J. DuHadaway

发表

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

G. Prendergast, B. Baban, Lauren M F Merlo, 2014, International immunology.

A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

G. Prendergast, D. Munn, A. Mellor, 2008, Oncogene.

RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.

A. Toker, G. Prendergast, O. Kocher, 2013, Cancer research.

mDia function is critical for the cell suicide program triggered by farnesyl transferase inhibition

G. Prendergast, A. Alberts, J. DuHadaway, 2007, Cancer biology & therapy.

Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase

G. Prendergast, A. P. Soler, Courtney M. Smith, 2011, Cancer biology & therapy.

Bcl-2 expressed using a retroviral vector is localized primarily in the nuclear membrane and the endoplasmic reticulum of chicken embryo fibroblasts.

S. Hughes, I. Tsarfaty, J. Resau, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

IDO 1 is an Integral Mediator of In fl ammatory Neovascularization

A. Mondal, G. Prendergast, Courtney M. Smith, 2018 .

IDO1 is an Integral Mediator of Inflammatory Neovascularization

A. Mondal, G. Prendergast, Courtney M. Smith, 2016, EBioMedicine.

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

G. Prendergast, D. Munn, A. P. Soler, 2008, Proceedings of the National Academy of Sciences.

Novel Colitis Immunotherapy Targets Bin1 and Improves Colon Cell Barrier Function

G. Prendergast, J. DuHadaway, Sunil Thomas, 2016, Digestive Diseases and Sciences.

IDO1 Signaling through GCN2 in a Subpopulation of Gr-1+ Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization

A. Mondal, G. Prendergast, Souvik Dey, 2021, Cancer Immunology Research.

Bin1 mediates apoptosis by c-Myc in transformed primary cells.

G. Prendergast, J. DuHadaway, D. Sakamuro, 2001, Cancer research.

Bin 1 Mediates Apoptosis by c-Myc in Transformed Primary Cells 1

G. Prendergast, J. DuHadaway, D. Sakamuro, 2001 .

Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor.

U. Rodeck, M. Jost, P. Jensen, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

G. Prendergast, R. Wechsler-Reya, J. DuHadaway, 2000, International journal of cancer.

Bau, a splice form of Neurabin-I that interacts with the tumor suppressor Bin1, inhibits malignant cell transformation.

G. Prendergast, J. DuHadaway, K. Elliott, 1999, Cell adhesion and communication.

The Immunoregulatory Enzyme IDO

G. Prendergast, J. DuHadaway, L. Mandik-Nayak, 2009 .

RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus

G. Prendergast, J. DuHadaway, L. Mandik-Nayak, 2017, Disease Models & Mechanisms.

Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging.

G. Prendergast, A. P. Soler, Yan Wang, 2008, Cancer research.

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.

G. Prendergast, D. Munn, C. Karp, 2012, The Journal of infectious diseases.

CCR5 governs DNA damage and breast cancer stem cell expansion

Sandra, H. Rui, G. Prendergast, 2017 .

Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.

G. Prendergast, R. Metz, J. DuHadaway, 2010, Cancer research.

Targeted Disruption of the Murine Bin1/Amphiphysin II Gene Does Not Disable Endocytosis but Results in Embryonic Cardiomyopathy with Aberrant Myofibril Formation

G. Prendergast, G. Farmer, A. P. Soler, 2003, Molecular and Cellular Biology.

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.

G. Prendergast, R. Metz, J. DuHadaway, 2007, Cancer research.

Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

G. Prendergast, Shauna M. Bennett, P. Gaspari, 2006, Journal of medicinal chemistry.

RhoB Regulates PDGFR-&bgr; Trafficking and Signaling in Vascular Smooth Muscle Cells

G. Prendergast, J. DuHadaway, Minzhou Huang, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial

M. Chernick, G. Prendergast, R. Metz, 2013, Journal of Radiation Oncology.

in a Mouse Model of Autoimmune Arthritis Production and Inflammatory Pathogenesis IDO2 Is a Critical Mediator of Autoantibody

G. Prendergast, R. Metz, J. DuHadaway, 2014 .

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR

G. Prendergast, D. Munn, C. Link, 2012, Oncoimmunology.

The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis.

G. Prendergast, G. Leoni, V. Faundez, 2013, Developmental biology.

Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: Diverse sites of nuclear expression and losses in prostate cancer

T. McDonnell, G. Prendergast, P. Troncoso, 2003, Journal of cellular biochemistry.

Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma

G. Prendergast, J. Tomaszewski, J. DuHadaway, 2000, International journal of cancer.

IDO2 Modulates T Cell–Dependent Autoimmune Responses through a B Cell–Intrinsic Mechanism

G. Prendergast, Lauren M F Merlo, J. DuHadaway, 2016, The Journal of Immunology.

Intrinsic Mechanism − Autoimmune Responses through a B Cell Dependent − IDO 2 Modulates T Cell

G. Prendergast, Lauren M F Merlo, J. DuHadaway, 2016 .

AutoimmunityParadoxically Drives B Cell-Mediated The Immunoregulatory Enzyme IDO

G. Prendergast, J. DuHadaway, L. Mandik-Nayak, 2009 .

Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer

G. Prendergast, J. DuHadaway, 2016, Oncotarget.

In ovo infection with the avian retrovirus RAV-1 leads to persistent infection of the central nervous system.

J. DuHadaway, D. Ewert, I. Steiner, 1990, Laboratory investigation; a journal of technical methods and pathology.

Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1

G. Prendergast, W. Du, J. DuHadaway, 2003, Oncogene.

O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.

Judith M. LaLonde, G. Prendergast, M. Winters, 2016, European journal of medicinal chemistry.

Zinc Protoporphyrin IX Stimulates Tumor Immunity by Disrupting the Immunosuppressive Enzyme Indoleamine 2,3-Dioxygenase

G. Prendergast, D. Munn, R. Metz, 2010, Molecular Cancer Therapeutics.

Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

Judith M. LaLonde, G. Prendergast, J. DuHadaway, 2008, Journal of medicinal chemistry.

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

Judith M. LaLonde, G. Prendergast, P. Carroll, 2008, Journal of medicinal chemistry.

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

Judith M. LaLonde, G. Prendergast, P. Carroll, 2008, Journal of medicinal chemistry.

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

P. Vandenabeele, G. Prendergast, A. Degterev, 2012, Cell Death and Disease.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

M. Geffard, S. Bicciato, B. Veyret, 2014, Nature.

Persistence of Marek's disease virus in a subpopulation of B cells that is transformed by avian leukosis virus, but not in normal bursal B cells

W. Olson, T. Block, J. DuHadaway, 1992, Journal of virology.

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses.

G. Prendergast, D. Munn, A. Mellor, 2007, Cancer research.

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

G. Prendergast, J. DuHadaway, A. Muller, 2005, Nature Medicine.

IDO is a nodal pathogenic driver of lung cancer and metastasis development.

G. Prendergast, A. P. Soler, R. Metz, 2012, Cancer discovery.

Discovery of IDO1 Inhibitors: From Bench to Bedside.

G. Prendergast, J. DuHadaway, A. Muller, 2017, Cancer research.

Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion

G. Prendergast, A. P. Soler, J. DuHadaway, 2010, Cancer Immunology, Immunotherapy.

The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria

E. Petricoin, Y. Pommier, P. Singh, 2021, Molecular Cancer Therapeutics.

Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

M. Herlyn, G. Prendergast, M. Herlyn, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

N. Schultz, K. Iczkowski, H. Rui, 2023, Research square.

Targeted deletion of the suppressor gene bin1/amphiphysin2 accentuates the neoplastic character of transformed mouse fibroblasts

G. Prendergast, J. DuHadaway, A. Muller, 2004, Cancer biology & therapy.

Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers

B. Leiby, G. Prendergast, C. Yeo, 2018, Clinical Cancer Research.

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.

Amy R. Peck, J. Gray, H. Rui, 2018, Cancer research.

Structural Analysis of the Human BIN1 Gene

G. Prendergast, R. Wechsler-Reya, J. DuHadaway, 1997, The Journal of Biological Chemistry.

Genomic Profiling of miRNAs in Two Human Lens Cell Lines

Kristen M. Huang, G. Prendergast, J. DuHadaway, 2010, Current eye research.

15 Role of immunohistochemical loss of bin1/amphiphysin2 in prostatic carcinoma

G. Prendergast, J. DuHadaway, 2002 .

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses

G. Prendergast, Lauren M F Merlo, P. Murray, 2020, Frontiers in Immunology.

1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis

G. Prendergast, J. DuHadaway, L. Mandik-Nayak, 2014, Autoimmunity.

IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis

G. Prendergast, Lauren M F Merlo, R. Metz, 2014, The Journal of Immunology.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.

G. Prendergast, M. Winters, J. DuHadaway, 2019, European journal of medicinal chemistry.

Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.

G. Prendergast, Lauren M F Merlo, J. DuHadaway, 2017, Clinical immunology.

Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression.

G. Prendergast, A. P. Soler, J. DuHadaway, 2007, Cancer research.

The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.

G. Prendergast, Lauren M F Merlo, W. Peng, 2021, Journal of immunology.

The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity1

G. Prendergast, J. DuHadaway, L. Mandik-Nayak, 2009, The Journal of Immunology.

Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

A. Mondal, Lauren M F Merlo, Souvik Dey, 2020, Journal for ImmunoTherapy of Cancer.

Cyclin B1 Is a Critical Target of RhoB in the Cell Suicide Program Triggered by Farnesyl Transferase Inhibition

G. Prendergast, E. Prochownik, J. DuHadaway, 2004, Cancer Research.

RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac

G. Prendergast, J. DuHadaway, Minzhou Huang, 2011, Journal of cellular biochemistry.

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition.

Wei Zhang, Ernest D Laue, Juan Fernandez-Recio, 2006, Biochemistry.

Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy

B. Leiby, C. Dunton, W. Peng, 2016, Oncotarget.

The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.

W. Wasserman, N. Copeland, N. Jenkins, 1999, Genomics.

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

N. Schultz, K. Iczkowski, H. Rui, 2023, Oncogene.

Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II.

G. Prendergast, K. Komuro, H. Aizaki, 2005, Biochemical and biophysical research communications.

Specific In Situ Detection of Murine Indoleamine 2, 3‐Dioxygenase

G. Prendergast, J. DuHadaway, Sunil Thomas, 2014, Journal of cellular biochemistry.

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

G. Prendergast, D. Munn, A. P. Soler, 2008, Proceedings of the National Academy of Sciences.

Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging.

G. Prendergast, A. P. Soler, Yan Wang, 2008, Cancer research.