Q. Guo

发表

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Miles W. Miller, M. Mattson, C. Ware, 1999, Nature Medicine.

Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation

Jun Xie, Q. Guo, Xiaojin Zhang, 2001, Brain Research.

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

M. Mattson, G. Martin, K. Furukawa, 1997, The Journal of Neuroscience.

Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity

Jun Xie, Q. Guo, H. Du, 2000, Brain Research.

Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

M. Mattson, Q. Guo, 1997, Journal of neuroscience research.

Par-4 in Neuronal Death and Survival in Alzheimer’s Disease and Other Neurogenerative Diseases

Jun Xie, Q. Guo, C.-J. Guo, 2021, Tumor Suppressor Par-4.

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

M. Mattson, Q. Guo, Haiyan Zhu, 1999, Brain Research.

RNAi knockdown of Par‐4 inhibits neurosynaptic degeneration in ALS‐linked mice

Jun Xie, Q. Guo, K. Awad, 2005, Journal of neurochemistry.

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

M. Mattson, J. Geddes, V. Rangnekar, 1998, Nature Medicine.

Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.

M. Mattson, Q. Guo, N. Robinson, 1997, Neuroreport.

Par-4 is a novel mediator of renal tubule cell death in models of ischemia-reperfusion injury.

Jun Xie, Q. Guo, 2007, American journal of physiology. Renal physiology.

Exacerbation of apoptosis of cortical neurons following traumatic brain injury in par-4 transgenic mice.

Jun Xie, Q. Guo, N. Shirwany, 2008, International journal of clinical and experimental pathology.

AATF protects neural cells against oxidative damage induced by amyloid β-peptide

Jun Xie, Q. Guo, 2004, Neurobiology of Disease.

Par-4 Inhibits Choline Uptake by Interacting with CHT1 and Reducing Its Incorporation on the Plasma Membrane*

Jun Xie, Q. Guo, 2004, Journal of Biological Chemistry.

Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice

Jun Xie, Q. Guo, Daniel J. Payette, 2007, Brain Research.

AATF protects neural cells against oxidative damage induced by amyloid beta-peptide.

Jun Xie, Q. Guo, 2004, Neurobiology of disease.

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.

Miles W. Miller, M. Mattson, C. Ware, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Presenilins, the Endoplasmic Reticulum, and Neuronal Apoptosis in Alzheimer's Disease

M. Mattson, K. Furukawa, Q. Guo, 1998, Journal of neurochemistry.

Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice

Qing Guo, Jun Xie, Q. Guo, 2001, Brain Research.

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

M. Mattson, C. Ware, M. Miller, 2008, Journal of neurochemistry.

Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

M. Mattson, A. Bruce-Keller, J. Keller, 1998, The Journal of Neuroscience.

Calcium and reactive oxygen species mediate staurosporine‐induced mitochondrial dysfunction and apoptosis in PC12 cells

M. Mattson, Q. Guo, I. Kruman, 1998, Journal of neuroscience research.

Apoptosis antagonizing transcription factor protects renal tubule cells against oxidative damage and apoptosis induced by ischemia-reperfusion.

Jun Xie, Q. Guo, 2006, Journal of the American Society of Nephrology : JASN.

Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide

M. Mattson, Jun Xie, Q. Guo, 2000 .

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function.

M. Mattson, S. Christakos, Q. Guo, 1998, Proceedings of the National Academy of Sciences of the United States of America.

PAR-4 Is Involved in Regulation of β-Secretase Cleavage of the Alzheimer Amyloid Precursor Protein*

Qing Guo, Jun Xie, Q. Guo, 2005, Journal of Biological Chemistry.

Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis*

M. Mattson, Q. Guo, N. Robinson, 1998, The Journal of Biological Chemistry.

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis.

M. Mattson, Q. Guo, N. Robinson, 1998, The Journal of biological chemistry.

The amyloid beta ion channel hypothesis of Alzheimer’s disease

Jun Xie, Q. Guo, N. Shirwany, 2007, Neuropsychiatric disease and treatment.

Superoxide mediates the cell‐death‐enhancing action of presenilin‐1 mutations

M. Mattson, Weiming Fu, Q. Guo, 1999, Journal of neuroscience research.

Nerve Growth Factor-independent Reduction in Choline Acetyltransferase Activity in PC12 Cells Expressing Mutant Presenilin-1*

B. K. Hartman, M. Mattson, Q. Guo, 1997, The Journal of Biological Chemistry.

Alzheimer's PS‐1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β‐peptide

M. Mattson, Jun Xie, G. Martin, 1996, Neuroreport.

Prostate Apoptosis Response-4 Enhances Secretion of Amyloid β Peptide 1–42 in Human Neuroblastoma IMR-32 Cells by a Caspase-dependent Pathway*

Jun Xie, Q. Guo, J Xie, 2001, The Journal of Biological Chemistry.

Neuronal apoptosis and the pathogenesis of Alzheimer's and Parkinson's diseases

M. Mattson, Sic L. Chan, Q. Guo, 2001 .

Regulation of intracellular calcium in cortical neurons transgenic for human Abeta40 and Abeta42 following nutritive challenge.

Qing Guo, Jun Xie, Q. Guo, 2009, International journal of clinical and experimental medicine.

Regulation of intracellular calcium in cortical neurons transgenic for human Abeta40 and Abeta42 following nutritive challenge.

Jun Xie, Q. Guo, N. Shirwany, 2009, International journal of clinical and experimental medicine.

Cortical neurons transgenic for human Abeta40 or Abeta42 have similar vulnerability to apoptosis despite their different amyloidogenic properties.

Jun Xie, Q. Guo, Najeeb A. Shiwany, 2009, International journal of clinical and experimental pathology.

Original Article Cortical Neurons Transgenic for Human Aβ40 or Aβ42 Have Similar Vulnerability to Apoptosis despite Their Different Amyloidogenic Properties

Jun Xie, Q. Guo, Najeeb A. Shiwany, 2009 .

AATF Inhibits Aberrant Production of Amyloid β Peptide 1-42 by Interacting Directly with Par-4*

Qing Guo, Jun Xie, Q. Guo, 2003, Journal of Biological Chemistry.

Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.

M. Mattson, H. Zhu, Q. Guo, 2000, Brain research. Molecular brain research.

Defects of immune regulation in the presenilin-1 mutant knockin mouse

M. Mattson, B. Osborne, D. Gary, 2007, NeuroMolecular Medicine.

Presenilin‐1 mutation alters NGF‐induced neurite outgrowth, calcium homeostasis, and transcription factor (AP‐1) activation in PC12 cells

G. Schellenberg, M. Mattson, K. Furukawa, 1998, Journal of neuroscience research.

Original Article Regulation of intracellular calcium in cortical neurons transgenic for human Aβ40 and Aβ42 following nutritive challenge

Jun Xie, Q. Guo, N. Shirwany, 2009 .