S. Shire

发表

TRAP, the trp RNA-binding attenuation protein of Bacillus subtilis, is a multisubunit complex that appears to recognize G/UAG repeats in the trpEDCFBA and trpG transcripts.

C. Yanofsky, J. Stults, P. Babitzke, 1994, The Journal of biological chemistry.

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime.

Sandeep Yadav, Steven J Shire, D. Kalonia, 2011, Analytical biochemistry.

The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions.

Sandeep Yadav, Steven J Shire, T. Laue, 2012, Molecular pharmaceutics.

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modeling.

Gregory A Voth, Sandeep Yadav, Steven J Shire, 2013, The journal of physical chemistry. B.

Formulation of proteins and monoclonal antibodies (mAbs)

S. Shire, 2015 .

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Steven J. Shire, S. Shire, Reed J. Harris, 2004 .

Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE.

S. Shire, J. Liu, P. Lester, 1995, Biochemistry.

Current trends in monoclonal antibody development and manufacturing

S. Shire, 2010 .

pH-dependent processes in proteins.

F. Gurd, K. March, J. B. Matthew, 1985, CRC critical reviews in biochemistry.

Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations

Steven J. Shire, Chung C. Hsu, S. Shire, 2003, AAPS PharmSci.

Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins.

S. Shire, S. Yadav, Jun Liu, 2015, Methods in enzymology.

Self-Association of Therapeutic Proteins

Heather Flores, M. Cromwell, S. Shire, 2006 .

Challenges in the development of high protein concentration formulations.

Steven J Shire, Jun Liu, Z. Shahrokh, 2004, Journal of pharmaceutical sciences.

Analytical ultracentrifugation in the pharmaceutical industry.

S. Shire, Jun Liu, J. Liu, 1999, Journal of pharmaceutical sciences.

Title Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor

N. Ferrara, S. Shire, S. Yadav, 2014 .

Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A.

E. Day, G. Fuh, N. Ferrara, 2014, Molecular pharmaceutics.

Characterization of a recombinant extracellular domain of the type 1 tumor necrosis factor receptor: evidence for tumor necrosis factor-alpha induced receptor aggregation.

D. Goeddel, W. Kohr, D. Pennica, 1992, Biochemistry.

Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin

J. Cole, D. Kalonia, J. Kaur, 2017, Pharmaceutical Research.

Biochemical characterization of the extracellular domain of the 75-kilodalton tumor necrosis factor receptor.

D. Goeddel, W. Kohr, A. Ashkenazi, 1993, Biochemistry.

Analytical Ultracentrifugation and its use in Biotechnology

S. Shire, 1994 .

A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation.

S. Shire, Jun Liu, Barthélemy Demeule, 2009, Analytical biochemistry.

Electron-microscopic and hydrodynamic characterization of recombinant apolipoprotein (a) and its association with LDL.

V. Schumaker, R. Lawn, S. Shire, 1994, Chemistry and physics of lipids.

Physical properties of recombinant apolipoprotein(a) and its association with LDL to form an LP(a)-like complex.

V. Schumaker, R. Lawn, S. Shire, 1993, Biochemistry.

Biophysical Signatures of Monoclonal Antibodies

S. Shire, T. Spitznagel, N. Harn, 2010 .

Challenges in Determining Intrinsic Viscosity Under Low Ionic Strength Solution Conditions

D. Kalonia, S. Shire, S. Yadav, 2017, Pharmaceutical Research.

7 – Strategies to deal with challenges of developing high-concentration subcutaneous (SC) formulations for monoclonal antibodies (mAbs)

S. Shire, 2015 .

Comparative study of analytical techniques for determining protein charge.

T. Laue, S. Shire, S. Yadav, 2015, Journal of pharmaceutical sciences.

Evidence for the involvement of histidine A(12) in the aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation.

R. Borchardt, S. Shire, M. Khossravi, 2000, Biochemistry.

Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

S. Shire, S. Yadav, T. Scherer, 2014 .

BIOSYNTHETIC VACCINE FOR FOOT-AND-MOUTH DISEASE

D. Dowbenko, D. Kleid, D. Yansura, 1983 .

Interaction of Human IgE with Soluble Forms of IgE High Affinity Receptors

S. Shire, J. Ruppel, Jim Liu, 1997, Pharmaceutical Research.

Biophysical Analysis in Support of Development of Protein Pharmaceuticals

M. Cromwell, S. Shire, S. Yadav, 2013 .

Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states.

C. Hsu, S. Shire, H. Costantino, 1999, Journal of pharmaceutical sciences.

The effect of cosolutes on the isomerization of aspartic acid residues and conformational stability in a monoclonal antibody.

Aditya A Wakankar, R. Borchardt, Y. J. Wang, 2007, Journal of pharmaceutical sciences.

A technical feasibility study of dornase alfa delivery with eFlow® vibrating membrane nebulizers: aerosol characteristics and physicochemical stability.

S. Shire, T. Scherer, M. Keller, 2011, Journal of pharmaceutical sciences.

Characterization of Aerosols of Human Recombinant Deoxyribonuclease I (rhDNase) Generated by Jet Nebulizers

S. Shire, I. Gonda, D. Cipolla, 1994, Pharmaceutical Research.

Assessment of aerosol delivery systems for recombinant human deoxyribonuclease

S. Shire, I. Gonda, D. Cipolla, 1994 .

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity.

Steven J Shire, Thomas W Patapoff, Jun Liu, 2008, Journal of pharmaceutical sciences.

Characterization of Particles in Protein Solutions: Reaching the Limits of Current Technologies

S. Shire, Jun Liu, Barthélemy Demeule, 2010, The AAPS Journal.

Studies on the mechanism of assembly of tobacco mosaic virus.

S. Shire, M. Potschka, T. M. Schuster, 1980, Biophysical journal.

Leachables from Saline-Containing IV Bags Can Alter Therapeutic Protein Properties

V. Katta, Jennifer Zhang, S. Shire, 2010, Pharmaceutical Research.

Viscosity behavior of high-concentration monoclonal antibody solutions: correlation with interaction parameter and electroviscous effects.

Sandeep Yadav, Steven J Shire, D. Kalonia, 2012, Journal of pharmaceutical sciences.

Viscosity Analysis of High Concentration Bovine Serum Albumin Aqueous Solutions

Steven J. Shire, Sandeep Yadav, D. Kalonia, 2011, Pharmaceutical Research.

3 – Stability of monoclonal antibodies (mAbs)

Steven J. Shire, S. Shire, 2015 .

Effect of Spray Drying and Subsequent Processing Conditions on Residual Moisture Content and Physical/Biochemical Stability of Protein Inhalation Powders

Steven J. Shire, Chung C. Hsu, Y. Maa, 1998, Pharmaceutical Research.

Self-association of human and porcine relaxin as assessed by analytical ultracentrifugation and circular dichroism.

S. Shire, L. A. Holladay, E. Rinderknecht, 1991, Biochemistry.

Monoclonal antibody self-association, cluster formation, and rheology at high concentrations.

Sandeep Yadav, Steven J Shire, S. Shire, 2013, The journal of physical chemistry. B.

Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter.

Sandeep Yadav, Steven J Shire, Barthélemy Demeule, 2012, Biophysical journal.

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution.

Steven J Shire, Jun Liu, S. Shire, 2005, Journal of pharmaceutical sciences.

2 – Analytical tools used in the formulation and assessment of stability of monoclonal antibodies (mAbs)

Steven J. Shire, S. Shire, 2015 .

Assessment and significance of protein–protein interactions during development of protein biopharmaceuticals

Sonoko Kanai, Y. Gokarn, S. Shire, 2013, Biophysical Reviews.

Challenges and Issues in the Development of Formulations of Protein Pharmaceuticals

S. Shire, 1999 .

Stability and characterization of recombinant human relaxin.

S. Shire, T. H. Nguyen, 1996, Pharmaceutical biotechnology.

Carboxylate-Dependent Gelation of a Monoclonal Antibody

T. Patapoff, Sonoko Kanai, S. Shire, 2009, Pharmaceutical Research.

Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies.

Gregory A Voth, Tim J Kamerzell, Steven J Shire, 2012, The journal of physical chemistry. B.

IL‐8 single‐chain homodimers and heterodimers: Interactions with the chemokine receptors CXCR1, CXCR2, and DARC

R. Mcdowell, H. Lowman, S. Shire, 1997, Protein science : a publication of the Protein Society.

Effect of Moisture on the Stability of a Lyophilized Humanized Monoclonal Antibody Formulation

Chung C. Hsu, C. Hsu, S. Shire, 2001, Pharmaceutical Research.

Upper and Lower Bounds to Long‐Range Intermolecular Potentials

D. A. Mcquarrie, S. Shire, J. Terebey, 1969 .

Monomeric variants of IL‐8: Effects of side chain substitutions and solution conditions upon dimer formation

W. Fairbrother, H. Lowman, S. Shire, 1997, Protein science : a publication of the Protein Society.

Kinetics and mechanism of tobacco mosaic virus assembly: direct measurement of relative rates of incorporation of 4S and 20S protein.

S. Shire, T. M. Schuster, M. L. Adams, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Formulation and manufacturability of biologics.

Steven J Shire, S. Shire, 2009, Current opinion in biotechnology.

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

J L Cleland, M. Powell, J. Cleland, 1993, Critical reviews in therapeutic drug carrier systems.

Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies.

Ronald T Borchardt, Aditya A Wakankar, Y John Wang, 2007, Biochemistry.

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

B. Kabakoff, S. Shire, K. Totpal, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Assessment and significance of protein–protein interactions during development of protein biopharmaceuticals

Sonoko Kanai, Y. Gokarn, S. Shire, 2013, Biophysical Reviews.

Purification and immunogenicity of fusion VP1 protein of foot and mouth disease virus.

D. Kleid, D. Moore, S. Shire, 1984, Biochemistry.

5 – Challenges in the intravenous (IV) administration of monoclonal antibodies (mAbs)

S. Shire, 2015 .

Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions

S. Shire, T. Scherer, Laura Owyang, 2012, The AAPS Journal.

Characteristics of rhVEGF Release from Topical Hydrogel Formulations

Y. J. Wang, Tim J. Kamerzell, S. Shire, 2010, Pharmaceutical Research.

Protein Inhalation Powders: Spray Drying vs Spray Freeze Drying

Steven J. Shire, Chung C. Hsu, Y. Maa, 1999, Pharmaceutical Research.

The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody1

Steven J. Shire, Chung C. Hsu, Y. Maa, 1999, Pharmaceutical Research.

Preparation and properties of recombinant DNA derived tobacco mosaic virus coat protein.

W. Wood, S. Shire, D. Leung, 1990, Biochemistry.

Small-angle neutron scattering characterization of monoclonal antibody conformations and interactions at high concentrations.

Yatin Gokarn, Norman J Wagner, Steven J Shire, 2013, Biophysical journal.

The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies.

D. Kalonia, S. Shire, S. Yadav, 2018, Molecular pharmaceutics.

A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation

S. Shire, Jun Liu, J. Andya, 2006, The AAPS Journal.

Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-IgE monoclonal antibody.

Chung C. Hsu, Y. Maa, C. Hsu, 1998, Journal of pharmaceutical sciences.

Electrostatic effects in myoglobin. Hydrogen ion equilibria in sperm whale ferrimyoglobin.

F. Gurd, S. Shire, G. Hanania, 1974, Biochemistry.

Mechanism of self-assembly of tobacco mosaic virus protein. II. Characterization of the metastable polymerization nucleus and the initial stages of helix formation.

S. Shire, T. M. Schuster, J. Steckert, 1979, Journal of molecular biology.

Assessing and Improving Asymmetric Flow Field-Flow Fractionation of Therapeutic Proteins

S. Shire, Jun Liu, Barthélemy Demeule, 2012 .

Separation‐Based Analytical Methods for Measuring Protein Aggregation

S. Shire, Jun Liu, Barthélemy Demeule, 2012 .

The Pharmaceutical Development of rhDNase (Dornase Alpha) for the Treatment of Cystic Fibrosis

S. Shire, T. Scherer, 2014 .

Stability characterization and formulation development of recombinant human deoxyribonuclease I [Pulmozyme, (dornase alpha)].

S. Shire, 1996, Pharmaceutical biotechnology.

Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies.

Sandeep Yadav, Steven J Shire, D. Kalonia, 2010, Journal of pharmaceutical sciences.

Fourier‐transform Infrared Spectroscopic Analysis of the Secondary Structure of Recombinant Humanized Immunoglobulin G

Chung C. Hsu, S. Shire, H. Costantino, 1997 .

Specific interactions in high concentration antibody solutions resulting in high viscosity.

Sandeep Yadav, Steven J Shire, Jun Liu, 2010, Journal of pharmaceutical sciences.

Therapeutic protein and peptide formulation and delivery

Z. Shahrokh, T. Randolph, J. Cleland, 1997 .

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

Steven J. Shire, Sandeep Yadav, Alavattam Sreedhara, 2011, Pharmaceutical Research.

Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions

S. Shire, T. Scherer, Laura Owyang, 2012, The AAPS Journal.

6 – Challenges in the subcutaneous (SC) administration of monoclonal antibodies (mAbs)

S. Shire, 2015 .

Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering.

A. Minton, S. Shire, T. Scherer, 2010, The journal of physical chemistry. B.

Fourier‐transform Infrared Spectroscopic Investigation of the Secondary Structure of Aqueous and Dried Recombinant Human Deoxyribonuclease I

Chung C. Hsu, K. Griebenow, S. Shire, 1998 .

Influence of the cosolute environment on IgG solution structure analyzed by small-angle X-ray scattering.

S. Shire, T. Scherer, W. Lilyestrom, 2012, The journal of physical chemistry. B.

9 – The molecular basis of high viscosity of monoclonal antibodies (mAbs) at high concentration

S. Shire, 2015 .

High‐Concentration Antibody Formulations

W. Friess, S. Shire, Jun Liu, 2010 .

The molecular interaction process.

T. Laue, S. Shire, 2020, Journal of pharmaceutical sciences.

pH-dependent polymerization of a human leukocyte interferon produced by recombinant deoxyribonucleic acid technology.

S. Shire, 1983, Biochemistry.

Oxygen Binding to Myoglobins and Their Cobalt Analogues

F. Gurd, B. Hoffman, S. Shire, 1979 .

Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions.

Sandeep Yadav, Rita L. Wong, Barthélemy Demeule, 2015, Molecular pharmaceutics.

Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties.

Tim J Kamerzell, Steven J Shire, Y John Wang, 2009, The journal of physical chemistry. B.

Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation

S. Shire, Jun Liu, J. Andya, 2010 .

Sedimentation equilibrium measurements of the intermediate-size tobacco mosaic virus protein polymers.

J. Correia, S. Shire, D. A. Yphantis, 1985, Biochemistry.

Electrostatic effects in myoglobin. Application of the modified Tanford-Kirkwood theory to myoglobins from horse, California grey whale, harbor seal, and California sea lion.

F. Gurd, S. Shire, G. Hanania, 1975, Biochemistry.

Electrostatic effects in myoglobin. pH and ionic strength variations of ionization equilibria for individual groups in sperm whale ferrimyoglobin.

F. Gurd, S. Shire, G. Hanania, 1974, Biochemistry.

The effect of sugars and buffer excipients on the stabilization of a lyophilized formulation for an anti-IgE humanized monoclonal antibody

Chung C. Hsu, S. Shire, J. Andya, 1996 .

Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration

Steven J. Shire, Sandeep Yadav, D. Kalonia, 2014, Pharmaceutical Research.

Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin

J. Cole, D. Kalonia, J. Kaur, 2017, Pharmaceutical Research.

Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies.

G. Voth, T. Patapoff, Tim J. Kamerzell, 2012, The journal of physical chemistry. B.