Steven Chen

发表

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery

Barry A. Bunin, C. Talcott, M. Sarker, 2015, PLoS neglected tropical diseases.

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

M. Arkin, C. Caffrey, Rahul Singh, 2019, Communications Biology.

A multi-dimensional, time-lapse, high content screening platform for the flatworm pathogen causing schistosomiasis

M. Arkin, C. Caffrey, Rahul Singh, 2019 .

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

A. Burlingame, J. Taunton, J. Gut, 2013, Beilstein journal of organic chemistry.

Lead Identification to Clinical Candidate Selection

F. Supek, J. Gut, A. Renslo, 2015, Journal of biomolecular screening.

Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

Brian M. Suzuki, J. Gut, M. Arkin, 2015, PLoS neglected tropical diseases.

In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets

Hao Li, M. Arkin, Jiashun Zheng, 2022, Frontiers in Pharmacology.

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

M. Arkin, K. Ang, J. McKerrow, 2011, PLoS neglected tropical diseases.

A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission.

Michael T. McManus, M. Arkin, K. Ang, 2018, Endocrinology.

Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries.

J. Marks, Steven Chen, P. Amersdorfer, 2002, Vaccine.

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.

J. Gut, A. Renslo, M. Arkin, 2015, Bioorganic & medicinal chemistry letters.

A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

M. Arkin, J. McKerrow, S. Reed, 2012, Nature Medicine.

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Michelle R. Arkin, Joseph Mulvaney, Jiri Gut, 2012, PLoS neglected tropical diseases.

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

J. McKerrow, G. De Muylder, W. Roush, 2015, PLoS neglected tropical diseases.

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

Michelle R. Arkin, Steven Chen, M. Arkin, 2010, Antimicrobial Agents and Chemotherapy.

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

Nick A. Paras, Hao Li, M. Sirota, 2021, eLife.

Multiparametric High‐Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug‐Induced Liver Injury

M. Arkin, K. Ang, Steven Chen, 2020, Current protocols in chemical biology.

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

A. Renslo, M. Arkin, P. Walter, 2016, eLife.

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development

M. Arkin, C. Caffrey, Steven Chen, 2018, Disease Models & Mechanisms.

High-Throughput Screening To Identify Potent and Specific Inhibitors of Microbial Sulfate Reduction.

M. Arkin, J. Coates, H. Carlson, 2017, Environmental science & technology.

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

M. Bogyo, M. Arkin, K. Ang, 2019, PloS one.

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Allison K. Doak, M. Arkin, T. J. Rettenmaier, 2014, Proceedings of the National Academy of Sciences.

A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery

M. Arkin, Su Guo, Z. Dong, 2016, PloS one.

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response

Michael T. McManus, M. Arkin, K. Ang, 2017, Diabetes.

Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis

Rahul Singh, Hyokyeong Lee, Daniel Asarnow, 2012, BMC Genomics.

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

M. Arkin, J. Reiter, Steven Chen, 2012, Proceedings of the National Academy of Sciences.

UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area.

Michelle R Arkin, Kenny K H Ang, Steven Chen, 2014, Combinatorial chemistry & high throughput screening.

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

M. Arkin, K. Ang, J. McKerrow, 2010, Antimicrobial Agents and Chemotherapy.

High-Throughput Screening To Identify Potent and Specific Inhibitors of Microbial Sulfate Reduction.

M. Arkin, J. Coates, H. Carlson, 2017, Environmental science & technology.