I. Schulman

发表

Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

Xiaohui S. Xie, E. Lander, D. Altshuler, 2004 .

Liver X receptors link lipid metabolism and inflammation

I. Schulman, 2017, FEBS letters.

Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.

I. Schulman, I. Ignatova, J. Angdisen, 2013, Molecular endocrinology.

Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice—Brief Report

R. Polanowska-Grabowska, N. Leitinger, K. Marqueen, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists.

I. Schulman, T. Burris, Thomas Koelblen, 2022, ACS chemical biology.

The phantom ligand effect: allosteric control of transcription by the retinoid X receptor.

R. Evans, R. Evans, J. Schwabe, 1997, Genes & development.

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

S. Kliewer, D. Mangelsdorf, M. Fu, 2012, The Journal of clinical investigation.

Activation of murine pre-proglucagon–producing neurons reduces food intake and body weight

R. Gaykema, T. Harris, K. Williams, 2017, The Journal of clinical investigation.

Three amino acids specify coactivator choice by retinoid X receptors.

R. Heyman, I. Schulman, G. Shao, 2000, Molecular endocrinology.

LXR as a therapeutic target for atherosclerosis

R. Heyman, I. Schulman, 2003 .

Macrophage Liver X Receptor Is Required for Antiatherogenic Activity of LXR Agonists

C. Daige, R. Tangirala, R. Heyman, 2004, Arteriosclerosis, thrombosis, and vascular biology.

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery.

Jae K. Lee, D. Theodorescu, Feng Cheng, 2011, Journal of theoretical biology.

Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice.

Andrew C. Li, C. Daige, I. Schulman, 2010, Journal of lipid research.

Cholesterol worships a new idol.

I. Schulman, 2009, Journal of molecular cell biology.

Research Highlight Cholesterol Worships a New Idol

I. Schulman, 2009 .

Three amino acids specify coactivator choice by retinoid X receptors.

R. Heyman, I. Schulman, G. Shao, 2000, Molecular endocrinology.

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).

Stefan Westin, Brett R. Murphy, C. Daige, 2009, Journal of medicinal chemistry.

Nuclear receptors as drug targets for metabolic disease.

I. Schulman, 2010, Advanced drug delivery reviews.

Phenotypic polarization of macrophages in atherosclerosis.

N. Leitinger, I. Schulman, 2013, Arteriosclerosis, thrombosis, and vascular biology.

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

S. Sauer, J. Deleuze, L. Nagy, 2018, Immunity.

Role of CBP/P300 in nuclear receptor signalling

M. Montminy, D. Chakravarti, T. Nakajima, 1996, Nature.

RXR-Specific Agonists and Modulators: A New Retinoid Pharmacology

R. Heyman, I. Schulman, G. Shao, 1999 .

Transactivation by Retinoid X Receptor–Peroxisome Proliferator-Activated Receptor γ (PPARγ) Heterodimers: Intermolecular Synergy Requires Only the PPARγ Hormone-Dependent Activation Function

R. Heyman, I. Schulman, G. Shao, 1998, Molecular and Cellular Biology.

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Xiaohui Xie, Nick Patterson, Christoph Handschin, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of metabolism by nuclear hormone receptors.

I. Schulman, Huey-Jing Huang, 2009, Progress in molecular biology and translational science.

Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand

Ping Wei, P. Wei, W. Stevens, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.

R. Evans, D. Chakravarti, I. Schulman, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

T. Osborne, S. Turner, I. Schulman, 2019, Molecular and Cellular Biology.

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

R. S. Kiss, K. Ravichandran, I. Schulman, 2015, The Journal of clinical investigation.

Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions

I. Schulman, G. Shao, H. Seidel, 2001, Molecular and Cellular Biology.

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

Aldons J. Lusis, Peter Tontonoz, D. Mangelsdorf, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Liver X receptors and liver physiology.

I. Schulman, Lillian Russo-Savage, 2021, Biochimica et biophysica acta. Molecular basis of disease.

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

L. Dardashti, R. Evans, R. Heyman, 1996, Nature.

Discovery of Highly Potent Liver X Receptor β Agonists

A. D. Rodrigues, P. Sleph, T. Kirchgessner, 2016, ACS medicinal chemistry letters.

Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states

R. Evans, I. Schulman, H. Juguilon, 1996, Molecular and cellular biology.

Regulation of Complement C3 Expression by the Bile Acid Receptor FXR*

I. Schulman, S. Westin, Jiali Li, 2005, Journal of Biological Chemistry.

Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function.

R. Heyman, I. Schulman, G. Shao, 1998, Molecular and cellular biology.

Macrophage-Independent Regulation of Reverse Cholesterol Transport by Liver X Receptors

I. Schulman, J. Angdisen, Sarah R. Breevoort, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.

T. Kirchgessner, M. Nanao, I. Schulman, 2015, Bioorganic & medicinal chemistry letters.

Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

I. Schulman, E. Lindstedt, E. Evertsson, 2019, Communications Biology.

The flip side: Identifying small molecule regulators of nuclear receptors.

R. Heyman, I. Schulman, 2004, Chemistry & biology.

Regulation of Cholesterol Homeostasis and Lipid Metabolism in Skeletal Muscle by Liver X Receptors*

G. Muscat, R. Tangirala, I. Schulman, 2002, The Journal of Biological Chemistry.

Liver X receptors and atherosclerosis: it is not all cholesterol.

I. Schulman, I. Ignatova, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Overview of Macrophage Polarization Phenotypes in Atherosclerosis

N. Leitinger, I. Schulman, 2013 .

Promoter-Specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression

C. Glass, M. Rosenfeld, S. H. Baek, 2003, Molecular and Cellular Biology.

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation*

R. Tangirala, I. Schulman, S. Westin, 2003, Journal of Biological Chemistry.

Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice[S]

Andrew C. Li, C. Daige, I. Schulman, 2010, Journal of Lipid Research.

Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.

Ping Wei, P. Wei, W. Stevens, 2004, Proceedings of the National Academy of Sciences of the United States of America.

LXRbeta ligand binding domain in comlpex with small molecule inhibitors

I. Schulman, E. Lindstedt, E. Evertsson, 2019 .