M. Kimple

Deyang Yu, Jacqueline A. Brinkman, D. Sherman, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

M. Kimple, Rachel J Fenske, Jaclyn A Wisinski, 2019, bioRxiv.

The Inhibitory G Protein &agr;-Subunit, G&agr;z, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

Kathryn A Carbajal, Q. Harenda, M. Kimple, 2017, Endocrinology.

Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

M. Kimple, Rachel J Fenske, Jaclyn A Wisinski, 2019, bioRxiv.

The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease

M. Kimple, Jaclyn A Wisinski, Michael D Schaid, 2017, The AAPS Journal.

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

D. Drucker, T. Alquier, V. Poitout, 2015, Diabetes.

The protection of Gαz-null NOD mice from hyperglycemia is sexually dimorphic and only partially β-cell autonomous

Kathryn A Carbajal, M. Kimple, Rachel J Fenske, 2021, bioRxiv.

The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma

D. Davis, M. Kimple, A. C. Weeks, 2015, Journal of investigative medicine high impact case reports.

Gαz Negatively Regulates Insulin Secretion and Glucose Clearance*

P. Casey, C. Newgard, C. Bailey, 2008, Journal of Biological Chemistry.

A Role for Gz in Pancreatic Islet β-Cell Biology*

P. Casey, T. Fields, A. Nixon, 2005, Journal of Biological Chemistry.

Human islet expression levels of Prostaglandin E2 synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity

D. Davis, M. Kimple, B. Wancewicz, 2021, bioRxiv.

Differential Effects of Prostaglandin E2 Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell Compensation

J. Moeller, M. Kimple, H. Sandhu, 2019, bioRxiv.

The EP3 Receptor: Exploring a New Target for Type 2 Diabetes Therapeutics.

M. Kimple, J. Neuman, 2013, Journal of endocrinology, diabetes & obesity.

Independent mechanisms underlie the protective effect of dietary polyunsaturated fatty acid supplementation and Gαz deficiency on the early type 1 diabetes phenotype of Non-obese diabetic (NOD) mice

A. Pennati, J. Galipeau, M. Kimple, 2021, bioRxiv.

Plasma Prostaglandin E2 Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation

D. Davis, M. Kimple, Allison L. Brill, 2022, Metabolites.

A single-islet microplate assay to measure mouse and human islet insulin secretion

M. Kimple, Nathan A Truchan, J. Neuman, 2015, Islets.

Overview of Affinity Tags for Protein Purification

M. Kimple, Allison L. Brill, R. Pasker, 2004, Current protocols in protein science.

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes

P. Casey, A. Linnemann, M. Kimple, 2014, Experimental & Molecular Medicine.

A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function

J. Koltes, M. Kimple, Michael D Schaid, 2019, Scientific Reports.

Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein–coupled receptor BAI3

J. Koltes, A. Balamurugan, G. W. Wong, 2018, The Journal of Biological Chemistry.

Spontaneous Tumor Lysis Syndrome

M. Kimple, A. C. Weeks, 2015, Journal of investigative medicine high impact case reports.

Restoration of metabolic health by decreased consumption of branched‐chain amino acids

S. A. Arriola Apelo, Deyang Yu, D. Sherman, 2017, The Journal of physiology.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

S. A. Arriola Apelo, Faizan A. Syed, Emma L. Baar, 2015, Aging cell.

Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes.

M. Kimple, Rachel J Fenske, Jaclyn A Wisinski, 2016, Molecular endocrinology.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.

The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition.

Elaina K. Jones, K. Kudsk, Carly R. Kibbe, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Affinity tag for protein purification and detection based on the disulfide-linked complex of InaD and NorpA.

J. Sondek, M. Kimple, 2002, BioTechniques.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity

Emma L. Baar, Dudley Lamming, J. Denu, 2016, Diabetes.

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

Jesse R. Dixon, C. Worby, P. Casey, 2005, Molecular cell.

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

Jacqueline A. Brinkman, D. Sherman, Dudley Lamming, 2018, Scientific Reports.

Functional relevance of the disulﬁde-linked complex of the N-terminal PDZ domain of InaD with NorpA

D P Siderovski, J. Sondek, D. Siderovski, 2022 .

Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research.

A. Barsch, A. Brasier, Yutong Jin, 2020, Journal of proteome research.

Signaling Through Gz

P. Casey, Rainbo Hultman, M. Kimple, 2009 .

Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment

M. Kimple, Rachel J Fenske, J. Neuman, 2016, Nutrition and healthy aging.

Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes

M. Kimple, Jaclyn A Wisinski, 2016, Diabetes.

Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

Kathryn A Carbajal, Dudley Lamming, M. Kimple, 2020, The Journal of biological chemistry.

The influence of intermittent hypoxia, obesity and diabetes on male genitourinary anatomy and voiding physiology.

Jonathan N. Ouellette, M. Baan, D. Davis, 2021, American journal of physiology. Renal physiology.

A method for mouse pancreatic islet isolation and intracellular cAMP determination.

M. Kimple, J. Joseph, Nathan A Truchan, 2014, Journal of visualized experiments : JoVE.

Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion

A. Attie, M. Kimple, Nathan A Truchan, 2013, Diabetes.

Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis.

D. Davis, A. Linnemann, M. Kimple, 2015, Molecular endocrinology.

Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage

R. Breyer, M. Gannon, D. Scott, 2021, Molecular metabolism.

What the BTBR/J mouse has taught us about diabetes and diabetic complications

C. Alpers, A. Attie, D. Davis, 2023, iScience.

The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease

M. Kimple, Jaclyn A Wisinski, Michael D Schaid, 2017, The AAPS Journal.

G protein alpha z

M. Kimple, D. Manning, 2009 .

Human Islet Expression Levels of Prostaglandin E2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity.

D. Davis, Ying Ge, M. Kimple, 2021, ACS Pharmacology & Translational Science.

Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

Dudley Lamming, I. Ong, A. Brasier, 2021, Metabolites.

EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance

M. Kimple, Michael D Schaid, Sophia M. Sdao, 2020, bioRxiv.

Overview of Affinity Tags for Protein Purification

J. Sondek, M. Kimple, 2004, Current protocols in protein science.

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

Jacqueline A. Brinkman, D. Sherman, Dudley Lamming, 2018, Scientific Reports.

A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function

J. Koltes, M. Kimple, Michael D Schaid, 2019, Scientific Reports.

Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort

D. Davis, Yanlong Zhu, M. Kimple, 2023, The Journal of Pharmacology and Experimental Therapeutics.

A method for mouse pancreatic islet isolation and intracellular cAMP determination.

M. Kimple, J. Joseph, J. Neuman, 2014, Journal of visualized experiments : JoVE.

EPAC–RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP

M. Kimple, V. Setaluri, Kirthana Prabhakar, 2017, Molecular Cancer Research.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.