C. Fernández

发表

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein.

C. Griesinger, T. Jovin, C. Bertoncini, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

S. Becker, K. Giller, M. Zweckstetter, 2014, Nature Communications.

Comparing the copper binding features of alpha and beta synucleins.

G. Castañeda-Hernández, F. González, C. Fernández, 2022, Journal of inorganic biochemistry.

Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.

M. Zweckstetter, Annekatrin König, T. Outeiro, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Effects of alpha‐synuclein post‐translational modifications on metal binding

Annekatrin König, T. Outeiro, N. González, 2019, Journal of neurochemistry.

Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

C. Griesinger, M. Zweckstetter, C. Fernández, 2017, Inorganic chemistry.

Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations.

P. Carloni, E. Abad, F. Musiani, 2016, Physical chemistry chemical physics : PCCP.

Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.

C. Griesinger, T. Jovin, A. Binolfi, 2006, Journal of the American Chemical Society.

Molecular Dynamics-Assisted Interpretation of Experimentally Determined Intrinsically Disordered Protein Conformational Components: The Case of Human α-Synuclein.

P. Carloni, R. Grandori, G. Rossetti, 2022, The journal of physical chemistry. B.

Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations

S. Eimer, P. Carloni, C. Griesinger, 2022, Protein science : a publication of the Protein Society.

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

S. Becker, A. Camacho-Zarco, M. Zweckstetter, 2017, Chemistry.

Aroylhydrazones constitute a promising class of ‘metal-protein attenuating compounds’ for the treatment of Alzheimer’s disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone

A. D. Falco, C. Fernández, Mauricio Lanznaster, 2018, JBIC Journal of Biological Inorganic Chemistry.

Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation.

C. Griesinger, A. Binolfi, C. Bertoncini, 2007, Journal of molecular biology.

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics

P. Carloni, S. Ventura, G. Rossetti, 2017, Communicative & integrative biology.

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features.

C. Griesinger, M. Zweckstetter, N. González, 2018, Metallomics : integrated biometal science.

Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding.

P. Carloni, C. Griesinger, A. Binolfi, 2015, Journal of the American Chemical Society.

New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in Alzheimer's disease.

Y. Cordeiro, C. Fernández, R. Diniz, 2022, Journal of inorganic biochemistry.

Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(ii) coordination at its His111 site.

C. Fernández, L. Quintanar, C. Sánchez‐López, 2018, Dalton transactions.

Axial ligand modulation of the electronic structures of binuclear copper sites: analysis of paramagnetic 1H NMR spectra of Met160Gln Cu(A).

H. Gray, J. Richards, C. Fernández, 2001, Journal of the American Chemical Society.

Bioinorganic chemistry of synucleinopathies: deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions.

C. Griesinger, A. Binolfi, M. Zweckstetter, 2014, Journal of inorganic biochemistry.

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

F. González, A. Vela, C. Fernández, 2016, JBIC Journal of Biological Inorganic Chemistry.

Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.

C. Griesinger, T. Jovin, C. Bertoncini, 2005, Journal of Biological Chemistry.

X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.

T. Outeiro, C. Fernández, R. Diniz, 2020, Dalton transactions.

Probing the metal site in Rhus vernicifera stellacyanin by Ni(II) substitution and paramagnetic NMR spectroscopy

A. Sannazzaro, C. Fernández, A. Vila, 1998 .

Binucleating Hydrazonic Ligands and Their μ-Hydroxodicopper(II) Complexes as Promising Structural Motifs for Enhanced Antitumor Activity.

M. Menacho-Márquez, C. Fernández, Chris H. J. Franco, 2019, Inorganic chemistry.

A. D. Falco, C. Fernández, Mauricio Lanznaster, 2018, JBIC Journal of Biological Inorganic Chemistry.

Copper Coordination Features of Human Islet Amyloid Polypeptide: The Type 2 Diabetes Peptide.

Jorge M Del Campo, A. Binolfi, C. Fernández, 2016, Inorganic chemistry.

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

C. Griesinger, A. Binolfi, C. Bertoncini, 2012 .

Structural Information through NMR Hyperfine Shifts in Blue Copper Proteins

I. Bertini, C. Luchinat, A. Nersissian, 2000 .

Metal-ligand interplay in blue copper proteins studied by 1H NMR spectroscopy: Cu(II)-pseudoazurin and Cu(II)-rusticyanin.

T. Kohzuma, R. Pierattelli, C. Fernández, 2002, Journal of the American Chemical Society.

Paramagnetic NMR of Electron Transfer Copper Proteins

C. Fernández, A. Vila, 2003 .

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.

C. Griesinger, T. Jovin, D. Cherny, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Structural properties of pore-forming oligomers of alpha-synuclein.

R. Benz, H. Lashuel, S. Becker, 2009, Journal of the American Chemical Society.

Probing the interaction between N(1),N(4)-dibenzylputrescine and tRNA through (15)N NMR: biological implications.

C. Fernández, G. Buldain, K. Samejima, 2000, Biochimica et biophysica acta.

Interactions between natural polyamines and tRNA: an 15N NMR analysis.

L. Frydman, V. Frydman, B. Frydman, 1992, Proceedings of the National Academy of Sciences of the United States of America.

A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.

J. Landeira-Fernández, R. Hauser-Davis, T. Outeiro, 2017, Journal of inorganic biochemistry.

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

C. Griesinger, A. Binolfi, M. Zweckstetter, 2014, Inorganic chemistry.

Backbone Dynamics of Plastocyanin in Both Oxidation States

I. Bertini, C. Luchinat, S. Ciurli, 2001, The Journal of Biological Chemistry.

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

G. Halliday, S. Becker, W. Kim, 2019, Nature Communications.

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

A. Binolfi, D. Papy-Garcia, Leandro R. S. Barbosa, 2017, Scientific Reports.

Long-range correlated dynamics in intrinsically disordered proteins.

Christian Griesinger, Andrea Giachetti, Martin Blackledge, 2014, Journal of the American Chemical Society.

Spectroscopic and Theoretical Study of CuI Binding to His111 in the Human Prion Protein Fragment 106–115

K. Hodgson, Lina Rivillas-Acevedo, B. Hedman, 2016, Inorganic chemistry.

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

E. Masliah, P. Aebischer, H. Lashuel, 2010, The Journal of Neuroscience.

Structural characterization of α‐synuclein in an aggregation prone state

Martin Blackledge, Stefan Becker, Pau Bernado, 2009, Protein science : a publication of the Protein Society.

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein*

P. Lansbury, H. Lashuel, D. Eliezer, 2008, Journal of Biological Chemistry.

Metal coordination and peripheral substitution modulate the activity of cyclic tetrapyrroles on αS aggregation: a structural and cell-based study

C. Griesinger, N. González, C. Fernández, 2019, JBIC Journal of Biological Inorganic Chemistry.

Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.

Dietmar Riedel, Markus Zweckstetter, D. Riedel, 2008, Angewandte Chemie.

Correlation of Amyloid Fibril β‐Structure with the Unfolded State of α‐Synuclein

M. Zweckstetter, M. Baldus, H. Heise, 2007, Chembiochem : a European journal of chemical biology.

Conserved core of amyloid fibrils of wild type and A30P mutant α‐synuclein

S. Becker, M. Zweckstetter, C. Fernández, 2011, Protein science : a publication of the Protein Society.

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

P. Carloni, D. Foguel, S. Ventura, 2016, Proceedings of the National Academy of Sciences.

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation*

C. Griesinger, T. Jovin, C. Bertoncini, 2005, Journal of Biological Chemistry.

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation.

A. Binolfi, C. Fernández, Verónica A. Lombardo, 2016, Accounts of chemical research.

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

Christian Griesinger, Stefan Becker, Roger S. Goody, 2014, Neurobiology of Disease.

Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

J. Landeira-Fernández, R. Hauser-Davis, C. Fernández, 2015, Metallomics : integrated biometal science.

Verbascoside, synthetic derivatives and other glycosides from Argentinian native plant species as potential antitumoral agents

M. Menacho-Márquez, C. Fernández, H. A. Garro, 2020, Natural product research.

Structural comparison of mouse and human α-synuclein amyloid fibrils by solid-state NMR.

S. Becker, D. Riedel, K. Giller, 2012, Journal of molecular biology.

Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau.

Martin Blackledge, Pau Bernado, Markus Zweckstetter, 2007, Journal of the American Chemical Society.

Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly*

X. Salvatella, C. Griesinger, C. Bertoncini, 2011, The Journal of Biological Chemistry.

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

C. Griesinger, A. Binolfi, C. Bertoncini, 2009, Proceedings of the National Academy of Sciences.

Structures behind the amyloid aggregation of alpha-synuclein: an NMR based approach.

C. Fernández, Maria L. Orcellet, 2011 .

Impact of Phosphorylation on alpha-Synuclein Structural Determinants

J. Schulz, P. Carloni, G. Rossetti, 2023, bioRxiv.

Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly

P. Carloni, G. Rossetti, C. Fernández, 2020, International journal of molecular sciences.

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.

C. Griesinger, D. Riedel, T. Outeiro, 2018, Biophysical journal.

The first solution structure of a paramagnetic copper(II) protein: the case of oxidized plastocyanin from the cyanobacterium Synechocystis PCC6803.

I. Bertini, C. Luchinat, S. Ciurli, 2001, Journal of the American Chemical Society.

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

T. Branco, E. Gerhardt, T. Outeiro, 2018, Acta neuropathologica communications.

Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation.

C. Griesinger, A. Binolfi, C. Bertoncini, 2007, Journal of molecular biology.

Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis.

Christian Griesinger, C. Griesinger, A. Binolfi, 2012, Journal of inorganic biochemistry.

Structural Properties of Pore-Forming Oligomers of r-Synuclein

R. Benz, H. Lashuel, S. Becker, 2009 .

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.

C. Griesinger, A. Binolfi, C. Bertoncini, 2008, Journal of the American Chemical Society.

Interactions of α-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease

A. Binolfi, C. Fernández, 2012 .

Identification and Quantification of an Adulterant in a Dietary Supplement Marketed for Sexual Enhancement

S. Lucangioli, C. Fernández, L. Muschietti, 2018, Journal of Advanced Pharmaceutical Science and Technology.

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

T. Branco, E. Gerhardt, T. Outeiro, 2018, Acta Neuropathologica Communications.

Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.

P. Carloni, C. Griesinger, A. Magistrato, 2010, Inorganic chemistry.

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

G. Braus, R. Goody, S. Becker, 2014, Neurobiology of Disease.

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.

C. Griesinger, D. Riedel, T. Outeiro, 2018, Biophysical journal.

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation.

A. Binolfi, C. Fernández, Verónica A. Lombardo, 2016, Accounts of chemical research.

Long-range correlated dynamics in intrinsically disordered proteins.

M. Blackledge, C. Luchinat, S. Becker, 2014, Journal of the American Chemical Society.

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features.

C. Griesinger, M. Zweckstetter, C. Fernández, 2018, Metallomics : integrated biometal science.

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

C. Griesinger, A. Binolfi, M. Zweckstetter, 2014, Inorganic chemistry.

Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy.

C. Griesinger, A. Binolfi, M. Zweckstetter, 2011, Journal of the American Chemical Society.

Alkaline transition of Rhus vernicifera stellacyanin, an unusual blue copper protein.

A. Sannazzaro, C. Fernández, A. Vila, 1997, Biochemistry.

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

S. Becker, M. Zweckstetter, Carla Schmidt, 2017, Chemistry.