M. Shiraki

M. Shiraki, M. Miura, Y. Shiraki, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Executive summary of clinical practice guide on fracture risk in lifestyle diseases

H. Hagino, M. Inaba, Y. Takeuchi, 2020, Journal of Bone and Mineral Metabolism.

Effects of 1α-hydroxyvitamin D3 on lumbar bone mineral density and vertebral fractures in patients with postmenopausal osteoporosis

H. Orimo, N. Ogawa, M. Shiraki, 1994, Calcified Tissue International.

An unusual form of vitamin D-dependent rickets in a child: alopecia and marked end-organ hyposensitivity to biologically active vitamin D.

H. Orimo, M. Shiraki, T. Suda, 1980, The Journal of clinical endocrinology and metabolism.

Preventive effects of raloxifene treatment on agerelated weight loss in postmenopausal women

S. Inoue, Shiro Tanaka, K. Uenishi, 2015, Journal of Bone and Mineral Metabolism.

Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women

A. Taguchi, M. Shiraki, M. Saito, 2022, Journal of Bone and Mineral Metabolism.

Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03

M. Fukunaga, E. Itoi, Y. Ohashi, 2017, Journal of Bone and Mineral Metabolism.

Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03)

M. Fukunaga, E. Itoi, Y. Ohashi, 2014, Journal of Bone and Mineral Metabolism.

Serum level of pepsinogen significantly associated with gastric distress induced by amino-bisphosphonates

M. Shiraki, S. Tanaka, T. Kuroda, 2011, Osteoporosis International.

A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis.

Y. Taketani, T. Sone, Y. Ohashi, 2009, Bone.

Daily nasal spray of hPTH(1–34) for 3 months increases bone mass in osteoporotic subjects: a pilot study

H. Hagino, M. Shiraki, T. Nakamura, 2006, Osteoporosis International.

Alendronate reduced vertebral fracture risk in postmenopausal Japanese women with osteoporosis: a 3-year follow-up study

K. Kaneda, M. Fukunaga, Toshitaka Nakamura, 2004, Journal of Bone and Mineral Metabolism.

A comparison of incidences of vertebral fracture in Japanese patients with involutional osteoporosis treated with risedronate and etidronate: a randomized, double-masked trial

K. Kaneda, M. Fukunaga, Y. Ohashi, 2004, Journal of Bone and Mineral Metabolism.

Alfacalcidol reduces accelerated bone turnover in elderly women with osteoporosis

M. Shiraki, H. Sakamoto, T. Kiriyama, 2004, Journal of Bone and Mineral Metabolism.

A double-blind dose-ranging study of risedronate in Japanese patients with osteoporosis (a study by the Risedronate Late Phase II Research Group)

Y. Taketani, M. Fukunaga, Y. Ohashi, 2003, Osteoporosis International.

A Comparison of the Effect of Risedronate and Etidronate on Lumbar Bone Mineral Density in Japanese Patients with Osteoporosis: A Randomized Controlled Trial

Y. Taketani, M. Fukunaga, Y. Ohashi, 2002, Osteoporosis International.

Statistical Analysis for Comparing Antifracture Efficacy among Antiresorptive Agents

Toshitaka Nakamura, K. Aoyagi, Masako Ito, 2001 .

A placebo-controlled, single-blind study to determine the appropriate alendronate dosage in postmenopausal Japanese patients with osteoporosis. The Alendronate Research Group.

K. Kaneda, M. Fukunaga, H. Orimo, 1998, Endocrine journal.

Association of the −381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss

S. Inoue, M. Emi, Y. Ezura, 2003, Journal of Human Genetics.

The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures

Satoshi Inoue, Shiro Tanaka, S. Inoue, 2008, Journal of Bone and Mineral Metabolism.

Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women

Y. Ouchi, S. Inoue, M. Saito, 2014, Geriatrics & gerontology international.

Q89R Polymorphism in the LDL Receptor-Related Protein 5 Gene Is Associated With Spinal Osteoarthritis in Postmenopausal Japanese Women

Y. Ouchi, S. Inoue, Toshitaka Nakamura, 2007, Spine.

Low serum estradiol levels in subjects with arterial calcification.

H. Orimo, M. Shiraki, J. Nakao, 1979, Atherosclerosis.

Possible involvement of the p57(Kip2) gene in bone metabolism.

Y. Ouchi, S. Inoue, H. Toyoshima, 2000, Biochemical and biophysical research communications.

Identification of a novel polymorphism of estrogen receptor-α gene that is associated with calcium excretion in urine

Y. Ouchi, S. Inoue, H. Orimo, 2000, Journal of Bone and Mineral Metabolism.

Efficacy and tolerability of once-weekly administration of 17.5 mg risedronate in Japanese patients with involutional osteoporosis: a comparison with 2.5-mg once-daily dosage regimen

M. Fukunaga, Y. Ohashi, K. Takaoka, 2006, Journal of Bone and Mineral Metabolism.

Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04

T. Sone, M. Fukunaga, A. Taguchi, 2020, Current medical research and opinion.

Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid

A. Taguchi, Toshitaka Nakamura, Shiro Tanaka, 2019, Journal of Bone and Mineral Metabolism.

Study design of multi-center, open-label randomized controlled, head-to-head trial comparing minodronic acid and raloxifene: Japanese Osteoporosis Intervention Trial (JOINT)-04

T. Sone, M. Fukunaga, A. Taguchi, 2018, Journal of Bone and Mineral Metabolism.

Changes in bone mineral density and fracture prevalence in Japanese women after oophorectomy.

Y. Hirai, M. Shiraki, M. Matsuura, 2010, Asia-Oceania journal of obstetrics and gynaecology.

Association of Transforming Growth Factor β1 Genotype with Therapeutic Response to Active Vitamin D for Postmenopausal Osteoporosis

K. Ikeda, M. Shiraki, T. Hosoi, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

Y. Ouchi, S. Inoue, M. Emi, 2004, Journal of Bone and Mineral Metabolism.

Rates of Change in Spinal Bone Density Among Japanese Women

T. Tomomitsu, M. Fukunaga, T. Hashimoto, 1998, Calcified Tissue International.

Eldecalcitol is more effective for the prevention of osteoporotic fractures than alfacalcidol

M. Fukunaga, Toshitaka Nakamura, Toshio Matsumoto, 2013, Journal of Bone and Mineral Metabolism.

The effects of once-weekly teriparatide on hip geometry assessed by hip structural analysis in postmenopausal osteoporotic women with high fracture risk.

T. Tomomitsu, T. Sone, M. Fukunaga, 2014, Bone.

Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT.

M. Fukunaga, Toshitaka Nakamura, Toshio Matsumoto, 2011, Bone.

Association of bone mineral density with polymorphism of the estrogen receptor gene

Y. Ouchi, S. Inoue, H. Orimo, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects

I. Endo, Toshio Matsumoto, T. Sugimoto, 2011, Journal of Bone and Mineral Metabolism.

Recent advances in vitamin K-dependent Gla-containing proteins and vitamin K nutrition

M. Shiraki, N. Tsugawa, T. Okano, 2015 .

Reduced occurrence of vertebral crush fractures in senile osteoporosis treated with 1 alpha (OH)-vitamin D3.

Toshitaka Nakamura, H. Orimo, M. Shiraki, 1987, Bone and mineral.

Renal Phosphate Reabsorption is Correlated with the Increase in Lumbar Bone Mineral Density in Patients Receiving Once-Weekly Teriparatide

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2015, Calcified Tissue International.

New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide

Sakae Tanaka, T. Adachi, J. Bilezikian, 2014, Bone Research.

Author’s Response to Letter to the Editor

Toshitaka Nakamura, Shiro Tanaka, T. Sugimoto, 2014, Current medical research and opinion.

Once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis: reply to T. Kawada

T. Sugimoto, M. Shiraki, T. Nakamura, 2014, Osteoporosis International.

The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT

M. Ito, T. Sone, M. Fukunaga, 2013, Osteoporosis International.

Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis

T. Sugimoto, M. Shiraki, T. Nakamura, 2013, Osteoporosis International.

Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women

T. Sugimoto, M. Shiraki, T. Nakamura, 2012, Osteoporosis International.

1-α-Hydroxyvitamin D3 treatment decreases bone turnover and modulates calcium-regulating hormones in early postmenopausal women

E. Ogata, Y. Hirai, Toshikazu Nakamura, 1997 .

Serum N‐terminal osteocalcin is a good indicator for estimating responders to hormone replacement therapy in postmenopausal women

M. Shiraki, E. Ogata, K. Hosoda, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis.

Y. Ouchi, S. Inoue, M. Emi, 1995, Biochemical and biophysical research communications.

Platelet thromboxane synthesizing activity in non-insulin-dependent diabetes: correlation with diabetic retinopathy and diabetic treatment.

I. Morita, S. Murota, H. Ito, 1985, Prostaglandins, leukotrienes, and medicine.

[The clinical study of hyponatremia in the elderly. Part Three. Plasma ADH secretion in dilutional hyponatremia].

H. Kobayashi, M. Shiraki, H. Ito, 1985, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

[Bone mineral density in postmenopausal elderly women with type 2 diabetes].

M. Shiraki, J. Inoue, H. Ito, 1995, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women

S. Inoue, F. Urano, Shiro Tanaka, 2018, Journal of Bone and Mineral Metabolism.

Risk Factors for Development of Retinopathy in Elderly Japanese Patients With Diabetes Mellitus

H. Orimo, M. Shiraki, Hideki Ito, 1993, Diabetes Care.

Prostaglandin D2 is the major prostaglandin of arachidonic acid metabolism in rat bone marrow homogenate.

I. Morita, S. Murota, H. Orimo, 1980, Prostaglandins.

Dietary arachidonic acid supplementation increases thromboxane synthesizing activity in platelets from diabetics.

I. Morita, S. Murota, H. Ito, 1983, Prostaglandins, leukotrienes, and medicine.

Separation and quantitation of plasma free fatty acids as phenacyl esters by HPLC.

M. Shiraki, A. Tsuji, H. Okabe, 1987, Biomedical chromatography : BMC.

Association of Bone Metabolism Regulatory Factor Gene Polymorphisms With Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine and Its Severity

Kozo Nakamura, H. Kawaguchi, M. Shiraki, 2002, Spine.

Ethnic difference in contribution of alleles of the interleukin‐1 receptor antagonist gene to predisposition to osteoporosis

Y. Ouchi, S. Inoue, M. Emi, 2002 .

Association of amino acid variation (Trp64Arg) in the beta3‐adrenergic receptor gene with bone mineral density

Y. Ouchi, S. Inoue, M. Emi, 2002 .

[Genome-wide SNP scanning for identification of susceptibility genes of osteoporosis].

M. Emi, Y. Ezura, H. Orimo, 2001, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

Y. Ouchi, S. Inoue, T. Nakajima, 2000, Journal of Human Genetics.

Association Study of Parathyroid Hormone Gene Polymorphism and Bone Mineral Density in Japanese Postmenopausal Women

Y. Ouchi, S. Inoue, H. Orimo, 1999, Calcified Tissue International.

Effects of 2 Years ' Treatment of Osteoporosis 1 ci-Hydroxy Vitamin D 3 on Bone Mineral Density and Incidence of Fracture : A Placebo-Controlled , Double-Blind Prospect with ive Study

H. Orimo, K. Kushida, K. Yamazaki, 2006 .

Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women

M. Shiraki, N. Tsugawa, T. Okano, 2018, Journal of Bone and Mineral Metabolism.

Saccharated ferric oxide-induced osteomalacia in Japan: iron-induced osteopathy due to nephropathy.

M. Shiraki, K. Sato, 1998, Endocrine journal.

A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women

Kozo Nakamura, H. Kawaguchi, M. Shiraki, 2001, Journal of Bone and Mineral Metabolism.

Bone and calcium metabolism in Werner's syndrome.

M. Shiraki, M. Goto, C. Aoki, 1998, Endocrine journal.

Effects of la , 25-Dihydroxyvitamin D 3 on Macrophage Colony-Stimulating Factor Production and Proliferation of Human Monocytic Cells

Y. Ouchi, S. Inoue, M. Kaneki, 2002 .

Evidence of hypovitaminosis D in patients with mitral ring calcification.

M. Shiraki, H. Ito, A. Miyagawa, 1988, Japanese heart journal.

Recent nutritional trends of calcium and vitamin D in East Asia

K. Uenishi, M. Shiraki, H. Ohta, 2016, Osteoporosis and sarcopenia.

Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.

S. Inoue, T. Nakajima, M. Emi, 2007, Bone.

A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.

M. Fukunaga, Toshitaka Nakamura, Y. Tanigawara, 2005, The Journal of clinical endocrinology and metabolism.

Antiresorptive agent-related osteonecrosis of the jaw in osteoporosis patients from Asian countries

A. Taguchi, M. Shiraki, A. Morrison, 2017, Osteoporosis and sarcopenia.

Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw

A. Taguchi, T. Sugimoto, M. Shiraki, 2016, Current medical research and opinion.

Role of calcium regulating hormones in the pathogenesis of senile osteoporosis.

H. Orimo, M. Shiraki, 1979, Endocrinologia japonica.

Clinical Evaluation of the Plasma Levels of Immunoreactive Atrial Natriuretic Peptide in Elderly Patients with Heart Diseases

S. Matsushita, K. Kuramoto, M. Shiraki, 1988, Journal of the American Geriatrics Society.

The ultra long-term treatment of senile osteoporosis with 1α-hydroxyvitamin D3

H. Orimo, M. Shiraki, Hideki Ito, 1993 .

Long-term treatment of postmenopausal osteoporosis with active vitamin D3, 1-alpha-hydroxycholecalciferol (1 alpha-OHD3) and 1, 24 Dihydroxycholecalciferol (1, 24(OH)2D3).

H. Orimo, M. Shiraki, H. Ito, 1985, Endocrinologia japonica.

Effects of active vitamin D3 on calcium and phosphorus metabolism in the elderly

T. Matsui, H. Orimo, Yasufumi Sato, 1984 .

Vitamin K2 promotes 1α,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts

M. Shiraki, Y. Koshihara, H. Ishibashi, 1996, Calcified Tissue International.

An enzyme immunoassay for osteocalcin.

K. Katayama, M. Shiraki, M. Kuwada, 1986, Journal of immunological methods.

Relation between body size and bone mineral density with special reference to sex hormones and calcium regulating hormones in elderly females.

M. Shiraki, H. Ito, T. Higuchi, 1991, Endocrinologia japonica.

Executive summary of the Japan Osteoporosis Society Guide for the Use of Bone Turnover Markers in the Diagnosis and Treatment of Osteoporosis (2018 Edition).

M. Fukunaga, H. Hagino, M. Inaba, 2019, Clinica chimica acta; international journal of clinical chemistry.

Association of a Single Nucleotide Polymorphism in the Insulin-Like Growth Factor-1 Receptor Gene With Spinal Disc Degeneration in Postmenopausal Japanese Women

Y. Ouchi, S. Inoue, Toshitaka Nakamura, 2008, Spine.

Clinical significance of serum levels of insulin like growth factors as bone metabolic markers in postmenopausal women

Y. Ouchi, Toshitaka Nakamura, H. Orimo, 1992 .

Loss of Bone Mineral Menopause

Y. Hirai, M. Shiraki, Jui-Tung Chen, 2006 .

Effect of 1 alpha-hydroxyvitamin D3 on loss of bone mineral density immediately after artificial menopause.

E. Ogata, Y. Hirai, M. Shiraki, 1997, Endocrine journal.

Correction to: Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis

K. Uenishi, M. Shiraki, M. Tokiwa, 2018, Osteoporosis International.

Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis

K. Uenishi, M. Shiraki, M. Tokiwa, 2017, Osteoporosis International.

Nationwide incidence survey of femoral neck fracture in Japan, 1992

M. Fukunaga, T. Hashimoto, Toshitaka Nakamura, 1997, Journal of Bone and Mineral Metabolism.

Calcium Requirement Estimated by Balance Study in Elderly Japanese People

H. Orimo, H. Ishida, K. Uenishi, 2001, Osteoporosis International.

Randomized trial comparing low-dose hormone replacement therapy and HRT plus 1α-OH-vitamin D3 (alfacalcidol) for treatment of postmenopausal bone loss

Kunihiko Hayashi, O. Ishihara, T. Kurabayashi, 2005, Journal of Bone and Mineral Metabolism.

Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels

Toshio Matsumoto, M. Shiraki, H. Saito, 2012, Current Medical Research and Opinion.

Response to the Editor

K. Uenishi, M. Shiraki, H. Ohta, 2017, Osteoporosis and sarcopenia.

Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin.

M. Shiraki, N. Tsugawa, M. Kamao, 2006, The American journal of clinical nutrition.

Effect of disuse on bone mineral content, lean mass, and fat mass in osteoarthritic patients

M. Shiraki, O. Karakida, G. Seo, 1996, Journal of Bone and Mineral Metabolism.

Bone metabolic marker levels in residents of a rural community in Japan

T. Kasamatsu, T. Hashimoto, N. Yoshimura, 1996, Journal of Bone and Mineral Metabolism.

Renal Phosphate Reabsorption is Correlated with the Increase in Lumbar Bone Mineral Density in Patients Receiving Once-Weekly Teriparatide

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2015, Calcified Tissue International.

Association of a single nucleotide polymorphism in the secreted frizzled‐related protein 4 (sFRP4) gene with bone mineral density

Y. Ouchi, S. Inoue, O. Tsutsumi, 2004 .

Improved periodontal disease and prevention of tooth loss in osteoporosis patients receiving once-yearly zoledronic acid: a randomized clinical trial.

A. Taguchi, Toshitaka Nakamura, M. Shiraki, 2019, Menopause.

Association of a Trp16Ser variation in the gonadotropin releasing hormone signal peptide with bone mineral density, revealed by SNP-dependent PCR typing.

S. Inoue, M. Emi, Y. Ezura, 2003, Bone.

Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture.

M. Fukunaga, E. Itoi, Y. Ohashi, 2014, Clinical therapeutics.

Parathyroid hormone stimulates phosphate efflux through an apparently adenosine 3',5'-monophosphate-independent process in rat parotid cell aggregates.

G. Roth, B. Baum, M. Shiraki, 1986, Endocrinology.

An organism resembling Hemophilus ducreyi; a species found at a high rate in genitals of prostitutes in Sasebo area.

M. Shiraki, H. Harada, Y. Aoki, 1952, Yokohama medical bulletin.

Association of Bone Mineral Density with a Polymorphism of the Peroxisome Proliferator-Activated Receptor γ Gene: PPARγ Expression in Osteoblasts

Y. Ouchi, S. Inoue, H. Orimo, 1999 .

Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.

Y. Ouchi, S. Inoue, S. Hedges, 2001, Nutrition.

Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: A double-blind placebo-controlled study

T. Fujita, H. Orimo, A. Tomita, 1998, Journal of Bone and Mineral Metabolism.

Multiple vitamin deficiencies additively increase the risk of incident fractures in Japanese postmenopausal women

K. Uenishi, M. Shiraki, H. Ohta, 2018, Osteoporosis International.

Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women

M. Shiraki, N. Tsugawa, R. Ozaki, 2008, Journal of Bone and Mineral Metabolism.

A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women.

Y. Ouchi, S. Inoue, M. Shiraki, 2009, Endocrine journal.

Menopausal flushes and calcitonin-gene-related peptide

Y. Hirai, M. Shiraki, K. Hasumi, 1993, The Lancet.

Menopausal hot flash and calciotonin gene-related peptide; effect of Keishi-bukuryo-gan, a kampo medicine, related to plasma calciotonin gene-related peptide level.

M. Shiraki, Jui‐Tung Chen, 2003, Maturitas.

Basal tail skin temperature elevation and augmented response to calcitonin gene-related peptide in ovariectomized rats.

M. Shiraki, T. Ohta, T. Kobayashi, 1995, The Journal of endocrinology.

Diagnostic criteria for primary osteoporosis: year 2012 revision

T. Tomomitsu, T. Sone, M. Fukunaga, 2013, Journal of Bone and Mineral Metabolism.

Diagnostic criteria for primary osteoporosis: year 2000 revision

Hajime Orimo, Masao Fukunaga, Teruki Sone, 2001, Journal of Bone and Mineral Metabolism.

Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women

Kozo Nakamura, K. Takeshita, H. Kawaguchi, 2006, European Spine Journal.

A randomized, double-blind, placebo-controlled study of once weekly elcatonin in primary postmenopausal osteoporosis

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2018, Current medical research and opinion.

GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density.

Makoto Sato, Y. Ouchi, S. Inoue, 2012, The Journal of clinical endocrinology and metabolism.

GPR 98 / Gpr 98 Gene Is Involved in the Regulation of Human and Mouse Bone Mineral Density

Makoto Sato, Y. Ouchi, S. Inoue, 2012 .

Common Variants in a Novel Gene, FONG on Chromosome 2q33.1 Confer Risk of Osteoporosis in Japanese

Yusuke Nakamura, Toshihiro Tanaka, S. Inoue, 2011, PloS one.

Identification of non-synonymous polymorphisms in the WDSOF1 gene as novel susceptibility markers for low bone mineral density in Japanese postmenopausal women.

Y. Ouchi, S. Inoue, M. Shiraki, 2010, Bone.

Estrogen receptor gene polymorphism and bone mineral density at the lumbar spine of pre- and postmenopausal women.

Y. Ouchi, S. Inoue, H. Mizunuma, 1997, Bone.

Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5′-flanking region of PRDM16 gene associated with lean body mass

Y. Ouchi, S. Inoue, M. Shiraki, 2014, Aging cell.

Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers

M. Saito, Yukio Nakamura, M. Shiraki, 2020, Scientific Reports.

Polymorphism of Insulin-like Growth Factor I Gene and Bone Mineral Density

Y. Ouchi, S. Inoue, H. Orimo, 1998, Calcified Tissue International.

Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary

Naoto Endo, Hajime Orimo, Takao Suzuki, 2012, Archives of Osteoporosis.

Plasma Level of Homocysteine Associated with Severe Vertebral Fracture in Postmenopausal Women

Shiro Tanaka, M. Saito, M. Shiraki, 2013, Calcified Tissue International.

Nitric oxide is associated with fracture risk in Japanese women

M. Saito, Yukio Nakamura, M. Shiraki, 2023, PloS one.

Urinary pentosidine improves risk classification using fracture risk assessment tools for postmenopausal women

Shiro Tanaka, M. Saito, M. Shiraki, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis patients under bisphosphonate treatment

Shiro Tanaka, M. Saito, M. Shiraki, 2010, Journal of Bone and Mineral Metabolism.

Effects of bone mineral density of the lumbar spine and prevalent vertebral fractures on the risk of immobility

M. Shiraki, S. Tanaka, T. Kuroda, 2010, Osteoporosis International.

Contributions of 25-hydroxyvitamin D, co-morbidities and bone mass to mortality in Japanese postmenopausal women.

Shiro Tanaka, M. Shiraki, H. Ohta, 2009, Bone.

Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures

M. Fukunaga, Toshitaka Nakamura, Shiro Tanaka, 2008, Journal of Bone and Mineral Metabolism.

Overweight/obesity and underweight are both risk factors for osteoporotic fractures at different sites in Japanese postmenopausal women

M. Saito, M. Shiraki, S. Tanaka, 2013, Osteoporosis International.

Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk.

T. Sone, M. Fukunaga, H. Yoshikawa, 2012, The Journal of clinical endocrinology and metabolism.

Clinical Trials Express: Fracture Risk Reduction With Denosumab in Japanese Postmenopausal Women and Men With Osteoporosis: Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

Sakae Tanaka, T. Sone, M. Fukunaga, 2014, The Journal of clinical endocrinology and metabolism.

Association of circulating sclerostin levels with fat mass and metabolic disease--related markers in Japanese postmenopausal women.

Y. Ouchi, S. Inoue, M. Shiraki, 2012, The Journal of clinical endocrinology and metabolism.

Vitamin K Nutrition and Bone Health

M. Shiraki, N. Tsugawa, 2020, Nutrients.

Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women

Y. Ouchi, S. Inoue, Toshitaka Nakamura, 2011, European Spine Journal.

Development and Evaluation of Novel ELISA for Determination of Urinary Pentosidine.

Rei-ichi Ohno, R. Nagai, M. Shiraki, 2019, Journal of nutritional science and vitaminology.

Effects of phosphorus-containing calcium preparation (bone meal powder) and calcium carbonate on serum calcium and phosphorus in young and old healthy volunteers: a double-blinded crossover study

M. Shiraki, M. Tsuboi, H. Shimodaira, 2000, Journal of Bone and Mineral Metabolism.

The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

Shiro Tanaka, M. Saito, M. Shiraki, 2019, Journal of Bone and Mineral Metabolism.

Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women

Shiro Tanaka, N. Yoshimura, M. Shiraki, 2014, Journal of Bone and Mineral Metabolism.

Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro

M. Shiraki, Y. Akiyama, T. Tajima, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure

Satoshi Inoue, Y. Ouchi, S. Inoue, 2000, Journal of Human Genetics.

Association of Estrogen Receptor β Gene Polymorphism with Bone Mineral Density

Y. Ouchi, S. Inoue, M. Emi, 2000 .

Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women

M. Saito, M. Shiraki, R. Okazaki, 2018, Osteoporosis International.

Saccharated Ferric Oxide-Induced Osteomalacia in Iron-Induced Osteopathy Due to Nephropathy Japan :

M. Shiraki, 2006 .

Two adipocytokines, leptin and adiponectin, independently predict osteoporotic fracture risk at different bone sites in postmenopausal women.

H. Kato, Yukio Nakamura, M. Shiraki, 2020, Bone.

Effects of alendronate plus alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis Intervention Trial (JOINT) – 02

M. Fukunaga, Y. Ohashi, Toshitaka Nakamura, 2011, Current medical research and opinion.

Association of Bone Mineral Density with Apolipoprotein E Phenotype

Y. Ouchi, S. Inoue, M. Kaneki, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Influence of symptomatic periodontal disease on changes in skeletal bone density during medication therapy for osteoporosis in postmenopausal women: the Japanese Osteoporosis Intervention Trial (JOINT)-04 and JOINT-05

A. Taguchi, Toshitaka Nakamura, Shiro Tanaka, 2021, Archives of Osteoporosis.

Distinct dietary risk factors for incident osteoporotic fractures in early and late postmenopausal phase women

Yukio Nakamura, K. Uenishi, M. Shiraki, 2023, Journal of Bone and Mineral Metabolism.

Sandwich immunoassay for intact human osteocalcin.

M. Shiraki, K. Hosoda, H. Eguchi, 1992, Clinical chemistry.

Bisphosphonates prevent age-related weight loss in Japanese postmenopausal women

S. Inoue, F. Urano, Shiro Tanaka, 2018, Journal of Bone and Mineral Metabolism.

Associations of homocysteine metabolism with the risk of spinal osteoarthritis progression in postmenopausal women.

Yukio Nakamura, M. Shiraki, T. Urano, 2021, The Journal of clinical endocrinology and metabolism.

A multicenter randomized double-masked comparative study of different preparations of alendronate in osteoporosis – monthly (four weeks) intravenous versus once weekly oral administrations

T. Sone, M. Fukunaga, M. Shiraki, 2012, Current medical research and opinion.

A Double-Masked Multicenter Comparative Study Between Alendronate and Alfacalcidol in Japanese Patients with Osteoporosis

K. Kaneda, M. Fukunaga, H. Orimo, 1999, Osteoporosis International.

The Long‐Term Effect of Menopause on Postmenopausal Bone Loss in Japanese Women: Results from a Prospective Study

Takao Suzuki, M. Shiraki, Y. Ibuki, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Assessment of bone density in the distal radius with computer assisted X-ray densitometry (CXD).

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Health state utility values and patient-reported outcomes before and after vertebral and non-vertebral fractures in an osteoporosis clinical trial

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Relationship Between Changes in Serum Levels of Intact Parathyroid Hormone and Sclerostin After a Single Dose of Zoledronic Acid: Results of a Phase 1 Pharmacokinetic Study

Toshitaka Nakamura, T. Sugimoto, M. Shiraki, 2021, Calcified tissue international.

The Interaction of Acute‐Phase Reaction and Efficacy for Osteoporosis After Zoledronic Acid: HORIZON Pivotal Fracture Trial

J. Cauley, I. Reid, Toshitaka Nakamura, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Impact of bone mineral density in reducing fracture risk in patients receiving alendronate plus alfacalcidol therapy.

M. Fukunaga, E. Itoi, Toshitaka Nakamura, 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

Efficacy of denosumab co-administered with vitamin D and Ca by baseline vitamin D status

Toshitaka Nakamura, Makiko Kobayashi, Toshio Matsumoto, 2020, Journal of Bone and Mineral Metabolism.

Number and severity of prevalent vertebral fractures and the risk of subsequent vertebral fractures in Japanese women with osteoporosis: results from the minodronate trial

M. Fukunaga, Y. Ohashi, K. Takaoka, 2013, Journal of Bone and Mineral Metabolism.

The importance of absolute bone mineral density in the assessment of antiresorptive agents used for the prevention of osteoporotic fractures.

Shiro Tanaka, M. Shiraki, T. Kuroda, 2012, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

Three years of treatment with minodronate in patients with postmenopausal osteoporosis

M. Fukunaga, Y. Ohashi, K. Takaoka, 2011, Journal of Bone and Mineral Metabolism.

Design of a pragmatic approach to evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures

M. Fukunaga, E. Itoi, Y. Ohashi, 2011, Journal of Bone and Mineral Metabolism.

High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment

M. Shiraki, T. Hosoi, N. Tsugawa, 2010, Journal of Bone and Mineral Metabolism.

Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporosis: a randomized prospective study

A. Itabashi, M. Shiraki, 2009, Journal of Bone and Mineral Metabolism.

Therapeutic effects of alendronate 35 mg once weekly and 5 mg once daily in Japanese patients with osteoporosis: a double-blind, randomized study

T. Tomomitsu, M. Fukunaga, Y. Ohashi, 2005, Journal of Bone and Mineral Metabolism.

Absolute height reduction and percent height ratio of the vertebral body in incident fracture in Japanese women

M. Fukunaga, Toshitaka Nakamura, H. Orimo, 2003, Journal of Bone and Mineral Metabolism.

The Fracture and Immobilization Score (FRISC) for risk assessment of osteoporotic fracture and immobilization in postmenopausal women--A joint analysis of the Nagano, Miyama, and Taiji Cohorts.

Shiro Tanaka, M. Saito, N. Yoshimura, 2010, Bone.

Study of twice-weekly injections of Teriparatide by comparing efficacy with once-weekly injections in osteoporosis patients: the TWICE study

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A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2011, Bone.

Title Efficacy and safety of monthly oral minodronate in patients withinvolutional osteoporosis

M. Ito, T. Sone, M. Fukunaga, 2017 .

Efficacy and safety of monthly oral minodronate in patients with involutional osteoporosis

M. Ito, T. Sone, M. Fukunaga, 2011, Osteoporosis International.

Estrogen and bone

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Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women.

S. Inoue, M. Emi, Y. Ezura, 2003, Bone.

Association of a Haplotype (196Phe/532Ser) in the Interleukin‐1‐Receptor‐Associated Kinase (IRAK1) Gene With Low Radial Bone Mineral Density in Two Independent Populations

S. Inoue, M. Emi, Y. Ezura, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Guidelines on the use of biochemical markers of bone turnover in osteoporosis (2001)

M. Fukunaga, Toshitaka Nakamura, K. Kushida, 2001, Journal of Bone and Mineral Metabolism.

Dose effects of oral estradiol on bone mineral density in Japanese women with osteoporosis

Y. Taketani, H. Mizunuma, A. Itabashi, 2010, Climacteric : the journal of the International Menopause Society.

Vertebral fracture risk after once-weekly teriparatide injections: follow-up study of Teriparatide Once-Weekly Efficacy Research (TOWER) trial

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2013, Current medical research and opinion.

Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study

M. Fukunaga, Y. Ohashi, K. Takaoka, 2008, Osteoporosis International.

Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Bone Mineral Density in Postmenopausal Japanese Women

Y. Ouchi, S. Inoue, Y. Yazaki, 2000, Calcified Tissue International.

Effect of Bone Resorption Inhibitors on Serum Cholesterol Level and Fracture Risk in Osteoporosis: Randomized Comparative Study Between Minodronic Acid and Raloxifene

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2023, Calcified Tissue International.

Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

Sakae Tanaka, M. Ito, T. Sone, 2015, Osteoporosis International.

Efficacy and safety of once-yearly zoledronic acid in Japanese patients with primary osteoporosis: two-year results from a randomized placebo-controlled double-blind study (ZOledroNate treatment in Efficacy to osteoporosis; ZONE study)

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Eldecalcitol reduces the risk of severe vertebral fractures and improves the health-related quality of life in patients with osteoporosis

M. Fukunaga, Toshitaka Nakamura, Toshio Matsumoto, 2012, Journal of Bone and Mineral Metabolism.

Bone mass effects of a Smad6 gene polymorphism in Japanese postmenopausal women

Y. Ouchi, S. Inoue, M. Shiraki, 2009, Journal of Bone and Mineral Metabolism.

The effect of once-yearly zoledronic acid on hip structural and biomechanical properties derived using computed tomography (CT) in Japanese women with osteoporosis.

T. Sone, Toshitaka Nakamura, Masako Ito, 2018, Bone.

Safety, pharmacokinetics, and changes in bone metabolism associated with zoledronic acid treatment in Japanese patients with primary osteoporosis

Toshitaka Nakamura, M. Shiraki, Hiroaki Suzuki, 2017, Journal of Bone and Mineral Metabolism.

Association of Molecular Variants, Haplotypes, and Linkage Disequilibrium Within the Human Vitamin D‐Binding Protein (DBP) Gene With Postmenopausal Bone Mineral Density

S. Inoue, T. Nakajima, M. Emi, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pharmacokinetics of eldecalcitol in primary osteoporosis patients - Randomized, double-blind, multicentre, long-term phase III clinical study

Toshitaka Nakamura, Y. Tanigawara, Toshio Matsumoto, 2011 .

Acute Phase Reactions After Intravenous Infusion of Zoledronic Acid in Japanese Patients with Osteoporosis: Sub-analyses of the Phase III ZONE Study

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2021, Calcified Tissue International.

Established osteoporosis associated with high mortality after adjustment for age and co-mobidities in postmenopausal Japanese women.

Shiro Tanaka, M. Shiraki, T. Kuroda, 2011, Internal medicine.

Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis

Toshitaka Nakamura, Toshio Matsumoto, S. Matsui, 2020, Calcified Tissue International.

Changes in bone mineral density, bone turnover markers, and vertebral fracture risk reduction with once weekly teriparatide

Toshitaka Nakamura, Shiro Tanaka, T. Sugimoto, 2014, Current medical research and opinion.

Human Parathyroid Hormone Radioimmunoassay : Properties of Antiserum Against Synthetic 1-34 Human Parathyroid Hormone and Its Clinical Application

H. Orimo, M. Shiraki, H. Yamauchi, 2010 .

Association of pentosidine and homocysteine levels with number of teeth present in Japanese postmenopausal women

A. Taguchi, M. Shiraki, M. Saito, 2022, Journal of Bone and Mineral Metabolism.

Spinal Osteoarthritis is Associated with Stature Loss Independently of Incident Vertebral Fracture in Postmenopausal Women.

Yukio Nakamura, M. Shiraki, J. Takahashi, 2020, Spine.

Hypercalcemia due to spontaneous hemorrhage in a parathyroid adenoma during recovery from acute renal failure.

M. Shiraki, H. Ito, S. Ohkawa, 1986, Japanese journal of medicine.

Dose–response study of denosumab on bone mineral density and bone turnover markers in Japanese postmenopausal women with osteoporosis

Toshitaka Nakamura, T. Sugimoto, M. Shiraki, 2012, Osteoporosis International.

Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics

M. Matsuo, Hideki Ito, M. Shiraki, 2006, Lipids.

Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women.

M. Kuro-o, H. Kawaguchi, K. Nakamura, 2002, Bone.

Treatment responses with once-weekly teriparatide therapy for osteoporosis

T. Sugimoto, M. Shiraki, T. Nakamura, 2016, Osteoporosis International.

Association of Multiple Nucleotide Variations in the Pituitary Glutaminyl Cyclase Gene (QPCT) With Low Radial BMD in Adult Women

S. Inoue, M. Emi, Y. Ezura, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Impact of Osteonecrosis of the Jaw on Osteoporosis Treatment in Japan: Results of a Questionnaire-Based Survey by the Adequate Treatment of Osteoporosis (A-TOP) Research Group

A. Taguchi, Toshitaka Nakamura, H. Orimo, 2015, Calcified Tissue International.

Breast arterial calcification and hypertension associated with vertebral fracture

Hiroshi Wada, M. Shiraki, Fuminori Hirano, 2012, Geriatrics & gerontology international.

[Calcitonin physiologically regulates the postmenopausal bone loss and possibly inhibits the bone loss in fast losers].

Y. Hirai, M. Shiraki, K. Katase, 1994, Nihon Sanka Fujinka Gakkai zasshi.

Comparison of expert and nonexpert physicians in the assessment of vertebral fractures using the semiquantitative method in Japan

Toshitaka Nakamura, H. Orimo, M. Shiraki, 2015, Journal of Bone and Mineral Metabolism.

Alendronate reduced vertebral fracture risk in postmenopausal Japanese women with osteoporosis: a 3-year follow-up study

K. Kaneda, M. Fukunaga, Toshitaka Nakamura, 2004, Journal of Bone and Mineral Metabolism.

Efficacy of odanacatib in postmenopausal women with osteoporosis: subgroup analyses of data from the phase 3 long-term odanacatib fracture trial (LOFT)

P. Alexandersen, C. Benhamou, K. Saag, 2016 .

Association of a single‐nucleotide polymorphism in the promoter region of leukemia inhibitory factor receptor gene with low bone mineral density in adult women

S. Inoue, M. Emi, Y. Ezura, 2004 .

Association of tumor necrosis factor receptor 1 gene polymorphism with bone mineral density

Y. Ouchi, S. Inoue, H. Orimo, 2003 .

Implications of historical height loss for prevalent vertebral fracture, spinal osteoarthritis, and gastroesophageal reflux disease

Yukio Nakamura, M. Shiraki, J. Takahashi, 2020, Scientific Reports.

Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPARgamma expression in osteoblasts.

Y. Ouchi, S. Inoue, H. Orimo, 1999, Biochemical and biophysical research communications.

Guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004)

Masao Fukunaga, Hiroaki Ohta, M. Fukunaga, 2004, Journal of Bone and Mineral Metabolism.

Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX

J. Kanis, E. McCloskey, H. Johansson, 2015, Osteoporosis International.

Treatment effects of bisphosphonates on ovariectomy-induced osteopenia in rats: Comparison between clodronate and etidronate

M. Shiraki, F. Itoh, M. Kojima, 1999, Journal of Bone and Mineral Metabolism.

Effects of 2 years' treatment of osteoporosis with 1 alpha-hydroxy vitamin D3 on bone mineral density and incidence of fracture: a placebo-controlled, double-blind prospective study.

H. Orimo, K. Kushida, K. Yamazaki, 1996, Endocrine journal.

Some problems of dual-energy x-ray absorptiometry in the clinical use

K. Kaneda, M. Fukunaga, H. Orimo, 2005, Osteoporosis International.

Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women

S. Inoue, M. Emi, Y. Ezura, 2005, Journal of Human Genetics.

Dose effects of oral estradiol on bone mineral density in Japanese women with osteoporosis

Y. Taketani, H. Mizunuma, A. Itabashi, 2010, Climacteric : the journal of the International Menopause Society.

Association of a Sequence Variation in the Gene Encoding Adiponectin Receptor 1 (ADIPOR1) with Body Mass Index in the Japanese Population

Y. Ouchi, S. Inoue, M. Shiraki, 2009 .

The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

Shiro Tanaka, M. Saito, M. Shiraki, 2019, Journal of Bone and Mineral Metabolism.

24-Month Open-Label Teriparatide Once-Weekly Efficacy Research Trial Examining Bone Mineral Density in Subjects with Primary Osteoporosis and High Fracture Risk

T. Sone, M. Fukunaga, H. Yoshikawa, 2017, Advances in Therapy.

The Relationship Between Back Pain and Future Vertebral Fracture in Postmenopausal Women

Toshitaka Nakamura, Shiro Tanaka, M. Shiraki, 2009, Spine.