D. Filpula

发表

A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G.

A. Gronenborn, G. Clore, P. Wingfield, 1993, Science.

Antibody engineering and modification technologies.

D. Filpula, 2007, Biomolecular engineering.

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

D J Jolly, A C Esty, T Friedmann, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Single-chain Fv designs for protein, cell and gene therapeutics

D. Filpula, J. McGuire, 1999 .

Construction and characterization of a single-chain catalytic antibody.

R. Gibbs, S. Benkovic, B. Posner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Controlled release of proteins from their poly(ethylene glycol) conjugates: drug delivery systems employing 1,6-elimination.

D. Filpula, Karen Yang, Hong Zhao, 2003, Bioconjugate chemistry.

Increased synthesis of ribonucleotide reductase after deoxyribonucleic acid inhibition in various species of bacteria

J. Fuchs, D. Filpula, 1979, Journal of bacteriology.

Releasable PEGylation of proteins with customized linkers.

D. Filpula, Hong Zhao, 2008, Advanced drug delivery reviews.

Utility of customized PEG linkers for the delivery of oligonucleotides without the use of transfection reagents

L. Greenberger, D. Filpula, I. Horak, 2007 .

CHAPTER 11 – Structure and evolution of the streptococcal genes encoding protein G

P. Alexander, J. Nagle, D. Filpula, 1990 .

Production of engineered IgM-binding single-chain antibodies inEscherichia coli

Timothy K Lee, J. Nagle, M. Rollence, 1995, Journal of Industrial Microbiology.

Single-chain Fv with manifold N-glycans as bifunctional scaffolds for immunomolecules.

J. D. Yang, M. Whitlow, D. Filpula, 1998, Protein engineering.

Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.

Mitchell Ho, I. Pastan, Jun Liu, 2007, Bioconjugate chemistry.

The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product.

M. Bibb, E. Katz, D. Filpula, 1985, Gene.

Regulation of the synthesis of ribonucleoside diphosphate reductase in Escherichia coli: specific activity of the enzyme in relationship to perturbations of DNA replication

J. Fuchs, D. Filpula, 1978, Journal of bacteriology.

Regulation of ribonucleoside diphosphate reductase synthesis in Escherichia coli: increased enzyme synthesis as a result of inhibition of deoxyribonucleic acid synthesis

J. Fuchs, D. Filpula, 1977, Journal of bacteriology.

Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy.

D. Filpula, G. Inana, Y. Hotta, 1989, The Journal of biological chemistry.

Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus

F. Tenover, D. Filpula, J. Plorde, 1988, Journal of bacteriology.

Structural and Functional Repetition in a Marine Mussel Adhesive Protein

R. Strausberg, D. Filpula, R L Strausberg, 1990, Biotechnology progress.

Single-chain Fv proteins and their fusion proteins

M. Whitlow, D. Filpula, 1991 .

Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein

J. Nagle, D. Filpula, N. Vasantha, 1984, Journal of bacteriology.

DNA polymerase-alpha. Common polypeptide core structure of three enzyme forms from human KB cells.

D. Filpula, P. Fisher, D. Korn, 1982, The Journal of biological chemistry.

Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA

T. Friedmann, D. Spector, D. Filpula, 1984, Journal of virology.

Sequence of the chicken delta 2 crystallin gene and its intergenic spacer. Extreme homology with the delta 1 crystallin gene.

J. Nagle, J. Piatigorsky, E. Wawrousek, 1986, The Journal of biological chemistry.

Engineering thermostability in subtilisin BPN' by in vitro mutagenesis.

P. Bryan, M. Pantoliano, M. Rollence, 1988, Critical reviews in biotechnology.

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

P. Bohlen, T. Friedmann, H. Okayama, 1983, Proceedings of the National Academy of Sciences of the United States of America.

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability.

K. D. Hardman, J. Schlom, M. Whitlow, 1993, Protein engineering.

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

M. Westergaard, L. Greenberger, H. Ørum, 2008, Molecular Cancer Therapeutics.

Hypoxanthine: Guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae

R. A. Woods, D. Filpula, D. Jolly, 2004, Molecular and General Genetics MGG.

Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.

R. A. Woods, D. Filpula, D. Stein, 1984, Journal of general microbiology.

Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: a comparison of conjugation chemistries and compounds.

M. Whitlow, D. Filpula, C. Shi, 1999, Bioconjugate chemistry.

Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.

T. Palm, Lisa Y Hwang, Yue Zhang, 2006, Bioconjugate chemistry.

Expression of bovine pancreatic ribonuclease A coded by a synthetic gene in Bacillus subtilis.

D. Filpula, N. Vasantha, 1989, Gene.

Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation.

D. Filpula, H. Janjua, David Filpula, 2003, Protein engineering.

Development of a Microbial System for Production of Mussel Adhesive Protein

Robert L. Strausberg, R. Strausberg, M. Finkelman, 1989 .

Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.

Hong Zhao, Jun Liu, T. Palm, 2006, Bioconjugate chemistry.

Gene for an immunoglobulin-binding protein from a group G streptococcus

P. Alexander, J. Nagle, D. Filpula, 1986, Journal of bacteriology.

Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.

Yang Wang, S. Dharap, T. Minko, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

T. Yokota, J. Schlom, M. Whitlow, 1991, Cancer research.

Nucleotide sequence of the protein G gene from Streptococcus GX7805, and comparison to previously reported sequences.

P. Alexander, D. Filpula, S. Fahnestock, 1987, Nucleic acids research.

Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene.

M. Schafer, P. Steinert, D. Roop, 1985, The Journal of biological chemistry.

Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv.

M. Whitlow, J. Wood, M. Rollence, 1994, Protein engineering.

cDNA and genomic cloning of yeast phenylalanine ammonia-lyase genes reveal genomic intron deletions.

R. Strausberg, C. Vaslet, D. Filpula, 1988, Nucleic acids research.

Nucleotide sequence of gene for phenylalanine ammonia-lyase from Rhodotorula rubra.

R. Strausberg, C. Vaslet, D. Filpula, 1988, Nucleic acids research.

Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.

D. Filpula, Maoliang Wang, A. Basu, 2006, Bioconjugate chemistry.

synthesis. deoxyribonucleic acid as a result of inhibition of increased enzyme synthesis synthesis in Escherichia coli: diphosphate reductase Regulation of ribonucleoside

J. Fuchs, D. Filpula, 2014 .