J. Kwakkel

发表

Tissue thyroid hormone metabolism is differentially regulated during illness in mice.

E. Fliers, M. Ackermans, A. H. van der Spek, 2017, The Journal of endocrinology.

A novel role for the thyroid hormone-activating enzyme type 2 deiodinase in the inflammatory response of macrophages.

E. Fliers, J. Stap, A. Boelen, 2014, Endocrinology.

Effects of adrenalectomy on daily gene expression rhythms in the rat suprachiasmatic and paraventricular hypothalamic nuclei and in white adipose tissue

A. Kalsbeek, E. Fliers, E. Foppen, 2015, Chronobiology international.

Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice

T. Kimman, T. Bestebroer, A. Boelen, 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Enhanced viral clearance in interleukin‐18 gene‐deficient mice after pulmonary infection with influenza A virus

S. Akira, R. Lutter, H. Jansen, 2005, Immunology.

Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism.

E. Fliers, W. Wiersinga, A. Boelen, 2010, Endocrinology.

Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness.

W. Wiersinga, A. Boelen, J. Kwakkel, 2008, The Journal of endocrinology.

Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake.

E. Fliers, W. Wiersinga, A. Boelen, 2006, The Journal of endocrinology.

Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells.

W. Wiersinga, A. Boelen, J. Kwakkel, 2007, The Journal of endocrinology.

Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA.

W. Wiersinga, A. Boelen, J. Kwakkel, 2006, The Journal of endocrinology.

Leptin administration restores the fasting-induced increase of hepatic type 3 deiodinase expression in mice.

A. Kalsbeek, E. Fliers, E. Vreugdenhil, 2012, Thyroid : official journal of the American Thyroid Association.

Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice.

E. Fliers, W. Wiersinga, A. Boelen, 2006, The Journal of endocrinology.

Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus‐induced interferon‐γ

T. Kimman, A. Boelen, J. Kwakkel, 2003 .

Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis.

W. Wiersinga, B. Mentrup, A. Boelen, 2004, European journal of endocrinology.

Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness.

W. Wiersinga, J. Köhrle, A. Boelen, 2004, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Thyroid hormone receptors in health and disease.

E. Fliers, A. Boelen, J. Kwakkel, 2012, Minerva endocrinologica.

Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.

E. Fliers, W. Wiersinga, J. Bassett, 2014, American journal of physiology. Endocrinology and metabolism.

Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat.

E. Fliers, W. Wiersinga, M. Ackermans, 2012, Thyroid : official journal of the American Thyroid Association.

Illness-induced changes in thyroid hormone metabolism: focus on the tissue level.

E. Fliers, A. Boelen, J. Kwakkel, 2011, The Netherlands journal of medicine.

Skeletal muscle deiodinase type 2 regulation during illness in mice.

E. Fliers, W. Wiersinga, M. Ackermans, 2009, The Journal of endocrinology.

Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae.

E. Fliers, A. Boelen, J. Kwakkel, 2009, Endocrinology.

Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice.

T. Kimman, T. Bestebroer, A. Boelen, 2000, Vaccine.

Interleukin-1β modulates endogenous thyroid hormone receptor α gene transcription in liver cells

W. Wiersinga, A. Boelen, J. Kwakkel, 2007 .

PGC-1α regulates the isoform mRNA ratio of the alternatively spliced thyroid hormone receptor α transcript

W. Wiersinga, W. Wiersinga, J. Kwakkel, 2006 .

Differential involvement of nuclear factor- (cid:1) B and activator protein-1 pathways in the interleukin-1 (cid:2) -mediated decrease of deiodinase type 1 and thyroid hormone receptor (cid:2) 1 mRNA

W. Wiersinga, A. Boelen, J. Kwakkel, 2006 .

NFκB signaling is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes.

A. Kalsbeek, E. Fliers, P. Barrett, 2014, Endocrinology.

Expression of 11β‐Hydroxysteroid Dehydrogenase Type 1 in the Human Hypothalamus

E. Fliers, D. Swaab, S. Lamberts, 2013, Journal of neuroendocrinology.

Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.

E. Fliers, A. Boelen, J. Kwakkel, 2011, Endocrine reviews.

Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation.

W. Wiersinga, A. Alkemade, T. Visser, 2005, Endocrinology.

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

V. Darras, H. van Toor, T. Visser, 2016, PloS one.

Thyroid Hormone Receptor β Mediates Acute Illness‐Induced Alterations in Central Thyroid Hormone Metabolism

E. Fliers, A. Boelen, J. Kwakkel, 2009, Journal of neuroendocrinology.

Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.

E. Fliers, W. Wiersinga, T. Visser, 2008, Thyroid : official journal of the American Thyroid Association.

Immunohistochemistry

Anke J. Borgers, A. Kalsbeek, E. Fliers, 2012 .

Down regulation of type 3 deiodinase in the hypothalamus during inflammation.

E. Fliers, M. Ackermans, A. Boelen, 2019, Thyroid : official journal of the American Thyroid Association.

Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice.

E. Fliers, W. Wiersinga, A. Alkemade, 2004, The Journal of endocrinology.

Thyroid hormone metabolism during inflammation and fasting

A. Kalsbeek, E. Fliers, F. Pfrieger, 2015 .

Effect of lack of Interleukin‐4, Interleukin‐12, Interleukin‐18, or the Interferon‐γ receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice

T. Kimman, A. Boelen, J. Kwakkel, 2002, Journal of medical virology.

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System

Anke J. Borgers, A. Kalsbeek, E. Fliers, 2012, Diabetes.

Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism.

E. Fliers, W. Wiersinga, A. Boelen, 2010, Endocrinology.