A. Bosque

发表

Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells.

V. Planelles, C. Rodesch, Peter W. Ramirez, 2014, Cell reports.

HIV latency and integration site placement in five cell-based models

Mary K. Lewinski, R. Siliciano, F. Bushman, 2013, Retrovirology.

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

E. Zimmerman, V. Planelles, Z. Davis, 2009, PLoS pathogens.

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

A. Spivak, D. Margolis, N. Archin, 2017, Cell reports.

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

A. Spivak, V. Planelles, A. Bosque, 2016, Retrovirology.

Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

J. Round, M. Lichterfeld, D. Margolis, 2013, Retrovirology.

An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes

Amit A. Joshi, A. Bosque, M. Catálfamo, 2021, Scientific Reports.

Cell cycle regulation by FasL and Apo2L/TRAIL in human T‐cell blasts. Implications for autoimmune lymphoproliferative syndromes

A. Anel, J. Naval, E. Paz-Artal, 2008, Journal of leukocyte biology.

Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr.

Kelsey R. Cone, N. Krogan, V. Planelles, 2015, Virology.

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents

A. Spivak, V. Planelles, R. B. Jones, 2020, Antimicrobial Agents and Chemotherapy.

Generation of rabbit antibodies against death ligands by cDNA immunization.

M. Martínez-Lorenzo, A. Anel, J. Naval, 2006, Journal of immunological methods.

Saturated free fatty acid release and intracellular ceramide generation during apoptosis induction are closely related processes.

A. Anel, A. Piñeiro, J. Naval, 2003, Biochimica et biophysica acta.

Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss.

A. Anel, J. Naval, A. Bosque, 2007, Molecular immunology.

Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL.

M. Martínez-Lorenzo, A. Anel, A. Piñeiro, 2007, Clinical immunology.

Down‐regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c‐ FLIP, Bim, or Bcl‐x isoform expression

M. Martínez-Lorenzo, A. Anel, A. Piñeiro, 2005, Journal of leukocyte biology.

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

C. White, C. Woelk, V. Planelles, 2014, Retrovirology.

Sulfonation pathway inhibitors block reactivation of latent HIV-1.

John A. Young, C. Spina, P. Ahlquist, 2014, Virology.

non-apoptopic Fas/CD95 signalling The induction of Bim expression in human T cell blasts is dependent on

A. Anel, J. Naval, M. Alava, 2013 .

THE INDUCTION OF BIM EXPRESSION IN HUMAN T CELL BLASTS IS DEPENDENT ON NON-APOPTOTIC FAS/CD95 SIGNALLING Running title: Bim expression and Fas/CD95 signalling

A. Anel, J. Naval, M. Alava, 2006 .

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells

A. Weyrich, V. Planelles, M. Famiglietti, 2011, PLoS pathogens.

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals

A. Butte, W. Greene, D. Aran, 2020, PLoS pathogens.

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation

K. Crandall, J. Richard, A. Finzi, 2022, Journal of virology.

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

Doron Betel, Paul Zumbo, T. Chun, 2022, Nature communications.

Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.

A. Spivak, V. Planelles, A. B. DePaula-Silva, 2016, AIDS research and human retroviruses.

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation In Vitro

R. Schinazi, V. Planelles, A. Bosque, 2014, Antimicrobial Agents and Chemotherapy.

The Cultured TCM Model of HIV Latency.

A. Bosque, 2022, Methods in molecular biology.

The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency

R. B. Jones, A. Bosque, Szu-han Huang, 2021, Journal of Virology.

Micro RNA targets in HIV latency - insights into novel layers of latency control.

Ashley I Heinson, C. Spina, B. MacArthur, 2020, AIDS research and human retroviruses.

Human Immunodeficiency Virus Type 1 Vif Induces Cell Cycle Delay via Recruitment of the Same E3 Ubiquitin Ligase Complex That Targets APOBEC3 Proteins for Degradation

R. Harris, V. Planelles, A. Bosque, 2008, Journal of Virology.

Human Immunodeﬁciency Virus Type 1 Vif Induces Cell Cycle Delay via Recruitment of the Same E3 Ubiquitin Ligase Complex That Targets APOBEC3 Proteins for Degradation (cid:1) ‡

R. Harris, V. Planelles, A. Bosque, 2008 .

Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL

M. Martínez-Lorenzo, A. Anel, J. Naval, 2005, European journal of immunology.

BIRC2/cIAP1 Suppresses HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

R. König, F. Bushman, John A. Young, 2015 .

PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function

Elizabeth E. Sweeney, R. B. Jones, A. Bosque, 2020, Nano Research.

Apo 2 L / TRAIL is an indirect mediator of apoptosis induced by interferon-a in human myeloma cells

A. Anel, J. Naval, A. Bosque, 2005 .

An ultrasensitive planar array p24 Gag ELISA to detect individual HIV-1 viral particles and infected cells

Amit A. Joshi, A. Bosque, C. Levinger, 2021 .

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

A. Bosque, I. Sarabia, 2019, Viruses.

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.

Alberto Bosque, Vicente Planelles, V. Planelles, 2009, Blood.

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

E. Verdin, V. Planelles, S. Kauder, 2009, PLoS pathogens.

Apo2L/TRAIL and immune regulation.

M. Martínez-Lorenzo, A. Anel, A. Piñeiro, 2007, Frontiers in bioscience : a journal and virtual library.

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists

A. Bosque, A. Macedo, C. Novis, 2019, Front. Immunol..

Interferon-Mediated Long Non-Coding RNA Response in Macrophages in the Context of HIV

A. Spivak, V. Planelles, L. Vandekerckhove, 2020, International journal of molecular sciences.

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Ryan M. O’Connell, J. Round, R. Fujinami, 2017, Proceedings of the National Academy of Sciences.

Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs

C. Kovacs, R. B. Jones, A. Bosque, 2021, Journal of virology.

Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs

R. B. Jones, C. Kovacs, A. Bosque, 2020, bioRxiv.

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activation

K. Crandall, A. Bosque, A. Macedo, 2021, bioRxiv.

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

R. Siliciano, B. Walker, D. Nixon, 2018, The Journal of clinical investigation.

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

A. Anel, J. Naval, M. Simon, 2004, The Journal of cell biology.

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

Eric Verdin, Celsa A. Spina, Alberto Bosque, 2013, PLoS pathogens.

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells.

V. Planelles, A. Bosque, 2011, Methods.

Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+ T Cells

A. Rice, V. Planelles, M. Famiglietti, 2012, Journal of Virology.

Quantitative DY‐maleimide‐based proteomic 2‐DE‐labeling strategies using human skin proteins

A. Anel, M. Schnölzer, Patrick R Merz, 2009, Proteomics.

An HIV-Encoded Antisense Long noncoding RnA Epigenetically Regulates Viral Transcription

K. Morris, Sheena M Saayman, Amanda Ackley, 2022 .

An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.

Alberto Bosque, Vicente Planelles, K. Morris, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

R. Siliciano, Shannan J. Ho Sui, S. Amr, 2016, Journal of Virology.

Kinase Control of Latent HIV-1 Infection: PIM-1 Kinase as a Major Contributor to HIV-1 Reactivation

O. Kutsch, C. Willey, Jennifer Jones, 2013, Journal of Virology.

BCL-2 antagonism sensitizes cytotoxic t cell-resistant hiv reservoirs to elimination ex vivo.

C. Kovacs, C. Bollard, R. B. Jones, 2020, The Journal of clinical investigation.

HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins

V. Planelles, M. Szaniawski, Peter W. Ramirez, 2015, Retrovirology.

BCL-2 Antagonism Sensitizes CTL-Resistant HIV Reservoirs to Elimination Ex Vivo

C. Bollard, R. B. Jones, W. Hardy, 2019, SSRN Electronic Journal.

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1

M. Hudgens, J. Parker, S. Selitsky, 2023, bioRxiv.

IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells

T. Myers, A. Bosque, C. Levinger, 2021, iScience.

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.

R. König, F. Bushman, John A. Young, 2015, Cell host & microbe.

Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4+ T Cells from Aviremic Patients

A. Spivak, V. Planelles, A. Bosque, 2015, Antimicrobial Agents and Chemotherapy.

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

C. Spina, N. Beliakova-Bethell, C. White, 2019, PloS one.

Influence of Biological Sex, Age, and HIV Status in an In Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus.

D. Nixon, A. Spivak, V. Planelles, 2018, AIDS research and human retroviruses.

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model

D. Richman, C. Spina, D. Margolis, 2016, PLoS pathogens.

Sex Influences SAMHD1 Activity and Susceptibility to Human Immunodeficiency Virus-1 in Primary Human Macrophages

A. Spivak, V. Planelles, M. Szaniawski, 2018, The Journal of infectious diseases.

Dual TLR2 and TLR7 agonists as HIV latency-reversing agents.

A. Spivak, V. Planelles, R. B. Jones, 2018, JCI insight.

OP 5.2 – 00070 Characterization of a dual PTPN1/PTPN2 inhibitor to target latent HIV reservoirs

L. Trautmann, R. B. Jones, A. Bosque, 2022, Journal of virus eradication.

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

B. Walker, C. Kovacs, J. Mellors, 2017, PLoS pathogens.

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.

A. Anel, J. Naval, M. Alava, 2007, Blood.

Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation.

A. Anel, J. Gómez-Rial, E. Paz-Artal, 2007, Immunobiology.

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.

A. Anel, J. Gómez-Rial, E. Paz-Artal, 2006, Blood.

Antibody and T-cell responses to coronavirus disease 2019 vaccination in common variable immunodeficiency and specific antibody deficiency

R. Lynch, R. Amdur, A. Bosque, 2023, Annals of Allergy, Asthma & Immunology.

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition

A. Spivak, M. Tremblay, V. Planelles, 2018, mBio.

Fingolimod inhibits multiple stages of the HIV-1 life cycle

M. Bukrinsky, L. Dubrovsky, R. Fromentin, 2020, PLoS pathogens.

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

A. Anel, J. Naval, M. Alava, 2016, Oncotarget.

PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent.

A. Bosque, Rohan Fernandes, P. Balakrishnan, 2023, Nanomedicine.

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS

A. Spivak, C. Hill, L. Trautmann, 2021, Frontiers in Immunology.

Ocular ultrasonography focused on the posterior eye segment: what radiologists should know

A. Bosque, Marcela De La Hoz Polo, Anna Torramilans Lluís, 2016 .

cells Induction of HIV-1 latency and reactivation in primary memory CD4+ T

V. Planelles, A. Bosque, 2013 .

Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits

D. Pennington, H. Hackstein, A. Bosque, 2023, Frontiers in Immunology.

HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins

V. Planelles, M. Szaniawski, Peter W. Ramirez, 2015, Retrovirology.

Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation

A. Bosque, R. Resop, 2022, Journal of virology.

Kinase Control Prevents HIV-1 Reactivation in Spite of High Levels of Induced NF-κB Activity

O. Kutsch, Jennifer Jones, V. Planelles, 2012, Journal of Virology.

Activity B κ in Spite of High Levels of Induced NF- Kinase Control Prevents HIV-1 Reactivation

O. Kutsch, Jennifer Jones, V. Planelles, 2012 .

Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon‐α in human myeloma cells

A. Anel, J. Naval, A. Bosque, 2005 .

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

A. Spivak, V. Planelles, A. Bosque, 2016, Retrovirology.

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro

V. Planelles, L. Barrows, A. Bosque, 2017, PloS one.

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

A. Anel, J. Naval, M. Simon, 2004, The Journal of cell biology.

IL-15 and N-803 for HIV Cure Approaches

A. Bosque, J. Howard, 2023, Viruses.

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

A. Anel, J. Naval, M. Alava, 2016, OncoTarget.

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.

V. Planelles, A. Bosque, 2009, Blood.

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model

D. Richman, C. Spina, D. Margolis, 2016, PLoS pathogens.

Dual TLR2 and TLR7 agonists as HIV latency-reversing agents.

A. Spivak, V. Planelles, A. Bosque, 2018, JCI insight.

Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

J. Round, M. Lichterfeld, D. Margolis, 2013, Retrovirology.

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

R. Siliciano, Shannan J. Ho Sui, S. Amr, 2016, Journal of Virology.

AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo

E. Boritz, A. Bosque, P. Ehrenberg, 2023, iScience.

Editorial: Immunotherapies Towards HIV Cure

A. Bosque, C. Garrido, M. Salgado, 2021, Frontiers in Cellular and Infection Microbiology.

An HIV-Encoded Antisense Long Noncoding RNA Epigenetically Regulates Viral Transcription.

K. Morris, Sheena M Saayman, Amanda Ackley, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

BIRC 2 / cIAP 1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency Graphical

F. Bushman, S. Chanda, A. Spivak, 2022 .

Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon-alpha in human myeloma cells.

A. Anel, J. Naval, A. Bosque, 2005, FEBS letters.

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1

Sara R. Selitsky, M. Hudgens, N. Goonetilleke, 2023, Frontiers in immunology.