J. Leis

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The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

Andrew Pincetic, Zhizhou Kuang, E. Seo, 2010, Journal of Virology.

Defining the DNA substrate binding sites on HIV-1 integrase.

I. Weber, R. Harrison, J. Leis, 2009, Journal of molecular biology.

Programming the Rous Sarcoma Virus Protease to Cleave New Substrate Sequences (*)

A Wlodawer, C. Cameron, A. Wlodawer, 1996, The Journal of Biological Chemistry.

Human Immunodeficiency Virus, Type 1 Protease Substrate Specificity Is Limited by Interactions between Substrate Amino Acids Bound in Adjacent Enzyme Subsites (*)

A Wlodawer, C. Cameron, A. Wlodawer, 1996, The Journal of Biological Chemistry.

Crystal structure of a retroviral protease proves relationship to aspartic protease family

Maria Miller, Alexander Wlodawer, M. Jaskólski, 1989, Nature.

Modification of the megaprimer method of PCR mutagenesis: improved amplification of the final product.

A. Aiyar, J. Leis, Jonathan Leis, 1993, BioTechniques.

Evidence for splicing of avian sarcoma virus 5'-terminal genomic sequences into viral-specific RNA in infected cells.

M. Perdue, M. Collett, A. Faras, 1978, Proceedings of the National Academy of Sciences of the United States of America.

A covalent complex between retroviral integrase and nicked substrate DNA.

A. Skalka, M. Katzman, J. Leis, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Role of carbohydrate in determining the immunochemical properties of the major glycoprotein (gp71) of Friend murine leukemia virus

D. Bolognesi, P. H. Atkinson, J. Leis, 1975, Journal of virology.

Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases.

C. Cameron, A. Wlodawer, I. Weber, 1994, The Journal of biological chemistry.

RNA-dependent DNA polymerase activity of RNA tumor viruses. V. Rous sarcoma virus single-stranded RNA-DNA covalent hybrids in infected chicken embryo fibroblast cells.

J. Hurwitz, J. Leis, R. Ishizaki, 1975, Journal of virology.

Role of Nedd4 and Ubiquitination of Rous Sarcoma Virus Gag in Budding of Virus-Like Particles from Cells

G. Medina, J. Leis, Aiping Chen, 2004, Journal of Virology.

Preliminary crystallographic study of a retroviral protease.

A. Wlodawer, M. Miller, J. Leis, 1988, Journal of molecular biology.

HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro

Patrick L. Hindmarsh, R. Reeves, A. Skalka, 1999, Journal of Virology.

Retrovirus reverse transcription and integration

A. Aiyar, J. Leis, 1995 .

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro

A. Skalka, R. Katz, G. Merkel, 1990, Cell.

The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration

A. Skalka, R. Katz, M. Katzman, 1989, Journal of virology.

Reconstitution of concerted DNA integration with purified components.

Patrick L. Hindmarsh, J. Leis, P. Hindmarsh, 1999, Advances in virus research.

Mechanisms for Priming DNA Synthesis

M. DePamphilis, Jennifer T. Miller, M. Salas, 1996 .

5 for Priming DNA Synthesis

M. DePamphilis, Jennifer T. Miller, M. Salas, 1996 .

Analysis of Rous sarcoma virus capsid protein variants assembled on lipid monolayers.

E. Barklis, J. Leis, D. Huseby, 2002, Journal of molecular biology.

Isolation and characterization of an endonuclease from Escherichia coli specific for ribonucleic acid in ribonucleic acid-deoxyribonucleic acid hybrid structures.

J. Hurwitz, I. Berkower, J. Leis, 1973, The Journal of biological chemistry.

Mechanism of Action of the Endonuclease Associated with the αβ and ββ Forms of Avian RNA Tumor Virus Reverse Transcriptase

G. Duyk, A. Skalka, S. Johnson, 1983 .

Retroviral DNA Integration

Patrick L. Hindmarsh, J. Leis, P. Hindmarsh, 1984, Microbiology and Molecular Biology Reviews.

Modeling the Late Steps in HIV-1 Retroviral Integrase-catalyzed DNA Integration*

A. Skalka, J. Leis, J. Yi, 2000, The Journal of Biological Chemistry.

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses I. Directing Influence of DNA in the Reaction

J. Hurwitz, J. Leis, 1972, Journal of virology.

The Major Site of Phosphorylation within the Rous Sarcoma Virus MA Protein Is Not Required for Replication

J. Wills, T. Nelle, J. Leis, 1998, Journal of Virology.

Characterization of eukaryotic initiation factor 4A, a protein involved in ATP-dependent binding of globin mRNA.

M. Morgan, A. Shatkin, W. Merrick, 1982, The Journal of biological chemistry.

In vitro transcription of reconstituted 35s RNA.tRNAtrp template.primer complexes by the avian oncornavirus DNA polymerase. Effect of temperature on the size of the DNA transcripts.

J. Parsons, M. Collett, J. Leis, 1978, Virology.

The Mechanism of Budding of Retroviruses from Cell Membranes

Andrew Pincetic, J. Leis, 2009, Advances in virology.

Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting.

G. Medina, Andrew Pincetic, J. Leis, 2008, Virology.

An assembly domain of the Rous sarcoma virus Gag protein required late in budding

C. Cameron, J. Wills, C. Wilson, 1994, Journal of virology.

Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain

C. Cameron, J. Wills, J. Leis, 1996, Journal of virology.

Mutations Affecting Cleavage at the P10-capsid Protease Cleavage Site Block Rous Sarcoma Virus Replication Recommended Citation

I. Weber, E. Barklis, J. Leis, 2022 .

Characteristics and regulation of interaction of avian retrovirus pp12 protein with viral RNA

J. Leis, J. Jentoft, 1983, Journal of virology.

In vitro translation of a 180,000-dalton Rous sarcoma virus precursor polypeptide containing both the DNA polymerase and the group-specific antigens.

A. Hizi, J. Leis, R. Smith, 1978, Virology.

Correlation of RNA binding affinity of avian oncornavirus p19 proteins with the extent of processing of virus genome RNA in cells

J. Leis, R. Smith, P. Scheible, 1980, Journal of virology.

Identification of a DNA clone to phosphoenolpyruvate carboxykinase (GTP) from rat cytosol. Alterations in phosphoenolpyruvate carboxykinase RNA levels detectable by hybridization.

H. Yoo-Warren, R. Hanson, J. Leis, 1981, The Journal of biological chemistry.

Site-directed mutagenesis using overlap extension PCR.

A. Aiyar, J. Leis, Y. Xiang, 1996, Methods in molecular biology.

Production of large amounts of 35S RNA and complementary DNA from avian RNA tumor viruses.

J. Leis, R. Smith, S. Nebes, 1977, Analytical biochemistry.

Proteolytic processing of avian sarcoma and leukosis viruses pol-endo recombinant proteins reveals another pol gene domain

A. Skalka, R. Crowl, J. Leis, 1987, Journal of virology.

RNA-dependent DNA polymerase activity of RNA tumor viruses. V. Rous sarcoma virus single-stranded RNA-DNA covalent hybrids in infected chicken embryo fibroblast cells

J. Hurwitz, J. Leis, R. Ishizaki, 1975 .

Standardized and simplified nomenclature for proteins common to all retroviruses

D. Baltimore, S. Goff, J. Coffin, 1988, Journal of virology.

Protein chain initiation by methionyl-tRNA in wheat embryo.

D. Weeks, A. Marcus, J. Leis, 1970, Proceedings of the National Academy of Sciences of the United States of America.

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses II. Directing Influence of RNA in the Reaction

J. Hurwitz, J. Leis, 1972, Journal of virology.

3 Regulation of Initiation of Reverse Transcription of Retroviruses

A. Aiyar, J. Leis, D. Cobrinik, 1993 .

Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription

H. Kung, A. Aiyar, J. Leis, 1992, Journal of virology.

A specific orientation of RNA secondary structures is required for initiation of reverse transcription

A. Aiyar, J. Leis, Z. Ge, 1994, Journal of virology.

Isolation and characterization of a ribonuclease from human leukemic blood cells specific for ribonucleic acid of ribonucleic acid-deoxyribonucleic acid hybrid molecules.

R. Gallo, J. Leis, M. Sarngadharan, 1975, The Journal of biological chemistry.

Mechanism of action of ribonuclease H isolated from avian myeloblastosis virus and Escherichia coli.

J. Hurwitz, I. Berkower, J. Leis, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Multiple biological roles associated with the Rous sarcoma virus 5' untranslated RNA U5-IR stem and loop

S. Morris, J. Leis, J. Miller, 1997, Journal of virology.

Selection of functional mutations in the U5-IR stem and loop regions of the Rous sarcoma virus genome

E. Stavnezer, J. Leis, Aiping Chen, 2004, BMC Biology.

Replication of Avian Sarcoma Virus In Vivo Requires an Interaction between the Viral RNA and the TψC Loop of the tRNATrp Primer

E. Stavnezer, J. Leis, S. Morris, 2002, Journal of Virology.

Effects of phosphorylation of avian retrovirus nucleocapsid protein pp12 on binding of viral RNA.

L. Collins, S. Johnson, J. Leis, 1984, The Journal of biological chemistry.

Development of Drug Resistance to HIV-1 Protease Inhibitors (*)

J. Leis, T. Ridky, 1995, The Journal of Biological Chemistry.

A. Aiyar, A. Kikonyogo, J. Leis, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag

L. Verplank, A. Kikonyogo, J. Leis, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Site-specific phosphorylation of avian retrovirus nucleocapsid protein pp12 regulates binding to viral RNA. Evidence for different protein conformations.

N. Phillips, J. Leis, X. Fu, 1985, The Journal of biological chemistry.

Avian sarcoma and leukosis virus pol-endonuclease recognition of the tandem long terminal repeat junction: minimum site required for cleavage is also required for viral growth

A. Skalka, R. Katz, J. Leis, 1987, Journal of virology.

Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini

A. Skalka, A. Aiyar, J. Leis, 1996, Journal of virology.

Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription

A. Aiyar, M. Katzman, J. Leis, 1991, Journal of virology.

Avian retroviral protease and cellular aspartic proteases are distinguished by activities on peptide substrates.

A. Skalka, M. Kotler, R. Katz, 1989, The Journal of biological chemistry.

Structure of the aspartic protease from Rous sarcoma retrovirus refined at 2-A resolution.

M. Jaskólski, A. Wlodawer, M. Miller, 1989, Biochemistry.

A retroviral RNA secondary structure required for efficient initiation of reverse transcription

J. Leis, D. Cobrinik, L. Soskey, 1988, Journal of virology.

Circles with two tandem long terminal repeats are specifically cleaved by pol gene-associated endonuclease from avian sarcoma and leukosis viruses: nucleotide sequences required for site-specific cleavage

P. Dehaseth, G. Duyk, A. Skalka, 1985, Journal of virology.

Phosphorylation of avian retrovirus matrix protein by Ca2+/phospholipid-dependent protein kinase.

N. Phillips, J. Leis, X. Fu, 1989, European journal of biochemistry.

Protein chain initiation by methionyl-tRNA.

J. Leis, E. Keller, 1970, Biochemical and biophysical research communications.

HIV-1 Integrase Interaction with U3 and U5 Terminal Sequences in Vitro Defined Using Substrates with Random Sequences* 210

J. Leis, E. Brin, 2002, The Journal of Biological Chemistry.

Changes in the Mechanism of DNA Integration in Vitro Induced by Base Substitutions in the HIV-1 U5 and U3 Terminal Sequences*

J. Leis, E. Brin, 2002, The Journal of Biological Chemistry.

Base-Pair Substitutions in Avian Sarcoma Virus U5 and U3 Long Terminal Repeat Sequences Alter the Process of DNA Integration In Vitro

Patrick L. Hindmarsh, R. Reeves, J. Leis, 2001, Journal of Virology.

Altered Rous sarcoma virus Gag polyprotein processing and its effects on particle formation

J. Leis, T. Ridky, J Leis, 1997, Journal of virology.

Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends*

I. Weber, R. Harrison, J. Leis, 2006, Journal of Biological Chemistry.

Selective cleavage in the avian retroviral long terminal repeat sequence by the endonuclease associated with the alpha beta form of avian reverse transcriptase.

G. Duyk, A. Skalka, J. Leis, 1983, Proceedings of the National Academy of Sciences of the United States of America.

A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains.

C. Cameron, I. Weber, A. Skalka, 1991, The Journal of biological chemistry.

Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli

A. Skalka, M. Katzman, J. Leis, 1988, Journal of virology.

Rous sarcoma virus p19 binds to specific double-stranded regions of viral RNA: effect of p19 on cleavage of viral RNA by RNase III.

R. W. Green, J. Leis, J. McGinnis, 1978, Virology.

Budding of Enveloped Viruses: Interferon-Induced ISG15—Antivirus Mechanisms Targeting the Release Process

E. Seo, J. Leis, 2012, Advances in virology.

Mechanism of Inhibition of Retrovirus Release from Cells by Interferon-Induced Gene ISG15

Zhizhou Kuang, E. Seo, J. Leis, 2011, Journal of Virology.

Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

C. Luan, J. Audia, J. Leis, 2021, Journal of Virology.

Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells

C. Luan, J. Audia, J. Leis, 2020, bioRxiv.

Molecular modeling of the HIV-1 protease and its substrate binding site.

A Wlodawer, M. Jaskólski, A. Wlodawer, 1989, Science.

N-formylmethionyl-tRNA of wheat chloroplasts. Its synthesis by a wheat transformylase.

J. Leis, E. Keller, 1971, Biochemistry.

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

N. Tjandra, C. Luan, M. Strub, 2017, Nature Communications.

The Functionally Exchangeable L Domains in RSV and HIV‐1 Gag Direct Particle Release Through Pathways Linked by Tsg101

E. Gottwein, G. Medina, J. Leis, 2005, Traffic.

Conserved cysteine and histidine residues of the avian myeloblastosis virus nucleocapsid protein are essential for viral replication but are not "zinc-binding fingers".

M. Johnson, L. M. Smith, J. Leis, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Site-directed mutagenesis of the avian retrovirus nucleocapsid protein, pp 12. Mutation which affects RNA binding in vitro blocks viral replication.

A. Skalka, R. Katz, J. Leis, 1988, The Journal of biological chemistry.

RNA-dependent DNA polymerase of avian sarcoma virus B77. II. Comparison of the catalytic properties of the alpha, beta2, and alphabeta enzyme forms.

A. Hizi, J. Leis, W. Joklik, 1977, The Journal of biological chemistry.

Changes in Rous Sarcoma Virus RNA Secondary Structure near the Primer Binding Site upon tRNATrpPrimer Annealing

J. Leis, S. Morris, 1999, Journal of Virology.

Avian retrovirus nucleocapsid protein, pp12, produced in Escherichia coli has biochemical properties identical to unphosphorylated viral protein.

A. Skalka, R. Katz, J. Leis, 1986, Gene.

Cyanogen bromide digestion of the avian myeloblastosis virus pp19 protein: isolation of an amino-terminal peptide that binds to viral RNA

T. Vanaman, M. Veigl, J. Leis, 1983, Journal of virology.

Unwinding-like activity associated with avian retrovirus RNA-directed DNA polymerase

M. Collett, J. Leis, M. Smith, 1978, Journal of virology.

Avian Sarcoma Virus and Human Immunodeficiency Virus, Type 1 Use Different Subsets of ESCRT Proteins to Facilitate the Budding Process*

G. Medina, Andrew Pincetic, J. Leis, 2008, Journal of Biological Chemistry.

Integrase: Structure, Function, and Mechanism

J. Leis, J. Dolan, 2009 .

RNA-dependent DNA polymerase activity of RNA tumor virus. VI. Processive mode of action of avian myeloblastosis virus polymerase

J. Leis, 1976, Journal of virology.

Studies on Transcription and Ligation of RNA

J. Hurwitz, J. Leis, R. Silber, 1972 .

Mutations that alter the activity of the Rous sarcoma virus protease.

A Wlodawer, C. Cameron, A. Wlodawer, 1992, The Journal of biological chemistry.

[15] RNA-dependent DNA polymerase from avian myeloblastosis virus

J. Hurwitz, J. Leis, 1974 .

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

N. Tjandra, C. Luan, M. Strub, 2017, Nature Communications.

Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases.

A Wlodawer, C. Cameron, A. Wlodawer, 1993, The Journal of biological chemistry.

Synthetic peptides as substrates and inhibitors of a retroviral protease.

A. Skalka, M. Kotler, R. Katz, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Rous Sarcoma Virus Retropepsin and Avian Myeloblastosis Virus Retropepsin

J. Leis, 2004 .

Structural basis for specificity of retroviral proteases.

J. Louis, I. Weber, R. Harrison, 1998, Biochemistry.

Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates.

A Wlodawer, C. Cameron, A. Wlodawer, 1992, The Journal of biological chemistry.

Site-directed mutagenesis of the avian retrovirus nucleocapsid protein, pp 12, at Serine 40, the primary site of phosphorylation in vivo.

J. Leis, X. Fu, P. T. Tuazon, 1988, Journal of Biological Chemistry.

The RNA-dependent DNA polymerase of avian sarcoma virus B77. Binding of viral and nonviral ribonucleic acids to the alpha, beta2, and alphabeta forms of the enzyme.

A. Hizi, J. Leis, W. Joklik, 1977, The Journal of biological chemistry.

Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.

A Wlodawer, A. Wlodawer, I. Weber, 1998, Biochemistry.

Isolation and characterization of a protein that stimulates DNA synthesis from avian myeloblastosis virus.

J. Hurwitz, J. Leis, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Mutations affecting cleavage at the p 10-capsid protease cleavage site block Rous sarcoma virus replication

I. Weber, E. Barklis, J. Leis, 2015 .

Characteristics andRegulation ofInteraction ofAvian Retrovirus ppl2Protein withViral RNA

J. Leis, J. Jentoft, 1983 .

Protein Chain-Initiating Methionine tRNAs in Chloroplasts and Cytoplasm of Wheat Leaves.

J. Leis, E. Keller, 1970, Proceedings of the National Academy of Sciences of the United States of America.