D. Richards

发表

Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes.

I. Adcock, P. Barnes, C. Hawrylowicz, 1998, The Journal of clinical investigation.

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.

M. Dallman, D. Robinson, C. Hawrylowicz, 2005, The Journal of clinical investigation.

Mycophenolic acid-induced GTP depletion also affects ATP and pyrimidine synthesis in mitogen-stimulated primary human T-lymphocytes.

B. Kirschbaum, H. Simmonds, D. Richards, 2000, Transplantation.

Monocytes and macrophages – friend or foe?

C. Hawrylowicz, B. O'connor, C. Corrigan, 2001 .

Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?

B. Kirschbaum, H. Simmonds, R. Swaminathan, 1999, The Biochemical journal.

Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.

C. Hawrylowicz, C. Corrigan, D. Richards, 2005, American journal of respiratory cell and molecular biology.

A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients.

C. Hawrylowicz, C. Corrigan, D. Richards, 2002, The Journal of allergy and clinical immunology.

Journal of Steroid Biochemistry and Molecular Biology Vitamin D (1,25(OH) 2 D3) induces α -1-antitrypsin synthesis by CD4 + T cells, which is required for 1,25(OH) 2 D3-driven IL-10

P. Pfeffer, C. Hawrylowicz, J. Raynes, 2022 .

T cells producing the anti‐inflammatory cytokine IL‐10 regulate allergen‐specific Th2 responses in human airways

C. Hawrylowicz, T. Lee, C. Corrigan, 2012, Allergy.

The role of 1α,25‐dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL‐10+ CD4+ T cells

C. Hawrylowicz, A. Bush, A. O’Garra, 2012, European journal of immunology.

Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses.

C. Hawrylowicz, G. Santis, D. Richards, 2007, American journal of respiratory cell and molecular biology.

CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

S. Thorpe, M. Knight, R. Beale, 2022, bioRxiv.

Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma.

C. Hawrylowicz, P. Timms, E. S. Chambers, 2012, The Journal of allergy and clinical immunology.

Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3

D. Robinson, C. Hawrylowicz, D. Richards, 2014, BMC Immunology.

Impaired secretion of interleukin‐4 and interleukin‐13 by allergen‐specific T cells correlates with defective nuclear expression of NF‐AT2 and jun B: relevance to immunotherapy

J. Lamb, C. Hawrylowicz, T. Lee, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances T(H)2 development.

C. Hawrylowicz, C. Corrigan, D. Richards, 2005, The Journal of allergy and clinical immunology.

1α,25-Dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells

C. Hawrylowicz, A. Bush, D. Richards, 2012, Thorax.

Repression of Interleukin-5 Transcription by the Glucocorticoid Receptor Targets GATA3 Signaling and Involves Histone Deacetylase Recruitment*

C. Hawrylowicz, Philip J. Smith, J. Gilmour, 2005, Journal of Biological Chemistry.

Calcitriol restores glucocorticoid responsiveness in steroid resistant asthmatics through reduction of IL-17A

P. Pfeffer, C. Hawrylowicz, E. S. Chambers, 2014 .

Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL‐10 and reduced IL‐4, IL‐5 and IL‐13 production

C. Hawrylowicz, D. Richards, J. Caulfield, 2000, European journal of immunology.

Regulation of GM-CSF expression by the transcription factor c-Maf.

J. Gilmour, D. Richards, P. Lavender, 2007, The Journal of allergy and clinical immunology.

1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin-2

C. Hawrylowicz, G. Lertmemongkolchai, E. S. Chambers, 2014, Immunology.

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion.

C. Hawrylowicz, P. Timms, E. S. Chambers, 2013, The Journal of allergy and clinical immunology.

Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function.

E. Hickman, C. Hawrylowicz, C. Corrigan, 2009, The Journal of clinical investigation.

Biochemical basis for the impaired immune response in chronic renal failure

H. Simmonds, A. Laurence, M. Bofill, 1998 .

Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

P. Pfeffer, C. Hawrylowicz, P. Timms, 2015, The Journal of allergy and clinical immunology.

Vitamin D binding protein and asthma severity in children.

C. Hawrylowicz, A. Bush, D. Richards, 2012, The Journal of allergy and clinical immunology.

Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma.

W. Banya, C. Hawrylowicz, A. Bush, 2011, American journal of respiratory and critical care medicine.

Serum vitamin D levels and severe therapy resistant asthma in children

C. Hawrylowicz, D. Richards, S. Saglani, 2011, Archives of Disease in Childhood.

The effects of calcitriol treatment in glucocorticoid-resistant asthma.

C. Hawrylowicz, P. Timms, E. S. Chambers, 2014, The Journal of allergy and clinical immunology.

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

David F. Richards, R. Coffman, C. Hawrylowicz, 2002, The Journal of experimental medicine.

Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids

P. Pfeffer, C. Hawrylowicz, E. S. Chambers, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Nanzer et al 1 Enhanced production of IL-17A in severe asthma is inhibited by 1 α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

C. Hawrylowicz, P. Timms, A. Martineau, 2017 .

Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3

D. Robinson, C. Hawrylowicz, D. Richards, 2014, BMC Immunology.

Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma

C. Hawrylowicz, A. Bush, E. S. Chambers, 2013, Thorax.

1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3– T cells

C. Hawrylowicz, E. S. Chambers, D. Richards, 2015, Immunology.

Biochemical basis for the impaired immune response in chronic renal failure?

H. Simmonds, A. Laurence, M. Bofill, 1997, Advances in Experimental Medicine and Biology.

Leflunomide Inhibits Pyrimidine de Novo Synthesis in Mitogen-stimulated T-lymphocytes from Healthy Humans*

B. Kirschbaum, H. Simmonds, C. Hawrylowicz, 1998, The Journal of Biological Chemistry.

1α,25-Dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells

C. Hawrylowicz, A. Bush, D. Richards, 2012, Thorax.