S. Lavandero

发表

HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor.

W. R. Taylor, A. San Martin, M. Chiong, 2016, Free radical biology & medicine.

Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients.

M. Chiong, G. Díaz-Araya, C. Quiroga, 2011, Journal of cardiac failure.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity.

M. Chiong, R. Troncoso, S. Lavandero, 2016, Toxicology.

Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure.

P. Sepúlveda, M. Chiong, S. Lavandero, 2012, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Cardiomyocyte death: mechanisms and translational implications

A. Criollo, Dian J. Cao, Joseph A. Hill, 2011, Cell Death and Disease.

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

J. Morales, M. Kogan, Mario F Navarro-Marquez, 2018, Theranostics.

A. Klip, K. Foley, P. Bilan, 2010 .

A. Klip, K. Foley, P. Bilan, 2010, American journal of physiology. Endocrinology and metabolism.

FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

Herman I. May, Xiang Luo, B. Rothermel, 2020, Nature Communications.

Looking back and thinking forwards — 15 years of cardiology and cardiovascular research

M. Yacoub, J. Kalman, M. Nahrendorf, 2019, Nature Reviews Cardiology.

[Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure].

M. Chiong, G. Díaz-Araya, R. Troncoso, 2004, Revista espanola de cardiologia.

Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusters.

J. Morales, A. Riveros, E. Araya, 2020, Journal of controlled release : official journal of the Controlled Release Society.

The integrated stress response in ischemic diseases

B. Rothermel, S. Lavandero, Zhao V. Wang, 2021, Cell Death & Differentiation.

FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.

V. Parra, R. Troncoso, Christian Pennanen, 2015, Biochemical pharmacology.

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia

A. Riveros, M. Kogan, P. Donoso, 2020, PloS one.

Trypanosoma cruzi calreticulin: a possible role in Chagas' disease autoimmunity.

M. Molina, Arturo Ferreira, R. Troncoso, 2009, Molecular immunology.

Organelle communication: signaling crossroads between homeostasis and disease.

A. Criollo, Joseph A. Hill, T. Simmen, 2014, The international journal of biochemistry & cell biology.

Left Atrial Dysfunction Is a Predictor of Postcoronary Artery Bypass Atrial Fibrillation: Association of Left Atrial Strain and Strain Rate Assessed by Speckle Tracking

S. Lavandero, R. Corbalán, L. Gabrielli, 2011, Echocardiography.

Targeting the Endothelium to Achieve Cardioprotection

S. Lavandero, J. A. Riquelme, Nicolas Herrera-Zelada, 2021, Frontiers in Pharmacology.

NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney

Daniela Santapau, L. Michea, S. Lavandero, 2012, PloS one.

A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes

G. Díaz-Araya, S. Lavandero, J. M. Eltit, 2001, Cell and Tissue Research.

IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB.

M. Chiong, G. Díaz-Araya, S. Lavandero, 2005, Biochemical and biophysical research communications.

Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.

M. Chiong, S. Lavandero, L. Gabrielli, 2011, American heart journal.

Mitochondria in Structural and Functional Cardiac Remodeling.

B. Rothermel, Natalia Torrealba, S. Lavandero, 2017, Advances in experimental medicine and biology.

An inositol 1,4,5-triphosphate (IP3)-IP3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes.

D. Mears, A. Klip, A. Contreras-Ferrat, 2010, Endocrinology.

Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.

B. Rothermel, Joseph A. Hill, V. Parra, 2015, Biochimica et biophysica acta.

Defective insulin signaling in diabetic cardiomyopathy and mitochondrial dynamics R O O F

B. Rothermel, Joseph A. Hill, V. Parra, 2015 .

Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.

M. Chiong, G. Díaz-Araya, S. Lavandero, 2003, The American journal of cardiology.

Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells

M. Vega, C. Romero, F. Gabler, 2016, Reproductive Sciences.

Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology

Pablo E. Morales, M. Chiong, A. Quest, 2017, Nature Reviews Cardiology.

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

E. Morselli, A. Criollo, C. Ramírez-Sarmiento, 2020, Autophagy.

Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes

E. Morselli, A. Criollo, V. Parra, 2019, Front. Endocrinol..

The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.

M. Chiong, V. Parra, R. Troncoso, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Polycystin-2-dependent control of cardiomyocyte autophagy.

Herman I. May, E. Morselli, A. Criollo, 2018, Journal of molecular and cellular cardiology.

Regulation of cardiomyocyte autophagy by calcium.

E. Morselli, A. Criollo, Joseph A. Hill, 2016, American journal of physiology. Endocrinology and metabolism.

Therapeutic targeting of autophagy in myocardial infarction and heart failure

Myra N. Chávez, J. Vicencio, A. Quest, 2016, Expert review of cardiovascular therapy.

The complex interplay between mitochondrial dynamics and cardiac metabolism

B. Rothermel, Joseph A. Hill, V. Parra, 2011, Journal of bioenergetics and biomembranes.

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

J. Vicencio, D. Yellon, S. Davidson, 2018, Scientific Reports.

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

M. Chiong, V. Parra, R. Troncoso, 2014, Journal of cardiovascular pharmacology.

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological Strategies

M. Chiong, S. Lavandero, L. Gabrielli, 2021, Frontiers in Cardiovascular Medicine.

Increased active phase atrial contraction is related to marathon runner performance

M. Sitges, M. Chiong, S. Lavandero, 2018, European Journal of Applied Physiology.

Oxidative stress in pericardial fluid and plasma and its association with ventricular function.

M. Chiong, G. Díaz-Araya, S. Lavandero, 2004, International journal of cardiology.

Ex vivo method to visualize and quantify vascular networks in native and tissue engineered skin

A. Condurache, S. Lavandero, H. Machens, 2009, Langenbeck's Archives of Surgery.

[Persistence of oxidative stress after heart transplantation: a comparative study of patients with heart transplant versus chronic stable heart failure].

M. Chiong, G. Díaz-Araya, S. Lavandero, 2002, Revista espanola de cardiologia.

Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners

M. Chiong, S. Lavandero, L. Gabrielli, 2021, Frontiers in Cardiovascular Medicine.

GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication.

M. Estrada, M. Cifuentes, Mario F Navarro-Marquez, 2019, Pharmacological research.

Gln(27)-->Glubeta(2)-adrenergic receptor polymorphism in heart failure patients: differential clinical and oxidative response to carvedilol.

M. Chiong, G. Díaz-Araya, R. Troncoso, 2009, Basic & clinical pharmacology & toxicology.

Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure.

M. Chiong, G. Díaz-Araya, R. Troncoso, 2005, The American journal of cardiology.

Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure

M. Chiong, G. Díaz-Araya, S. Lavandero, 2005, European journal of heart failure.

Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans

J. Michel, C. Fardella, S. Lavandero, 2004, Journal of Human Hypertension.

Angiotensin I-Converting Enzyme Modulates Neutral Endopeptidase Activity in the Rat

S. Lavandero, J. Jalil, M. Ocaranza, 2001, Hypertension.

Mitochondria, Myocardial Remodeling, and Cardiovascular Disease

R. Troncoso, C. Quiroga, S. Lavandero, 2012, Current Hypertension Reports.

Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model

S. Lavandero, J. Jalil, M. Ocaranza, 2002, Journal of hypertension.

Angiotensin-(1–9) regulates cardiac hypertrophy in vivo and in vitro

M. Chiong, S. Lavandero, I. Godoy, 2010, Journal of hypertension.

Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism.

S. Lavandero, J. Jalil, M. Ocaranza, 2006, Life sciences.

Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype.

M. Chiong, S. Lavandero, I. Godoy, 2003, The American journal of cardiology.

FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation.

M. Chiong, G. Díaz-Araya, S. Lavandero, 2016, Biochimica et biophysica acta.

Heart Disease and Cancer: Are the Two Killers Colluding?

R. Kitsis, S. Lavandero, J. A. Riquelme, 2018, Circulation.

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1.

Joseph A. Hill, G. Díaz-Araya, S. Lavandero, 2020, Biochimica et biophysica acta. Molecular cell research.

Angiotensin I-converting enzyme insertion/deletion polymorphism and adrenergic response to exercise in hypertensive patients.

C. Fardella, S. Lavandero, J. Jalil, 2002, Medical science monitor : international medical journal of experimental and clinical research.

Prevalence of the angiotensin I converting enzyme insertion/deletion polymorphism, plasma angiotensin converting enzyme activity, and left ventricular mass in a normotensive Chilean population.

S. Lavandero, J. Jalil, S. Braun, 1999, American journal of hypertension.

Early left atrial dysfunction is associated with suboptimal cardiovascular health

C. Ferreccio, M. Chiong, R. Troncoso, 2019, Echocardiography.

Regulation of cardiac autophagy by insulin‐like growth factor 1

Joseph A. Hill, G. Díaz-Araya, Mario F Navarro-Marquez, 2013, IUBMB life.

Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes.

M. Colombo, M. Chiong, V. Parra, 2010, Biochimica et biophysica acta.

Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients

M. Chiong, R. Troncoso, S. Lavandero, 2016, Echocardiography.

Mitochondria fine-tune the slow Ca(2+) transients induced by electrical stimulation of skeletal myotubes.

V. Parra, E. Jaimovich, C. Hidalgo, 2010, Cell calcium.

Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart.

G. Echevarría, G. Díaz-Araya, S. Lavandero, 2012, Biochimica et biophysica acta.

Cell death and survival through the endoplasmic reticulum-mitochondrial axis.

T. Gillette, M. Chiong, R. Bravo-Sagua, 2012, Current molecular medicine.

Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Thaís A. R. Ramos, T. Gillette, Joseph A. Hill, 2022, bioRxiv.

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy

Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, A. San Martin, 2019, Front. Pharmacol..

Endoplasmic reticulum−mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells

Pablo F. Castro, B. Rothermel, R. Bravo-Sagua, 2021, Cell Death & Disease.

Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function

Thaís A. R. Ramos, Kristin M. French, Herman I. May, 2020, Circulation.

β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle

M. Castro-Sepulveda, Pablo E. Morales, M. Chiong, 2020, Nutrients.

Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy

A. Rudich, M. Cifuentes, S. Lavandero, 2020, International journal of molecular sciences.

Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.

M. Cifuentes, R. Bravo-Sagua, R. Troncoso, 2018, Biochimica et biophysica acta. Molecular basis of disease.

[Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling].

M. Chiong, S. Lavandero, J. Jalil, 2005, Revista espanola de cardiologia.

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.

M. Jensen, D. Bernlohr, E. Arriaga, 2014, American journal of physiology. Endocrinology and metabolism.

Senescence, Apoptosis or Autophagy?

E. Morselli, L. Galluzzi, J. Vicencio, 2008, Gerontology.

4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast.

G. Díaz-Araya, S. Lavandero, I. Olmedo, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol.

J. Vicencio, G. Díaz-Araya, R. Troncoso, 2012, Experimental and molecular pathology.

Unsaturated fatty acids induce non‐canonical autophagy

Nektarios Tavernarakis, L. Galluzzi, O. Kepp, 2015, The EMBO journal.

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival.

T. Campos, A. F. Castro, R. Pincheira, 2016, Biochimica et biophysica acta.

IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress.

G. Díaz-Araya, S. Lavandero, J. M. Eltit, 2000, Biochemical and biophysical research communications.

intestinal epithelial (Caco-2) cells Endocytic pathway of exogenous iron-loaded ferritin in

M. Núñez, M. Chiong, Juan Fernández, 2013 .

Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells.

M. Núñez, M. Chiong, Juan Fernández, 2013, American journal of physiology. Gastrointestinal and liver physiology.

ENDOCYTIC PATHWAY OF EXOGENOUS IRON-LOADED FERRITIN IN INTESTINAL 1

Francisco, M. Núñez, M. Chiong, 2013 .

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy.

J. Vicencio, D. Leroith, T. Gillette, 2012, Cardiovascular research.

Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners

M. Sitges, M. Chiong, S. Lavandero, 2021, Journal of cardiovascular development and disease.

Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications

M. Cifuentes, R. Bravo-Sagua, S. Lavandero, 2016, Front. Physiol..

BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism

C. Behl, M. Chiong, V. Parra, 2016, Autophagy.

Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes.

D. Leroith, P. Sugden, G. Díaz-Araya, 2000, Biochemical and biophysical research communications.

Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator

M. Cifuentes, R. Bravo-Sagua, S. Lavandero, 2016 .

Anabolic androgenic steroids and intracellular calcium signaling: a mini review on mechanisms and physiological implications.

J. Vicencio, B. Rothermel, M. Estrada, 2011, Mini reviews in medicinal chemistry.

Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction.

Herman I. May, Nan Jiang, T. Gillette, 2019, Circulation.

Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma

E. Morselli, A. Criollo, C. Ramírez-Sarmiento, 2020, Frontiers in Oncology.

Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment.

D. Klionsky, M. Chiong, S. Lavandero, 2022, Trends in molecular medicine.

TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways.

G. Díaz-Araya, S. Lavandero, I. Olmedo, 2013, Biochimica et biophysica acta.

Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion

M. Chiong, G. Díaz-Araya, S. Lavandero, 2002, Critical care medicine.

Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.

P. Lampe, J. Sáez, S. Lavandero, 2015, Biochimica et biophysica acta.

Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death

A. Criollo, M. Chiong, V. Parra, 2006, FEBS letters.

Autophagy in the cardiovascular system

A. Criollo, S. Lavandero, R. Corbalán, 2022, Autophagy in Health and Disease.

Parkin Gone Wild: Unbridled Ubiquitination.

Dian J. Cao, Joseph A. Hill, S. Lavandero, 2015, Circulation research.

Serotonin (5‐HT) regulates neurite outgrowth through 5‐HT1A and 5‐HT7 receptors in cultured hippocampal neurons

S. Lavandero, J. Fiedler, P. Rojas, 2014, Journal of neuroscience research.

Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

G. Kroemer, V. Parra, F. Paredes, 2014, Cell cycle.

Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake.

A. Contreras-Ferrat, Tomás Gutiérrez, Pablo E. Morales, 2014, American journal of physiology. Endocrinology and metabolism.

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics.

B. Rothermel, Tomás Gutiérrez, M. Chiong, 2012, The international journal of biochemistry & cell biology.

Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy.

M. Acevedo, S. Lavandero, R. Corbalán, 1998, Biochemical and biophysical research communications.

Xanthine-oxidase inhibitors and statins in chronic heart failure: effects on vascular and functional parameters.

M. Chiong, S. Lavandero, L. Gabrielli, 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells.

Y. Israel, M. Núñez, D. Rodriguez, 2004, Alcohol.

Impaired cardiac autophagy in patients developing postoperative atrial fibrillation.

S. Lavandero, R. Corbalán, H. Verdejo, 2012, The Journal of thoracic and cardiovascular surgery.

IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice.

P. Pinton, S. Marchi, A. Contreras-Ferrat, 2018, Biochimica et biophysica acta. Molecular basis of disease.

HDAC Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

Herman I. May, Nan Jiang, Xiang Luo, 2014 .

Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes*

M. Estrada, M. Chiong, G. Díaz-Araya, 2004, Journal of Biological Chemistry.

Aldose Reductase Induced by Hyperosmotic Stress Mediates Cardiomyocyte Apoptosis

A. Criollo, M. Chiong, S. Lavandero, 2003, Journal of Biological Chemistry.

ER-to-mitochondria miscommunication and metabolic diseases.

B. Rothermel, A. Quest, M. Cifuentes, 2015, Biochimica et biophysica acta.

Binding and production of insulin-like growth factor-I in rat mammary gland.

J. Santibañez, S. Lavandero, M. Ocaranza, 1991, Comparative biochemistry and physiology. A, Comparative physiology.

Effects of early decrease in oxidative stress after medical therapy in patients with class IV congestive heart failure.

G. Díaz-Araya, S. Lavandero, R. Corbalán, 2002, The American journal of cardiology.

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion.

C. Hidalgo, P. Donoso, Natalia Torrealba, 2010, Biochimica et biophysica acta.

Perindopril Regulates β-Agonist-Induced Cardiac Apoptosis

G. Díaz-Araya, S. Lavandero, J. Jalil, 2005, Journal of cardiovascular pharmacology.

Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.

L. Lobos, L. Michea, E. Marusic, 2005, Endocrinology.

Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes.

S. Lim, M. Chiong, S. Lavandero, 2008, Biochemical and biophysical research communications.

Bafilomycin-A1 and ML9 exert different lysosomal actions to induce cell death.

S. Nandy, S. Lavandero, C. Cantí, 2019, Current molecular pharmacology.

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Dong I. Lee, D. Kass, E. Verdin, 2021, Circulation research.

[Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure].

S. Uribe, M. Chiong, S. Lavandero, 2010, Revista medica de Chile.

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.

Kristin M. French, Herman I. May, E. Morselli, 2019, Circulation.

Phospholipase C/Protein Kinase C Pathway Mediates Angiotensin II-Dependent Apoptosis in Neonatal Rat Cardiac Fibroblasts Expressing AT1 Receptor

M. Chiong, G. Díaz-Araya, S. Lavandero, 2008, Journal of cardiovascular pharmacology.

Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure

M. Chiong, G. Díaz-Araya, S. Lavandero, 2008, European journal of heart failure.

Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy

M. Chiong, Natalia Torrealba, S. Lavandero, 2021, PloS one.

Enalapril Attenuates Downregulation of Angiotensin-Converting Enzyme 2 in the Late Phase of Ventricular Dysfunction in Myocardial Infarcted Rat

G. Díaz-Araya, S. Lavandero, P. Castro, 2006, Hypertension.

The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

M. Chiong, G. Díaz-Araya, C. Hidalgo, 2009, Biochemical and biophysical research communications.

Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis

R. Alzamora, M. Chiong, G. Díaz-Araya, 2014, Journal of hypertension.

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling

B. Rothermel, V. Parra, A. Quest, 2016, Scientific Reports.

Tumor necrosis factor-alpha activates nuclear factor-kappaB but does not regulate progesterone production in cultured human granulosa luteal cells

L. Devoto, C. Quiroga, S. Lavandero, 2007, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Hyperosmotic stress‐dependent NFκB activation is regulated by reactive oxygen species and IGF‐1 in cultured cardiomyocytes

A. Criollo, J. Santibañez, M. Chiong, 2006, FEBS letters.

muscle cells in primary culture B activation in skeletal κ phosphorylation and NF- Hypoxia stimulates via separate pathways ERK

A. Klip, A. Contreras-Ferrat, Mark R. Johnson, 2015 .

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Local Control of Nuclear Ca 2+ Signalling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal IGF-1 Receptors

J. Vicencio, M. Estrada, P. Uhlén, 2012 .

Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF‐1

A. Criollo, M. Chiong, C. Quiroga, 2014, Journal of cellular biochemistry.

INFLUENCE OF THE HMG-CoA REDUCTASE ( TTA ) n REPEAT GENE POLYMORPHISM ON THE EFFECTS OF ATORVASTATIN IN CORONARY ARTERY DISEASE PATIENTS

S. Lavandero, M. Llancaqueo, Viviana Noriega MSca, 2007 .

Herp depletion protects from protein aggregation by up-regulating autophagy.

J. Vicencio, C. Hetz, M. Chiong, 2013, Biochimica et biophysica acta.

Angiotensin-(1-9) in hypertension.

Ignacio Norambuena-Soto, M. Chiong, V. Parra, 2022, Biochemical pharmacology.

Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

V. Velarde, G. Díaz-Araya, S. Lavandero, 2012, Toxicology and applied pharmacology.

Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II.

M. Chiong, G. Díaz-Araya, R. Troncoso, 2009, American journal of hypertension.

[The role of uric acid in heart failure].

M. Chiong, G. Díaz-Araya, C. Quiroga, 2011, Revista medica de Chile.

Uric acid, xanthine oxidase and heart failure: Unresolved issues

M. Chiong, S. Lavandero, P. Castro, 2008, European journal of heart failure.

Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes.

J. Vicencio, M. Estrada, M. Chiong, 2006, Endocrinology.

Autophagy in aging-related oral diseases

E. Morselli, A. Criollo, P. Burgos, 2022, Frontiers in Endocrinology.

Increased production of functional small extracellular vesicles in senescent endothelial cells

D. Yellon, X. Rosselló, S. Davidson, 2020, Journal of cellular and molecular medicine.

VCAM-1 as a predictor biomarker in cardiovascular disease.

Fernanda Sanhueza-Olivares, M. Chiong, S. Lavandero, 2021, Biochimica et biophysica acta. Molecular basis of disease.

Preoperative soluble VCAM‐1 contributes to predict late mortality after coronary artery surgery

M. Chiong, S. Lavandero, R. Corbalán, 2020, Clinical cardiology.

Mitochondrial control of cell death induced by hyperosmotic stress

L. Galluzzi, A. Criollo, G. Kroemer, 2006 .

Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death.

A. Criollo, B. Rothermel, V. Parra, 2013, Biochimica et biophysica acta.

Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA

P. Schneider, M. Chiong, K. Burridge, 2009, Journal of Cell Science.

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

M. Estrada, S. Lavandero, B. Westenbrink, 2021, Biological Research.

Testosterone increases GLUT4‐dependent glucose uptake in cardiomyocytes

M. Estrada, A. Contreras-Ferrat, S. Lavandero, 2013, Journal of cellular physiology.

Increased Aortic NADPH Oxidase Activity in Rats With Genetically High Angiotensin-Converting Enzyme Levels

S. Lavandero, J. Jalil, M. Ocaranza, 2005, Hypertension.

Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells.

M. Chiong, V. Torres, A. Quest, 2008, Free radical biology & medicine.

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy

Herman I. May, Nan Jiang, Xiang Luo, 2021, Circulation.

Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide.

M. Núñez, M. Chiong, V. Parra, 2010, Free radical biology & medicine.

Polycystin-1 Assembles with Kv Channels to Govern Cardiomyocyte Repolarization and Contractility.

Kristin M. French, C. Ramírez-Sarmiento, T. Gillette, 2019, Circulation.

Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species

D. Rojas-Rivera, M. Chiong, V. Parra, 2009, FEBS letters.

Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism

P. Lijnen, C. Vio, G. Díaz-Araya, 2008, Journal of the renin-angiotensin-aldosterone system : JRAAS.

System Journal of Renin-angiotensin-aldosterone Journal of Renin-angiotensin-aldosterone System Polymorphism Isoproterenol-induced Cardiac Fibrosis in Rats with Distinct Angiotensin-converting Enzyme Early Expression of Monocyte Chemoattractant Protein-1 Correlates with the Onset of Journal of Renin

P. Lijnen, C. Vio, G. Díaz-Araya, 2022 .

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.

A. Zorzano, Joseph A. Hill, V. Parra, 2013, International review of cell and molecular biology.

Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

J. Vicencio, A. Zorzano, B. Rothermel, 2011, Journal of Cell Science.

Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells

Ignacio Norambuena-Soto, A. San Martin, M. Chiong, 2022, Journal of cellular and molecular medicine.

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress

B. Rothermel, Joseph A. Hill, T. Simmen, 2018, Cell Death & Differentiation.

Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes

X. Bustamante-Marin, C. Quiroga, S. Lavandero, 2012, Apoptosis.

Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.

M. Jensen, D. Bernlohr, M. Chiong, 2014, Biochemical pharmacology.

Rho‐kinase pathway activation and apoptosis in circulating leucocytes in patients with heart failure with reduced ejection fraction

A. Kalergis, S. Lavandero, L. Gabrielli, 2019, Journal of cellular and molecular medicine.

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.

J. Vicencio, D. Yellon, L. Sobrevia, 2016, Pharmacological research.

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an eNOS / NO / PKG dependent mechanism

J. Vicencio, D. Yellon, L. Sobrevia, 2016 .

Insulin signaling in the heart is directly and early impaired by growth hormone.

Yimin Fang, F. Dominici, A. Bartke, 2022, Journal of molecular endocrinology.

Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.

A. Klip, Z. Yao, K. Foley, 2014, American journal of physiology. Endocrinology and metabolism.

Mitochondrial Fission and Autophagy in the Normal and Diseased Heart

B. Rothermel, Joseph A. Hill, S. Lavandero, 2010, Current hypertension reports.

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, M. Chiong, 2022, Frontiers in Endocrinology.

Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat.

S. Lavandero, J. Jalil, J. Meléndez, 1999, Life sciences.

Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway DISSERTATION ZUR ERLANGUNG DES

S. Lavandero, Cristián Flores, 2022 .

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.

M. Estrada, P. Uhlén, S. Lavandero, 2009, The Journal of endocrinology.

Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

M. Estrada, S. Lavandero, Javier Durán, 2017, Front. Pharmacol..

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.

M. Chiong, L. Michea, S. Lavandero, 2014, Clinical science.

Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure.

M. Chiong, L. Michea, S. Lavandero, 2014, Journal of hypertension.

Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction

Ignacio Norambuena-Soto, M. Chiong, V. Parra, 2022, IUBMB life.

IGF-1 Modulation of Rat Cardiac Fibroblast Behavior and Gene Expression is Age-Dependent

T. Borg, G. Díaz-Araya, S. Lavandero, 2003, Cell communication & adhesion.

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

A. Criollo, Nan Jiang, Xiang Luo, 2014, Cell.

AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells

M. Chiong, L. Leyton, A. Quest, 2019, Cancers.

Vaccines against components of the renin–angiotensin system

G. García-Rivas, S. Lavandero, C. Guerrero-Beltrán, 2020, Heart Failure Reviews.

A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes.

J. Vicencio, G. Díaz-Araya, S. Lavandero, 2014, Toxicology and applied pharmacology.

The role of thyroid hormones in the control of beta-adrenergic receptors in rat mammary gland.

S. Lavandero, M. Sapag-Hagar, M. Depix, 1989, Research communications in chemical pathology and pharmacology.

β-Adrenergic receptors during the lactogenic cycle in rat mammary gland

S. Lavandero, E. Donoso, M. Sapag-Hagar, 1986 .

A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle

S. Lavandero, E. Donoso, M. Sapag-Hagar, 1985, FEBS letters.

β-adrenergic receptors in rat mammary gland

S. Lavandero, E. Donoso, M. Sapag-Hagar, 1985 .

Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes

X. Bustamante-Marin, C. Quiroga, S. Lavandero, 2012, Apoptosis.

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

E. Morselli, L. Galluzzi, O. Kepp, 2009, Cell Death and Differentiation.

Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

J. Vicencio, A. Zorzano, B. Rothermel, 2011, Journal of Cell Science.

New insights into IGF-1 signaling in the heart

J. Vicencio, E. Jaimovich, R. Troncoso, 2014, Trends in Endocrinology & Metabolism.

TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals

E. Lavelle, Augusto Manubens, Gordon D. Brown, 2019, Front. Immunol..

Omeprazole, a specific gastric secretion inhibitor on oxynticopeptic cells, reduces gizzard erosion in broiler chicks fed with toxic fish meals.

M. Rutman, J. Blamey, M. Chiong, 1997, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Research note: ability of fenthion to increase gizzard erosion in broiler chicks.

M. Rutman, S. Lavandero, E. Guerrero, 1991, Poultry science.

Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network

B. Rothermel, Joseph A. Hill, J. Schneider, 2018, Circulation research.

Tumor Suppression and Promotion by Autophagy

A. Criollo, A. Quest, R. Bravo-Sagua, 2014, BioMed research international.

Autophagy in cardiovascular biology.

B. Rothermel, Joseph A. Hill, M. Chiong, 2015, The Journal of clinical investigation.

Counter-regulatory renin–angiotensin system in cardiovascular disease

Sergio Lavandero, R. Santos, M. Chiong, 2019, Nature Reviews Cardiology.

Regulation of autophagy by the inositol trisphosphate receptor

D. Andrews, A. Criollo, M. Maiuri, 2007, Cell Death and Differentiation.

A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

S. Korsmeyer, E. Cheng, C. Hetz, 2012, PLoS ONE.

Cardiac Plasticity in Health and Disease

R. Gondalia, B. Rothermel, T. Gillette, 2012 .

Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.

Cecilia Hidalgo, Steffen Härtel, Antonio Zorzano, 2008, Cardiovascular research.

Molecular Mechanisms of Autophagy in the Cardiovascular System

D. Klionsky, M. Chiong, D. Gatica, 2015, Circulation research.

Cardiovascular autophagy

B. Rothermel, J. Sadoshima, W. Martinet, 2013, Autophagy.

Calcium Transport and Signaling in Mitochondria.

V. Parra, A. Quest, R. Bravo-Sagua, 2017, Comprehensive Physiology.

The IKK complex contributes to the induction of autophagy

L. Zitvogel, E. Morselli, L. Galluzzi, 2010, The EMBO journal.

Mitochondrial dynamics, mitophagy and cardiovascular disease

Sergio Lavandero, B. Rothermel, Joseph A. Hill, 2016, The Journal of physiology.

Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?

B. Rothermel, J. Krycer, Pablo E. Morales, 2020, Endocrine reviews.

Oxidative stress and autophagy in cardiovascular homeostasis.

Joseph A. Hill, S. Lavandero, Z. Pedrozo, 2014, Antioxidants & redox signaling.

New Molecular Insights of Insulin in Diabetic Cardiomyopathy

S. Lavandero, P. Castro, H. Verdejo, 2016, Front. Physiol..

[Mitochondrial dynamics: a potential new therapeutic target for heart failure].

Pablo E. Morales, M. Chiong, V. Parra, 2011 .

Glutathione Depletion Induces Spermatogonial Cell Autophagy

J. Vera, S. Lavandero, M. Castro, 2015, Journal of cellular biochemistry.

Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

Herman I. May, Nan Jiang, B. Rothermel, 2016, Science Signaling.

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.

Nan Jiang, Xiang Luo, J. Shelton, 2012, The Journal of clinical investigation.

An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.

J. Vicencio, B. Rothermel, Joseph A. Hill, 2014, Journal of molecular and cellular cardiology.

Autophagy Networks in Cardiovascular Diseases

R. Troncoso, C. Quiroga, S. Lavandero, 2016 .

Protection of the myocardium against ischemia/reperfusion injury by angiotensin‐(1–9) through an AT2R and Akt‐dependent mechanism

B. Rothermel, R. Bravo-Sagua, S. Lavandero, 2018, Pharmacological research.

Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).

M. Chiong, S. Lavandero, L. García, 2015, Pharmacological research.

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension

M. Chiong, S. Lavandero, P. Castro, 2015, Therapeutic advances in cardiovascular disease.

Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024

C. Ferreccio, J. Miquel, J. Koshiol, 2015, BMC Public Health.

Cell death and survival through the endoplasmic reticulum-mitochondrial axis.

B. Rothermel, T. Gillette, M. Chiong, 2012, Current molecular medicine.

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway

A. Zorzano, B. Rothermel, Pablo E. Morales, 2014, Journal of Cell Science.

Control of growth and differentiation of the mammary gland by growth factors.

T. Oka, M. Yoshimura, S. Lavandero, 1991, Journal of dairy science.

Use of human mesenchymal cells to improve vascularization in a mouse model for scaffold-based dermal regeneration.

Hans-Günther Machens, Ralf Huss, Martin Bornhäuser, 2009, Tissue engineering. Part A.

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy.

T. Gillette, Joseph A. Hill, P. Donoso, 2013, Cardiovascular research.

Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets.

T. Gillette, Joseph A. Hill, S. Lavandero, 2010, Drug discovery today. Disease mechanisms.

Insulin-like Growth Factor-I Rapidly Activates Multiple Signal Transduction Pathways in Cultured Rat Cardiac Myocytes*

D. Leroith, P. Sugden, A. Ketterman, 1997, The Journal of Biological Chemistry.

Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1–9) axis in experimental hypertension

M. Chiong, S. Lavandero, J. Jalil, 2011, Journal of hypertension.

Rho Kinase Activation and Gene Expression Related to Vascular Remodeling in Normotensive Rats With High Angiotensin I–Converting Enzyme Levels

S. Lavandero, J. Jalil, M. Ocaranza, 2007, Hypertension.

Converting Enzyme Levels − Normotensive Rats With High Angiotensin

S. Lavandero, J. Jalil, M. Ocaranza, 2007 .

Skeletal muscle type‐specific mitochondrial adaptation to high‐fat diet relies on differential autophagy modulation

E. Abel, R. Pereira, Pablo E. Morales, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Manipulation of ACE2 expression in COVID-19

P. Levy, J. Narula, S. Lavandero, 2020, Open Heart.

Cohort Profile.

J. Araya, C. Ferreccio, J. Koshiol, 2020, International journal of epidemiology.

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease

A. Quest, R. Bravo-Sagua, S. Lavandero, 2021, Frontiers in Cell and Developmental Biology.

Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation.

M. Chiong, S. Lavandero, R. Corbalán, 2017, Journal of cardiology.

Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation.

B. Garayar, M. Chiong, S. Lavandero, 2011, International journal of cardiology.

Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients

C. Carvajal, L. Mosso, C. Fardella, 2010, Journal of hypertension.

Science and Health Policies to Tackle Chronic Diseases in Chile

P. Margozzini, R. Bravo-Sagua, S. Lavandero, 2019, Trends in Endocrinology & Metabolism.

Emerging role of mitophagy in cardiovascular physiology and pathology.

Pablo E. Morales, V. Parra, S. Lavandero, 2020, Molecular aspects of medicine.

Hyperosmotic stress stimulates autophagy via polycystin-2

E. Morselli, A. Criollo, R. Troncoso, 2017, Oncotarget.

Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation.

Jimena Canales, Sergio Lavandero, J. Vicencio, 2011, Biochimica et biophysica acta.

Helicobacter Pylori Infection Triggers PERK-Associated Survivin Loss in Gastric Tissue Samples and Cell Lines

S. Lavandero, Gonzalo Carrasco-Avino, Paula Díaz, 2021 .

TonEBP suppresses IL-10-mediated immunomodulation

J. Lee, M. Chiong, S. Lavandero, 2016, Scientific Reports.

Angiotensin-(1-9) prevents vascular remodeling by decreasing vascular smooth muscle cell dedifferentiation through a FoxO1-dependent mechanism.

Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, M. Chiong, 2020, Biochemical pharmacology.

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

E. Morselli, A. Criollo, C. Ferreccio, 2018, Free radical biology & medicine.

Calcium signaling in insulin action on striated muscle.

A. Klip, A. Contreras-Ferrat, E. Jaimovich, 2014, Cell calcium.

Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation

A. Klip, A. Contreras-Ferrat, E. Jaimovich, 2014, Journal of Cell Science.

Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation

J. Roa, K. Kokame, M. Chiong, 2017, Scientific Reports.

Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease.

A. Contreras-Ferrat, M. Chiong, V. Parra, 2020, International review of cell and molecular biology.

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

Herman I. May, Nan Jiang, Xiang Luo, 2014, Circulation.

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Kristin M. French, Herman I. May, Theodore M. Hill, 2021, Nature Communications.

Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells

A. Klip, A. Contreras-Ferrat, E. Jaimovich, 2013, Diabetes.

Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes

B. Rothermel, A. Contreras-Ferrat, Pablo E. Morales, 2014, Cell Communication and Signaling.

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway

D. Bernlohr, A. Klip, A. Zorzano, 2013, Diabetes.

The Inositol Trisphosphate Receptor in the Control of Autophagy

J. Vicencio, A. Criollo, M. Maiuri, 2007, Autophagy.

Targeting VCAM-1: a therapeutic opportunity for vascular damage

Fernanda Sanhueza-Olivares, M. Chiong, S. Lavandero, 2023, Expert opinion on therapeutic targets.

Ca2+, autophagy and protein degradation: thrown off balance in neurodegenerative disease.

J. Vicencio, G. Szabadkai, S. Lavandero, 2010, Cell calcium.

Mitochondrial control of cell death induced by hyperosmotic stress

L. Galluzzi, A. Criollo, G. Kroemer, 2006, Apoptosis.

Effects of Trimetazidine on Right Ventricular Function and Ventricular Remodeling in Patients with Pulmonary Artery Hypertension: A Randomised Controlled Trial

M. Chiong, S. Lavandero, V. Maracaja-Coutinho, 2023, Journal of clinical medicine.

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism.

T. Gillette, M. Chiong, A. Córdova-Casanova, 2018, Biochimica et biophysica acta. Molecular cell research.

Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors

O. Larsson, J. Vicencio, M. Estrada, 2013, Circulation research.

Protein Carbonylation and Adipocyte Mitochondrial Function*

T. Griffin, D. Bernlohr, E. Arriaga, 2012, The Journal of Biological Chemistry.

An immunogenetically defined and immunodominant Trypanosoma cruzi antigen.

A. Ferreira, J. Aguillón, S. Lavandero, 1991, The American journal of tropical medicine and hygiene.

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury.

P. Donoso, S. Lavandero, I. Olmedo, 2019, Biochimica et biophysica acta. Molecular basis of disease.

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion

R. Rodrigo, G. Díaz-Araya, S. Lavandero, 2019, Antioxidants.

The role of autophagy in cardiovascular pathology.

D. Klionsky, M. Chiong, D. Gatica, 2021, Cardiovascular research.

Pleiotropic effects of atorvastatin in heart failure: role in oxidative stress, inflammation, endothelial function, and exercise capacity.

M. Chiong, S. Lavandero, L. Gabrielli, 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts.

M. Chiong, L. Leyton, G. Díaz-Araya, 2011, Toxicology and applied pharmacology.

Nitrosative stress drives heart failure with preserved ejection fraction

Kavita Sharma, Francisco Altamirano, David A. Kass, 2019, Nature.

Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress

J. Vicencio, A. Criollo, G. Kroemer, 2010, Apoptosis.

Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats.

G. Díaz-Araya, S. Lavandero, J. Jalil, 2004, American journal of physiology. Heart and circulatory physiology.

A Polymorphism in the Gene Coding for Angiotensin Converting Enzyme Determines Different Development of Myocardial Fibrosis in the Rat

G. Díaz-Araya, S. Lavandero, J. Jalil, 2003 .

Membrane Electrical Activity Elicits Inositol 1,4,5-Trisphosphate-dependent Slow Ca2+ Signals through a Gβγ/Phosphatidylinositol 3-Kinase γ Pathway in Skeletal Myotubes*

Jorge Hidalgo, Sergio Lavandero, M. Chiong, 2006, Journal of Biological Chemistry.

Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway

G. Meister, A. Corvalán, J. Roa, 2020, Cell Death & Differentiation.

Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway

G. Meister, A. Corvalán, J. Roa, 2020, Cell Death & Differentiation.

Effect of inhibitors of signal transduction on IGF‐1‐induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes

S. Lavandero, M. Sapag-Hagar, R. Foncea, 1998, FEBS letters.

Nitrosative stress drives heart failure with preserved ejection fraction

Kristin M. French, Herman I. May, Theodore M. Hill, 2019, Nature.

Effects of trimetazidine in nonischemic heart failure: a randomized study.

P. Sepúlveda, M. Chiong, S. Lavandero, 2014, Journal of cardiac failure.

Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.

Ignacio Norambuena-Soto, M. Chiong, V. Parra, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis.

A. Klip, K. Kokame, Pablo E. Morales, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Diabetic cardiomyopathy and metabolic remodeling of the heart.

Joseph A. Hill, S. Lavandero, Zhao V. Wang, 2013, Life sciences.

Autophagy as a therapeutic target in cardiovascular disease.

Joseph A. Hill, M. Chiong, S. Lavandero, 2011, Journal of molecular and cellular cardiology.

Organelle Communication: Joined in Sickness and in Health.

A. Criollo, R. Inagi, R. Bravo-Sagua, 2023, Physiology.

Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension

M. Sitges, P. Sepúlveda, M. Chiong, 2017, Echocardiography.

Cardiomyocyte Autophagy Histone Deacetylase Inhibition Blunts Ischemia / Reperfusion Injury by Inducing

Herman I. May, Nan Jiang, Xiang Luo, 2014 .

Autophagy Activation in Zebrafish Heart Regeneration

Myra N. Chávez, M. Allende, J. Roa, 2020, Scientific Reports.

Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability

A. Criollo, S. Somlo, M. Caplan, 2015, Circulation.

Inhibition of autophagy by TAB2 and TAB3

J. Rain, E. Morselli, L. Galluzzi, 2011, The EMBO journal.

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

J. Vicencio, D. Yellon, S. Davidson, 2018, Scientific Reports.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

New emerging roles of Polycystin-2 in the regulation of autophagy.

E. Morselli, A. Criollo, S. Lavandero, 2020, International review of cell and molecular biology.

IKK connects autophagy to major stress pathways

L. Zitvogel, E. Morselli, L. Galluzzi, 2010, Autophagy.

(TTA)n polymorphism in 3-hydroxy-3-methylglutaryl-coenzyme A and response to atorvastatin in coronary artery disease patients.

M. Chiong, Christian Pennanen, S. Lavandero, 2009, Basic & clinical pharmacology & toxicology.

Use of octadecyl silica as an alternative non-conventional solid phase in immunoradiometric assays.

A. Ferreira, S. Lavandero, 1988, Journal of immunological methods.

Octadecyl silica: a solid phase for protein purification by immunoadsorption.

A. Ferreira, J. Aguillón, M. Chiong, 1991, Analytical biochemistry.

Isoproterenol and Angiotensin I-Converting Enzyme in Lung, Left Ventricle, and Plasma During Myocardial Hypertrophy and Fibrosis

P. Irarrazaval, M. Chiong, G. Díaz-Araya, 2002, Journal of cardiovascular pharmacology.

FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

Herman I. May, Xiang Luo, B. Rothermel, 2020, Nature Communications.

The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage.

S. Lawo, T. Langer, P. Giavalisco, 2023, Cell reports.

Polycystin‐1 regulates cardiomyocyte mitophagy

Ignacio Norambuena-Soto, M. Chiong, V. Parra, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tuning flux: autophagy as a target of heart disease therapy

Joseph A. Hill, S. Lavandero, Min Xie, 2011, Current opinion in cardiology.

IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes

Ignacio Norambuena-Soto, M. Chiong, P. van der Meer, 2023, Frontiers in Physiology.

In vivo and in vitro evidence of basic fibroblast growth factor action in mouse mammary gland development

T. Oka, S. Lavandero, M. Sapag-Hagar, 1998, FEBS letters.

Autophagy in Cardiac Physiology and Disease

B. Rothermel, Joseph A. Hill, S. Lavandero, 2012 .

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non‐diabetic exosomes in vitro

J. Vicencio, D. Yellon, S. Davidson, 2017, Journal of cellular and molecular medicine.

Myristate induces mitochondrial fragmentation and cardiomyocyte hypertrophy through mitochondrial E3 ubiquitin ligase MUL1

Pablo E. Morales, M. Chiong, V. Parra, 2023, Frontiers in Cell and Developmental Biology.

Type II Diabetes and Ischemic Heart disease: pathophysiology, gen regulation and future therapeutic options

S. Lavandero, Jafet Ortiz-Quintero, Andrea Ramírez-Sagredo, 2018 .

Inhibition of autophagy by TAB 2 and TAB 3

J. Rain, E. Morselli, L. Galluzzi, 2011 .

Potential adverse cardiac remodelling in highly trained athletes: still unknown clinical significance

M. Sitges, M. Chiong, S. Lavandero, 2018, European journal of sport science.

Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases.

J. Morales, M. Kogan, S. Lavandero, 2015, Current pharmaceutical design.

Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome.

M. Chiong, G. Díaz-Araya, R. Troncoso, 2010, International journal of cardiology.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Angiotensin‐(1‐9) reduces cardiovascular and renal inflammation in experimental renin‐independent hypertension

M. Chiong, S. Lavandero, L. Gabrielli, 2018, Biochemical pharmacology.

Resolvin-D1 attenuation of Angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension.

G. Díaz-Araya, S. Lavandero, C. Peiró, 2021, Biochimica et biophysica acta. Molecular basis of disease.

Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes.

D. Rojas-Rivera, M. Chiong, S. Lavandero, 2006, Biochemical and biophysical research communications.

Increased active phase atrial contraction is related to marathon runner performance

M. Sitges, M. Chiong, S. Lavandero, 2018, European Journal of Applied Physiology.

Editorial commentary: Cardiometabolic diseases and gut microbiota-removing the veil.

C. Ferreccio, S. Lavandero, J. A. Riquelme, 2019, Trends in cardiovascular medicine.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability.

M. Chiong, L. Leyton, G. Díaz-Araya, 2012, Toxicology.

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

M. Estrada, S. Lavandero, B. Westenbrink, 2021, Biological research.

Polycystin-1 is a Cardiomyocyte Mechanosensor That Governs L-type Ca 2 + Channel Protein Stability Running title : Pedrozo et al . ; PC1-dependent mechanotransduction in heart

A. Criollo, S. Somlo, M. Caplan, 2015 .

The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration.

Hans-Günther Machens, Julian F Dye, Ursula Hopfner, 2009, Biomaterials.

Mechanisms of cell death: molecular insights and therapeutic perspectives

M. Chiong, A. Quest, A. Stutzin, 2005, Cell Death and Differentiation.

Subcellular Remodeling of the T-Tubule Membrane System: The Limits of Myocardial Recovery Revealed?

J. Rame, S. Lavandero, 2017, Circulation.

Impaired AMP-Activated Protein Kinase Signaling in Heart Failure With Preserved Ejection Fraction-Associated Atrial Fibrillation.

M. Link, Nan Jiang, T. Gillette, 2022, Circulation.

Novel molecular insights and public omics data in pulmonary hypertension.

P. Sepúlveda, S. Lavandero, Raúl Arias-Carrasco, 2021, Biochimica et Biophysica Acta - Molecular Basis of Disease.

Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells

R. Troncoso, S. Lavandero, O. Porras, 2017, Molecular and Cellular Endocrinology.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).

M. Chiong, S. Lavandero, M. Ocaranza, 2015, Pharmacological research.

An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.

J. Vicencio, B. Rothermel, Joseph A. Hill, 2014, Journal of molecular and cellular cardiology.

The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

M. Chiong, G. Díaz-Araya, C. Hidalgo, 2009, Biochemical and biophysical research communications.

Endothelial activation impairs the function of small extracellular vesicles

Ignacio Norambuena-Soto, S. Lavandero, M. Troncoso, 2023, Frontiers in Pharmacology.

Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.

Ignacio Norambuena-Soto, M. Chiong, V. Parra, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Oxidative stress and autophagy in cardiovascular homeostasis.

Joseph A. Hill, S. Lavandero, Z. Pedrozo, 2014, Antioxidants & redox signaling.

Angiotensin‐(1‐9) reduces cardiovascular and renal inflammation in experimental renin‐independent hypertension

M. Chiong, S. Lavandero, L. Gabrielli, 2018, Biochemical pharmacology.

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension

M. Chiong, S. Lavandero, P. Castro, 2015, Therapeutic advances in cardiovascular disease.

Cardiomyocyte autophagy: A new adaptative mechanism to stress or new form of cell death?

M. Chiong, V. Parra, G. Díaz-Araya, 2006 .

Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

Herman I. May, Nan Jiang, B. Rothermel, 2016, Science Signaling.

IGFBP7 on the road to heart failure: driver or passenger?

S. Lavandero, Jaime A Riquelme, 2022, Nature Cardiovascular Research.

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.

Kristin M. French, Herman I. May, E. Morselli, 2019, Circulation.

Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.

S. Lavandero, R. Corbalán, I. Godoy, 1996, Journal of molecular and cellular cardiology.

NAD in pathological cardiac remodeling: Metabolic regulation and beyond.

Ignacio Norambuena-Soto, S. Lavandero, Yingfeng Deng, 2024, Biochimica et biophysica acta. Molecular basis of disease.