D. Kleinjan

发表

Long-range control of gene expression: emerging mechanisms and disruption in disease.

D. Kleinjan, V. van Heyningen, 2005, American journal of human genetics.

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

S. Aota, S. Dunwoodie, A. Cvekl, 2008, Development.

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

Philippe Gautier, Ralf Dahm, Giuseppe Damante, 2008, PLoS genetics.

Explorer Discovery and assessment of conserved Pax 6 target genes and enhancers

Kevin J. Chalmers, D. Kleinjan, P. Coutinho, 2017 .

Functional characteristics of novel pancreatic Pax6 regulatory elements

Adam Buckle, N. Gilbert, D. Kleinjan, 2018, Human molecular genetics.

Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

P. Klenerman, A. Mentzer, J. Marsh, 2022, medRxiv.

Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver

M. Mello, N. Gilbert, D. Kleinjan, 2014, BMC Endocrine Disorders.

Explorer Effects of Elevated Pax 6 Expression and Genetic Background on Mouse Eye Development

S. Chanas, R. Hill, D. Kleinjan, 2017 .

Effects of elevated Pax6 expression and genetic background on mouse eye development.

S. Chanas, R. Hill, D. Kleinjan, 2009, Investigative ophthalmology & visual science.

Escherichia coli chaperonins cpn60 (groEL) and cpn10 (groES) do not catalyse the refolding of mitochondrial malate dehydrogenase.

A. Miller, K. Maghlaoui, D. Kleinjan, 1993, The Biochemical journal.

Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences

D. Kleinjan, Shipra Bhatia, 2014, Human Genetics.

Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium

R. Mort, D. Kleinjan, J. West, 2009, BMC Developmental Biology.

Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.

Margaret B. Fish, R. Grainger, D. Kleinjan, 2013, American journal of human genetics.

Long-range downstream enhancers are essential for Pax6 expression

T. Ian Simpson, David J. Price, John O. Mason, 2006, Developmental biology.

Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6.

A. Schedl, D. Kleinjan, V. van Heyningen, 2001, Human molecular genetics.

Lampreys, the jawless vertebrates, contain three Pax6 genes with distinct expression in eye, brain and pancreas

B. Venkatesh, B. Tay, V. Ravi, 2019, Scientific Reports.

A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos.

S. Brenner, B. Venkatesh, V. Ravi, 2014, Developmental biology.

Identification of Genomic Regions Regulating Pax6 Expression in Embryonic Forebrain Using YAC Reporter Transgenic Mouse Lines

D. Price, J. Mason, Da Mi, 2013, PloS one.

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences

S. Brenner, B. Venkatesh, B. Tay, 2013, PLoS genetics.

DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region

D. McBride, Adam Buckle, D. Kleinjan, 2011, PloS one.

Long-range gene control and genetic disease.

L. Lettice, D. Kleinjan, 2008, Advances in genetics.

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

D. Price, J. Mason, Ian Simpson, 2006, BMC Developmental Biology.

Rounding up active cis-elements in the triple C corral: combining conservation, cleavage and conformation capture for the analysis of regulatory gene domains.

D. McBride, D. Kleinjan, Dirk A Kleinjan, 2004, Briefings in functional genomics & proteomics.

Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription.

A. Childs, D. Kleinjan, V. van Heyningen, 2004, Developmental biology.

Turned off by RNA

D. Kleinjan, V. Heyningen, 2003, Nature Genetics.

New 3′ elements control Pax6 expression in the developing pretectum, neural retina and olfactory region

B. Doe, D. Kleinjan, V. Heyningen, 2002, Mechanisms of Development.

PII: S0925-4773(01)00646-3

B. Doe, D. Kleinjan, V. Heyningen, 2002 .

Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance

G. Elgar, D. Kleinjan, V. van Heyningen, 2002, Mammalian Genome.

Discovery and assessment of conserved Pax6 target genes and enhancers.

Kevin J. Chalmers, D. Kleinjan, V. van Heyningen, 2011, Genome research.

Explorer The developmental regulator Pax 6 is essential for maintenance of islet cell function in the adult mouse pancreas

D. Kleinjan, Sébastien Mella, V. Heyningen, 2017 .

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas

D. Kleinjan, V. van Heyningen, Sébastien Mella, 2013, PloS one.

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

John D West, T Ian Simpson, Thomas Pratt, 2006, Development.

Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

S. Rosser, D. Kleinjan, C. Wardrope, 2017, Nature Communications.

Functional Assessment of Disease-Associated Regulatory Variants In Vivo Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

M. Vazquez, S. Lyonnet, J. Amiel, 2015, PLoS genetics.

Identification of Novel Craniofacial Regulatory Domains Located far Upstream of SOX9 and Disrupted in Pierre Robin Sequence

Axel Visel, Morad Ansari, Arnold Munnich, 2014, Human mutation.

Cloning and sequencing of the CRABP-I locus from chicken and pufferfish: analysis of the promoter regions in transgenic mice

F. Grosveld, J. Guy, D. Kleinjan, 2004, Transgenic Research.

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.

R. Anney, J. Quinn, G. O’Keeffe, 2015, Human molecular genetics.

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.

R. Anney, J. Quinn, G. O’Keeffe, 2015, Human molecular genetics.

Regulation of the CRABP-I gene during mouse embryogenesis

F. Grosveld, D. Kleinjan, S. Dekker, 1997, Mechanisms of Development.

Correction: Functional Assessment of Disease-Associated Regulatory Variants In Vivo Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

M. Vazquez, S. Lyonnet, F. Spitz, 2015, PLoS genetics.

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD

D. Cooper, N. Chuzhanova, M. Kamat, 2015, Human Genomics.

Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence

S. Sisodiya, M. Matarin, M. Dixon, 2013, Human molecular genetics.

Explorer Effects of Elevated Pax 6 Expression and Genetic Background on Mouse Eye Development

S. Chanas, D. Kleinjan, J. Collinson, 2016 .

Effects of elevated Pax6 expression and genetic background on mouse eye development.

R. Hill, D. Kleinjan, J. Collinson, 2009, Investigative ophthalmology & visual science.

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

G. Damante, P. Yeyati, R. Dahm, 2008, PLoS Genetics.

Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences

D. Kleinjan, Shipra Bhatia, Dirk A. Kleinjan, 2014, Human Genetics.

Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.

Margaret B. Fish, R. Grainger, D. Kleinjan, 2013, American journal of human genetics.