C. Seki

发表

F. Yasuno, T. Asada, T. Suhara, 2006 .

Development of a high resolution beta camera for a direct measurement of positron distribution on brain surface

K. Kashikura, I. Kanno, Seiichi Yamamoto, 1996 .

Biological washout modelling for in-beam PET: rabbit brain irradiation by 11C and 15O ion beams

I. Kanno, C. Seki, T. Yamaya, 2020, Physics in medicine and biology.

Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia

I. Kanno, K. Masamoto, Hiroshi Ito, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Title: Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand Short running title: Prediction of SUVR for amyloid PET probe Authors:

H. Watabe, M. Tashiro, N. Okamura, 2017 .

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors

B. Richmond, R. Shin, Ming-Rong Zhang, 2016, The Journal of Neuroscience.

Evaluation of [

S. Obayashi, Ming-Rong Zhang, H. Kusuhara, 2022 .

No inhibitory effect on P-glycoprotein function at blood–brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil

Hidehiko Takahashi, T. Suhara, Hiroshi Ito, 2010, Annals of nuclear medicine.

Quantification of Neuroreceptors and Neurotransporters

I. Kanno, T. Suhara, Hiroshi Ito, 2012 .

Visualization of AMPA receptors in living human brain with positron emission tomography

T. Arisawa, M. Mimura, Ming-Rong Zhang, 2020, Nature Medicine.

Binding of Dopamine D1 Receptor and Noradrenaline Transporter in Individuals with Autism Spectrum Disorder: A PET Study.

R. Hashimoto, N. Kato, Ming-Rong Zhang, 2020, Cerebral cortex.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

F. Yasuno, T. Asada, T. Suhara, 2006, Life sciences.

A new method to quantify tau pathologies with 11C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter

Ming-Rong Zhang, T. Suhara, M. Ichise, 2016, EJNMMI Research.

First-in-human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F-T-401

Ming-Rong Zhang, S. Kitamura, M. Ichise, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.

Ming-Rong Zhang, J. Maeda, Yuji Nagai, 2019, Journal of medicinal chemistry.

Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

Ming-Rong Zhang, T. Minamimoto, J. Maeda, 2020, bioRxiv.

Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis

I. Kanno, T. Matsuura, K. Masamoto, 2013, Brain Research.

Novel system using microliter order sample volume for measuring arterial radioactivity concentrations in whole blood and plasma for mouse PET dynamic study

I. Kanno, Y. Kimura, K. Hatano, 2013, Physics in medicine and biology.

[11C]TASP457, a novel PET ligand for histamine H3 receptors in human brain

Ming-Rong Zhang, S. Kitamura, T. Suhara, 2016, European Journal of Nuclear Medicine and Molecular Imaging.

Evaluation of Rho-Kinase Activity in Mice Brain Using N-[11C]Methyl-hydroxyfasudil with Positron Emission Tomography

I. Kanno, Ming-Rong Zhang, Hiroshi Ito, 2014, Molecular Imaging and Biology.

Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand Short running Prediction of for PET probe

M. Tashiro, K. Gonda, S. Furumoto, 2017 .

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Samuel T. Slocum, Xi-Ping Huang, B. Roth, 2019, Nature Neuroscience.

Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy

Ming-Rong Zhang, T. Obata, T. Suhara, 2022, Journal of the Neurological Sciences.

Measurement Error Analysis for the Determination of Dopamine D2 Receptor Occupancy Using the Agonist Radioligand [11C]MNPA

F. Turkheimer, I. Kanno, Hidehiko Takahashi, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457

Ming-Rong Zhang, S. Kitamura, T. Suhara, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model

T. Suhara, T. Minamimoto, Yuji Nagai, 2022, Brain, behavior, & immunity - health.

A Machine Learning–Based Approach to Discrimination of Tauopathies Using [ 18F]PM‐PBB3 PET Images

Ming-Rong Zhang, K. Oishi, A. Kakita, 2022, Movement disorders : official journal of the Movement Disorder Society.

An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607)

K. Matsuoka, K. Tagai, K. Kawamura, 2022, NeuroImage.

Quantification of Dopamine Transporter in Human Brain Using PET with 18F-FE-PE2I

Fumitoshi Kodaka, Harumasa Takano, Yasuyuki Kimura, 2012, The Journal of Nuclear Medicine.

Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system

Ming-Rong Zhang, T. Suhara, Hiroshi Ito, 2022, Brain Imaging and Behavior.

Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model

Ming-Rong Zhang, T. Suhara, I. Aoki, 2020, The Journal of Neuroscience.

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

Ming-Rong Zhang, S. Kitamura, T. Suhara, 2015, The Journal of Nuclear Medicine.

Activation of Nav1.1 ameliorates tau pathology and brain atrophy in a mouse model of tauopathy

J. Maeda, M. Higuchi, N. Sahara, 2020 .

Improvement of likelihood estimation in Logan graphical analysis using maximum a posteriori for neuroreceptor PET imaging

Iwao Kanno, Yuichi Kimura, Kiichi Ishiwata, 2009, Annals of nuclear medicine.

Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain

Fumitoshi Kodaka, Harumasa Takano, Christer Halldin, 2009, Journal of Nuclear Medicine.

Measurement of glycine binding site of N‐methyl‐d‐asparate receptors in living human brain using 4‐acetoxy derivative of L‐703,717, 4‐acetoxy‐7‐chloro‐3‐[3‐(4‐[11c] methoxybenzyl) phenyl]‐2(1H)‐quinolone (AcL703) with positron emission tomography

Hidehiko Takahashi, K. Fukui, Y. Fujimura, 2007, Synapse.

Prediction of the Clinical SUV Ratio in Amyloid PET Imaging Using a Biomathematic Modeling Approach Toward the Efficient Development of a Radioligand

H. Watabe, M. Tashiro, N. Okamura, 2017, The Journal of Nuclear Medicine.

Changes in Cortical Microvasculature during Misery Perfusion Measured by Two-Photon Laser Scanning Microscopy

I. Kanno, K. Masamoto, Hiroshi Ito, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models

I. Kanno, Hidehiko Takahashi, Y. Kimura, 2010, Annals of nuclear medicine.

Microvascular Sprouting, Extension, and Creation of New Capillary Connections with Adaptation of the Neighboring Astrocytes in Adult Mouse Cortex under Chronic Hypoxia

I. Kanno, K. Masamoto, Hiroshi Ito, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Visualization of AMPA receptors in living human brain with positron emission tomography

T. Arisawa, M. Mimura, H. Kato, 2020, Nature Medicine.

Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope

I. Kanno, K. Masamoto, Hiroshi Ito, 2017, The Journal of Physiological Sciences.

Hemodynamics evoked by microelectrical direct stimulation in rat somatosensory cortex.

I Kanno, C Seki, K. Kashikura, 1999, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein

T. Suhara, I. Aoki, M. Higuchi, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Biomathematical screening of amyloid radiotracers with clinical usefulness index

Hiroshi Watabe, Chie Seki, Ying-Hwey Nai, 2017, Alzheimer's & dementia.

Evaluation of semi-quantitative method for quantification of dopamine transporter in human PET study with 18F-FE-PE2I

T. Suhara, Y. Okubo, Hiroshi Ito, 2015, Annals of Nuclear Medicine.

Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors

Fumitoshi Kodaka, Harumasa Takano, Hitoshi Shimada, 2017, NeuroImage.

Quantitative Analysis of Norepinephrine Transporter in the Human Brain Using PET with (S,S)-18F-FMeNER-D2

Hidehiko Takahashi, C. Halldin, T. Suhara, 2008, Journal of Nuclear Medicine.

A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7

M. Ichise, K. Matsuoka, M. Higuchi, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol

J. Maeda, M. Higuchi, M. Yamada, 2016, Psychopharmacology.

Development of a High Resolution Beta Camera for a Direct istribution on Brain Surface

I. Kanno, H. Fujita, C. Seki, 1997 .

Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model

H. Onoe, T. Suhara, M. Higuchi, 2013, Brain Research.

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey

T. Suhara, T. Minamimoto, Yuji Nagai, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Association of Glutamate and N-Acetylaspartate Levels with Abnormal Protein Deposition in Alzheimer's Disease: Insights from Magnetic Resonance Spectroscopic Imaging

K. Matsuoka, K. Tagai, K. Takahata, 2023, medRxiv.

A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model

M. Higuchi, N. Sahara, K. Kawamura, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

CENP‐C unwraps the human CENP‐A nucleosome through the H2A C‐terminal tail

Ingmar B. Schäfer, T. Suhara, T. Minamimoto, 2019, EMBO reports.

Genetically targeted reporter imaging of deep neuronal network in the mammalian brain

T. Suhara, T. Minamimoto, J. Maeda, 2020, bioRxiv.

First prototyping of a dedicated PET system with the hemisphere detector arrangement

Hideaki Tashima, Eiji Yoshida, Taiga Yamaya, 2019, Physics in medicine and biology.

Distinct binding of amyloid imaging ligands to unique amyloid‐β deposited in the presubiculum of Alzheimer's disease

T. Suhara, L. Farde, H. Shiraishi, 2015, Journal of neurochemistry.

Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow

J. Kershaw, T. Obata, Hiroshi Ito, 2018, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.

Noncompartmental and compartmental modeling of the kinetics of carbon‐11 labeled pyrilamine in the human brain

T. K. Natarajan, Chie Seki, Zsolt Szabo, 1993, Synapse.

Quantitative Analysis of NK1 Receptor in the Human Brain Using PET with 18F-FE-SPA-RQ

Hidehiko Takahashi, T. Suhara, Y. Okubo, 2008, Journal of Nuclear Medicine.

Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia

Hidehiko Takahashi, K. Matsuoka, M. Higuchi, 2022, Schizophrenia bulletin.

Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[&bgr;-11C]DOPA

Ryuji Nakao, Hiroshi Ito, Chie Seki, 2006, Nuclear medicine communications.

Effects of image reconstruction algorithm on neurotransmission PET studies in humans: Comparison between filtered backprojection and ordered subsets expectation maximization

Katsuyuki Tanimoto, Taiga Yamaya, Hiroshi Ito, 2006, Annals of nuclear medicine.

Quantitative Analysis of Peripheral Benzodiazepine Receptor in the Human Brain Using PET with 11C-AC-5216

Hidehiko Takahashi, T. Suhara, Hiroshi Ito, 2009, Journal of Nuclear Medicine.

Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

R. Hashimoto, T. Obata, Motoaki Nakamura, 2023, Scientific reports.

Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with 18F-FEDAA1106

Iwao Kanno, Yuichi Kimura, Hiroshi Ito, 2008, European Journal of Nuclear Medicine and Molecular Imaging.

Myocardial perfusion with [11C]methyl triphenyl phosphonium: measurements of the extraction fraction and myocardial uptake.

L. Becker, B. Krause, Z. Szabo, 1994, Journal of nuclear biology and medicine.

Scatter, spatial resolution, and quantitative recovery in high resolution SPECT.

J M Links, H N Wagner, C Seki, 1992, Journal of computer assisted tomography.

PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2

T. Suhara, M. Ichise, Masaru Mimura, 2016, The Journal of Nuclear Medicine.

Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET

I. Kanno, Nobuhiro Nitta, C. Seki, 2022, Physics in medicine and biology.

Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

H. Tsukada, Y. Kimura, K. Ishiwata, 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [18F]T-401 and PET

T. Minamimoto, J. Maeda, Yuji Nagai, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457

Iwao Kanno, Yuichi Kimura, Hiroshi Ito, 2008, NeuroImage.

Reproducibility of measuring cerebral blood flow by laser-Doppler flowmetry in mice.

Kazuto Masamoto, Iwao Kanno, Hiroshi Ito, 2014, Frontiers in bioscience.

Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457

S. Kitamura, T. Suhara, M. Ichise, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans

Hidehiko Takahashi, T. Suhara, M. Ichise, 2018, EJNMMI Research.

Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

T. Suhara, T. Minamimoto, J. Maeda, 2016, EJNMMI Research.

Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases

Ming-Rong Zhang, A. Kakita, M. Ichise, 2020, bioRxiv.

Development and Performance Assessment of a Novel Plasma p-Tau181 Assay Reflecting Tau Tangle Pathology in Alzheimer's Disease

K. Matsuoka, M. Higuchi, K. Tagai, 2023, medRxiv.

High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy

A. Kakita, T. Suhara, K. Matsuoka, 2022, Movement disorders : official journal of the Movement Disorder Society.

Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain.

K. Matsuoka, Masaru Mimura, K. Tagai, 2023, European journal of nuclear medicine and molecular imaging.

A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies

Harumasa Takano, Masanori Ichise, Takashi Yokoi, 2010, NeuroImage.

Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis

Iwao Kanno, Yasuyuki Kimura, Masanori Ichise, 2017, Annals of Nuclear Medicine.

Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer 11C-AZD2184

Fumitoshi Kodaka, Harumasa Takano, Hitoshi Shimada, 2014, The Journal of Nuclear Medicine.

[The effect of sevoflurane on regional cerebral metabolism and cerebral blood flow in rhesus monkeys].

J. Takeda, H. Tsukada, C. Seki, 1997, Masui. The Japanese journal of anesthesiology.

Microvascular Sprouting, Extension, and Creation of New Capillary Connections with Adaptation of the Neighboring Astrocytes in Adult Mouse Cortex under Chronic Hypoxia

I. Kanno, K. Masamoto, Hiroshi Ito, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.

Y. Fujibayashi, H. Kusuhara, Y. Sugiyama, 2013, Nuclear medicine and biology.

Evaluation of [11C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection

S. Obayashi, H. Kusuhara, Y. Sugiyama, 2014, EJNMMI Research.

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

S. Kitamura, T. Suhara, M. Ichise, 2015, The Journal of Nuclear Medicine.

Serotonergic neural network related to behavioral inhibition system

T. Suhara, Hiroshi Ito, M. Higuchi, 2021, bioRxiv.

PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2

T. Suhara, M. Ichise, Masaru Mimura, 2016, The Journal of Nuclear Medicine.

Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models

S. Kitamura, J. Maeda, M. Higuchi, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Cerebral hemodynamic response to acute hyperoxia in awake mice

I. Kanno, T. Matsuura, K. Masamoto, 2014, Brain Research.

15O Radioactivity Clearance is Faster after Intracarotid Bolus Injection of 15O-Labeled Oxyhemoglobin than after 15O-Water Injection

K. Kashikura, J. Kershaw, I. Kanno, 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Application of a beta microprobe for quantification of regional cerebral blood flow with15O-water and PET in rhesus monkeys

S. Nishiyama, T. Kakiuchi, H. Tsukada, 1998, Annals of nuclear medicine.

Effect of tracer metabolism on PET measurement of [11C]pyrilamine binding to histamine H1 receptors

Chie Seki, Zsolt Szabo, Z. Szabo, 1999, Annals of nuclear medicine.

Tumour status prediction by means of carbon-ion beam irradiation: comparison of washout rates between in-beam PET and DCE-MRI in rats

I. Kanno, Y. Ikoma, Nobuhiro Nitta, 2023, Physics in medicine and biology.

[The effect of cerebral perfusion pressure on cerebral blood flow in the rhesus monkey during sevoflurane anesthesia].

J. Takeda, H. Tsukada, C. Seki, 1997, Masui. The Japanese journal of anesthesiology.

A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease

K. Matsuoka, K. Tagai, K. Kawamura, 2024, Translational neurodegeneration.

Investigating neural dysfunction with abnormal protein deposition in Alzheimer’s disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography

K. Matsuoka, M. Higuchi, K. Tagai, 2023, NeuroImage: Clinical.

A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies

Hidehiko Takahashi, Y. Kimura, T. Suhara, 2010, NeuroImage.

Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457

I. Kanno, Hidehiko Takahashi, Y. Kimura, 2008, NeuroImage.