D. Belelli

发表

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

B. Orser, J. Macdonald, J. Lambert, 2004 .

Neurosteroids: endogenous regulators of the GABAA receptor

J. Lambert, D. Belelli, Delia Belelli, 2005, Nature Reviews Neuroscience.

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

Matthew C. Walker, Neil L. Harrison, David W. Cope, 2009, The Journal of Neuroscience.

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

R. B. Carter, P. Wood, J. Lambert, 1997, The Journal of pharmacology and experimental therapeutics.

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

M. Bolger, K. Gee, D. Belelli, 1989 .

The Concise Guide to Pharmacology 2013/14: Overview

Adam J Pawson, Stephen P. H. Alexander, A. A. Khan, 2013, British journal of pharmacology.

GABAA receptor subtype involvement in addictive behaviour

T. Duka, D. Stephens, J. Lambert, 2017, Genes, brain, and behavior.

Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABAA receptors

Gerome Breen, Gunter Schumann, Camila Guindalini, 2010, Proceedings of the National Academy of Sciences.

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA &agr;2 receptor expression

D. Stephens, J. Lambert, S. King, 2019, Behavioural pharmacology.

University of Dundee Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA 2 receptor expression Dixon,

D. Stephens, J. Lambert, D. Belelli, 2019 .

Extrasynaptic Glycine Receptors of Rodent Dorsal Raphe Serotonergic Neurons: A Sensitive Target for Ethanol

S. J. Greig, J. Lambert, D. Balfour, 2014, Neuropsychopharmacology.

MUTATIONS IN THE GABRB1 GENE PROMOTE ALCOHOL CONSUMPTION THROUGH INCREASED TONIC INHIBITION

Alastair M. Hosie, Jimmy D Bell, E. Fisher, 2013, Nature Communications.

Neurosteroids and GABA, receptor function

J. A. Peters, D. Belelli, C. Hill‐Venning, 1995 .

The GABAA receptor: An important target for the general anaesthetic etomidate

J. Lambert, T. Rosahl, K. Wafford, 2005 .

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.

J. A. Peters, J. Lambert, N. Lan, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

T. Blackburn, J. A. Peters, A. Hope, 1995, Molecular pharmacology.

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

J. Atack, J. Lambert, D. Belelli, 2021, Journal of neuroendocrinology.

The influence of subunit composition on the interaction of neurosteroids with GABAA receptors

J. Lambert, D. Belelli, A. Casula, 2002, Neuropharmacology.

endogenous and synthetic neuroactive steroids

B. Frenguelli, J. A. Peters, J. Lambert, 2001 .

Functional Alternatives to Alcohol

D. Nutt, M. Spriggs, R. Tyacke, 2022, Nutrients.

Molecular determinants of (+)-tubocurarine binding at recombinant 5-hydroxytryptamine3A receptor subunits.

J. A. Peters, A. Hope, J. Lambert, 1999, Molecular pharmacology.

The interaction of trichloroethanol with murine recombinant 5‐HT3 receptors

J. A. Peters, N. Barnes, A. Hope, 1995, British journal of pharmacology.

Modulation of Human Recombinant GABAA Receptors by Pregnanediols

J. A. Peters, J. Lambert, K. Gee, 1996, Neuropharmacology.

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex

K. Gee, N. Lan, D. Belelli, 1990, Neuroscience & Biobehavioral Reviews.

A single amino acid confers barbiturate sensitivity upon the GABA r1 receptor

J. A. Peters, J. Lambert, D. Belelli, 1999 .

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

J. Lambert, N. Lan, J. Hawkinson, 1994, Molecular pharmacology.

5α-pregnan-3α,20α-diol behaves like a partial agonist in the modulation of GABA-stimulated chlride ion uptake by synaptoneurosomes

K. Gee, D. Belelli, 1989 .

A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor.

P. Seeburg, K. Gee, N. Lan, 1990, European journal of pharmacology.

GABAA receptors in GtoPdb v.2021.3.

R. Olsen, W. Sieghart, J. A. Peters, 2021, IUPHAR/BPS guide to pharmacology CITE.

A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.

G. Simig, M. Spedding, L. Hársing, 2015, European journal of pharmacology.

Neurosteroids on our minds.

G. Puia, D. Belelli, 2001, Trends in pharmacological sciences.

Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors: commentary on Brown et al

J. Lambert, D. Belelli, Jeremy J. Lambert, 2002 .

Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus

J. Lambert, K. Wafford, Q. Ma, 2009, Neuropharmacology.

Neurosteroid modulation of GABAA receptors

J. A. Peters, J. Lambert, D. Belelli, 2003, Progress in Neurobiology.

Neurosteroids and GABAA Receptor Interactions: A Focus on Stress

J. Lambert, D. Belelli, A. R. Brown, 2011, Front. Neurosci..

Neurosteroid modulation of GABAA receptors: Molecular determinants and significance in health and disease

J. Lambert, D. Belelli, E. Mitchell, 2008, Neurochemistry International.

The expression of GABAAβ subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells

G. Homanics, J. Lambert, T. Rosahl, 2008, The Journal of physiology.

GABAA and glycine receptor‐mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids

L. Gentet, D. Belelli, J. Dempster, 2007, The Journal of physiology.

Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics

J. Lambert, T. Rosahl, K. Wafford, 2005, The Journal of Neuroscience.

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

B. Frenguelli, J. A. Peters, J. Lambert, 2001, Brain Research Reviews.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

B. Orser, J. Macdonald, J. Lambert, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance

L. Gentet, J. Lambert, D. Belelli, 2006, Neuroscience.

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

J. Lambert, K. Gee, D. Belelli, 2019, Neurobiology of Stress.

Realizing the therapeutic potential of GABAAR-active neurosteroids

J. Lambert, K. Gee, D. Belelli, 2019 .

The Interaction of Intravenous Anesthetic Agents with Native and Recombinant GABAA Receptors

M. Pistis, J. A. Peters, J. Lambert, 1997 .

Neurosteroids and GABAA receptor function.

J. A. Peters, J. Lambert, D. Belelli, 1995, Trends in pharmacological sciences.

The interaction of general anaesthetics and neurosteroids with GABAA and glycine receptors

M. Pistis, J. A. Peters, J. Lambert, 1999, Neurochemistry International.

Characterization of the anticonvulsant properties of Ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid(A) receptor

R. B. Carter, P. Wood, J. Lambert, 1997 .

Steroid Modulation of GABAA Receptors

J. A. Peters, J. Lambert, D. Belelli, 2001 .

Neurosteroid modulation of recombinant and synaptic GABAA receptors.

J. A. Peters, J. Lambert, D. Belelli, 2001, International review of neurobiology.

The Selective Interaction of Neurosteroids with the GABA A Receptor

M. Pistis, J. A. Peters, J. Lambert, 1999 .

The Contraceptive Agent Provera Enhances GABAA Receptor-Mediated Inhibitory Neurotransmission in the Rat Hippocampus: Evidence for Endogenous Neurosteroids?

D. Belelli, M. Herd, 2003, The Journal of Neuroscience.

Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response

J. Lambert, D. Belelli, J. Swinny, 2013, The Journal of Neuroscience.

Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses

M. Tremblay, T. Baram, M. Cahalan, 2022, Cell reports.

Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.

N. Burnashev, A. Rozov, T. Tsintsadze, 2015, Cerebral cortex.

A Transmembrane Residue Influences the Interaction of Propofol with the Strychnine-Sensitive Glycine α1 and α1β Receptor

J. Lambert, D. Belelli, K. Krampfl, 2008, Anesthesia and analgesia.

Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo‐axonic synapses on CA1 pyramidal cells

P. Scheiffele, J. Lambert, J. Fritschy, 2011, The Journal of physiology.

Heterotropic Cooperativity Between Putative Recognition Sites for Progesterone Metabolites and the Atypical Benzodiazepine Ro 5–4864

K. Gee, D. Belelli, L. McCauley, 1990, Journal of neurochemistry.

Molecular and Functional Diversity of GABA-A Receptors in the Enteric Nervous System of the Mouse Colon

P. Bhandari, J. Lambert, D. Belelli, 2014, The Journal of Neuroscience.

The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study

M Pistis, D Belelli, J A Peters, 1997, British journal of pharmacology.

Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

G. Dawson, T. Iwatsubo, I. Nishimoto, 2003, The Journal of Neuroscience.

Neurosteroids: Endogenous allosteric modulators of GABAA receptors

J. Lambert, D. Belelli, M. Cooper, 2009, Psychoneuroendocrinology.

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

K. Sillar, L. Gentet, S. Merrywest, 2003, Neuropharmacology.

Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life

M. Tremblay, T. Baram, M. Cahalan, 2021, bioRxiv.

GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

R. Olsen, W. Sieghart, J. A. Peters, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones

G. Homanics, J. Lambert, J. Fritschy, 2008, The Journal of physiology.

GABAA receptor-acting neurosteroids: A role in the development and regulation of the stress response

J. Lambert, D. Belelli, J. Swinny, 2015, Frontiers in Neuroendocrinology.

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

J. Lambert, D. Belelli, J. Swinny, 2015, Brain Structure and Function.

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule

M. Spedding, D. Choquet, J. Lambert, 2012, Molecular Psychiatry.

Neurosteroid modulation of native and recombinant GABAA receptors

J. A. Peters, J. Lambert, D. Belelli, 1996, Cellular and Molecular Neurobiology.

Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.

J. Lambert, D. Belelli, M. Herd, 2007, Pharmacology & therapeutics.

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

P. Whiting, J. A. Peters, J. Lambert, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor

J. A. Peters, J. Lambert, D. Belelli, 1997, British journal of pharmacology.

Complementary regulation of anaesthetic activation of human (α6β3γ2L) and Drosophila (RDL) GABA receptors by a single amino acid residue

M. Pistis, J. A. Peters, J. Lambert, 1999 .

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones

J. Lambert, D. Belelli, M. Herd, 2015, The Journal of physiology.

Inhibition of thalamic excitability by 4,5,6,7‐tetrahydroisoxazolo[4,5‐c]pyridine‐3‐ol: a selective role for δ‐GABAA receptors

V. Brown, G. Homanics, D. Chandra, 2009, The European journal of neuroscience.

The immediate and maintained effects of neurosteroids on GABAA receptors

J. A. Peters, D. Belelli, G. Phillips, 2022, Current Opinion in Endocrine and Metabolic Research.

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development

G. Phillips, D. Belelli, J. Swinny, 2018, Journal of neuroendocrinology.

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

J. Lambert, D. Belelli, J. Swinny, 2016, Neuropharmacology.

University of Dundee During postnatal development endogenous neurosteroids influence GABAergic neurotransmission of mouse cortical neurons

J. Lambert, D. Belelli, J. Swinny, 2016 .

The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors.

J. A. Peters, J. Lambert, D. Belelli, 2004, British journal of anaesthesia.

Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brain

D. S. Joy, K. Gee, D. Belelli, 1989, Brain Research.

5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes.

K. Gee, D. Belelli, 1989, European journal of pharmacology.

Extrasynaptic GABAA Receptors Couple Presynaptic Activity to Postsynaptic Inhibition in the Somatosensory Thalamus

J. Lambert, D. Belelli, M. Herd, 2013, The Journal of Neuroscience.

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

J. Lambert, K. Wafford, D. Belelli, 2013, British journal of pharmacology.

Tonic Inhibition of Accumbal Spiny Neurons by Extrasynaptic α4βδ GABAA Receptors Modulates the Actions of Psychostimulants

D. Stephens, Tom Macpherson, J. Lambert, 2014, The Journal of Neuroscience.

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

M. Spedding, J. Lambert, S. Kertész, 2017, Neuropharmacology.

Electrophysiological Studies of Neurosteroid Modulation of γ-Aminobutyric Acid Type A Receptor

J. A. Peters, J. Lambert, D. Belelli, 1994 .

The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol

R. Harris, J. Lambert, K. Wafford, 2006, Journal of Pharmacology and Experimental Therapeutics.

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents

D. Rusakov, Alexey Semyanov, M. Walker, 2013, The Journal of Neuroscience.

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

R. Harris, J. Lambert, K. Wafford, 2006, The Journal of pharmacology and experimental therapeutics.

Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes

J. A. Peters, J. Lambert, D. Belelli, 1996, British journal of pharmacology.

A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor

J. A. Peters, J. Lambert, D. Belelli, 1999 .

GEMS–RCPSG: ‘Is Academic Medicine for Me?’ National Conference 2011, 19 November 2011

H. Branigan, D. Webb, H. Grabsch, 2012 .

The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor

M. Pistis, A. Hope, J. Lambert, 1998, British journal of pharmacology.

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine

D. Stephens, J. Lambert, S. King, 2018, Neuropharmacology.

General anaesthetic action at transmitter-gated inhibitory amino acid receptors.

D Belelli, J A Peters, J J Lambert, 1999, Trends in pharmacological sciences.

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition

J. Lambert, D. Belelli, M. Herd, 2014, The European journal of neuroscience.

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.

M. Bolger, K. Gee, D. Belelli, 1989, European journal of pharmacology.

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

J. Lambert, D. Belelli, M. Herd, 2014, The Journal of physiology.

Receptors on Hippocampal Neurons Carrier-Mediated GABA Release Activates GABA

C. B. Ransom, D. Rusakov, Alexey Semyanov, 2015 .

Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue.

M. Pistis, J. A. Peters, J. Lambert, 1999, The Journal of physiology.

α-Amino Acid Phenolic Ester Derivatives: Novel Water-Soluble General Anesthetic Agents Which Allosterically Modulate GABAA Receptors

R. McGuire, J. A. Peters, J. Lambert, 2001 .

GABAA receptor modulation by the novel intravenous general anaesthetic E-6375

J. A. Peters, J. Lambert, J. Dunlop, 2003, Neuropharmacology.

Neurosteroid modulation of GABAA receptors.

J. A. Peters, J. Lambert, D. Belelli, 2003, Progress in neurobiology.

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

M. Spedding, J. Lambert, S. Kertész, 2017, Neuropharmacology.

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

J. Atack, J. Lambert, D. Belelli, 2021, Journal of neuroendocrinology.

Neurosteroid modulation of GABAA receptors

J. A. Peters, J. Lambert, D. Belelli, 2003, Progress in Neurobiology.

Serotonin release and metabolism in rat cortex as studied by transcerebral dialysis.

G. Di Chiara, E. Carboni, L. Perezzani, 1988, Pharmacological research communications.

receptor openings

D. Rusakov, S. Sylantyev, D. Belelli, 2013 .

α4-Containing GABAA Receptors on DRD2 Neurons of the Nucleus Accumbens Mediate Instrumental Responding for Conditioned Reinforcers and Its Potentiation by Cocaine

P. Janak, D. Stephens, Tom Macpherson, 2023, eNeuro.