. Kang, 2021, The Journal of biological chemistry.

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Xin Lin, S. Queener, A. Gangjee, 2003 .

7-Methyl Trimethoprim Analogues as Inhibitors of the Folate Metabolizing Enzymes.

Xin Lin, S. Queener, A. Gangjee, 2003 .

Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris.

L. Guddat, T. Lonhienne, J. Fraser, 2020, ACS infectious diseases.

Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase.

L. Guddat, T. Lonhienne, W. M. Hussein, 2020, Chemistry.

Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.

D. Cane, Chieh-Mei Wang, Xin Lin, 2009, Journal of the American Chemical Society.