D. Maclennan

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Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.

G. Shull, J. Lytton, M. Westlin, 1992, The Journal of biological chemistry.

'Compartmentation' of acids in plant tissues.

D. Maclennan, H. Beevers, J. L. Harley, 1963, The Biochemical journal.

Calcium: Phospholamban: a crucial regulator of cardiac contractility

E. Kranias, D. Maclennan, David H. MacLennan, 2003, Nature Reviews Molecular Cell Biology.

Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban

Ulrike Mende, Christine E Seidman, Ferhaan Ahmad, 2003, Science.

Multidimensional protein identification technology (MudPIT): Technical overview of a profiling method optimized for the comprehensive proteomic investigation of normal and diseased heart tissue

Andrew Emili, Thomas Kislinger, A. Emili, 2005, Journal of the American Society for Mass Spectrometry.

Cardiovascular proteomics: tools to develop novel biomarkers and potential applications.

Peipei Ping, Andrew Emili, Thomas Kislinger, 2006, Journal of the American College of Cardiology.

Comparative Proteomics Profiling of a Phospholamban Mutant Mouse Model of Dilated Cardiomyopathy Reveals Progressive Intracellular Stress Responses*S

Andrew Emili, Anitha Kannan, Thomas Kislinger, 2008, Molecular & Cellular Proteomics.

Interaction sites among phospholamban, sarcolipin, and the sarco(endo)plasmic reticulum Ca(2+)-ATPase.

C. Toyoshima, T. Tsuda, T. Morita, 2008, Biochemical and biophysical research communications.

Roles of Conserved P Domain Residues and Mg2+ in ATP Binding in the Ground and Ca2+-activated States of Sarcoplasmic Reticulum Ca2+-ATPase*

D. Maclennan, J. Andersen, B. Vilsen, 2004, Journal of Biological Chemistry.

The Regulation of SERCA‐Type Pumps by Phospholamban and Sarcolipin

D. Maclennan, M. Asahi, A. R. Tupling, 2003, Annals of the New York Academy of Sciences.

Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban

Y. Sugita, C. Toyoshima, D. Maclennan, 2003, Proceedings of the National Academy of Sciences of the United States of America.

ATP Binding Residues of Sarcoplasmic Reticulum Ca2+‐ATPase

D. Maclennan, J. Andersen, B. Vilsen, 2003, Annals of the New York Academy of Sciences.

Structural biology: Calcium callisthenics

N. Green, D. Maclennan, 2002, Nature.

Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases

N. Green, D. Maclennan, M. Asahi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The Ca2+ ATPase of Cardiac Muscle Sarcoplasmic Reticulum

N. Green, C. Brandl, D. Maclennan, 1987 .

Chapter 4 Calsequestrin

K. Campbell, D. Maclennan, 2005 .

Chapter 8 Assembly of the Sarcoplasmic Reticulum during Muscle Development

D. Maclennan, A. O. Jorgensen, E. Zubrzycka-Gaarn, 1985 .

The Calcium Transport ATPase of Sarcoplasmic Reticulum

P. Holland, D. Maclennan, 1976 .

The nucleotide binding/hinge domain plays a crucial role in determining isoform-specific Ca2+ dependence of organellar Ca(2+)-ATPases.

T. Toyofuku, J. Lytton, D. Maclennan, 1992, The Journal of biological chemistry.

Formation of membranes by repeating units.

H. Baum, D. E. Green, D. Maclennan, 1967, Archives of biochemistry and biophysics.

The preparation of microsomal electron-transfer complexes

D. Maclennan, A. Tzagoloff, D. McConnell, 1967 .

The Mitochondrial System of Enzymes

D. E. Green, D. Maclennan, 1967 .

Studies on the electron transfer system. LXVII. Polyacrylamide gel electrophoresis of the mitochondrial electron transfer complexes.

K. Takayama, D. Maclennan, C. D. Stoner, 1966, Archives of biochemistry and biophysics.

Studies on the electron transfer system: LXIII. Solubilization and fractionation of mitochondrial proteins by succinylation

D. Maclennan, A. Tzagoloff, J. S. Rieske, 1965 .

Calreticulin Is Essential for Cardiac Development

K. Krause, M. Michalak, M. Opas, 1999, The Journal of cell biology.

Mutations in the gene–encoding SERCA1, the fast–twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease

P. Taschner, A. Odermatt, M. Breuning, 1996, Nature Genetics.

The Cytoplasmic Loops between Domains II and III and Domains III and IV in the Skeletal Muscle Dihydropyridine Receptor Bind to a Contiguous Site in the Skeletal Muscle Ryanodine Receptor*

D. Maclennan, P. Leong, David H. MacLennan, 1998, The Journal of Biological Chemistry.

Structural determination of the phosphorylation domain of the ryanodine receptor

M. Ikura, T. Kislinger, A. Gramolini, 2012, The FEBS journal.

Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum.

D. Maclennan, 1970, The Journal of biological chemistry.

Sarcolipin Regulates the Activity of SERCA1, the Fast-twitch Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase*

A. Odermatt, D. Pette, D. Maclennan, 1998, The Journal of Biological Chemistry.

The mutation of Pro789 to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) and is associated with Brody disease

A. Odermatt, T. Kuntzer, J. Mathieu, 2000, Human Genetics.

Ca2+ signalling and muscle disease.

D. Maclennan, 2000, European journal of biochemistry.

Physical Interactions between Phospholamban and Sarco(endo)plasmic Reticulum Ca2+-ATPases Are Dissociated by Elevated Ca2+, but Not by Phospholamban Phosphorylation, Vanadate, or Thapsigargin, and Are Enhanced by ATP*

D. Maclennan, M. Asahi, M. Tada, 2000, The Journal of Biological Chemistry.

Sarcolipin Overexpression in Rat Slow Twitch Muscle Inhibits Sarcoplasmic Reticulum Ca2+ Uptake and Impairs Contractile Function*

D. Maclennan, M. Asahi, A. R. Tupling, 2002, The Journal of Biological Chemistry.

Structure-function relationships in Ca(2+) cycling proteins.

C. Kang, M. Abu-Abed, D. Maclennan, 2002, Journal of molecular and cellular cardiology.

Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase.

T. Toyofuku, D. Maclennan, N Narayanan, 1994, The Journal of biological chemistry.

The Vmax of the Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum (SERCA2a) Is Not Altered by Ca2+/Calmodulin-dependent Phosphorylation or by Interaction with Phospholamban*

A. Odermatt, D. Maclennan, K. Kurzydlowski, 1996, The Journal of Biological Chemistry.

mitochondria during ischemia-reperfusion B-crystallin to heart α Localization of phosphorylated

A. Emili, Ruth Isserlin, Vincent Fong, 2012 .

Localization of phosphorylated B-crystallin to heart mitochondria during ischemia-reperfusion

A. Emili, Ruth Isserlin, T. Kislinger, 2008 .

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy

G. Dorn, A. Gramolini, G. Fan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Superinhibition of Sarcoplasmic Reticulum Function by Phospholamban Induces Cardiac Contractile Failure*

G. Dorn, B. Hoit, E. Kranias, 2001, The Journal of Biological Chemistry.

Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cells.

D. Maclennan, K. Maruyama, K. Maruyama, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Amino acids Glu2 to Ile18 in the cytoplasmic domain of phospholamban are essential for functional association with the Ca(2+)-ATPase of sarcoplasmic reticulum.

T. Toyofuku, D. Maclennan, M. Tada, 1994, The Journal of biological chemistry.

Purification and characterization of calsequestrin from canine cardiac sarcoplasmic reticulum and identification of the 53,000 dalton glycoprotein.

K. Campbell, D. Maclennan, A. O. Jorgensen, 1983, The Journal of biological chemistry.

Sarcolipin Inhibits Polymerization of Phospholamban to Induce Superinhibition of Sarco(endo)plasmic Reticulum Ca2+-ATPases (SERCAs)*

D. Maclennan, M. Asahi, M. Tada, 2002, The Journal of Biological Chemistry.

Alterations of Phospholamban Function Can Exhibit Cardiotoxic Effects Independent of Excessive Sarcoplasmic Reticulum Ca2+-ATPase Inhibition

Ferhaan Ahmad, J. Schmitt, J. Seidman, 2009, Circulation.

Rabbit cardiac and slow‐twitch muscle express the same phospholamban gene

J. Lytton, D. Maclennan, Junichi Fujii, 1988, FEBS letters.

Response to “Malignant Hyperthermia — human stress triggering” in reference to original article “Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum” http://dx.doi.org/10.1016/j.bbamcr.2010.11.009

D. Maclennan, E. Zvaritch, 2011 .

Chronic SR Ca 2 (cid:1) -ATPase Inhibition Causes Adaptive Changes in Cellular Ca 2 (cid:1) Transport

D. Bers, B. Wolska, D. Maclennan, 2003 .

Expression and site-specific mutagenesis of phospholamban. Studies of residues involved in phosphorylation and pentamer formation.

J. Fujii, D. Maclennan, Junichi Fujii, 1989, The Journal of biological chemistry.

Sites of Regulatory Interaction between Calcium ATPases and Phospholambana

T. Toyofuku, D. Maclennan, Y. Kimura, 1998, Annals of the New York Academy of Sciences.

Sites of regulatory interaction between calcium ATPases and phospholamban

T. Toyofuku, D. Maclennan, Y. Kimura, 2004, Basic Research in Cardiology.

Calmidazolium and compound 48/80 inhibit calmodulin-dependent protein phosphorylation and ATP-dependent Ca2+ uptake but not Ca2+-ATPase activity in skeletal muscle sarcoplasmic reticulum.

D. Maclennan, B. Tuana, 1984, The Journal of biological chemistry.

A proton gradient controls a calcium-release channel in sarcoplasmic reticulum.

D. S. Wood, D. Maclennan, V. Shoshan, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Measurement of Resting Cytosolic Ca2+ Concentrations and Ca2+ Store Size in HEK-293 Cells Transfected with Malignant Hyperthermia or Central Core Disease Mutant Ca2+ Release Channels*

D. Maclennan, T. McCarthy, J. Tong, 1999, The Journal of Biological Chemistry.

Ca2+ Inactivation Sites Are Located in the COOH-terminal Quarter of Recombinant Rabbit Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors)*

D. Maclennan, G. Du, 1999, The Journal of Biological Chemistry.

Functional expression of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells.

R. Coronado, D. Maclennan, J. Airey, 1993, Biochemistry.

Topology and Transmembrane Organization of Ryanodine Receptors

D. Maclennan, G. Du, 2005 .

Mutation of Divergent Region 1 Alters Caffeine and Ca2+ Sensitivity of the Skeletal Muscle Ca2+Release Channel (Ryanodine Receptor)*

D. Maclennan, G. Du, V. Khanna, 2000, The Journal of Biological Chemistry.

Characterization of Recombinant Rabbit Cardiac and Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors) with a Novel [3H]Ryanodine Binding Assay*

D. Maclennan, J. Imredy, G. Du, 1998, The Journal of Biological Chemistry.

Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12

H. Willard, P. Holland, C. Brandl, 1987, Somatic cell and molecular genetics.

Slow/cardiac sarcoplasmic reticulum Ca2+-ATPase and phospholamban mRNAs are expressed in chronically stimulated rabbit fast-twitch muscle.

C. Brandl, J. Fujii, E. Leberer, 1989, European journal of biochemistry.

Quercetin interaction with the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum.

D. Maclennan, V. Shoshan, 1981, The Journal of biological chemistry.

Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

N. Alpert, M. Arai, P. Barton, 1993, Circulation research.

Sarcoplasmic reticulum gene expression in pressure overload-induced cardiac hypertrophy in rabbit.

N. Alpert, M. Periasamy, D. Maclennan, 1995, The American journal of physiology.

Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development.

K. Otsu, M. Arai, M. Periasamy, 1992, The American journal of physiology.

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

N. Alpert, C. Brandl, J. Fujii, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase.

J. Lytton, Á. Zarain-Herzberg, M. Periasamy, 1989, The Journal of biological chemistry.

Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype

K. Fogarty, Karl Bellve, J. Walsh, 2011, Proceedings of the National Academy of Sciences.

HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine

D. Maclennan, G. Du, S. Chen, 1999 .

Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum.

D. Maclennan, E. Zvaritch, 2011, Biochimica et biophysica acta.

Store overload‐induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes

D. Maclennan, S. Chen, 2009, The Journal of physiology.

Role of the Sequence Surrounding Predicted Transmembrane Helix M4 in Membrane Association and Function of the Ca2+ Release Channel of Skeletal Muscle Sarcoplasmic Reticulum (Ryanodine Receptor Isoform 1)*

G. Ávila, D. Maclennan, Parveen Sharma, 2004, Journal of Biological Chemistry.

Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene.

Á. Zarain-Herzberg, M. Periasamy, D. Maclennan, 1990, The Journal of biological chemistry.

Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.

A. Gramolini, M. Hori, K. Otsu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The Transgenic Expression of Highly Inhibitory Monomeric Forms of Phospholamban in Mouse Heart Impairs Cardiac Contractility*

B. Hoit, F. Jirik, P. Backx, 2000, The Journal of Biological Chemistry.

Transmembrane Helix M6 in Sarco(endo)plasmic Reticulum Ca2+-ATPase Forms a Functional Interaction Site with Phospholamban

D. Maclennan, M. Asahi, M. Tada, 1999, The Journal of Biological Chemistry.

Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein.

D. Maclennan, L. Zhang, S. Chen, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of a second form of calsequestrin.

D. Maclennan, 1974, The Journal of biological chemistry.

Ca2+ Signaling in HEK-293 and Skeletal Muscle Cells Expressing Recombinant Ryanodine Receptors Harboring Malignant Hyperthermia and Central Core Disease Mutations*

M. Brini, E. Carafoli, D. Maclennan, 2005, Journal of Biological Chemistry.

The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia.

M. Phillips, B. Britt, A. Archibald, 1992, Symposia of the Society for Experimental Biology.

Identification of regions in the Ca(2+)-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban.

T. Toyofuku, D. Maclennan, M. Tada, 1993, The Journal of biological chemistry.

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes

A. Gramolini, Liyong Zhang, D. Maclennan, 2015, Proceedings of the National Academy of Sciences.

Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPases.

A. Emili, T. Kislinger, A. Gramolini, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation

A. Emili, T. Kislinger, A. Gramolini, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Cardiac-specific Overexpression of a Superinhibitory Pentameric Phospholamban Mutant Enhances Inhibition of Cardiac Functionin Vivo *

B. Hoit, E. Kranias, D. Maclennan, 2000, The Journal of Biological Chemistry.

Assembly of the sarcoplasmic reticulum. Synthesis of calsequestrin and the Ca2+ + Mg2+ -adenosine triphosphatase on membrane-bound polyribosomes.

D. Maclennan, D. Greenway, 1978, Canadian journal of biochemistry.

Membrane formation by the adenosine triphosphatase of sarcoplasmic reticulum.

P. Seeman, C. Yip, D. Maclennan, 1971, The Journal of biological chemistry.

Staining of the Ca2+-binding proteins, calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye "Stains-all".

K. Campbell, D. Maclennan, A. O. Jorgensen, 1983, The Journal of biological chemistry.

Structure-function relationships in the Ca(2+)-binding and translocation domain of SERCA1: physiological correlates in Brody disease.

N. Green, A. Odermatt, W. Rice, 1998, Acta physiologica Scandinavica. Supplementum.

[22] cDNA cloning of sarcoplasmic reticulum proteins

C. Brandl, L. Fliegel, D. Maclennan, 1988 .

Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia.

M. Phillips, K. Otsu, D. Maclennan, 1992, Genomics.

Solubilization and reconstitution of cholinephosphotransferase from sarcoplasmic reticulum: stabilization of solubilized enzyme by diacylglycerol and glycerol.

R. Cornell, D. Maclennan, 1985, Biochimica et biophysica acta.

Functional consequences of alterations to Gly310, Gly770, and Gly801 located in the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.

D. Maclennan, J. Andersen, B. Vilsen, 1992, The Journal of biological chemistry.

Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease.

M. Phillips, J. Fujii, D. Cornblath, 1995, Genomics.

Functional consequences of mutations in the beta-strand sector of the Ca2(+)-ATPase of sarcoplasmic reticulum.

E. Leberer, D. Maclennan, J. Andersen, 1989, The Journal of biological chemistry.

Studies on the mitochondrial adenosine triphosphatase system. IV. Purification and characterization of the oligomycin sensitivity conferring protein.

D. Maclennan, A. Tzagoloff, 1968, Biochemistry.

Structure of the rabbit fast-twitch skeletal muscle calsequestrin gene.

L. Fliegel, Á. Zarain-Herzberg, D. Maclennan, 1988, The Journal of biological chemistry.

Characterization of the adenosinetriphosphatase and calsequestrin isolated from sarcoplasmic reticulum of normal and dystrophic chickens.

D. Maclennan, J. L. Yap, 1976, Canadian journal of biochemistry.

Isolation of Sarcoplasmic Reticulum Proteins

P. Seeman, C. Yip, D. Maclennan, 1973 .

Studies on the electron transfer system. LXV. Formation of membranes by purified cytochrome oxidase.

D. E. Green, D. Maclennan, A. Tzagoloff, 1966, The Journal of biological chemistry.

Structure‐Function Relationships in Sarcoplasmic or Endoplasmic Reticulum Type Ca2+ Pumps a

T. Toyofuku, J. Lytton, D. Maclennan, 1992, Annals of the New York Academy of Sciences.

Differential effects of mercurial compounds on excitable tissues.

A. Shamoo, M. Eldefrawi, D. Maclennan, 1976, Chemico-biological interactions.

Presence of glycosphingolipids in the sarcoplasmic reticulum fraction of rabbit skeletal muscle

R. Murray..., D. Maclennan, R. Narasimhan, 1974, FEBS letters.

Targeted Disruption of the ATP2A1 Gene Encoding the Sarco(endo)plasmic Reticulum Ca2+ ATPase Isoform 1 (SERCA1) Impairs Diaphragm Function and Is Lethal in Neonatal Mice*

C. McKerlie, M. Rudnicki, B. Banwell, 2003, The Journal of Biological Chemistry.

Surface particles of sarcoplasmic reticulum membranes. Structural features of the adenosine triphosphatase.

D. Maclennan, P. Stewart, 1974, The Journal of biological chemistry.

Comparison of the Segregation of the RYR1 C1840T Mutation with Segregation of the Caffeine/Halothane Contracture Test Results for Malignant Hyperthermia Susceptibility in a Large Manitoba Mennonite Family

M. Phillips, D. Bose, C. Greenberg, 1996, Anesthesiology.

The capacity of the sarcoplasmic reticulum for phospholipid synthesis: a developmental study.

R. Cornell, D. Maclennan, 1985, Biochimica et biophysica acta.

Refined genetic localization for central core disease.

F. Couch, J. Mulley, R. Gregg, 1993, American journal of human genetics.

Structure of the rabbit fast-twitch skeletal muscle Ca2+-ATPase gene.

C. Ingles, N. Green, C. Brandl, 1988, The Journal of biological chemistry.

Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene

H. Willard, J. Fujii, D. Maclennan, 1990, Somatic cell and molecular genetics.

Co‐expression of slow‐twitch/cardiac muscle Ca2+‐ATPase (SERCA2) and phospholamban

J. Fujii, K. Maruyama, D. Maclennan, 1990, FEBS letters.

Ryanodine sensitizes the cardiac Ca2+ release channel (ryanodine receptor isoform 2) to Ca2+ activation and dissociates as the channel is closed by Ca2+ depletion

D. Maclennan, G. Du, V. Khanna, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Antibodies as probes for Ca2+ activation sites in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

D. Maclennan, L. Zhang, S. Chen, 1993, The Journal of biological chemistry.

Brody’s Syndrome: a Disorder of Calcium Uptake by the Sarcoplasmic Reticulum

D. Maclennan, G. Karpati, 1999 .

Structure/Function Analysis of the Ca2+ Binding and Translocation Domain of SERCA1 and the Role in Brody Disease of the ATP2A1 Gene Encoding SERCA1 a

A. Odermatt, W. Rice, D. Maclennan, 1997, Annals of the New York Academy of Sciences.

Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum.

D. Maclennan, J. Airey, S. Chen, 1993, The Journal of biological chemistry.

Mitochondrial "structural protein." A reassessment.

A. E. Senior, D. Maclennan, 1970, The Journal of biological chemistry.

Studies on the mechanism of oxidative phosphorylation. X. The effect of cytochrome C on energy-linked processes in submitochondrial particles.

G. Lenaz, D. Maclennan, 1966, The Journal of biological chemistry.

Studies of the electron-transfer system. LXIV. Role of phospholipid in cytochrome oxidase.

D. Maclennan, A. Tzagoloff, Alexander Tzagoloff, 1965, Biochimica et biophysica acta.

THE ISOLATION OF A COPPER PROTEIN FROM CYTOCHROME OXIDASE.

D. Maclennan, A. Tzagoloff, 1965, Biochimica et biophysica acta.

The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia.

M. Phillips, B. Britt, D. Maclennan, 1994, Human molecular genetics.

How carefully can we phenotype patients suspected of malignant hyperthermia susceptibility?

D. Maclennan, M. G. Larach, 1999, Anesthesiology.

Bayesian modeling of muscle biopsy contracture testing for malignant hyperthermia susceptibility.

D. Maclennan, J. Loke, 1998 .

Malignant Hyperthermia and Central Core Disease

B. Britt, D. Maclennan, 1998 .

Caffeine and Halothane Sensitivity of Intracellular Ca2+ Release Is Altered by 15 Calcium Release Channel (Ryanodine Receptor) Mutations Associated with Malignant Hyperthermia and/or Central Core Disease*

S. Grinstein, N. Demaurex, D. Maclennan, 1997, The Journal of Biological Chemistry.

Mutations in the Skeletal Muscle Ryanodine Receptor (RYR1) Gene Are Linked to Malignant Hyperthermia and Central-Core Disease

D. Maclennan, 1996 .

The Genetic and Physiological Basis of Malignant Hyperthermia

M. Phillips, D. Maclennan, Yilin Zhang, 1996 .

Mutations to Gly2370, Gly2373 or Gly2375 in malignant hyperthermia domain 2 decrease caffeine and cresol sensitivity of the rabbit skeletal-muscle Ca2+-release channel (ryanodine receptor isoform 1).

D. Maclennan, G. Du, V. Khanna, 2001, The Biochemical journal.

Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.

K. Otsu, J. Fujii, P. O'Brien, 1991, Science.

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

M. Phillips, B. Britt, J. Fujii, 1990, Nature.

Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia.

B. Britt, K. Otsu, J. Fujii, 1992, Genomics.

Isolation of a calcium-sequestering protein from sarcoplasmic reticulum.

D. Maclennan, P. Wong, 1971, Proceedings of the National Academy of Sciences of the United States of America.

A calmodulin-dependent protein kinase system from skeletal muscle sarcoplasmic reticulum. Phosphorylation of a 60,000-dalton protein.

K. Campbell, D. Maclennan, 1982, The Journal of biological chemistry.

Molecular Architecture of the Mitochondrion

D. Maclennan, 1971 .

Isolation and properties of an iron-protein from the (reduced coenzyme Q)-cytochrome C reductase complex of the respiratory chain

Roger Coleman, David H. MacLennan, D. Maclennan, 1964 .

Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum.

D. Maclennan, T. Ostwald, 1974, The Journal of biological chemistry.

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.

G. Dorn, A. Gramolini, S. Liggett, 2003, The Journal of clinical investigation.

Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

H. Willard, N. Green, K. Otsu, 1990, The Journal of biological chemistry.

Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

M. Phillips, N. Green, K. Otsu, 1990, The Journal of biological chemistry.

cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump.

G. Shull, J. Lytton, S. E. Burk, 1989, The Journal of biological chemistry.

Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.

D. Ward, K. Otsu, J. Fujii, 1993, Genomics.

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

J. Lytton, D. Maclennan, Jonathan Lytton, 1988, The Journal of biological chemistry.

Studies on the electron transfer system. LXVI. Effect of diphosphopyridine nucleotide deficiency on respiration, respiratory control, and phosphorylation in mitochondria.

D. Maclennan, A. Tzagoloff, 1966, The Journal of biological chemistry.

ATP driven ion pumps: an evolutionary mosaic.

N. Green, D. Maclennan, 1989, Biochemical Society transactions.

Studies on the mitochondrial adenosine triphosphatase system. II. The isolation and characterization of an oligomycin-sensitive adenosine triphosphatase from bovine heart mitochondria.

D. Maclennan, A. Tzagoloff, K. H. Byington, 1968, The Journal of biological chemistry.

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

N. Green, C. Brandl, B. Korczak, 1985, Nature.

Structure-function relationships in the Ca2+ pump of the sarcoplasmic reticulum.

T. Toyofuku, D. Maclennan, 1992, Biochemical Society transactions.

Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins.

D. Maclennan, P. Leong, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Trans-aconitate in plant tissues

D. Maclennan, H. Beevers, 1964 .

Structure–Function Relationships in Ca2+ Cycling Proteins

C. Kang, M. Abu-Abed, D. Maclennan, 2002 .

Biology of Growth Factors

A. Bernstein, A. Gotlieb, D. Maclennan, 1988, Advances in Experimental Medicine and Biology.

Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12.

R. Berger, I. Järvelä, D. Callen, 1991, American journal of human genetics.

Studies on the mitochondrial adenosine triphosphatase system. V. Localization of the oligomycin-sensitivity conferring protein.

D. Maclennan, J. Asai, 1968, Biochemical and biophysical research communications.

Studies on the electron transfer system. 68. Formation of membranes as the basis of the reconstitution of the mitochondrial electron transfer system.

D. E. Green, D. Maclennan, A. Tzagoloff, 1967, The Journal of biological chemistry.

Functional consequences of alterations to amino acids located in the catalytic center (isoleucine 348 to threonine 357) and nucleotide-binding domain of the Ca2+-ATPase of sarcoplasmic reticulum.

J. Fujii, D. Clarke, T. W. Loo, 1989, The Journal of biological chemistry.

Functional Characterization of Mutants in the Predicted Pore Region of the Rabbit Cardiac Muscle Ca2+ Release Channel (Ryanodine Receptor Isoform 2)*

Xinghua Guo, D. Maclennan, G. Du, 2001, The Journal of Biological Chemistry.

Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

N. Green, C. Brandl, B. Korczak, 1986, Cell.

Amino-acid sequence of a Ca2++Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

N. Green, C. Brandl, B. Korczak, 1985, Nature.

Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.

N. Alpert, K. Otsu, M. Arai, 1991, Circulation research.

An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor.

N. Romero, N. Monnier, J. Lunardi, 2000, Human molecular genetics.

HSP70 Binds to the Fast-twitch Skeletal Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1a) and Prevents Thermal Inactivation*

A. Gramolini, M. Hori, K. Otsu, 2004, Journal of Biological Chemistry.

Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families.

A. Archibald, K. Otsu, D. Maclennan, 1991, Genomics.

Monoclonal antibodies to the Ca2+ + Mg2+-dependent ATPase of sarcoplasmic reticulum identify polymorphic forms of the enzyme and indicate the presence in the enzyme of a classical high-affinity Ca2+ binding site

D. Maclennan, A. O. Jorgensen, E. Zubrzycka-Gaarn, 1984, Journal of bioenergetics and biomembranes.

Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.

K Burns, K. Burns, M. Michalak, 1989, The Journal of biological chemistry.

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

D. Clarke, T. W. Loo, D. Maclennan, 1989, Nature.

Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility

B. Brandom, O. Sizova, D. Maclennan, 2014, Molecular genetics & genomic medicine.

The Mechanism of Ca2+ Transport by Sarco(Endo)plasmic Reticulum Ca2+-ATPases*

N. Green, D. Maclennan, W. Rice, 1997, The Journal of Biological Chemistry.

Scanning Mutagenesis Reveals a Similar Pattern of Mutation Sensitivity in Transmembrane Sequences M4, M5, and M6, but Not in M8, of the Ca2+-ATPase of Sarcoplasmic Reticulum (SERCA1a)*

D. Maclennan, W. Rice, W. J. Rice, 1996, The Journal of Biological Chemistry.

Functional consequences of alterations to amino acids located in the hinge domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.

D. Maclennan, J. Andersen, B. Vilsen, 1991, Journal of Biological Chemistry.

Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

D. Clarke, T. W. Loo, D. Maclennan, 1990, The Journal of biological chemistry.

The Mechanism of Ca 2 1 Transport by Sarco ( Endo ) plasmic Reticulum Ca 2 1-ATPases *

N. Green, W. Rice, D. Maclennan, 1997 .

Functional consequences of mutations of conserved amino acids in the beta-strand domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

D. Clarke, T. W. Loo, D. Maclennan, 1990, Journal of Biological Chemistry.

Functional characterization of alternatively spliced human SERCA3 transcripts.

E. Poch, J. Lytton, D. Maclennan, 1998, American journal of physiology. Cell physiology.

Defective Endothelium-dependent Relaxation of Vascular Smooth Muscle and Endothelial Cell Ca2+ Signaling in Mice Lacking Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 3*

T. Doetschman, J. Lorenz, G. Shull, 1997, The Journal of Biological Chemistry.

Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle.

C. Brandl, D. Maclennan, D. R. Martin, 1987, The Journal of biological chemistry.

A mutation in the human ryanodine receptor gene associated with central core disease

M. Phillips, B. Britt, K. Schappert, 1993, Nature Genetics.

Evidence for genetic heterogeneity of malignant hyperthermia susceptibility.

T. Meitinger, A. Meindl, D. Schindelhauer, 1992, American journal of human genetics.

Purification, calcium binding properties, and ultrastructural localization of the 53,000- and 160,000 (sarcalumenin)-dalton glycoproteins of the sarcoplasmic reticulum.

K. Campbell, E. Leberer, D. Maclennan, 1990, The Journal of biological chemistry.

The genetic basis of malignant hyperthermia.

D. Maclennan, 1992, Trends in pharmacological sciences.

Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by α-crystallin-B

A. Emili, Ruth Isserlin, Vincent Fong, 2010, Proceedings of the National Academy of Sciences.

Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population

D. Maclennan, S. Riazi, A. Kraev, 2011, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Interaction of Nucleotides with Asp351 and the Conserved Phosphorylation Loop of Sarcoplasmic Reticulum Ca2+-ATPase*

D. Maclennan, J. Andersen, B. Vilsen, 1999, The Journal of Biological Chemistry.

Sarcoplasmic reticulum Ca2+ ATPases

D. Maclennan, S. Becker, 1996 .

The Use of Site-Directed Mutagenesis to Identify Functional Sites in the Ca2+ ATPase

W. Rice, D. Clarke, T. W. Loo, 1994 .

Molecular tools to elucidate problems in excitation-contraction coupling.

D. Maclennan, 1990, Biophysical journal.

Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease.

S. Scherer, P. Taschner, A. Odermatt, 1997, Genomics.

Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

D. Clarke, T. W. Loo, D. Maclennan, 1990, The Journal of biological chemistry.

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

M. Ikura, P. Stathopulos, F. van Petegem, 2013, Journal of molecular biology.

Protocol for the Sequence Analysis of Ryanodine Receptor Subtype 1 Gene Transcripts from Human Leukocytes

D. Maclennan, A. Kraev, N. Kraev, 2003, Anesthesiology.

Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing.

R. Reithmeier, L. Fliegel, D. Maclennan, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Phospholamban Regulates the Ca2+-ATPase through Intramembrane Interactions*

D. Maclennan, M. Tada, K. Kurzydlowski, 1996, The Journal of Biological Chemistry.

Studies on the mitochondrial adenosine triphosphatase system. 3. Isolation from the oligomycin-sensitive adenosine triphosphatase complex of the factors which bind F-1 and determine oligomycin sensitivity of bound F-1.

D. Maclennan, A. Tzagoloff, K. H. Byington, 1968, Biochemistry.

Isolation of the calmodulin‐dependent protein kinase system from rabbit skeletal muscle sarcoplasmic reticulum

D. Maclennan, B. Tuana, 1988, FEBS letters.

Structure and Function of the Mitochondrial Cristael Membrane

David E. Green, David H. MacLennan, D. E. Green, 1969 .

Salt-dependent conformational changes in the cell membrane of Halobacterium salinarium.

D. Maclennan, J. Hsia, P. Wong, 1971, Biochemical and biophysical research communications.

Resolution of the calcium transport system of saecoplasmic reticulum.

D. Maclennan, 1975, Canadian journal of biochemistry.

Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum

G. Meissner, D. Maclennan, R. Dirksen, 2011, The Journal of general physiology.

ryanodine receptor Ca 2+ ion permeation and release from the sarcoplasmic reticulum

G. Meissner, D. Maclennan, R. Dirksen, 2010 .

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

D. Maclennan, R. Dirksen, Wenting Guo, 2017, The Biochemical journal.

Bayesian Modeling of Muscle Biopsy Contracture Testing for Malignant Hyperthermia Susceptibility

D. Maclennan, J. Loke, 1998, Anesthesiology.

A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.

B. Britt, K. Otsu, J. Fujii, 1991, Genomics.

A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease.

M. Lehane, L. Giblin, D. Maclennan, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene.

M. Phillips, P. D. de Jong, P. Jong, 1996, Genomics.

Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease

A. E. Rossi, D. Maclennan, R. Dirksen, 2013, Neuromuscular Disorders.

Ca2+ dysregulation in Ryr1I4895T/wt mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods

J. Seidman, C. Seidman, D. Maclennan, 2009, Proceedings of the National Academy of Sciences.

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

J. Seidman, A. Gramolini, C. Seidman, 2007, Proceedings of the National Academy of Sciences.

Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)

Xinghua Guo, D. Maclennan, G. Du, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Muscle spindles exhibit core lesions and extensive degeneration of intrafusal fibers in the Ryr1(I4895T/wt) mouse model of core myopathy.

D. Maclennan, E. Zvaritch, 2015, Biochemical and biophysical research communications.

Mutations in ryr1 gene associated with malignant hyperthermia and a non-anaesthetic phenotype

D. Maclennan, J. Loke, N. Kraeva, 2007 .

Studies on the mitochondrial adenosine triphosphatase system. I. Restoration of adenosine triphosphate-dependent reactions in salt-extracted submitochondrial particles.

D. Maclennan, A. Tzagoloff, J. M. Smoly, 1968, The Journal of biological chemistry.

Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility

J. Payen, P. Mezin, D. Figarella-Branger, 2005, Human mutation.

Discordance between phenotype and genotype in malignant hyperthermia.

D. Maclennan, 1995, Current opinion in neurology.

Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR.

M. Ikura, M. Kainosho, M. Abu-Abed, 2002, Biochemistry.

Identification of Novel Ryanodine Receptor 1 (RyR1) Protein Interaction with Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP)*♦

A. Ignatchenko, T. Kislinger, A. Gramolini, 2011, The Journal of Biological Chemistry.

Studies on the mechanims of oxidative phosphorylation. IX. Effect of cytochrome c on energy-linked processes.

G. Lenaz, D. Maclennan, L. Szarkowska, 1966, The Journal of biological chemistry.

Tbx5-dependent pathway regulating diastolic function in congenital heart disease

B. Bruneau, R. Henkelman, A. Gramolini, 2008, Proceedings of the National Academy of Sciences.

A calmodulin-dependent protein kinase system from skeletal muscle sarcoplasmic reticulum.

K. Campbell, H. Takisawa, D. Maclennan, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

Functional consequences of alterations to hydrophobic amino acids located at the M4S4 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum.

D. Maclennan, J. Andersen, B. Vilsen, 1991, The Journal of biological chemistry.

A cosmid and yeast artificial chromosome contig containing the complete ryanodine receptor (RYR1) gene.

B. Trask, M. Phillips, P. D. de Jong, 1993, Genomics.

STRUCTURAL ANALYSIS OF THE Ca2+ + Mg2+-ATPase OF SARCOPLASMIC RETICULUM

R. Reithmeier, D. Maclennan, 1985 .

Detection of a Novel Ryanodine Receptor Subtype 1 Mutation (R328W) in a Malignant Hyperthermia Family by Sequencing of a Leukocyte Transcript

D. Maclennan, Parveen Sharma, G. Du, 2003, Anesthesiology.

Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release.

Xinghua Guo, D. Maclennan, G. Du, 2004, The Biochemical journal.

A comparison of the caffeine halothane muscle contracture test with the molecular genetic diagnosis of malignant hyperthermia.

R. Korneluk, D. Maclennan, R. Worton, 1991, Anesthesiology.

Multipoint mapping of the central core disease locus.

C. Hübner, D. Maclennan, T. Grimm, 1993, Genomics.

Functional characterization of alternatively spliced human SERCA3 transcripts.

E. Poch, J. Lytton, D. Maclennan, 1998, The American journal of physiology.

The NH2 terminus of the (Ca2+ + Mg2+)-adenosine triphosphatase is located on the cytoplasmic surface of the sarcoplasmic reticulum membrane.

R. Reithmeier, D. Maclennan, 1981, The Journal of biological chemistry.

Purification and characterization of the 53,000-dalton glycoprotein from the sarcoplasmic reticulum.

K. Campbell, D. Maclennan, 1981, The Journal of biological chemistry.

Calcium transport in sarcoplasmic reticulum.

P. Holland, D. Maclennan, 1975, Annual review of biophysics and bioengineering.

skeletal muscle from sarcolipin-null mice transport and muscle relaxation in

A. Gramolini, Subash C. Gupta, M. Trivieri, 2016 .

Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.

A. Gramolini, Subash C. Gupta, M. Trivieri, 2011, American journal of physiology. Cell physiology.

Effects of cation binding on the conformation of calsequestrin and the high affinity calcium-binding protein of sarcoplasmic reticulum.

D. Maclennan, K. J. Dorrington, T. Ostwald, 1974, The Journal of biological chemistry.

[45] Biosynthesis of sarcoplasmic reticulum proteins

D. Maclennan, S. D. Leon, 1983 .

The Structure of the Ca2+/Mg2+-ATPase of Sarcoplasmic Reticulum

R. Reithmeier, D. Maclennan, 1982 .

Diastolic Properties of the Failing Myocardium

N. Alpert, M. Arai, P. Barton, 2005 .

Isolation and characterization of tryptic fragments of the adenosine triphosphatase of sarcoplasmic reticulum.

D. Maclennan, P. Stewart, 1976, The Journal of biological chemistry.

ASSEMBLY OF THE SARCOPLASMIC RETICULUM Localization by Immunofluorescence of Sarcoplasmic Reticulum Proteins in Differentiating Rat Skeletal Muscle Cell Cultures

D. Maclennan, V. Kalnins, A. O. Jorgensen, 2003 .

Regional MappingoftheBattenDisease Locus(CLN3)to HumanChromosome16p12

L. Peltonen, R. Berger, G. Sutherland, 1991 .

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

T. Toyofuku, D. Maclennan, M. Tada, 1994, The Journal of biological chemistry.

Assembly of the sarcoplasmic reticulum. Cell-free synthesis of te Ca2+ + Mg2+-adenosine triphosphatase and calsequestrin.

R. Reithmeier, D. Maclennan, S. de Leon, 1980, The Journal of biological chemistry.

Alignment of the major tryptic fragments of the adenosine triphosphatase from sarcoplasmic reticulum.

A. Klip, R. Reithmeier, D. Maclennan, 1980, The Journal of biological chemistry.

Localization of ionophore activity in a 20,000-dalton fragment of the adenosine triphosphatase of Sarcoplasmic reticulum.

A. Shamoo, T. E. Ryan, D. Maclennan, 1976, The Journal of biological chemistry.

Structural and mechanistic implications of the amino acid sequence of calcium-transporting ATPases.

W R Taylor, N M Green, W. Taylor, 1986, Ciba Foundation symposium.

Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum.

E. Leberer, D. Clarke, T. W. Loo, 1989, The Journal of biological chemistry.

Characterization of a Ca2+ binding and regulatory site in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

D. Maclennan, L. Zhang, S. Chen, 1992, The Journal of biological chemistry.

The Molecular Biology of Membranes

S. Fleischer, Y. Hatefi, D. Maclennan, 1978, Springer US.

Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.

D. Maclennan, S. Chen, Shihao Chen, 1994, The Journal of biological chemistry.

CHAPTER 130 – Ryanodine Receptors

D. Maclennan, G. Du, 2003 .

Functional consequences of proline mutations in the cytoplasmic and transmembrane sectors of the Ca2(+)-ATPase of sarcoplasmic reticulum.

D. Clarke, D. Maclennan, J. Andersen, 1989, The Journal of biological chemistry.

Single-channel properties of the recombinant skeletal muscle Ca2+ release channel (ryanodine receptor).

D. Maclennan, J. Imredy, L. Zhang, 1997, Biophysical journal.

Calreticulin is a candidate for a calsequestrin-like function in Ca2(+)-storage compartments (calciosomes) of liver and brain.

J. Meldolesi, T. Pozzan, N. Green, 1990, The Biochemical journal.

Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.

A. Gramolini, R. Sah, G. Oudit, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Ca++-dependent and -selective ionophore as part of the Ca++ plus Mg++-dependent adenosinetriphosphatase of sarcoplasmic reticulum.

A. Shamoo, D. Maclennan, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Labeling of high affinity ATP binding sites on the 53,000- and 160,000-dalton glycoproteins of the sarcoplasmic reticulum with the photoaffinity probe 8-N3-[alpha-32P]ATP.

K. Campbell, D. Maclennan, 1983, Journal of Biological Chemistry.

CASQ1 Gene Is an Unlikely Candidate for Malignant Hyperthermia Susceptibility in the North American Population

O. Sizova, D. Maclennan, S. Riazi, 2013, Anesthesiology.

Monoclonal antibodies to the Ca2++Mg2+-dependent ATPase of skeletal muscle sarcoplasmic reticulum--cross-reactivity with ATPase isozymes and other Ca2+-binding proteins.

D. Maclennan, E. Zubrzycka-Gaarn, L. Phillips, 1984, Progress in clinical and biological research.

Molecular cloning and expression of cDNA encoding the 53,000-dalton glycoprotein of rabbit skeletal muscle sarcoplasmic reticulum.

N. Green, E. Leberer, D. Clarke, 1989, The Journal of biological chemistry.

Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase

Y. Sugita, C. Toyoshima, T. Tsuda, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Proteome Dynamics during C2C12 Myoblast Differentiation*S

Andrew Emili, Thomas Kislinger, David H. MacLennan, 2005, Molecular & Cellular Proteomics.

HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine.

D. Maclennan, G. Du, S. Chen, 1999, The Biochemical journal.

Quercetin inhibits Ca2+ uptake but not Ca2+ release by sarcoplasmic reticulum in skinned muscle fibers.

B. Britt, K. Campbell, D. Maclennan, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Functional Consequences of Mutations of Conserved, Polar Amino Acids in Transmembrane Sequences of the Ca2+ Release Channel (Ryanodine Receptor) of Rabbit Skeletal Muscle Sarcoplasmic Reticulum*

D. Maclennan, G. Du, 1998, The Journal of Biological Chemistry.

Assembly of the sarcoplasmic reticulum. Biosynthesis of the adenosine triphosphatase in rat skeletal muscle cell culture.

P. Holland, D. Maclennan, 1976, The Journal of biological chemistry.

Localization of the high affinity calcium binding protein and an intrinsic glycoprotein in sarcoplasmic reticulum membranes.

K. Campbell, M. Michalak, D. Maclennan, 1980, The Journal of biological chemistry.

[27] Isolation of proteins of the sarcoplasmic reticulum

D. Maclennan, 1974 .

Toward Comparative Genomics of Calcium Transporters

D. Maclennan, DAVID H. MacLENNAN, Alexander Kraev, 2002, Annals of the New York Academy of Sciences.

Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.

H. Willard, J. Fujii, Á. Zarain-Herzberg, 1991, The Journal of biological chemistry.

Phospholamban Inhibitory Function Is Activated by Depolymerization*

D. Maclennan, M. Tada, K. Kurzydlowski, 1997, The Journal of Biological Chemistry.

Expression and mutation of Ca2+ ATPases of the sarcoplasmic reticulum.

J. Fujii, D. Clarke, D. Maclennan, 1989, Cell motility and the cytoskeleton.

The Role of the Calcium Release Channel of Skeletal Muscle Sarcoplasmic Reticulum in Malignant Hyperthermia a

D. Maclennan, S. Chen, DAVID H. MacLENNAN, 1993, Annals of the New York Academy of Sciences.

Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum.

N. Green, E. Leberer, D. Maclennan, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Phospholamban Domain Ib Mutations Influence Functional Interactions with the Ca2+-ATPase Isoform of Cardiac Sarcoplasmic Reticulum*

D. Maclennan, M. Asahi, M. Tada, 1998, The Journal of Biological Chemistry.

Restoration of calcium transport in the trypsin-treated (Ca+ + Mg2+)-dependent adenosine triphosphatase of sarcoplasmic reticulum exposed th sodium dodecyl sulfate.

D. Maclennan, P. Stewart, V. Khanna, 1976, The Journal of biological chemistry.

Immunohistochemical and electron microscopic assessment of childhood rhabdomyosarcoma. Increased frequency of diagnosis over routine histologic methods

H. Yeger, D. Maclennan, H. Kahn, 1983, Cancer.

A 37-Amino Acid Sequence in the Skeletal Muscle Ryanodine Receptor Interacts with the Cytoplasmic Loop between Domains II and III in the Skeletal Muscle Dihydropyridine Receptor*

D. Maclennan, P. Leong, 1998, The Journal of Biological Chemistry.

Analyzing the cardiac muscle proteome by liquid chromatography-mass spectrometry-based expression proteomics.

A. Emili, T. Kislinger, A. Gramolini, 2007, Methods in molecular biology.

Phosphorylation of bound adenosine monophosphate in the electron transfer particle, driven by succinate.

T. Ozawa, D. Maclennan, 1965, Biochemical and biophysical research communications.

Chronic SR Ca2+‐ATPase Inhibition Causes Adaptive Changes in Cellular Ca2+ Transport

D. Bers, E. Kranias, B. Wolska, 2003, Circulation research.

Chapter 116 – Ryanodine Receptors

D. Maclennan, S. Chen, S. Chen, 2010 .

Crystal structure of type I ryanodine receptor amino-terminal β-trefoil domain reveals a disease-associated mutation “hot spot” loop

M. Ikura, N. Ishiyama, D. Maclennan, 2009, Proceedings of the National Academy of Sciences.

Assembly of the sarcoplasmic reticulum. Biosynthesis of calsequestrin in rat skeletal muscle cell cultures.

D. Maclennan, E. Zubrzycka, 1976, The Journal of biological chemistry.

Studies on the electron transfer system. LXIX. "Solubilization" of the mitochondrial inner membrane by sonic oscillation.

D. Maclennan, A. Tzagoloff, D. McConnell, 1968, The Journal of biological chemistry.

DIDS INHIBITION OF SARCOPLASMIC RETICULUM ANION EFFLUX AND CALCIUM TRANSPORT

K. Campbell, D. Maclennan, 1980, Annals of the New York Academy of Sciences.

Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.

Andrew Emili, Thomas Kislinger, A. Emili, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A711 A COMPARISON OP THE CAFFEINE HALOTHANE CONTRACTURE TEST WITH MOLECULAR GENETICS DIAGNOSIS OF MALIGNANT HYPERTHERMIA (MH)

R. Korneluk, D. Maclennan, R. Worton, 1990 .

Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12

H. Willard, P. Holland, D. Maclennan, 1988 .

Phospholamban domain I/cytochrome b 5 transmembrane sequence chimeras do not inhibit SERCA2a

D. Maclennan, M. Asahi, M. Tada, 1998, FEBS letters.

Assembly of the sarcoplasmic reticulum. Biosynthesis of the high affinity calcium binding protein in rat skeletal muscle cell cultures.

M. Michalak, D. Maclennan, 1980, The Journal of biological chemistry.

Structure, function and biosynthesis of sarcoplasmic reticulum proteins

K. Campbell, D. Maclennan, 1979 .

Localization of Ca + +-Mg + + A TPase and Calsequestrin in Slow-Twitch and Fast-Twitch Myofibers

D. Maclennan, V. Kalnins, A. O. Jorgensen, 2003 .

The fast‐twitch muscle calsequestrin isoform predominates in rabbit slow‐twitch soleus muscle

N. Green, L. Fliegel, E. Leberer, 1989, FEBS letters.

The epitope for monoclonal antibody A20 (amino acids 870-890) is located on the luminal surface of the Ca2(+)-ATPase of sarcoplasmic reticulum.

D. Clarke, D. Maclennan, T. Loo, 1990, The Journal of biological chemistry.

Malignant hyperthermia and central core disease: disorders of Ca2+ release channels.

D. Maclennan, D. MacLennan, J. Loke, 1998, The American journal of medicine.

Mössbauer study of iron bleomycin and its activation intermediates.

G. Coruzzi, J. Steitz, J. Brisson, 1983, The Journal of biological chemistry.

Localization of sarcoplasmic reticulum proteins in rat skeletal muscle by immunofluorescence

D. Maclennan, V. Kalnins, A. O. Jorgensen, 1979, The Journal of cell biology.

Site-directed Disulfide Mapping of Helices M4 and M6 in the Ca2+ Binding Domain of SERCA1a, the Ca2+ ATPase of Fast Twitch Skeletal Muscle Sarcoplasmic Reticulum*

N. Green, D. Maclennan, W. J. Rice, 1997, The Journal of Biological Chemistry.

Isolation of proteins of the sarcoplasmic reticulum.

D. Maclennan, 1974, Methods in Enzymology.

Separate effects of mercurial compounds on the ionophoric and hydrolytic functions of the (Ca+++Mg++)-ATPase of sarcoplasmic reticulum

A. Shamoo, D. Maclennan, 1975, The Journal of Membrane Biology.

Deletion of NH2− and COOH‐terminal sequences destroys function of the Ca2+ ATPase of rabbit fast‐twitch skeletal muscle sarcoplasmic reticulum

D. Clarke, D. Maclennan, I. Skerjanc, 1993, FEBS letters.

Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum.

W. Rice, D. Clarke, D. Maclennan, 1993, The Journal of biological chemistry.

Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum.

D. Maclennan, E. Zvaritch, 2011, Biochimica et biophysica acta.

Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels

N. Vardi, K. Palczewski, J. Foskett, 2002, Proceedings of the National Academy of Sciences of the United States of America.

STRUCTURAL COMPONENTS OF THE SARCOPLASMIC RETICULUM MEMBRANE *

D. Maclennan, P. Stewart, David H. MacLennan, 1974, Annals of the New York Academy of Sciences.

ISOLATION AND CHARACTERIZATION OF TRYPTIC FRAGMENTS OF THE SARCOPLASMIC RETICULUM ADENOSINE TRIPHOSPHATASE fn1

D. Maclennan, P. Stewart, David H. MacLennan, 1975 .

Assembly of the Sarcoplasmic Reticulum

D. Maclennan, V. Kalnins, A. O. Jorgensen, 1978 .

Restoration by fatty acids of active transport in a lactose transport mutant of Escherichia coli.

D. Maclennan, P. Wong, 1973, Canadian journal of biochemistry.

STUDIES OF Ca2+ RELEASE FROM SARCOPLASMIC RETICULUM *

D. Maclennan, D. Wood, V. Shoshan, 1982, Annals of the New York Academy of Sciences.

ION PATHWAYS IN PROTEINS OF THE SARCOPLASMIC RETICULUM *

K. Campbell, A. Shamoo, R. Reithmeier, 1980, Annals of the New York Academy of Sciences.

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