A. Wise

发表

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*

S. Dowell, F. Marshall, M. Wigglesworth, 2003, The Journal of Biological Chemistry.

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Melanie G. Lee, S. Foord, Jason Brown, 1998, Nature.

Heterodimerization is required for the formation of a functional GABAB receptor

Alan Wise, Martin J. Main, Steven M. Foord, 1998, Nature.

Gabapentin is not a GABAB receptor agonist

M. Pangalos, M. Wood, Jon T. Brown, 2001, Neuropharmacology.

Characterization of [3H]‐CGP54626A binding to heterodimeric GABAB receptors stably expressed in mammalian cells

F. Marshall, S. Walls, A. Wise, 2000, British journal of pharmacology.

The identification of ligands at orphan G-protein coupled receptors.

Alan Wise, S. Rees, S. Jupe, 2004, Annual review of pharmacology and toxicology.

Calcium sensing properties of the GABAB receptor

F. Marshall, N. Fraser, A. Wise, 1999, Neuropharmacology.

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

Stefan Offermanns, Adriaan P. IJzerman, Alan Wise, 2011, Pharmacological Reviews.

Hydroxycarboxylic acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

T. Lovenberg, A. IJzerman, S. Offermanns, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.

M. Pangalos, G. W. Price, S. Rice, 2003, Biochemical pharmacology.

Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.

S. Rees, G. Milligan, F. Fanelli, 1998, Biochemistry.

Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist for Gi1,Gi2, and Gi3

S. Rees, J. R. Lane, G. Milligan, 2007, Molecular Pharmacology.

Pharmacology of GPR 55 in Yeast and Identification of GSK 494581 A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR 55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011 .

Ectopically expressed gamma-aminobutyric acid receptor B is functionally down-regulated in isolated lipid raft-enriched membranes.

Julia H. M. White, A. Wise, A. Green, 2004, Biochemical and biophysical research communications.

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

I. Chessell, J. Richardson, M. Fulleylove, 2008, PAIN.

Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles: Differential Role in Vasoconstriction

G. Nixon, A. Wise, R. H. Scott, 2002, Circulation research.

Functional analysis of a human A1 adenosine receptor/green fluorescent protein/Gi1α fusion protein following stable expression in CHO cells

S. Rees, T. Palmer, G. Milligan, 1999, FEBS letters.

The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.

G. Milligan, A. Magee, M. Parenti, 1995, The Biochemical journal.

Measurement of agonist efficacy using an α2A‐adrenoceptor‐Gi1α fusion protein

G. Milligan, A. Wise, I. C. Carr, 1997 .

Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein.

G. Milligan, A. Wise, I. C. Carr, 1997, FEBS letters.

GW627368X ((N‐{2‐[4‐(4,9‐diethoxy‐1‐oxo‐1,3‐dihydro‐2H‐benzo[f]isoindol‐2‐yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist

T. Kenakin, D. W. Gray, A. Wise, 2006, British journal of pharmacology.

Identification of a nicotinic acid receptor: is this the molecular target for the oldest lipid-lowering drug?

N. Pike, A. Wise, 2004, Current opinion in investigational drugs.

The rabbit motilin receptor: molecular characterisation and pharmacology

A. Muir, A. Wise, G. Sanger, 2003, British journal of pharmacology.

A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.

S. Rees, G. Milligan, M. Parenti, 1997, Biochemistry.

Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants.

S. Rees, G. Milligan, A. Wise, 1997, The Biochemical journal.

Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity GlyT1 inhibitor and GPR55 agonist.

D. Daniels, Andrew J. Brown, A. Wise, 2010 .

Expression of the Arabidopsis G-protein GPα1: purification and characterisation of the recombinant protein

P. Millner, P. Thomas, T. Carr, 1997, Plant Molecular Biology.

GTP-Binding Proteins in Higher Plant Cells

P. Finan, P. Millner, J. Clarkson, 1992 .

Quantitative analysis of a cysteine351glycine mutation in the G protein Gi1α: effect on α2A‐adrenoceptor‐Gi1α fusion protein activation

S. Rees, G. Milligan, V. Jackson, 1998 .

Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1alpha when constrained within an alpha2A-adrenoceptor-Gi1alpha fusion protein.

G. Milligan, A. Wise, I. C. Carr, 1997, The Biochemical journal.

Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid*

S. Dowell, F. Marshall, P. Murdock, 2003, The Journal of Biological Chemistry.

G-protein palmitoylation: regulation and functional significance.

G. Milligan, D. MacEwan, A. Magee, 1995, Biochemical Society transactions.

Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells.

J. González-Maeso, A. Wise, A. Green, 2003, European journal of pharmacology.

Structure‐function studies of the C3a‐receptor: C‐terminal serine and threonine residues which influence receptor internalization and signaling

R. Ames, J. Köhl, A. Klos, 2003, European journal of immunology.

Degradation of G/G Is Accelerated by Agonist Occupancy of , , and Adrenergic Receptors (*)

G. Milligan, D. MacEwan, A. Wise, 1995, The Journal of Biological Chemistry.

Binding of zinc and calcium to inositol phosphates (phytate) in vitro

A. Wise, C. Simpson, 1990, British Journal of Nutrition.

Interaction of inositol phosphates with calcium, zinc, and histidine

A. Wise, P. Aggett, J. Price, 1992 .

Orphan seven transmembrane receptor screening.

M. Wigglesworth, A. Wise, A Wise, 2006, Ernst Schering Foundation symposium proceedings.

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

Jackie S. Scott, Alan Wise, A. Muir, 2007, Bioorganic & medicinal chemistry letters.

Antibodies that identify only the active conformation of Gi family G protein α subunits

S. Rees, J. R. Lane, G. Milligan, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors

Graeme Milligan, Alan Wise, S. Rees, 2008, Journal of Pharmacology and Experimental Therapeutics.

Target validation of G-protein coupled receptors.

Alan Wise, S. Rees, A. Wise, 2002, Drug discovery today.

Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment

C. Ward, A. Turnbull, S. Langdon, 2018, BMC Cancer.

The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.

F. Ciruela, P. Emson, F. Marshall, 2000, Proceedings of the National Academy of Sciences of the United States of America.

GABA(B) receptors function as heterodimers.

F. Marshall, J. White, A. Wise, 1999, Biochemical Society transactions.

Presence of rhodopsin-like proteins in Sorghum bicolor and Pisum sativum.

P. Millner, J. Findlay, C. Ricart, 2000 .

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

C. Ward, A. Turnbull, S. Langdon, 2015, Oncotarget.

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.

S. Rees, G. Milligan, A. Wise, 1998, The Journal of biological chemistry.

Rescue of Functional Interactions between the α2A-Adrenoreceptor and Acylation-resistant Forms of Gi1α by Expressing the Proteins from Chimeric Open Reading Frames*

G. Milligan, A. Wise, 1997, The Journal of Biological Chemistry.

Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011, Journal of Pharmacology and Experimental Therapeutics.

Calcium Regulatory Endomembranes of the Prophase Mitotic Apparatus of Sand Dollar Cells Contain Enzyme Activities That Produce Leukotriene B4 but Not 1,4,5-Inositol Trisphosphate.

R. Silver, A. Wise, L. King, 1998, The Biological Bulletin.

The industrialisation of cellular screening

Stephen Rees, Alan Wise, S. Rees, 2008, Expert opinion on drug discovery.

Paradoxical Behavior of Neuromedin U in Isolated Smooth Muscle Cells and Intact Tissue

A. Wise, G. Willars, N. Dass, 2008, Journal of Pharmacology and Experimental Therapeutics.

Signaling and Ligand Binding by Recombinant Neuromedin U Receptors: Evidence for Dual Coupling to Gαq/11 and Gαi and an Irreversible Ligand-Receptor Interaction

P. Szekeres, A. Wise, G. Willars, 2004, Molecular Pharmacology.

The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.

S. Foord, N. Fraser, A. Wise, 1999, Molecular pharmacology.

Interaction of the G‐protein G11α with receptors and phosphoinositidase C:

G. Milligan, M. Parenti, A. Wise, 1997 .

GABA(B) receptor heterodimer-component localisation in human brain.

P. Emson, R. Faull, F. Marshall, 2000, Brain research. Molecular brain research.

Comparative Analysis of the Efficacy of A1 Adenosine Receptor Activation of Gi/oα G Proteins following Coexpression of Receptor and G Protein and Expression of A1 Adenosine Receptor−Gi/oα Fusion Proteins†

S. Rees, G. Milligan, Melanie G. Lee, 1999 .

Kinetics of Ternary Complex Formation with Fusion Proteins Composed of the A1-Adenosine Receptor and G Protein α-Subunits*

G. Milligan, M. Freissmuth, C. Nanoff, 1999, The Journal of Biological Chemistry.

Hydroxycarboxylic acid receptors in GtoPdb v.2023.1

T. Lovenberg, A. IJzerman, S. Offermanns, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

The N-terminus of RAMPs is a critical determinant of the glycosylation state and ligand binding of calcitonin receptor-like receptor.

S. Foord, N. Fraser, A. Wise, 1999, Biochemical Society transactions.

Identification of small molecule agonists of the motilin receptor.

Alan Wise, G. Macdonald, A. Muir, 2008, Bioorganic & medicinal chemistry letters.

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gαo1 by the Ghrelin Receptor

C. Langmead, G. Milligan, A. Wise, 2009, Molecular Pharmacology.

Heterodimerization of γ-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system

F. Marshall, Julia H. M. White, A. Wise, 2002 .

Isolation of a putative receptor from Zea mays microsomal membranes that interacts with the G‐protein, GPα1

P. Millner, P. Thomas, A. Wise, 1994, FEBS letters.

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

C. Ward, A. Turnbull, S. Langdon, 2015 .

Stimulation of guanosine 5'-O-(3-thio)triphosphate binding to higher plant plasma membranes by the mastoparan-analogue, Mas 7.

P. Millner, A. Wise, I. White, 1993, Biochemical Society transactions.

Expression of the Human β2‐Adrenoceptor in NCB20 Cells Results in Agonist Activation of Adenylyl Cyclase and Agonist‐Mediated Selective Down‐Regulation of Gsα

B. H. Shah, G. Milligan, A. Wise, 1995 .

Evidence for G-protein-linked receptors in higher plants: stimulation of GTP-gamma-S binding to membrane fractions by the mastoparan analogue mas 7

P. Millner, A. Wise, I. White, 1993, Planta.

The industrialisation of cellular screening

S. Rees, A. Wise, 2008, Expert opinion on drug discovery.

Palmitoylation negative mutants of murine G11 alpha have decreased ability to interact with the plasma membrane when expressed in COS-1 cells.

G. Milligan, M. Parenti, A. Wise, 1995, Biochemical Society transactions.

Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins.

S. Rees, G. Milligan, A. Wise, 1999, Biochemistry.

Degradation of G11 alpha/Gq alpha is accelerated by agonist occupancy of alpha 1A/D, alpha 1B, and alpha 1C adrenergic receptors.

G. Milligan, D. MacEwan, A. Wise, 1995, The Journal of biological chemistry.