E. Hamel

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Antimitotic natural products and their interactions with tubulin

E. Hamel, 1996, Medicinal research reviews.

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

D. Zaharevitz, P. Wipf, R. Gussio, 2005, Journal of medicinal chemistry.

Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.

H. Rosenkranz, E. ter Haar, B. Day, 1996, Bioorganic & medicinal chemistry.

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

H. Rosenkranz, E. ter Haar, B. Day, 1996, Biochemistry.

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

K D Paull, K. Paull, E. Hamel, 1992, Cancer research.

Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula.

W. Gerwick, E. Hamel, B. Marquez, 1998, Phytochemistry.

4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents.

A. Willis, E. Hamel, D. Hockless, 2006, Bioorganic & medicinal chemistry.

Isolation and Structure of Halistatin 1 from the Eastern Indian Ocean Marine Sponge Phakellia carteri

F. Gao, M. Boyd, Michael D. Williams, 1993 .

Novel indole‐based compounds that differentiate alkylindole‐sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration

K. Mackie, E. Hamel, N. Stella, 2017, Pharmacological research.

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

T. E. Strecker, E. Hamel, M. L. Trawick, 2019, MedChemComm.

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.

R. Mason, D. Chaplin, T. E. Strecker, 2016, MedChemComm.

Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Journal of medicinal chemistry.

The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.

Daniel J. Kerr, E. Hamel, B. Flynn, 2007, Bioorganic & medicinal chemistry.

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

E. Hamel, C. Lin, G. Pettit, 1988, Molecular pharmacology.

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.

E. Hamel, C. Lin, G. Pettit, 1989, Biochemistry.

Antineoplastic agents. 379. Synthesis of phenstatin phosphate.

M. Boyd, R. Pettit, E. Hamel, 1998, Journal of medicinal chemistry.

Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization

M. Boyd, G. Cragg, J. Beutler, 1993 .

Addendum. Antitumor Agents, 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra

J. Estes, A. McPhail, T. Konoshima, 1995 .

Antimitotic natural products and their interactions with tubulin

E. Hamel, 1996, Medicinal research reviews.

Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

W. Gerwick, D. Nagle, E. Hamel, 1994 .

Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.

M. Boyd, R. Pettit, E. Hamel, 1998, Anti-cancer drug design.

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

A. McPhail, K. Lee, E. Hamel, 1993, Journal of medicinal chemistry.

Antitumor Agents. Part 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids.

A. Tropsha, A. Brossi, A. McPhail, 1998 .

Antitumor Agents. 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids

A. Brossi, A. Tropsha, A. McPhail, 1998 .

Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.

A. Brancale, G. Viola, Roberta Bortolozzi, 2020, European journal of medicinal chemistry.

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly

Arun K. Ghosh, K. Nicolaou, J. Miller, 2006, Molecular Pharmacology.

Direct incorporation of guanosine 5'-diphosphate into microtubules without guanosine 5'-triphosphate hydrolysis.

E. Hamel, J. Batra, C. Lin, 1986, Biochemistry.

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents.

María Kimatrai Salvador, G. Basso, G. Viola, 2014, European journal of medicinal chemistry.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

C. Martini, A. Coluccia, R. Silvestri, 2018, European journal of medicinal chemistry.

Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine (*)

A. Brossi, E. Hamel, R. Bai, 1996, The Journal of Biological Chemistry.

Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

R. Gussio, S. J. Hickford, J. Blunt, 2006, Molecular Pharmacology.

Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents.

A. Brancale, P. Pinton, G. Viola, 2021, Bioorganic chemistry.

Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin.

E. Hamel, C. Lin, Chii M. Lin, 1981, Archives of biochemistry and biophysics.

Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

B. Cacciari, A. Brancale, G. Viola, 2022, Pharmaceutics.

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198

E. Hamel, A. Treston, G. Swartz, 2008, Molecular Cancer Therapeutics.

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

J. Snyder, P. Giannakakou, D. Liotta, 2008, Cell cycle.

Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells.

R. Gambari, E. Fabbri, P. Baraldi, 2010, Letters in drug design & discovery.

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.

R. Gambari, E. Fabbri, O. Cruz-López, 2009, Letters in drug design & discovery.

Ukrain(TM), a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerization in normal and malignant cell lines.

J. Seegers, A. Joubert, E. Hamel, 2000, Cancer letters.

Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.

R. D'Amato, E. Flynn, E. Hamel, 1996, Biochemistry.

Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2‐(3′,4′,5′‐Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

A. Brancale, O. Cruz-López, J. Balzarini, 2011, ChemMedChem.

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

Andrew J. Robles, F. Islam, E. Hamel, 2022, Molecules.

Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors.

G. Viola, Roberta Bortolozzi, E. Hamel, 2020, European journal of medicinal chemistry.

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.

M. Ihnat, E. Hamel, S. Mooberry, 2020, Bioorganic & medicinal chemistry.

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.

R. Kiss, S. Rogelj, A. Kornienko, 2013, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

Mark P Thomas, B. Potter, E. Hamel, 2011, ACS medicinal chemistry letters.

Preclinical Development Peloruside-and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have b I-Tubulin Mutations and Altered Expression of b II-and b III-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011 .

Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011, Molecular Cancer Therapeutics.

A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

A. Musacchio, R. Gussio, R. Silvestri, 2010, PloS one.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.

G. Basso, G. Viola, Roberta Bortolozzi, 2010, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2009, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

I. Barasoain, E. Calvo, R. Buey, 2007, Nature chemical biology.

CB694, a novel antimitotic with antitumor activities

E. Hamel, S. Mooberry, L. Polin, 2006, International journal of cancer.

Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.

D. Sackett, E. Hamel, R. Bai, 1999, Biochemistry.

(E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: design, antiproliferative activity and inhibition of tubulin polymerization.

B. Kolundžija, E. Hamel, M. Vitorović-Todorović, 2013, European journal of medicinal chemistry.

Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells.

H. Cottam, D. Carson, E. Hamel, 2000, Journal of the National Cancer Institute.

Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain.

K. Lee, E. Hamel, A. Banerjee, 1999, Biochemical and biophysical research communications.

Synthesis of 14C labelled electrophilic ligands of the colchicine binding site of tubulin: Chloroacetates of demethylthiocolchicines and of N‐acetylcolchinol; isothiocyanate of 9‐deoxy‐N‐acetylcolchinol

A. Brossi, E. Hamel, Z. Getahun, 1993 .

Colchicine models: Synthesis and Antitubulin Activity of 2′‐Monosubstituted and 2′, 5‐Disubstituted 2,3,4,4′‐Tetramethoxy‐1,1′‐biphenyls. Synthesis of 4,4′, 5′, 6′‐tetramethoxy‐1,1′‐biphenyl‐2,3′‐dicarboxylic acid

C. George, J. Flippen-Anderson, A. Brossi, 1989 .

Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin.

E. Hamel, C. Lin, Chii M. Lin, 1983, Biochemical pharmacology.

Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2013 .

Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug.

M. Stratford, D. Chaplin, R. Pettit, 1998, Anti-cancer drug design.

Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a)

M. Boyd, R. Pettit, E. Hamel, 1995, Journal of medicinal chemistry.

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.

L. Cascione, M. Steinmetz, A. Prota, 2022, European journal of medicinal chemistry.

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in Vitro and in Vivo evaluation as antitumor agents.

F. Islam, M. Ihnat, E. Hamel, 2021, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

E. Hamel, S. Mooberry, A. Gangjee, 2016, Journal of medicinal chemistry.

A simple method for the rapid determination of the stereospecificity of NAD-dependent dehydrogenases applied to mammalian IMP dehydrogenase and bacterial NADH peroxidase.

E. Hamel, D. Cooney, M. Cohen, 1987, Biochimica et biophysica acta.

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

E. Hamel, G. Pettit, R. Bai, 1990, Biochemical pharmacology.

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2014, Bioorganic & medicinal chemistry.

Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.

A. Brancale, G. Basso, Su-zhan Zhang, 2013, Journal of medicinal chemistry.

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Journal of medicinal chemistry.

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.

A. Brancale, G. Basso, Su-zhan Zhang, 2011, European journal of medicinal chemistry.

Synthesis and in vitro Evaluation of 3H‐Pyrrolo[3,2‐f]quinolin‐9‐one Derivatives That Show Potent and Selective Anti‐leukemic Activity

P. Brun, G. Basso, G. Viola, 2010, ChemMedChem.

Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

G. Basso, G. Viola, Roberta Bortolozzi, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

A. Brancale, G. Basso, G. Viola, 2010, Journal of medicinal chemistry.

Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.

R. Gambari, E. Fabbri, G. Basso, 2009, Bioorganic & medicinal chemistry letters.

A steroid derivative with paclitaxel-like effects on tubulin polymerization.

Z. Wang, M. Cushman, E. Hamel, 2000, Molecular pharmacology.

Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin.

G. Georg, L. Higgins, Todd W. Markowski, 2016, Journal of medicinal chemistry.

Synthesis and biological activity of a novel C4–C6 bridged paclitaxel analog

D. Sackett, D. Kingston, E. Hamel, 1999 .

Optimisation of Tetrahydroisoquinoline‐Based Chimeric Microtubule Disruptors

B. Potter, E. Hamel, M. Leese, 2014, ChemMedChem.

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

T. Liu, E. Hamel, C. Lin, 1989, Biochemistry.

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin.

A. B. Huang, E. Hamel, C. Lin, 1985, Biochemical and biophysical research communications.

An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly

E. Hamel, 2008 .

Synthesis and biological evaluation of ( − )-dictyostatin and stereoisomers

B. Day, D. Curran, E. Hamel, 2022 .

Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin

E. Hamel, 2007, Cell Biochemistry and Biophysics.

Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid.

James D White, E. Hamel, Helmars Smits, 2006, Organic letters.

Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.

Arun K. Ghosh, E. Hamel, R. Bai, 2004, Molecular pharmacology.

Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

E. Hamel, R. Luduena, G. Pettit, 1993, Biochemical pharmacology.

Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine.

A. Safa, R. L. Felsted, E. Hamel, 1987, Biochemistry.

Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.

M. Boyd, E. Hamel, G. Pettit, 1995, Anti-cancer drug design.

Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.

W. Gerwick, D. Sackett, E. Hamel, 1999, Archives of biochemistry and biophysics.

Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.

W. Gerwick, D. Nagle, E. Hamel, 1995, Molecular pharmacology.

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1‐Substituted Tetrahydroisoquinolines

B. Potter, B. Potter, A. Purohit, 2014, ChemMedChem.

The interaction of spongistatin 1 with tubulin.

E. Hamel, Amos B. Smith, R. Bai, 2022, Archives of biochemistry and biophysics.

Interaction of diazonamide a with tubulin.

E. Hamel, W. Fenical, Z. Cruz-Monserrate, 2019, Archives of biochemistry and biophysics.

Modulation of tubulin-nucleotide interactions by microtubule-associated proteins: polymerization with ribose-modified analogues of guanosine 5'-triphosphate.

E. Hamel, C. Lin, J. Lustbader, 1983, Biochemistry.

Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

A. Brancale, G. Basso, G. Viola, 2011, Journal of medicinal chemistry.

1 Design , Synthesis , in Vitro and in Vivo Biological Evaluation of 2-Amino-3-Aroylbenzo [ b ] furan Derivatives as Highly Potent Tubulin Polymerization Inhibitors

A. Brancale, G. Viola, Roberta Bortolozzi, 2022 .

Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole

A. Brancale, G. Basso, G. Viola, 2016, Scientific Reports.

Synthesis and Biological Evaluation of 6 , 7 , 2 ′ , 3 ′ , 4 ′-Substituted-1 , 2 , 3 , 4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

S. Kuo, Yi Xia, K. Lee, 1998 .

Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure. Interactions with tubulin.

E. Hamel, C. Lin, H. Ho, 1988, Biochemical pharmacology.

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

E. Hamel, G. Pettit, R. Bai, 1992, Biochemical pharmacology.

A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents.

María Kimatrai Salvador, A. Brancale, G. Viola, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.

María Kimatrai Salvador, A. Brancale, G. Viola, 2019, European journal of medicinal chemistry.

Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones.

M. Sturlese, S. Moro, G. Viola, 2019, European journal of medicinal chemistry.

Effects of organic acids on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis.

E. Hamel, C. Lin, M. Lowe, 1982, Biochemistry.

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

A. Coluccia, A. Ciogli, R. Silvestri, 2022, Journal of medicinal chemistry.

(-)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin.

E. Hamel, R. Bai, 2016, Archives of biochemistry and biophysics.

Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

P. Giannakakou, D. Kingston, C. Fairchild, 1998, Journal of medicinal chemistry.

A convenient tubulin-based quantitative assay for paclitaxel (Taxol) derivatives more effective in inducing assembly than the parent compound

Yuan Jiang, D. Kingston, J. Rimoldi, 1996, Cancer Chemotherapy and Pharmacology.

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles.

E. Hamel, C. Lin, C. Lin, 1984, Biochemistry.

The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer

D. Sherris, M. Redrado, A. Calvo, 2009, British Journal of Cancer.

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.

W. Gerwick, M. Roberts, P. Scheuer, 2002, Journal of natural products.

Actin is the primary cellular receptor of bistramide A

Vishal A. Verma, P. Wender, J. Baryza, 2005, Nature chemical biology.

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Z. Cichacz, E. Hamel, G. Pettit, 1995, Biochemistry.

Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one.

E. Hamel, R. Luduena, J. B. Jiang, 1991, Molecular pharmacology.

Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.

A. Tropsha, A. Brossi, S. Kuo, 2000, Journal of medicinal chemistry.

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

E. Hamel, G. Pettit, R. Bai, 1990, Biochemical pharmacology.

Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.

L. Pieters, A. Vlietinck, E. Hamel, 1999, Journal of medicinal chemistry.

Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula.

W. Gerwick, E. Hamel, B. Marquez, 1998, Phytochemistry.

1 Synthesis , Antimitotic and Antivascular Activity of 1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-3-Arylamino-5-Amino-1 , 2 , 4-Triazoles

María Kimatrai Salvador, A. Brancale, P. Baraldi, 2015 .

Interactions of guanosine triphosphate analogues with elongation factor G of Escherichia coli.

E. Hamel, 1976, European journal of biochemistry.

Role of guanine nucleotides in protein synthesis. Elongation factor G and guanosine 5'-triphosphate,3'-diphosphate.

M. Cashel, E. Hamel, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin.

C. Duanmu, E. Hamel, R. Bai, 1989, Biochimica et biophysica acta.

Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.

Ganesh Suresh Jedhe, G. Sanjayan, E. Hamel, 2015, Bioorganic & medicinal chemistry letters.

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.

Andrea Brancale, Gabriela Chiosis, Ernest Hamel, 2006, Journal of medicinal chemistry.

Arylthioindoles, potent inhibitors of tubulin polymerization.

Andrea Brancale, Ernest Hamel, Antonio Coluccia, 2004, Journal of medicinal chemistry.

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

M. Cushman, E. Hamel, C M Lin, 1992, Journal of medicinal chemistry.

Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.

M. Hidalgo, P. Diest, E. Hamel, 2008, Journal of medicinal chemistry.

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Ernest Hamel, A. Chakraborti, M. Cushman, 1991, Journal of medicinal chemistry.

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

R. Shoemaker, N. Calonghi, L. Masotti, 2012, Journal of medicinal chemistry.

Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

T. Nguyen, Ganesh Suresh Jedhe, G. Sanjayan, 2013, Bioorganic & medicinal chemistry letters.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Liying Zhang, Hao Zhu, K. Lee, 2011, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

D. Dexter, E. Hamel, J. B. Jiang, 1990, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.

R. Gambari, M. Borgatti, P. Baraldi, 2006, Journal of medicinal chemistry.

Convergent syntheses of the pyrrolic marine natural products lamellarin-O, lamellarin-Q, lukianol-A and some more highly oxygenated congeners

E. Hamel, B. Flynn, D. Hockless, 1997 .

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

D. Dexter, E. Hamel, J. B. Jiang, 1990, Journal of medicinal chemistry.

Natural products. Antitubulin effect of congeners of N-acetylcolchinyl methyl ether: synthesis of optically active 5-acetamidodeaminocolchinyl methyl ether and of demethoxy analogues of deaminocolchinyl methyl ether

A. Brossi, H. Yeh, B. Wegrzynski, 1992 .

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development.

C. Supuran, E. Hamel, R. Bai, 2021, Pharmacology & therapeutics.

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold

R. Gambari, A. Finotti, B. Cacciari, 2020, Molecules.

Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.

K. Paull, J. Plowman, K. Lee, 1996, Biochemical pharmacology.

6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, Li‐Jiau Huang, M. Hour, 2000, Journal of medicinal chemistry.

Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.

P. Blumberg, R. Pettit, N. Lewin, 2004, The Journal of organic chemistry.

Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.

A. Mauger, K. Lee, E. Hamel, 2001, Journal of medicinal chemistry.

Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 2002, Bioorganic & Medicinal Chemistry Letters.

Antitumor Agents. Part 184. Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids†‡

A. Brossi, A. McPhail, K. Lee, 1998 .

Natural Products. Antitubulin Effect of Congeners of N-Acetylcolchinyl Methyl Ether: Synthesis of Optically Active 5- Acetamidodeaminocolchinyl Methyl Ether and of Demethoxy Analogues of Deaminocolchinyl Methyl Ether.

A. Brossi, H. Yeh, B. Wegrzynski, 1993 .

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

S. Kuo, Li‐Jiau Huang, Keduo Qian, 2009, Journal of medicinal chemistry.

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

S. Kuo, M. Hour, Yi Xia, 2001, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.

S. Dakshanamurthy, W. Minor, M. Chruszcz, 2008, Journal of medicinal chemistry.

Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation.

J. Porco, J. Beutler, E. Hamel, 2012, Journal of the American Chemical Society.

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Jan Balzarini, John A Hadfield, Andrea Brancale, 2007, Journal of medicinal chemistry.

Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.

E. Hamel, H. Ho, D. Chi, 1989, Cancer research.

Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole.

T. Nguyen, E. Hamel, M. Krasavin, 2013, Bioorganic & medicinal chemistry letters.

Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1999, Journal of medicinal chemistry.

A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.

Kan Wang, M. Paige, E. Hamel, 2010, Bioorganic & medicinal chemistry.

New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.

E. Novellino, B. Maresca, A. Coluccia, 2009, Journal of medicinal chemistry.

Synthesis, X-Ray Crystal Structure and Tubulin- Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4

A. Willis, E. Hamel, B. Flynn, 1999 .

Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.

I. Konstantinov, R. Karapetian, E. Hamel, 2014, Bioorganic & medicinal chemistry letters.

Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones.

E. Hamel, D. Schillaci, R. Bai, 2004, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

R. Gambari, A. Brancale, O. Cruz-López, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

H. Hsieh, A. Brancale, O. Cruz-López, 2008, Journal of medicinal chemistry.

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

R. Mason, D. Chaplin, E. Hamel, 2013, Journal of natural products.

Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.

V. Villalobos, E. Hamel, P. Verdier-Pinard, 2000, Bioorganic & medicinal chemistry.

Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.

R. Pettit, C. John, E. Hamel, 2005, Journal of natural products.

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

Anna Ivana Scovassi, Ettore Novellino, Andrea Brancale, 2007, Journal of medicinal chemistry.

Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2013, Bioorganic & medicinal chemistry.

Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.

R. Pettit, E. Hamel, Jean M. Schmidt, 2002, Journal of medicinal chemistry.

Synthesis, Cytotoxicity, and Inhibitory Effects on Tubulin Polymerization of a New 3‐Heterocyclo Substituted 2‐Styrylquinazolinones.

E. Hamel, D. Schillaci, R. Bai, 2004 .

A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents.

E. Hamel, B. Flynn, P. Verdier-Pinard, 2001, Organic letters.

Design, synthesis, and biological evaluation of thiophene analogues of chalcones.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.

Y. P. Sachdeva, J. Katzenellenbogen, M. Cushman, 1997, Journal of medicinal chemistry.

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

J. Katzenellenbogen, M. Cushman, E. Hamel, 1995, Journal of medicinal chemistry.

Identification and Characterization of a New Tubulin-Binding Tetrasubstituted Brominated Pyrrole

Jonathan E. Hempel, S. Dakshanamurthy, E. Hamel, 2007, Molecular Pharmacology.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.

J. Balzarini, M. Jordan, P. Baraldi, 2006, Journal of medicinal chemistry.

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

K. Paull, S. Kuo, H. Lee, 1993, Journal of medicinal chemistry.

Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

W. Gerwick, M. Nambu, J. Falck, 1998, Molecular pharmacology.

Effect of methanol on the partial reactions of polypeptide chain elongation.

T. Nakamoto, E. Hamel, 1972, Biochemistry.

Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.

E. Sausville, E. Hamel, P. Verdier-Pinard, 2001, Molecular pharmacology.

Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.

S. Howell, Michael D. Williams, D. Newman, 2003, Molecular pharmacology.

Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors.

M. Conconi, A. Coluccia, P. Brun, 2014, Journal of medicinal chemistry.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

M. Steinmetz, B. Potter, A. Prota, 2018, Journal of medicinal chemistry.

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Ettore Novellino, Andrea Brancale, Ilaria Granata, 2011, Journal of medicinal chemistry.

Direct Photoaffinity Labeling by Dolastatin 10 of the Amino-terminal Peptide of β-Tubulin Containing Cysteine 12*

D. Covell, T. Copeland, E. Hamel, 2004, Journal of Biological Chemistry.

Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents

E. Hamel, S. Mooberry, A. Gangjee, 2012, Pharmaceutical Research.

Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, D. Lednicer, K. Lee, 1994, Journal of medicinal chemistry.

Benzoylphenylurea sulfur analogues with potent antitumor activity.

S. Sukumar, A. Jimeno, M. Hidalgo, 2006, Journal of medicinal chemistry.

Interactions of antimitotic peptides and depsipeptides with tubulin.

E. Hamel, 2002, Biopolymers.

Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.

G. Giannini, N. Gebbia, R. Baruchello, 2005, Journal of medicinal chemistry.

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.

E. Hamel, B. Flynn, M. K. Jung, 2002, Journal of medicinal chemistry.

The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.

E. Hamel, B. Flynn, M. K. Jung, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

María Kimatrai Salvador, A. Brancale, G. Basso, 2017, Scientific Reports.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

E. Novellino, L. Di Marcotullio, C. Martini, 2015, Journal of medicinal chemistry.

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization

A. Oda, K. Lee, X. Hao, 2019, Molecules.

Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy.

Arun K. Ghosh, E. Hamel, R. Bai, 2012, European journal of organic chemistry.

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

K. Altmann, I. Barasoain, J. Díaz, 2012, Chemistry & biology.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

Ettore Novellino, Andrea Brancale, Ruoli Bai, 2014, Journal of medicinal chemistry.

Requirement of an Escherichia coli 50 S ribosomal protein component for effective interaction of the ribosome with T and G factors and with guanosine triphosphate.

T. Nakamoto, E. Hamel, M. Koka, 1972, The Journal of biological chemistry.

Activities of guanosine triphosphate analogues in reactions catalyzed by elongation factor Tu and initiation factor 2 of Escherichia coli.

E. Hamel, 1975, Biochimica et biophysica acta.

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

D. Alberts, E. Hamel, Sheo B. Singh, 1989, Experientia.

Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

A. Olğaç, G. Viola, Roberta Bortolozzi, 2014, Bioorganic & medicinal chemistry.

Mapping the Binding Site of Colchicinoids on β-Tubulin

D. Covell, A. Brossi, E. Hamel, 2000, The Journal of Biological Chemistry.

Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354.

D. Covell, A. Brossi, E. Hamel, 2000, The Journal of biological chemistry.

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin.

B. Day, D. Curran, E. Hamel, 2005, Organic letters.

Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine).

A. Brossi, E. Hamel, A. Muzaffar, 1990, Journal of natural products.

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides.

E. Hamel, M. Tolomeo, M. V. Raimondi, 2011, European journal of medicinal chemistry.

Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives

M. Amini, E. Hamel, Z. Shahsavari, 2019, DARU Journal of Pharmaceutical Sciences.

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

P. Giannakakou, B. Day, S. Gunasekera, 1997, Molecular pharmacology.

Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.

L. Pieters, A. Vlietinck, E. Hamel, 1999, Journal of medicinal chemistry.

Colchicine and its analogues: Recent findings

A. Brossi, J. Wolff, H. Yeh, 1988, Medicinal research reviews.

Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

A. D’Anneo, M. Lauricella, E. Hamel, 2015, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs.

Arun K. Ghosh, E. Hamel, Zachary L. Dawson, 2010, Bioorganic & medicinal chemistry letters.

The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways.

J. Seegers, A. Joubert, E. Hamel, 2001, European journal of cell biology.

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.

A. Brancale, G. Basso, G. Viola, 2013, Journal of medicinal chemistry.

Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi.

K. Jolliffe, E. Hamel, A. Edwards, 2003, Organic & biomolecular chemistry.

Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.

P. Blumberg, R. Pettit, N. Lewin, 2004, Journal of medicinal chemistry.

Colchicine Models: Synthesis and Binding to Tubulin of Tertamethoxybiphenyls

A. Brossi, E. Hamel, Chii M. Lin, 1988 .

Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.

E. De Clercq, J. Balzarini, P. Baraldi, 2005, Bioorganic & medicinal chemistry letters.

Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.

E. Hamel, M. L. Trawick, R. Tanpure, 2009, Bioorganic & medicinal chemistry.

The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.

M. Hollingshead, M. Cushman, E. Hamel, 2002, Journal of medicinal chemistry.

Stereoselective Synthesis of Trisubstituted Ole fi nic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design , Synthesis , and Biological Evaluation of Potent Antitumor Agents

K. Nicolaou, M. Aujay, E. Hamel, 2017 .

Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues

K. Nicolaou, E. Hamel, Sotirios Totokotsopoulos, 2015, ChemMedChem.

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

K. Nicolaou, D. Sackett, E. Hamel, 1999, Biochemistry.

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.

D. Covell, J. Porco, J. Beutler, 2009, Angewandte Chemie.

Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.

I. Barasoain, J. Díaz, E. Calvo, 2012, Biochemistry.

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

A. Marcus, R. Gussio, P. Giannakakou, 2005, Biochemistry.

Differential effects of paclitaxel (Taxol) analogs modified at positions C-2, C-7, and C-3' on tubulin polymerization and polymer stabilization: identification of a hyperactive paclitaxel derivative.

D. Kingston, J. Rimoldi, E. Hamel, 1995, Biochemistry.

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

E. Hamel, L. Jurd, C. Lin, 1992, Journal of medicinal chemistry.

A new anti-tubulin agent containing the benzo[b]thiophene ring system.

A. Bounds, E. Hamel, V. Mocharla, 1999, Bioorganic & medicinal chemistry letters.

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2015, Bioorganic & medicinal chemistry.

N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin.

Xiao‐Feng Wang, Keduo Qian, K. Lee, 2013, European journal of medicinal chemistry.

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.

R. Mason, D. Saha, D. Chaplin, 2019, Journal of medicinal chemistry.

Convergent synthesis and preliminary biological evaluation of (±)-B-norrhazinal

E. Hamel, A. Edwards, P. Verdier-Pinard, 2000 .

Antitumor Agents. 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids

A. Brossi, A. McPhail, K. Lee, 1999 .

Total syntheses of the structures assigned to salimine and jerusalemine, alkaloids from Colchicum decaisnei boiss. (Liliaceae)

R. Gable, E. Hamel, M. Banwell, 1994 .

Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogs of Allocolchicine

J. Cameron, E. Hamel, M. Banwell, 1992 .

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.

A. Brossi, K. Lee, E. Hamel, 2010, Bioorganic & medicinal chemistry letters.

Antitumor agents 238. anti-tubulin and in vitro cytotoxic effects of N-substituted allocolchicinoids

A. Brossi, Chin‐Chung Wu, K. Lee, 2005 .

Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.

A. Brossi, A. McPhail, K. Lee, 1997, Journal of medicinal chemistry.

N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties.

A. Brossi, E. Hamel, Z. Getahun, 1990, The Journal of biological chemistry.

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

A. Brossi, E. Hamel, C. Lin, 1990, Journal of medicinal chemistry.

Synthesis, x-ray crystal structure, and antimitotic properties of 6-chloro-2-methoxy-5-(2',3',4'-trimethoxyphenyl)cyclohepta-2,4,6-trien-1-one, a bicyclic analog of colchicine

E. Hamel, C. Rickard, M. Banwell, 1988 .

Antitumor Agents. Part 215. Antitubulin Effects of Cytotoxic B‐Ring Modified Allocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 2003 .

The Palladium-Mediated Cross Coupling of Bromotropolones With Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogs

J. Cameron, R. Gable, G. Crisp, 1991 .

Antitumor Agents. Part 184. Syntheses and Antitubulin Activity of Compounds Derived from Reaction of Thiocolchicone with Amines: Lactams, Alcohols, and Ester Analogues of Allothiocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 1998 .

Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.

A. Brossi, K. Lee, E. Hamel, 1997, Bioorganic & medicinal chemistry.

Evolution of the total syntheses of ustiloxin natural products and their analogues.

E. Hamel, M. Joullié, Pixu Li, 2008, Journal of the American Chemical Society.

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.

R. Mason, D. Chaplin, E. Hamel, 2016, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Novel Paclitaxel (Taxol) D-Ring Modified Analogues.

D. Sackett, D. Kingston, A. Gunatilaka, 1999, The Journal of organic chemistry.

Differential effects of magnesium on tubulin-nucleotide interactions.

A. B. Huang, E. Hamel, C. Lin, 1985, Biochimica et biophysica acta.

Deguelin, a plant-derived rotenoid, mediates potent chemopreventive responses through transcriptional regulation of phorbol ester-induced

R. Mehta, R. Moriarty, Sang Kook Lee, 2006 .

Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.

J. Pezzuto, R. Mehta, R. Moriarty, 1997, Cancer research.

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

R. Schwartz, E. Hamel, G. Pettit, 1996, Cancer research.

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.

A. Brancale, G. Viola, Roberta Bortolozzi, 2020, Bioorganic chemistry.

Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Keduo Qian, K. Lee, S. Morris-Natschke, 2014, Journal of medicinal chemistry.

Di-and triphosphate derivatives of acyclo- and arabinosylguanine. Effects on the polymerization of purified tubulin.

E. Hamel, J. Lustbader, 1982, Biochimica et biophysica acta.

Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.

E. Hamel, G R Pettit, S B Singh, 1988, Journal of natural products.

Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum.

E. Hamel, G R Pettit, S B Singh, 1987, Journal of natural products.

1 3-Aryl / Heteroaryl-5-Amino-1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-1 , 2 , 4-Triazoles as Antimicrotubule Agents . Design , Synthesis , Antiproliferative Activity and Inhibition of Tubulin Polymerization

A. Brancale, G. Viola, Roberta Bortolozzi, 2018 .

Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.

A. Brossi, K. Lee, E. Hamel, 1998, Bioorganic & medicinal chemistry.

Colchicine and its analogues: Recent findings

A. Brossi, J. Wolff, H. Yeh, 1988, Medicinal research reviews.

Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.

M. Boyd, D. Sackett, R. Fuller, 1999, Bioorganic & Medicinal Chemistry.

Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.

E. Hamel, L. Jurd, J. Batra, 1985, Molecular pharmacology.

MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells.

S. Moro, P. Brun, G. Basso, 2012, Biochemical pharmacology.

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

R. D'Amato, S. Parangi, E. Flynn, 1997, Cancer research.

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.

D. Covell, J. Porco, J. Beutler, 2009, Angewandte Chemie.

Modified taxols, 9. Synthesis and biological evaluation of 7-substituted photoaffinity analogues of taxol.

D. Kingston, J. Rimoldi, E. Hamel, 1993, Journal of natural products.

E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.

B. Moser, R. Pettit, E. Hamel, 2009, Bioorganic & medicinal chemistry.

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells†

K. Nicolaou, Tianhu Li, D. Vourloumis, 1997 .

Cover Picture: Tetrahydroisoquinolinone‐Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014)

B. Potter, E. Hamel, M. Leese, 2014 .

Synthesis and biological activity of A-nor-paclitaxel analogues.

D. Kingston, M. Chordia, E. Hamel, 1997, Bioorganic & medicinal chemistry.

Limitations in the use of tubulin polymerization assays as a screen for the identification of new antimitotic agents: The potent marine natural product curacin A as an example

W. Gerwick, D. Nagle, E. Hamel, 1995 .

Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia.

Zhe Shi, D. Chaplin, E. Hamel, 2017, Bioorganic & medicinal chemistry letters.

The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells.

Jai-Sing Yang, Yi-Chien Lin, S. Kuo, 2013, International journal of oncology.

Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.

E. Hamel, 1992, Pharmacology & therapeutics.

Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.

María Kimatrai Salvador, A. Brancale, G. Basso, 2014, Journal of medicinal chemistry.

Interactions of Halichondrin B and Eribulin with Tubulin

Amos B. Smith, Murray H. G. Munro, Rick Gussio, 2011, J. Chem. Inf. Model..

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Z. Cichacz, E. Hamel, G. Pettit, 1993, Molecular pharmacology.

Anti neoplastic agents. CCLII. Isolation and structure of Halistatin 2 from the Comoros marine sponge Axinella carteri

M. Boyd, E. Hamel, Jean M. Schmidt, 1993 .

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.

Jan Balzarini, Andrea Brancale, Ernest Hamel, 2011, Bioorganic & Medicinal Chemistry Letters.

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity.

E. Hamel, D. D. de Lima, A. Beatriz, 2020, Bioorganic chemistry.

Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).

M. Bibby, R. Pettit, E. Hamel, 2005, Journal of natural products.

Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.

J. Grembecka, J. Rieger, E. Hamel, 2005, Chemistry & biology.

Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

P. Tassone, E. Gaudio, G. Viola, 2020, Journal of medicinal chemistry.

Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.

R. Pettit, E. Hamel, D. L. Herald, 2005, Journal of medicinal chemistry.

Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.

M. Boyd, R. Pettit, E. Hamel, 2000, Journal of medicinal chemistry.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

A. Oda, K. Lee, E. Hamel, 2016, Bioorganic & medicinal chemistry.

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.

A. Brancale, G. Basso, G. Viola, 2009, Journal of medicinal chemistry.

Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted α,β-unsaturated sulfoxide

E. Hamel, V. Mocharla, G. Pettit, 2000 .

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

A. Antunes, E. Hamel, J. Burnett, 2013, Bioorganic & medicinal chemistry letters.

Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2.

E. Hamel, D. L. Herald, G. Pettit, 2009, Journal of natural products.

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

A. Brancale, G. Viola, Roberta Bortolozzi, 2022, Pharmaceuticals.

Design and Synthesis of Novel Substituted Indole-acrylamide Derivatives and Evaluation of Their Anti-Cancer Activity as Potential Tubulin-Targeting Agents

A. Olğaç, R. Cetin-Atalay, D. Kahraman, 2022, Journal of Molecular Structure.

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.

R. Mason, D. Chaplin, Heling Zhou, 2018, MedChemComm.

Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation.

P. Baraldi, R. Romagnoli, E. Hamel, 2016, European journal of medicinal chemistry.

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006).

D. Chaplin, E. Hamel, M. L. Trawick, 2013, Bioorganic & medicinal chemistry.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.

Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

R. Pettit, E. Hamel, D. L. Herald, 2003, Journal of medicinal chemistry.

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

M. Cushman, E. Hamel, C. Lin, 1993, Journal of medicinal chemistry.

A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.

E. Hamel, D. D. de Lima, A. Beatriz, 2009, European journal of medicinal chemistry.

Derivatives of guanosine triphosphate with ribose 2'-hydroxyl substituents. Interactions with the protein synthetic enzymes of Escherichia coli.

E. Hamel, 1976, European journal of biochemistry.

(−)-Doliculide, a New Macrocyclic Depsipeptide Enhancer of Actin Assembly*

Arun K. Ghosh, D. Covell, E. Hamel, 2002, The Journal of Biological Chemistry.

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

S. Rogelj, A. Kornienko, S. Pelly, 2016, Journal of medicinal chemistry.

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

K D Paull, K. Paull, E. Hamel, 1991, The Journal of biological chemistry.

Antineoplastic Agents. Part 252. Isolation and Structure of Halistatin 2 from the Comoros Marine Sponge Axinella carteri

M. Boyd, E. Hamel, Jean M. Schmidt, 1993 .

Guanine nucleotides in protein synthesis. Utilization of pppGpp and dGTP by initiation factor 2 and elongation factor Tu.

M. Cashel, E. Hamel, 1974, Archives of biochemistry and biophysics.

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

S. Kuo, A. Mauger, K. Lee, 1997, Journal of medicinal chemistry.

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.

R. Mason, D. Chaplin, E. Hamel, 2015, Bioorganic & medicinal chemistry.

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Eric A. Horne, R. Gussio, M. Wagenbach, 2018, European journal of medicinal chemistry.

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

B. Cacciari, J. Balzarini, D. Schols, 2018, Journal of enzyme inhibition and medicinal chemistry.

Stabilization of the colchicine-binding activity of tubulin by organic acids.

E. Hamel, C. Lin, 1981, Biochimica et biophysica acta.

S‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent

E. Hamel, J. Burnett, A. Beatriz, 2019, ChemMedChem.

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.

Alejandro J. Ramirez, R. Mason, Zhe Shi, 2020, Journal of natural products.

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)*

P. Giannakakou, E. Hamel, R. Kowalski, 1997, The Journal of Biological Chemistry.

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation

G. Viola, Roberta Bortolozzi, A. Sacchetti, 2014, Molecular Diversity.

Tubulin-dependent biochemical assay for the antineoplastic agent taxol and application to measurement of the drug in serum.

E. Hamel, C. Lin, D. Johns, 1982, Cancer treatment reports.

Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.

F. Hess, E. Hamel, J. Batra, 1986, Cancer research.

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

R. D'Amato, J. Folkman, E. Flynn, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A bifunctional colchicinoid that binds to the androgen receptor

W. Farrar, M. Lill, J. Dalton, 2007, Molecular Cancer Therapeutics.

Direct Photoaffinity Labeling of Cysteine 211 or a Nearby Amino Acid Residue of β-Tubulin by Guanosine 5′-Diphosphate Bound in the Exchangeable Site*

E. Hamel, R. Bai, N. Nguyen, 1999, The Journal of Biological Chemistry.

Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.

G. Basso, G. Viola, S. Antus, 2014, European journal of medicinal chemistry.

Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.

M. Ihnat, E. Hamel, S. Mooberry, 2018, Bioorganic & medicinal chemistry letters.

Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.

K. Ain, R. Pettit, E. Hamel, 2012, Journal of natural products.

Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action.

H. Cottam, E. Hamel, L. Leoni, 2002, Cancer research.

Studies on the role of an Escherichia coli 50 S ribosomal component in polypeptide chain elongation.

T. Nakamoto, E. Hamel, 1972, The Journal of biological chemistry.

Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization.

E. Hamel, C M Lin, E Hamel, 1981, The Journal of biological chemistry.

Microtubule assembly with the guanosine 5'-diphosphate analogue 2',3'-dideoxyguanosine 5'-diphosphate.

E. Hamel, C. Lin, A. D. del Campo, 1983, Biochemistry.

Interrelationships of tubulin-GDP and tubulin-GTP in microtubule assembly.

E. Hamel, C. Lin, C. Lin, 1987, Biochemistry.

A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

E. Holland, Eric A. Horne, M. Wagenbach, 2020, Neuro-oncology advances.

Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue.

E. Hamel, Amos B. Smith, Jean M. Schmidt, 2002, Bioorganic & Medicinal Chemistry Letters.

Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9

M. Boyd, Z. Cichacz, E. Hamel, 1994 .

Azatoxin derivatives with potent and selective action on topoisomerase II.

Y. Pommier, K. Paull, D. Sackett, 1995, Biochemical pharmacology.

Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.

E. Hamel, P. Verdier-Pinard, G. Pettit, 2000, Molecular pharmacology.

Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.

A. Brossi, Yi Xia, K. Lee, 2003, Bioorganic & medicinal chemistry letters.

Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.

D. Scudiero, Y. Pommier, K. Paull, 1993, Biochemical pharmacology.

Synthesis and biological evaluation of paclitaxel analogs modified in ring C

D. Kingston, Xian Liang, E. Hamel, 1995 .

Synthesis and biological evaluation of 4-deacetoxypaclitaxel

D. Kingston, M. Chordia, E. Hamel, 1994 .

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.

A. Brancale, G. Viola, Roberta Bortolozzi, 2019, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of a Spongistatin AB‐Spiroketal Analogue.

E. Hamel, Amos B. Smith, Jean M. Schmidt, 2002 .

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

M. Ihnat, J. Thorpe, E. Hamel, 2014, Bioorganic & medicinal chemistry.

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2010, Journal of medicinal chemistry.

Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer

A. Jimeno, M. Hidalgo, E. Garrett-Mayer, 2007, Molecular Cancer Therapeutics.

Structure-activity requirements for flavone cytotoxicity and binding to tubulin.

M. Boyd, A. Vlietinck, J. Beutler, 1998, Journal of medicinal chemistry.

Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly.

E. Hamel, C. Lin, C. Lin, 1984, The Journal of biological chemistry.

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

E. Hamel, C M Lin, E Hamel, 1981, The Journal of biological chemistry.

Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity

P. Bonate, T. Copeland, E. Hamel, 2009, Molecular Pharmacology.

Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

E. Hamel, P. Harran, Z. Cruz-Monserrate, 2003, European journal of biochemistry.

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.

F. Meneghetti, G. Viola, Roberta Bortolozzi, 2015, Organic & biomolecular chemistry.

A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp.

M. K. Harper, A. Richardson, C. Ireland, 2003, Organic letters.

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

E. Hamel, G. Pettit, R. Bai, 1990, The Journal of biological chemistry.

Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.

D. Chaplin, E. Hamel, B. Siim, 2011, Journal of natural products.

Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action.

T. Nguyen, E. Hamel, Cecilia Prata, 2013, European journal of medicinal chemistry.

Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

A. Brancale, O. Cruz-López, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Effects of pH on tubulin-nucleotide interactions.

A B Huang, A. B. Huang, E. Hamel, 1986, Archives of biochemistry and biophysics.

An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.

D. Chaplin, E. Hamel, M. L. Trawick, 2012, MedChemComm.

Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization.

E. Hamel, L. Jurd, J. Batra, 1988, Biochemical pharmacology.

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

Arun K. Ghosh, P. Giannakakou, A. O'brate, 2002, Biochemistry.

3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.

A. Coluccia, A. Brancale, R. Silvestri, 2017, ACS medicinal chemistry letters.

Morpholino derivatives of benzyl-benzodioxole, a study of structural requirements for drug interactions at the colchicine/podophyllotoxin binding site of tubulin.

E. Hamel, L. Jurd, J. Batra, 1986, Biochemical pharmacology.

Deoxyguanosine nucleotide analogues: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin.

E. Hamel, C. Lin, J. Lustbader, 1984, Biochemistry.

Interactions of a new antimitotic agent, NSC-181928, with purified tubulin.

E. Hamel, C. Lin, 1982, Biochemical and biophysical research communications.

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents.

K. Lee, S. Morris-Natschke, E. Hamel, 2017, Journal of medicinal chemistry.

Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2014, ACS medicinal chemistry letters.

Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities

D. Kingston, M. Chordia, J. Rimoldi, 1994 .

Direct Photoaffinity Labeling of Cysteine-295 of α-Tubulin by Guanosine 5′-Triphosphate Bound in the Nonexchangeable Site*

E. Hamel, E Hamel, R. Bai, 1998, The Journal of Biological Chemistry.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

K. Giuliano, B. Day, D. Curran, 2005, Biochemistry.

Tetrahydroisoquinolinone‐Based Steroidomimetic and Chimeric Microtubule Disruptors

B. Potter, E. Hamel, M. Leese, 2014, ChemMedChem.

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.

A. Oda, K. Lee, E. Hamel, 2015, Journal of medicinal chemistry.

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

C. Martini, A. Coluccia, R. Silvestri, 2019, European journal of medicinal chemistry.

Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2013, Journal of medicinal chemistry.

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.

A. Marcus, F. Khuri, Jun Zhou, 2005, Cancer research.

Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.

B. Potter, A. Purohit, M. Reed, 2010, Journal of medicinal chemistry.

Antineoplastic agents 365. Dolastatin 10 SAR probes.

M. Boyd, R. Pettit, E. Hamel, 1998, Anti-cancer drug design.

Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.

Z. Wang, P. Fanwick, P. Nampoothiri, 2000, Journal of medicinal chemistry.

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.

Andrew J. Robles, E. Hamel, S. Mooberry, 2023, Bioorganic & medicinal chemistry.

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization.

R. Riccio, R. Esposito, A. Tosco, 2014, Molecular bioSystems.

Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.

T. Konoshima, E. Hamel, M. Kozuka, 1995, Journal of Natural Products.

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

S. Kuo, A. Mauger, K. Lee, 1994, Journal of medicinal chemistry.

Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide.

S. Hosseinkhani, S. Ostad, M. Amini, 2020, Medicinal chemistry (Shariqah (United Arab Emirates)).

Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.

M. Cushman, E. Hamel, A. Mohanakrishnan, 2004, Journal of medicinal chemistry.

Two new cytotoxic chalcones from Calythropsis aurea.

M. Boyd, R. Shoemaker, G. Cragg, 1993, Journal of natural products.

Tubulin polymerization with ATP is mediated through the exchangeable GTP site.

C. Duanmu, E. Hamel, C. Lin, 1986, Biochimica et biophysica acta.

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

A. Brancale, G. Viola, Roberta Bortolozzi, 2019, European journal of medicinal chemistry.

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.

A. Brancale, G. Basso, G. Viola, 2018, European journal of medicinal chemistry.

Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.

M. Sturlese, S. Moro, G. Viola, 2018, European journal of medicinal chemistry.

Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.

M. Sturlese, S. Moro, G. Basso, 2017, European journal of medicinal chemistry.

Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives.

Jan Balzarini, Roberto Gambari, Ernest Hamel, 2010, Medicinal chemistry (Shariqah (United Arab Emirates)).

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.

M. Ihnat, E. Hamel, S. Mooberry, 2021, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 4-deacetylpaclitaxel

D. Kingston, J. Rimoldi, E. Hamel, 1994 .

Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.

E. Hamel, S. Mooberry, A. Gangjee, 2017, Bioorganic & medicinal chemistry letters.

Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.

W. Bornmann, E. Hamel, Guangli Yang, 2009, Archives of biochemistry and biophysics.

Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.

M. Cushman, E. Hamel, D. Pryor, 2002, Journal of medicinal chemistry.

Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

M. Cushman, E. Hamel, D. Pryor, 2003, Journal of medicinal chemistry.

Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.

R. Pettit, E. Hamel, D. L. Herald, 2000, Journal of natural products.

Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors

Elif Ozkirimli, Fusun Kazan, Z Begum Yagci, 2019, Comput. Biol. Chem..

Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.

K. Lee, E. Hamel, C. Lin, 1993, Journal of medicinal chemistry.

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

M. Ihnat, E. Hamel, S. Mooberry, 2015, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 4-Deacetylpaclitaxel.

D. Kingston, J. Rimoldi, E. Hamel, 1995 .

Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogues with Increased Activities.

D. Kingston, M. Chordia, J. Rimoldi, 1994 .

Reexamination of the role of nonhydrolyzable guanosine 5'-triphosphate analogues in tubulin polymerization: reaction conditions are a critical factor for effective interactions at the exchangeable nucleotide site.

E. Hamel, C. Lin, 1990, Biochemistry.

Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity.

Arun K. Ghosh, Xiaoming Xu, J. Miller, 2010, The Journal of organic chemistry.

Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.

M. Boyd, R. Pettit, E. Hamel, 1999, Journal of medicinal chemistry.

Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds

L. Lo Presti, R. Gussio, P. De Wulf, 2012, Molecular Cancer Therapeutics.

Antineoplastic agents 442. Synthesis and biological activities of dioxostatin.

M. Boyd, E. Hamel, P. Verdier-Pinard, 2000, Anti-cancer drug design.

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

D. Trisciuoglio, R. Silvestri, G. La Regina, 2022, European journal of medicinal chemistry.

Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.

S. Moro, G. Basso, G. Viola, 2015, Journal of medicinal chemistry.

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.

E. Hamel, G. Pettit, M. Williams, 1995, Molecular pharmacology.

Synthesis of two fluorescent GTPγS molecules and their biological relevance

M. Coleman, E. Hamel, P. Henderson, 2017, Nucleosides, nucleotides & nucleic acids.

Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.

E. Hamel, S. Mooberry, A. Gangjee, 2018, Bioorganic & medicinal chemistry.

Interaction of pseudolaric acid B with the colchicine site of tubulin.

S. Qiu, R. Gussio, T. Nguyen, 2012, Biochemical pharmacology.

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2013, Bioorganic & medicinal chemistry.

Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies.

A. Olğaç, R. Cetin-Atalay, D. Kahraman, 2023, Journal of molecular structure.

Interactions of Tubulin with Guanine Nucleotides That Have Paclitaxel-like Effects on Tubulin Assembly: 2′,3′-Dideoxyguanosine 5′-[α,β-Methylene] Triphosphate Guanoine 5′-[α,β-Methylene] Triphosphate, and 2′,3′-Dideoxyguanosine 5′-Triphosphate

E. Hamel, Chii M. Lin, Z. Getahun, 1995 .

The magnesium-GTP interaction in microtubule assembly.

E. Hamel, S. Grover, 1994, European journal of biochemistry.

Interactions of tubulin with guanine nucleotides that have paclitaxel-like effects on tubulin assembly: 2',3'-dideoxyguanosine 5'-[alpha,beta-methylene]triphosphate, guanosine 5'-[alpha,beta-methylene]triphosphate, and 2',3'-dideoxyguanosine 5'-triphosphate.

E. Hamel, C. Lin, Z. Getahun, 1995, Archives of biochemistry and biophysics.

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.

C. Martini, A. Coluccia, R. Silvestri, 2021, European journal of medicinal chemistry.

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation

G. Basso, G. Viola, Roberta Bortolozzi, 2014, Molecular Diversity.

Antimitotic peptides and depsipeptides.

D. Covell, E. Hamel, 2012, Current medicinal chemistry. Anti-cancer agents.

The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A

Xiaoming Xu, Rick Gussio, Ernest Hamel, 2010, J. Chem. Inf. Model..

Stability of tubulin polymers formed with dideoxyguanosine nucleotides in the presence and absence of microtubule-associated proteins.

E. Hamel, C. Lin, A. D. del Campo, 1984, The Journal of biological chemistry.

Antitumor Agents. Part 236. Synthesis of Water-Soluble Colchicine Derivatives

A. Brossi, Chin‐Chung Wu, K. Lee, 2005 .

Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.

A. Brossi, K. Lee, E. Hamel, 1998, Journal of medicinal chemistry.

Structure-activity relationships of ustiloxin analogues.

E. Hamel, M. Joullié, S. Berritt, 2011, Tetrahedron letters.

Total synthesis and biological evaluation of ustiloxin natural products and two analogs.

E. Hamel, M. Joullié, Pixu Li, 2006, Bioorganic & medicinal chemistry letters.

Antifungal and cancer cell growth inhibitory activities of 1‐(3′,4′,5′‐trimethoxyphenyl)‐2‐nitro‐ethylene

R. Pettit, R. Roberson, E. Hamel, 2002, Mycoses.

Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.

Taylor A. Gentile, E. Hamel, S. Mooberry, 2018, Bioorganic & medicinal chemistry.

Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate.

P. Skehan, S. Kenney, E. Hamel, 1991, Archives of biochemistry and biophysics.

Modulation of tubulin-nucleotide interactions by metal ions: comparison of beryllium with magnesium and initial studies with other cations.

P. Skehan, S. Kenney, E. Hamel, 1992, Archives of biochemistry and biophysics.

Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents

E. Hamel, S. Mooberry, A. Gangjee, 2012, Pharmaceutical Research.

Nucleotide interconversions in microtubule protein preparations, a significant complication for accurate measurement of GTP hydrolysis in the presence of adenosine 5'-(beta, gamma-imidotriphosphate).

E. Hamel, J. Batra, C. Lin, 1987, Biochemistry.

Inhibition of tubulin polymerization with ribose-modified analogs of GDP and GTP. Reduced inhibition with microtubule-associated proteins and magnesium.

E. Hamel, C. Lin, C. Lin, 1984, Biochimica et biophysica acta.

Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives

M. Amini, E. Hamel, Z. Shahsavari, 2019, DARU Journal of Pharmaceutical Sciences.

Inhibition of tubulin polymerization by select alkenyldiarylmethanes.

E. De Clercq, C. Pannecouque, M. Cushman, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues.

F. Bihel, J. Bourguignon, M. Schmitt, 2013, Anti-cancer agents in medicinal chemistry.

Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.

E. Hamel, S. Mooberry, A. Gangjee, 2011, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents

A. Brancale, S. Manfredini, R. Romagnoli, 2020, Molecules.

Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: synthesis, stereochemistry, and NMR line broadening.

E. Hamel, G. Pettit, R. Bates, 2002, Journal of natural products.

Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas.

G. Viola, Roberta Bortolozzi, F. Bertoni, 2023, European journal of medicinal chemistry.

A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel

Ian Paterson, Ernest Hamel, E. Hamel, 2004, Cancer Chemotherapy and Pharmacology.

Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP.

R. Gussio, E. Hamel, C. McGrath, 2009, Archives of biochemistry and biophysics.

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure

M. Steinmetz, A. Prota, B. Potter, 2019, ACS omega.

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

M. Cushman, E. Hamel, D. Nagarathnam, 1992, Journal of medicinal chemistry.

Interaction of tubulin with ribose-modified analogs of GTP and GDP: evidence for two mutually exclusive exchangeable nucleotide binding sites.

E. Hamel, C. Lin, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

S. Parangi, E. Flynn, E. Hamel, 1997, Cancer research.

Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors.

P. Fanwick, M. Cushman, Yunlong Song, 2008, The Journal of organic chemistry.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)*

P. Giannakakou, E. Hamel, R. Kowalski, 1997, The Journal of Biological Chemistry.

Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011, Molecular Cancer Therapeutics.

2,4-Dichlorobenzyl thiocyanate, an antimitotic agent that alters microtubule morphology.

M. Gottesman, E. Hamel, R. L. Dion, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Induction of polymerization of purified tubulin by sulfonate buffers. Marked differences between 4-morpholineethanesulfonate (Mes) and 1,4-piperazineethanesulfonate (Pipes).

E. Hamel, M. Lowe, A. D. del Campo, 1981, European journal of biochemistry.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

E. Novellino, L. Di Marcotullio, A. Brancale, 2014, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.

María Kimatrai Salvador, A. Brancale, G. Viola, 2015, Journal of medicinal chemistry.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.

Evolution of the total syntheses of ustiloxin natural products and their analogues.

E. Hamel, M. Joullié, Pixu Li, 2008, Journal of the American Chemical Society.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

M. Steinmetz, B. Potter, A. Prota, 2018, Journal of medicinal chemistry.

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

D. Trisciuoglio, R. Silvestri, G. La Regina, 2022, European journal of medicinal chemistry.

Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity

P. Bonate, T. Copeland, E. Hamel, 2009, Molecular Pharmacology.

3-Aroyl-1-arylpyrroles: a New Class of Potent Inhibitors of Tubulin Polymerization.

E. Novellino, R. Silvestri, E. Hamel, 2014 .

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

A. Antunes, E. Hamel, D. D. de Lima, 2013, Bioorganic & medicinal chemistry letters.

Dolastatin 11 conformations, analogues and pharmacophore.

Jacob C. Marcischak, E. Hamel, G. Pettit, 2005, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.

J. Balzarini, P. Baraldi, R. Romagnoli, 2008, Medicinal chemistry (Shariqah (United Arab Emirates)).