C. Savva

发表

Molecular basis of toxicity of Clostridium perfringens epsilon toxin

R. Titball, C. Naylor, A. Basak, 2011, The FEBS journal.

Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia

D. Moss, R. Titball, C. Naylor, 2014, Vaccine.

Crystal Structure of Rsr, an Ortholog of the Antigenic Ro Protein, Links Conformational Flexibility to RNA Binding Activity*

J. Sacchettini, A. Holzenburg, A. Ramesh, 2007, Journal of Biological Chemistry.

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

A. Barducci, Loïc GrandVuillemin, W. Bourguet, 2022, bioRxiv.

Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase

J. Sacchettini, M. Braunstein, D. Ronning, 2003 .

The terminase subunits pUL56 and pUL89 of human cytomegalovirus are DNA-metabolizing proteins with toroidal structure.

A. Holzenburg, L. Kolesnikova, C. Savva, 2002, Nucleic acids research.

Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes.

A. Holzenburg, E. Clerico, C. Savva, 2011, Biochemistry.

Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects.

A. Holzenburg, M. Soberón, A. Bravo, 2009, Biochimica et biophysica acta.

Conformational Changes That Effect Oligomerization and Initiate Pore Formation Are Triggered throughout Perfringolysin O upon Binding to Cholesterol*

A. Holzenburg, C. Savva, A. Johnson, 2007, Journal of Biological Chemistry.

The holin of bacteriophage lambda forms rings with large diameter

A. Holzenburg, D. Struck, C. Savva, 2008, Molecular microbiology.

Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids☆

R. Titball, F. Van Immerseel, A. Basak, 2013, Vaccine.

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens*

D. Moss, R. Titball, C. Naylor, 2012, The Journal of Biological Chemistry.

Clostridium perfringens from Analysis of NetB , a Pore-forming Toxin Molecular Architecture and Functional Protein Structure and Folding :

D. Moss, A. Cole, A. Basak, 2013 .

Asymmetric binding of membrane proteins to GroEL.

A. Holzenburg, H. Kaback, Jingchuan Sun, 2005, Archives of biochemistry and biophysics.

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

J. Sacchettini, W. Jacobs, Vivek Sharma, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein

T. G. Martin, R. Titball, C. Naylor, 2016, Nature Communications.

Structural Insights into Clostridium perfringens Delta Toxin Pore Formation

C. Naylor, M. Gibert, M. Popoff, 2013, PloS one.

Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies

D. Moss, R. Titball, C. Naylor, 2013, Protein science : a publication of the Protein Society.

Micron-scale holes terminate the phage infection cycle

Stanislav Vitha, Ry Young, S. Vitha, 2010, Proceedings of the National Academy of Sciences.

Structural relationships between small β-pore-forming toxins from Clostridium perfringens

R. Titball, C. Naylor, M. Popoff, 2015 .

The pore structure of Clostridium perfringens epsilon toxin

Alice R. Clark, A. R. Clark, D. Moss, 2019, Nature Communications.

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

P. Cole, J. Schwabe, N. Robertson, 2020, Cell reports.

Structure of the processive human Pol δ holoenzyme

S. Hamdan, A. De Biasio, F. Blanco, 2019, Nature Communications.

Insights into the structure of human cytomegalovirus large terminase subunit pUL56

A. Holzenburg, C. Savva, E. Bogner, 2004, FEBS letters.

Structural characterization of ribosome recruitment and translocation by type IV IRES

J. Murray, V. Ramakrishnan, I. S. Fernández, 2016, eLife.

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Sjors H. W. Scheres, Xiao-chen Bai, K. Nagai, 2015, Nature.

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

A. Hinnebusch, V. Ramakrishnan, J. Lorsch, 2014, Cell.

Structure of a bacterial type IV secretion core complex at subnanometre resolution

E. Orlova, G. Waksman, E. Pardon, 2013, The EMBO journal.

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

J. Ball, J. Sale, J. Schwabe, 2021, bioRxiv.

The topology of chromatin-binding domains in the NuRD deacetylase complex

J. Schwabe, L. Fairall, T. J. Ragan, 2020, Nucleic acids research.

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Kyle L. Morris, A. Roseman, S. Cowley, 2020, Nature Communications.

Holin triggering in real time

Kit Pogliano, Ry Young, K. Pogliano, 2010, Proceedings of the National Academy of Sciences.

Stable micron‐scale holes are a general feature of canonical holins

A. Holzenburg, C. Savva, R. Young, 2014, Molecular microbiology.

Structure of the lethal phage pinhole

Ry Young, D. Struck, C. Savva, 2009, Proceedings of the National Academy of Sciences.

The lambda spanin components Rz and Rz1 undergo tertiary and quaternary rearrangements upon complex formation

Ry Young, A. Holzenburg, C. Savva, 2010, Protein science : a publication of the Protein Society.

Burkholderia cenocepacia phage BcepMu and a family of Mu-like phages encoding potential pathogenesis factors.

J. Lipuma, Carlos Gonzalez, C. Savva, 2004, Journal of molecular biology.

Organization of DNA partners and strand exchange mechanisms during Flp site-specific recombination analyzed by difference topology, single molecule FRET and single molecule TPM.

R. Russell, A. Holzenburg, M. Jayaram, 2014, Journal of molecular biology.

Conformational changes and CO2-induced channel gating in connexin26

N. Dale, A. Cameron, D. Brotherton, 2022, Structure.

Conformational changes and channel gating induced by CO2 binding to Connexin26

N. Dale, M. Cann, A. Cameron, 2020, bioRxiv.

X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization

S. Scheres, J. Löwe, Shaoda He, 2016, Proceedings of the National Academy of Sciences.

Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB

D. Moss, R. Titball, C. Naylor, 2014, Toxins.

Structure of a C. perfringens enterotoxin mutant in complex with a modified Claudin-2 extracellular loop 2.

D. Moss, B. McClane, I. Blasig, 2014, Journal of molecular biology.

Solubilization and delivery by GroEL of megadalton complexes of the λ holin

A. Holzenburg, Jingchuan Sun, C. Savva, 2004 .

Author response: Structural characterization of ribosome recruitment and translocation by type IV IRES

J. Murray, V. Ramakrishnan, I. S. Fernández, 2016 .

Structural characterization of ribosome recruitment and translocation by type IV IRES

I. S. Fernández, B. Shin, C. Savva, 2016, eLife.

A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABA(A) counterpart.

H. Xue, A. Holzenburg, S. Tsang, 2001, Journal of molecular biology.