S. Sommer

发表

Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity.

G. Sarkar, S. Sommer, Gobinda Sarkar, 1989, Science.

Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG.

J. Buerstedde, C. Bottema, D. Koeberl, 1989, American journal of human genetics.

Identification of mutations in two families with sporadic hemophilia A

G. Sarkar, S. Sommer, C. Paynton, 1991, Human Genetics.

Nonrandom patterns of simple and cryptic triplet repeats in coding and noncoding sequences.

D. Ricke, B. Gostout, S. Sommer, 1995, Genomics.

[45] – Polymerase Chain Reaction Amplification of Specific Alleles: A General Method of Detection of Mutations, Polymorphisms, and Haplotypes

C. Bottema, G. Sarkar, S. Sommer, 1995 .

PCR amplification of specific alleles: rapid detection of known mutations and polymorphisms.

C. Bottema, S. Sommer, S. Sommer, 1993, Mutation research.

Polymerase chain reaction amplification of specific alleles: a general method of detection of mutations, polymorphisms, and haplotypes.

C. Bottema, G. Sarkar, S. Sommer, 1993, Methods in Enzymology.

Single-tube polymerase chain reaction for rapid diagnosis of the inversion hotspot of mutation in hemophilia A.

S. Sommer, Q. Liu, G. Nozari, 1998, Blood.

Bi-directional dideoxy fingerprinting (Bi-ddF): a rapid method for quantitative detection of mutations in genomic regions of 300-600 bp.

J. Feng, S. Sommer, S S Sommer, 1996, Human molecular genetics.

Detection of mutations by single-strand conformation polymorphism (SSCP) analysis and SSCP-hybrid methods.

E. Hovig, W. H. Warren, A. Børresen, 2001, Current protocols in human genetics.

Detection of virtually all mutations-SSCP (DOVAM-S): a rapid method for mutation scanning with virtually 100% sensitivity.

J. Feng, S. Sommer, L. Crawford, 1999, BioTechniques.

Dideoxy fingerprinting (ddE): a rapid and efficient screen for the presence of mutations.

G. Sarkar, S. Sommer, H. Yoon, 1992, Genomics.

Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP.

G. Sarkar, S. Sommer, H. Yoon, 1992, Nucleic acids research.

Phage Promoter-Based Methods for Sequencing and Screening for Mutations

S. Sommer, E. Vielhaber, 1994 .

Parameters affecting the sensitivities of dideoxy fingerprinting and SSCP.

S. Sommer, Q. Liu, 1994, PCR methods and applications.

Restriction endonuclease fingerprinting (REF): a sensitive method for screening mutations in long, contiguous segments of DNA.

S. Sommer, Q. Liu, 1995, BioTechniques.

Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting

D. Persing, Diana J L Williams, D. Williams, 1995, Journal of clinical microbiology.

"Cryptic" repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic: analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (TBP) genes.

B. Gostout, S. Sommer, Q. Liu, 1993, American journal of human genetics.

Specific amplification with PCR of a refractory segment of genomic DNA.

G. Sarkar, S. Sommer, T. Haqqi, 1988, Nucleic acids research.

Single-base discrimination mediated by proofreading inert allele specific Primers.

S. Sommer, Jia Zhang, Kai Li, 2005, Journal of biochemistry and molecular biology.

Proofreading genotyping assays mediated by high fidelity exo+ DNA polymerases.

K. Yao, S. Sommer, J. Pardinas, 2005, Trends in biotechnology.

Parameters affecting the yield of DNA from human blood.

S. Sommer, E. Bowie, J. Proper, 1987, Analytical biochemistry.

Mutagenic and Recombinagenic Responses to Defective DNA Polymerase δ Are Facilitated by the Rev1 Protein in pol3-t Mutants of Saccharomyces cerevisiae

A. Bailis, S. Sommer, Victoria L. Buettner, 2008, Genetics.

Segments containing alternating purine and pyrimidine dinucleotides: patterns of polymorphism in humans and prevalence throughout phylogeny.

G. Sarkar, S. Sommer, C. Paynton, 1991, Nucleic acids research.

Is Hydroxyurea Leukemogenic in Essential Thrombocythemia?

S. Antonarakis, S. Sommer, G. Nozari, 1998 .

Subcycling-PCR for multiplex long-distance amplification of regions with high and low GC content: application to the inversion hotspot in the factor VIII gene.

S. Sommer, Q. Liu, Qiang Liu, 1998, BioTechniques.

Characterization of polymerase chain reaction amplification of specific alleles.

C. Bottema, G. Sarkar, S. Sommer, 1990, Analytical biochemistry.

Toward a Fluorescent SSCP Technique that Detects all Mutations: F-DOVAM-S

C. Mroske, Jinong Feng, Jin Yan, 2009 .

Superb nucleotide discrimination by a novel on/off switch for DNA polymerization and its applications

S. Sommer, Lin-ling Chen, Jia Zhang, 2005, Molecular biotechnology.

PCR assay for the inversion causing severe Hemophilia A and its application.

Y. Guan, Y. Liang, S. Sommer, 1999, Chinese medical journal.

Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae.

R. Wickner, T. Icho, H. Lee, 1986, Basic life sciences.

Discrete mobility of single-stranded DNA in non-denaturing gel electrophoresis.

S. Sommer, W. Scaringe, Q. Liu, 2000, Nucleic acids research.

RNA amplification with transcript sequencing (RAWTS).

G. Sarkar, S. Sommer, 1988, Nucleic acids research.

DIRECT CARRIER TESTING IN 14 FAMILIES WITH HAEMOPHILIA B

D. Koeberl, S. Sommer, C. Bottema, 1989, The Lancet.

Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species.

D. Koeberl, G. Sarkar, S. Sommer, 1990, Genomics.

The "megaprimer" method of site-directed mutagenesis.

G. Sarkar, S. Sommer, G Sarkar, 1990, BioTechniques.

Formamide can dramatically improve the specificity of PCR.

G. Sarkar, S. Sommer, G Sarkar, 1990, Nucleic acids research.

PAP: Detection of ultra rare mutations depends on P* oligonucleotides: “Sleeping Beauties” awakened by the kiss of pyrophosphorolysis

S. Sommer, Qiang Liu, 2004, Human mutation.

Pyrophosphorolysis-activatable oligonucleotides may facilitate detection of rare alleles, mutation scanning and analysis of chromatin structures.

S. Sommer, Qiang Liu, 2002, Nucleic acids research.

Shedding light on PCR contamination

G. Sarkar, S. Sommer, GOBINDA SARKAR, 1990, Nature.

pK-matched running buffers for gel electrophoresis.

S. Sommer, Q. Liu, X. Li, 1999, Analytical biochemistry.

Toward Efficient Analysis of Mutations in Single Cells from Ethanol-Fixed, Paraffin-Embedded, and Immunohistochemically Stained Tissues

K. Hill, S. Sommer, Qiang Liu, 2002, Laboratory Investigation.

The generation of radiolabeled DNA and RNA probes with polymerase chain reaction.

S. Sommer, S S Sommer, D B Schowalter, 1989, Analytical biochemistry.

Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection.

M. O’Donovan, P. Oefner, P. McGuffin, 1998, Genomics.

Truncated amplification: a method for high-fidelity template-driven nucleic acid amplification.

P. Swiderski, S. Sommer, Qiang Liu, 2002, BioTechniques.

Microdissection and Molecular Analysis of Single Cells or Small Cell Clusters in Pathology and Diagnosis – Significance and Challenges

J. Rüschoff, K. Hill, S. Sommer, 2002, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

Pyrophosphorolysis-activated polymerization (PAP): application to allele-specific amplification.

S. Sommer, Q. Liu, Qiang Liu, 2000, BioTechniques.

Multiplex dosage pyrophosphorolysis-activated polymerization: application to the detection of heterozygous deletions.

S. Sommer, Qiang Liu, V. Nguyen, 2006, BioTechniques.

Genomic amplification with transcript sequencing.

D. Koeberl, G. Sarkar, S. Sommer, 1988, Science.

A novel method for detecting point mutations or polymorphisms and its application to population screening for carriers of phenylketonuria.

C. Bottema, S. Sommer, J. Sobell, 1989, Mayo Clinic proceedings.

More light on PCR contamination

G. Sarkar, S. Sommer, 1990, Nature.

Yeast L dsRNA consists of at least three distinct RNAs; evidence that the non-mendelian genes [HOK], [NEX] and [EXL] are on one of these dsRNAs

R. Wickner, S. Sommer, 1982, Cell.

SSCP analysis of long DNA fragments in low pH gel

T. Tahira, Y. Kukita, S. Sommer, 1997, Human mutation.

Sequencing of PCR Products — Analysis of Factor IX Genes and of Recombination Events in Immunoglobulin Genes

J. Buerstedde, S. Sommer, 1991 .

PCR amplification of specific alleles.

S. Sommer, 1992, Science.

PCR amplification of specific alleles (PASA) is a general method for rapidly detecting known single-base changes.

C. Bottema, S. Sommer, S S Sommer, 1992, BioTechniques.

Accurate prenatal diagnosis with novel polymerase chain reaction primers in a family with sporadic hemophilia A.

S. Kogan, M. Evans, J. Lusher, 1989, Obstetrics and gynecology.

Gene disruption indicates that the only essential function of the SKI8 chromosomal gene is to protect Saccharomyces cerevisiae from viral cytopathology.

R. Wickner, S. Sommer, Reed B. Wickner, 1987, Virology.

Simultaneous detection of multiple single-base alleles at a polymorphic site.

S. Sommer, C. Dutton, Sommer Ss, 1991, BioTechniques.

Detection of extremely rare alleles by bidirectional pyrophosphorolysis-activated polymerization allele-specific amplification (Bi-PAP-A): measurement of mutation load in mammalian tissues.

S. Sommer, Qiang Liu, 2004, BioTechniques.

Terbium identifies double-stranded RNA on gels by quenching the fluorescence of intercalated ethidium bromide.

S. Sommer, M. Al-Hakeem, 1987, Analytical biochemistry.

Removal of DNA contamination in polymerase chain reaction reagents by ultraviolet irradiation.

G. Sarkar, S. Sommer, G Sarkar, 1993, Methods in enzymology.

Comparison of direct and indirect methods of carrier detection in an X-linked disease.

C. Bottema, D. Koeberl, S. Sommer, 1990, American journal of medical genetics.

25 – DIRECT SEQUENCING WITH THE AID OF PHAGE PROMOTERS

J. Buerstedde, D. Koeberl, G. Sarkar, 1990 .

A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold Achlya ambisexualis.

D. Toft, S. Sommer, D. Schowalter, 1990, Genomics.

PAP-LMPCR for improved, allele-specific footprinting and automated chromatin fine structure analysis

A. Riggs, C. Bonifer, M. Hoogenkamp, 2008, Nucleic acids research.

Pyrophosphorolysis by Type II DNA polymerases: implications for pyrophosphorolysis-activated polymerization.

S. Sommer, Qiang Liu, 2004, Analytical biochemistry.

NIRCA: a rapid robust method for screening for unknown point mutations.

L. A. Martín, S. Sommer, S S Sommer, 1996, BioTechniques.

Overlapping PCR for bidirectional PCR amplification of specific alleles: a rapid one-tube method for simultaneously differentiating homozygotes and heterozygotes.

E. Thorland, J. Heit, S. Sommer, 1997, Genome research.

Double-stranded RNAs that encode killer toxins in Saccharomyces cerevisiae: unstable size of M double-stranded RNA and inhibition of M2 replication by M1

R. Wickner, S. Sommer, 1984, Molecular and cellular biology.

Microarray-based DNA resequencing using 3' blocked primers.

S. Sommer, Qiang Liu, J. Sram, 2008, Analytical biochemistry.

The size distributions of proteins, mRNA, and nuclear RNA

S. Sommer, J. Cohen, 1980, Journal of Molecular Evolution.

Screening the dopamine D1 receptor gene in 131 schizophrenics and eight alcoholics: identification of polymorphisms but lack of functionally significant sequence changes.

L. Heston, S. Sommer, J. Sobell, 1995, American journal of medical genetics.

Scanning by DOVAM-S detects all unique sequence changes in blinded analyses: evidence that the scanning conditions are generic.

R. Gatti, J. S. Chen, S. Sommer, 2000, BioTechniques.

Robust Dosage PCR (RD‐PCR) for Highly Accurate Dosage Analysis

S. Sommer, Qiang Liu, V. Nguyen, 2009, Current protocols in human genetics.

A large-scale validation of dosage analysis by robust dosage-polymerase chain reaction.

S. Sommer, Qiang Liu, V. Nguyen, 2007, Analytical biochemistry.

Elimination of locus-specific inter-individual variation in quantitative PCR.

S. Sommer, Jinxiu Shi, Qiang Liu, 2004, BioTechniques.

Robust dosage-PCR for detection of heterozygous chromosomal deletions.

S. Sommer, Jiesheng Chen, Qiang Liu, 2003, BioTechniques.

General method for amplifying regions of very high G+C content.

S. Sommer, C. Paynton, C. Dutton, 1993, Nucleic acids research.

The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth

H. Bussey, D. Slipetz, K. Hill, 1990, Molecular and cellular biology.

Haplotyping by double PCR amplification of specific alleles.

G. Sarkar, S. Sommer, 1991, BioTechniques.

Parameters affecting susceptibility of PCR contamination to UV inactivation.

G. Sarkar, S. Sommer, 1991, BioTechniques.

The pattern of spontaneous germ-line mutation: relative rates of mutation at or near CpG dinucleotides in the factor IX gene

B. Gostout, A. Shapiro, R. Ketterling, 1993, Human Genetics.

Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN

R. Wickner, S. Sommer, S. Ridley, 1984, Molecular and cellular biology.

Toward a fluorescent single-strand conformation polymorphism technique that detects all mutations: F-DOVAM-S.

C. Mroske, Jinong Feng, Jin Yan, 2007, Analytical biochemistry.

REF Select: expert system software for selecting restriction endonucleases for restriction endonuclease fingerprinting.

W A Scaringe, D Liao, Q Liu, 1999, BioTechniques.

The lognormal distribution fits the decay profile of eukaryotic mRNA.

S. Sommer, N. A. Rin, 1979, Biochemical and biophysical research communications.

Single‐cell immunohistochemical mutation load assay (SCIMLA) using human paraffin‐embedded tissues

L. Weiss, K. Hill, S. Sommer, 2003, Environmental and molecular mutagenesis.

Yeast KRE genes provide evidence for a pathway of cell wall beta-glucan assembly

C. Boone, H. Bussey, A. Hensel, 1990, The Journal of cell biology.

Inhibition of PCR amplification by a point mutation downstream of a primer.

E. Thorland, S. Sommer, Q. Liu, 1997, BioTechniques.

Co-curing of plasmids affecting killer double-stranded RNAs of Saccharomyces cerevisiae: [HOK], [NEX], and the abundance of L are related and further evidence that M1 requires L

R. Wickner, S. Sommer, 1982, Journal of bacteriology.

Response : Are Tissues a Patch Quilt of Ectopic Gene Expression?

G. Sarkar, S. Sommer, 1989, Science.

The sensitivity of denaturing gradient gel electrophoresis: a blinded analysis.

P. Gejman, F. Guedj, S. Sommer, 1998, Mutation research.

Denaturation fingerprinting: two related mutation detection methods especially advantageous for high G + C regions.

B. Weinshenker, D. Wingerchuk, S. Sommer, 1998, BioTechniques.

Yeast KRE Genes Provide Evidence for a Pathway of Cell Wall/ -Glucan Assembly

C. Boone, H. Bussey, A. Hensel, 2002 .