P. Goldsmith

发表

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

D. Rubinsztein, A. Roach, A. Fleming, 2008, The Journal of Neuroscience.

Brightfield Proximity Ligation Assay Reveals Both Canonical and Mixed Transforming Growth Factor-β/Bone Morphogenetic Protein Smad Signaling Complexes in Tissue Sections

L. Wakefield, K. Flanders, S. Hewitt, 2014, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Monoclonal Antibodies Against Synthetic Peptides Corresponding to the Extracellular Domain of the Human Ca2+ Receptor: Characterization and Use in Studying Concanavalin A Inhibition

J. Miller, Jeffery L. Miller, A. Spiegel, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Carboxyl Terminus of the Human Calcium Receptor

A. Spiegel, P. Goldsmith, K. Ray, 1997, The Journal of Biological Chemistry.

Follicular Thyroglobulin (TG) Suppression of Thyroid-restricted Genes Involves the Apical Membrane Asialoglycoprotein Receptor and TG Phosphorylation*

F. Pacifico, S. Formisano, Koichi Suzuki, 1999, The Journal of Biological Chemistry.

Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A151

S. Yuspa, P. Goldsmith, T. Chavakis, 2008, The Journal of Immunology.

LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.

M. Raffeld, M. Merino, Y. Ward, 2011, Cancer research.

Identification and localization of G protein subunits in human spermatozoa.

P. de Mazancourt, L. Weinstein, J. Hall, 1999, Molecular human reproduction.

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

G. Milligan, M. Pines, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Polypeptide variants of beta-arrestin and arrestin3.

C. Sanders, J. Benovic, V. Gurevich, 1993, The Journal of biological chemistry.

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.

A. Shenker, A. Spiegel, P. Goldsmith, 1991, Transactions of the Association of American Physicians.

Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Gs mediates hormonal inhibition of the calcium pump in liver plasma membranes.

S. Lotersztajn, F. Pecker, P. Goldsmith, 1993, The Journal of biological chemistry.

Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver.

J. Hanoune, A. Mallat, S. Lotersztajn, 1994, The Journal of biological chemistry.

Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

J. Feramisco, J. Meinkoth, V. Lamorte, 1992, The Journal of biological chemistry.

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

D. Venzon, S. Epstein, D. Segal, 2011, The Journal of Immunology.

Decreased BDNF Levels Are a Major Contributor to the Embryonic Phenotype of Huntingtin Knockdown Zebrafish

D. Rubinsztein, M. Futter, A. Roach, 2009, The Journal of Neuroscience.

Immunolocalization of G protein alpha-subunits in the Drosophila CNS

A. Spiegel, P. Goldsmith, M. Forte, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Gr‐1+CD11b+ cells are responsible for tumor promoting effect of TGF‐β in breast cancer progression

B. R. Achyut, P. Goldsmith, S. Gara, 2012, International journal of cancer.

Functionally Distinct S100A15 Inflammation with Highly Homologous but Glycation End Products and Potentiates Mediated by the Receptor for Advanced Chemotactic Activity of S100A7 (Psoriasin) Is

S. Yuspa, P. Goldsmith, T. Chavakis, 2008 .

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

G. Milligan, P. Gierschik, H. Malech, 1987, The Journal of biological chemistry.

Stable overexpression of MEN1 suppresses tumorigenicity of RAS

F. Collins, Y. Kim, S. Chandrasekharappa, 1999, Oncogene.

G proteins in adipocytes and preadipocytes: characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation.

P. de Mazancourt, Y. Giudicelli, P. Goldsmith, 1996, Cellular signalling.

Response: CARP1 regulates induction of NF-κB by TNFα

S. Srinivasula, W. El-Deiry, Wensheng Yang, 2009, Current Biology.

Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.

R. B. Merrifield, T. Sakmar, P. Goldsmith, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone.

H. Jüppner, A. Abou-Samra, L. Y. Xie, 1994, Endocrinology.

Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.

M. Caron, R. Lefkowitz, E. Lapetina, 1991, Cellular signalling.

The direct effects of interleukin 1, interleukin 2, Interferon-α, Interferon-γ, B-cell growth factor, and a B-cell differentiation factor on resting and activated human B cells

A. Fauci, J. Kehrl, A. Muraguchi, 1985 .

Activation of human peripheral blood B cells following immunization with hepatitis B surface antigen vaccine.

R. Purcell, A. Fauci, J. Gerin, 1984, Cellular immunology.

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

D. Venzon, S. Epstein, D. Segal, 2011, The Journal of Immunology.

Antiviral Protection Cross-Presentation, CTL Responses, and Oligonucleotide Adjuvants Induce Dendritic Cell TLR3-Specific Double-Stranded RNA

D. Venzon, S. Epstein, J. Leonard, 2011 .

In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

R. Purcell, A. Fauci, J. Gerin, 1984, The Journal of clinical investigation.

Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl‐terminal decapeptide

W. Simonds, A. Spiegel, P. Goldsmith, 1989, FEBS letters.

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor

A. Spiegel, P. Goldsmith, O. Hauache, 1999, FEBS letters.

Receptor Heterodimerizes with CD 97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells

M. Raffeld, M. Merino, Y. Ward, 2011 .

Two hexokinases of Homarus americanus (lobster), one having great affinity for mannose and fructose and low affinity for glucose.

P. Goldsmith, M. R. Stetten, 1981, Biochimica et biophysica acta.

A Limulus glucose-6-phosphatase with phosphotransferase activity characteristic of vertebrate liver microsomes. Its possible evolutionary significance.

P. Goldsmith, M. R. Stetten, 1976, Biochimica et biophysica acta.

Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

D. Cooper, A. Spiegel, P. Goldsmith, 1990, Brain Research.

Ia Antigen Expression and Autoimmunity in MRL‐lpr/lpr Mice

A. Steinberg, P. Goldsmith, J. Ohara, 1986, Annals of the New York Academy of Sciences.

B cell growth and differentiation factors interact with receptors distinct from the interleukin 2 receptor

A. Fauci, J. Grove, J. Kehrl, 1986, European journal of immunology.

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

W. Simonds, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

P. Blumberg, S. Garfield, G. Czifra, 2011, Biochemical Pharmacology.

Functional Effects of Monoclonal Antibodies to the Purified Amino‐Terminal Extracellular Domain of the Human Ca2+ Receptor

Jeffery L. Miller, Jianxin Hu, P. Goldsmith, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

IgE antibodies to Staphylococcus aureus and Candida albicans in patients with the syndrome of hyperimmunoglobulin E and recurrent infections.

P. Goldsmith, C. Kirkpatrick, J. Gallin, 1980, Journal of immunology.

Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins

W. Simonds, T. L. Jones, A. Spiegel, 1992 .

Metabolism of immunoglobulin E in patients with markedly elevated serum immunoglobulin E levels.

S. Dreskin, P. Goldsmith, W. Strober, 1987, The Journal of clinical investigation.

Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.

J. Thorner, H. Dohlman, A. Spiegel, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line.

S. Muallem, L. Suva, M. Pines, 1996, Bone.

An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.

R. Cerione, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors.

G. Milligan, A. Spiegel, P. Goldsmith, 1988, Endocrinology.

A highly sensitive enzyme-linked immunosorbent assay for human immunoglobulin E: comparison of microtiter plate and disk methodologies.

P. Goldsmith, 1981, Analytical biochemistry.

Smooth muscle myosin is composed of homodimeric heavy chains.

J. Sellers, R. Adelstein, C. Kelley, 1992, The Journal of biological chemistry.

Expression of the calcium-sensing receptor in gastrinomas.

M. Raffeld, R. Jensen, A. Spiegel, 2000, The Journal of clinical endocrinology and metabolism.

Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A.

S. Dreskin, P. Goldsmith, J. Gallin, 1985, The Journal of clinical investigation.

Antibodies as Probes of G-Protein Structure and Function

W. Simonds, A. Spiegel, P. Goldsmith, 1990 .

Signal transduction by guanine nucleotide-binding proteins.

M. Brann, W. Simonds, A. Spiegel, 1988, Recent progress in hormone research.

Differential distribution of signal-transducing G-proteins in retina

C. Gerfen, G. Milligan, P. Gierschik, 1987, Brain Research.

Detection of multiple forms of Giα in HL60 cells

M. Brann, P. Gierschik, H. Malech, 1987 .

GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.

G. Milligan, P. Gierschik, A. Spiegel, 1987, Biochemical and biophysical research communications.

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides

J. Falloon, G. Milligan, H. Malech, 1986, FEBS letters.

The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.

C. Parent, E. Rericha, P. Goldsmith, 2009, Molecular biology of the cell.

Different developmental changes in latency for two functions of a single membrane bound enzyme: glucose-6-phosphatase activities as a function of age.

P. Goldsmith, M. R. Stetten, 1979, Biochimica et biophysica acta.

Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cδ Provides an Integrated Measure of Its Modulation in Response to Ligands

P. Blumberg, P. Goldsmith, A. Telek, 2014, Journal of medicinal chemistry.

Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.

P. Blumberg, P. Goldsmith, Peter M Blumberg, 2013, Analytical biochemistry.

Postnatal development of some membrane-bound enzymes of rat liver and kidney.

P. Goldsmith, 1981, Biochimica et biophysica acta.

TUSC1, a Putative Tumor Suppressor Gene, Reduces Tumor Cell Growth In Vitro and Tumor Growth In Vivo

J. Wiest, Jennifer M. Jin, P. Goldsmith, 2013, PloS one.

The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.

Vladimir Larionov, Greg Solomon, Christopher A Walsh, 2005, Human molecular genetics.

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

D. Rubinsztein, S. Sarkar, Farah H. Siddiqi, 2008, Nature chemical biology.

Multiplexing siRNAs to compress RNAi-based screen size in human cells

J. Weinstein, N. Caplen, P. Lorenzi, 2007, Nucleic acids research.

Urinary excretion of aquaporin-2 in humans: a potential marker of collecting duct responsiveness to vasopressin.

M. Knepper, P. Goldsmith, M. Haughey, 1996, Journal of the American Society of Nephrology : JASN.

Menin, the product of the MEN1 gene, is a nuclear protein.

F. Collins, S. Chandrasekharappa, S. Guru, 1998, Proceedings of the National Academy of Sciences of the United States of America.

An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma

X. Wang, M. Forgues, P. Goldsmith, 2007, Oncogene.

Characterization of Δ7/11, a functional prolactin-binding protein.

J. Rodriguez-Canales, B. Vonderhaar, B. Vonderhaar, 2012, Journal of molecular endocrinology.

Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity.

N. Caplen, M. Mackiewicz, W. Dubois, 2014, Cancer letters.

Capillary Isoelectric-Focusing Immunoassays to Study Dynamic Oncoprotein Phosphorylation and Drug Response to Targeted Therapies in Non–Small Cell Lung Cancer

Jih-Hsiang Lee, Yi-Song Wang, G. Giaccone, 2013, Molecular Cancer Therapeutics.

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

Fei Tan, Yu Wang, Yasuhiro Katagiri, 2008, Journal of Cell Science.

Expression of G protein alpha-subunits in bovine parathyroid.

A. Mithal, E. Brown, A. Spiegel, 1995, Endocrinology.

Cloning and Characterization of a Calcium‐Sensing Receptor from the Hypercalcemic New Zealand White Rabbit Reveals Unaltered Responsiveness to Extracellular Calcium

A. Mithal, E. Brown, S. Quinn, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits

P. Goldsmith, M. Diversé-Pierluissi, K. Dunlap, 1995, Neuron.

Asparagine synthetase as a causal, predictive biomarker for l-asparaginase activity in ovarian cancer cells

Gabriel S. Eichler, U. Scherf, J. Weinstein, 2006, Molecular Cancer Therapeutics.

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

W. Simonds, A. Spiegel, J. Codina, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants.

P. J. Steinbach, A. Spiegel, P. Goldsmith, 2001, The Journal of biological chemistry.

Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae

R. Baker, T. Veenstra, P. Goldsmith, 2013, Molecular biology of the cell.

The gene for multiple endocrine neoplasia type 1: recent findings.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Bone.

Identification of the Sites of N-Linked Glycosylation on the Human Calcium Receptor and Assessment of Their Role in Cell Surface Expression and Signal Transduction*

A. Spiegel, P. Goldsmith, K. Ray, 1998, The Journal of Biological Chemistry.

Analysis of albumin-associated peptides and proteins from ovarian cancer patients.

E. Petricoin, D. Fishman, L. Liotta, 2005, Clinical chemistry.

The PH domain of Ras-GAP is sufficient forin Vitro binding toβγ subunits of heterotrimeric G proteins

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and Molecular Neurobiology.

Evolutionary Diversification of SPANX-N Sperm Protein Gene Structure and Expression

V. Noskov, D. Schlessinger, J. Jurka, 2007, PloS one.

Label-retaining liver cancer cells are relatively resistant to sorafenib

S. Thorgeirsson, A. Stojadinovic, T. Koizumi, 2013, Gut.

Prolactin Receptor Isoforms in Human Breast Cancer

B. Vonderhaar, P. Goldsmith, C. Heger, 2013 .

Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer

B. Vonderhaar, P. Goldsmith, Shannon D. Oliver, 2012, BMC Cancer.

Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin

S. Thorgeirsson, A. Stojadinovic, T. Koizumi, 2016, Journal of Cancer.

Antibodies against synthetic peptides as probes of G protein structure and function.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Society of General Physiologists series.

Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Recent progress in hormone research.

Asparagine synthetase is a predictive biomarker of l-asparaginase activity in ovarian cancer cell lines

J. Weinstein, E. Kohn, W. Reinhold, 2008, Molecular Cancer Therapeutics.

Serum S100A6 Concentration Predicts Peritoneal Tumor Burden in Mice with Epithelial Ovarian Cancer and Is Associated with Advanced Stage in Patients

Octavio A. Quiñones, E. Petricoin, L. Liotta, 2009, PloS one.

Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.

P. de Mazancourt, L. Weinstein, P. Goldsmith, 1994, The Biochemical journal.

Identification of the Cysteine Residues in the Amino-terminal Extracellular Domain of the Human Ca2+ Receptor Critical for Dimerization

A. Spiegel, P. Goldsmith, P J Steinbach, 1999, The Journal of Biological Chemistry.

Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies

B. Vonderhaar, P. Goldsmith, Stefanie Alexander, 2010, BMC Cancer.

Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.

Peter H Watson, P. Watson, S. Yuspa, 2009, Cancer letters.

Expression, Purification, and Biochemical Characterization of the Amino-terminal Extracellular Domain of the Human Calcium Receptor*

J. Shiloach, A. Spiegel, P. Goldsmith, 1999, The Journal of Biological Chemistry.

Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction

A. Spiegel, P. Goldsmith, K. Ray, 1998, FEBS letters.

N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface.

C. Dunn, A. Spiegel, P. Goldsmith, 1997, Endocrinology.

The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and molecular neurobiology.

The Venus's-flytrap and Cysteine-rich Domains of the Human Ca2+ Receptor Are Not Linked by Disulfide Bonds*

Jianxin Hu, P. Goldsmith, G. Reyes-Cruz, 2001, The Journal of Biological Chemistry.

The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation.

S. Yuspa, P. FitzGerald, T. Ruzicka, 2006, The Journal of investigative dermatology.

Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor

R. B. Merrifield, T. Sakmar, P. Goldsmith, 1995, The Journal of Biological Chemistry.

GBR12909 Possesses Anticonvulsant Activity in Zebrafish and Rodent Models of Generalized Epilepsy but Cardiac Ion Channel Effects Limit Its Clinical Utility

P. Newton, J. Stables, P. Goldsmith, 2007, Pharmacology.

Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

T. Hökfelt, R. Cortės, M. Schalling, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Human Ca2+ Receptor Extracellular Domain

A. Spiegel, Jianxin Hu, P. Goldsmith, 2001, The Journal of Biological Chemistry.

Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Biochemical Society symposium.

Functional characterization of five V2 vasopressin receptor gene mutations

J. Wess, A. Spiegel, P. Goldsmith, 1996, Molecular and Cellular Endocrinology.

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

H. M. Geller, Fei Tan, Thomas E. McCann, 2008, Journal of Cell Science.

Y. Giudicelli, D. Lacasa, P. Goldsmith, 1996 .

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

J. Feramisco, J. Meinkoth, A. Spiegel, 1992, The Journal of biological chemistry.

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

D. Rubinsztein, A. Roach, A. Fleming, 2008, The Journal of Neuroscience.

Antiviral Protection Cell Cross-Presentation , CTL Responses , and Oligonucleotide Adjuvants Induce Dendritic TLR 3-Specific Double-Stranded RNA

D. Venzon, S. Epstein, D. Segal, 2011 .

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

P. Blumberg, S. Garfield, G. Czifra, 2011, Biochemical pharmacology.

Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.

P. Blumberg, P. Goldsmith, N. Kedei, 2013, Analytical biochemistry.