S. Thellung

发表

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds.

M. Mazzanti, Roberto Würth, S. Thellung, 2016, Drug discovery today.

Prion protein fragment 106–126 induces apoptotic cell death and impairment of L‐type voltage‐sensitive calcium channel activity in the GH3 cell line

G. Forloni, F. Tagliavini, M. Salmona, 1998, Journal of neuroscience research.

Amyloid Precursor Protein Modulates ERK‐1 and ‐2 Signaling

G. Schettini, S. Thellung, T. Florio, 2006, Annals of the New York Academy of Sciences.

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

M. Robello, V. Leuzzi, S. Thellung, 2012, BMC Neuroscience.

Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells

Roberto Würth, S. Thellung, T. Florio, 2020, Frontiers in Endocrinology.

Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis

D. Noonan, A. Albini, G. Schettini, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis

A. Ratto, S. Thellung, T. Florio, 2012, BMC Veterinary Research.

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

A. Simi, A. Pagano, S. Thellung, 2011, Cell Death and Disease.

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH‐secreting pituitary adenoma cells in vitro

S. Arena, G. Schettini, S. Thellung, 2003, Clinical endocrinology.

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro.

G. Gussoni, S. Arena, G. Schettini, 1999, European journal of endocrinology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2

P. Stork, S. Arena, G. Schettini, 2000, Journal of Physiology-Paris.

Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets

S. Thellung, T. Florio, M. Nizzari, 2022, Frontiers in Neuroscience.

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

A. Aceto, S. Thellung, T. Florio, 2012, Omics : a journal of integrative biology.

Amyloid Precursor Protein and Presenilin 1 Interaction Studied by FRET in Human H4 Cells

A. Diaspro, P. Bianchini, V. Caorsi, 2007, Annals of the New York Academy of Sciences.

MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment

G. Tonini, C. Zanon, P. Modesto, 2020, Biomedicines.

[The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PCCl3 thyroid cell proliferation].

A. Fusco, S. Arena, G. Schettini, 2001, Minerva endocrinologica.

Chemokine Stromal Cell-Derived Factor 1α Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals

M. Robello, S. Arena, G. Schettini, 2006, Molecular Pharmacology.

THE CHEMOKINE SDF1α INDUCES PROLIFERATION AND GROWTH HORMONE RELEASE IN GH4C1 RAT PITUITARY ADENOMA CELL LINE, THROUGH MULTIPLE INTRACELLULAR SIGNALS.

S. Arena, G. Schettini, S. Thellung, 2005 .

Expression of Somatostatin Receptor mRNA in Human Meningiomas and their Implication in in vitro Antiproliferative Activity

G. Lapertosa, S. Arena, G. Schettini, 2004, Journal of Neuro-Oncology.

SDF‐1 Controls Pituitary Cell Proliferation through the Activation of ERK1/2 and the Ca2+‐Dependent, Cytosolic Tyrosine Kinase Pyk2

M. Robello, S. Arena, G. Schettini, 2006, Annals of the New York Academy of Sciences.

Characterization of the Proapoptotic Intracellular Mechanisms Induced by a Toxic Conformer of the Recombinant Human Prion Protein Fragment 90–231

A. Aceto, G. Schettini, S. Thellung, 2006 .

p38 MAP Kinase Mediates the Cell Death Induced by PrP106–126 in the SH-SY5Y Neuroblastoma Cells

G. Damonte, F. Tagliavini, E. Millo, 2002, Neurobiology of Disease.

Ca2+-ATPase Pump Forms and an Endogenous Inhibitor in Bovine Brain Synaptosomes

I. Panfoli, A. Morelli, A. Cupello, 1997, Neurochemical Research.

Nitric Oxide Production Stimulated by the Basic Fibroblast Growth Factor Requires the Synthesis of Ceramide

G. Damonte, M. Filocamo, G. Spoto, 2002, Annals of the New York Academy of Sciences.

Amino‐Terminally Truncated Prion Protein PrP90‐231 Induces Microglial Activation in Vitro

A. Aceto, G. Schettini, M. Bisaglia, 2007, Annals of the New York Academy of Sciences.

Multiple biochemical similarities between infectious and non‐infectious aggregates of a prion protein carrying an octapeptide insertion

D. Harris, R. Chiesa, S. Thellung, 2008, Journal of neurochemistry.

P2X7 pre‐synaptic receptors in adult rat cerebrocortical nerve terminals: a role in ATP‐induced glutamate release

M. Marcoli, G. Maura, C. Cervetto, 2008, Journal of neurochemistry.

Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis.

Gianluca Damonte, Giuseppe Spoto, Umberto Benatti, 2003, Molecular pharmacology.

Oncogene transformation of PC Cl3 clonal thyroid cell line induces an autonomous pattern of proliferation that correlates with a loss of basal and stimulated phosphotyrosine phosphatase activity.

A. Fusco, M. T. Berlingieri, S. Salzano, 1997, Endocrinology.

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

A. Pagano, S. Thellung, A. Bajetto, 2020, Stem cells translational medicine.

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

S. Schenone, M. Mazzanti, P. Fiaschi, 2022, Journal of experimental & clinical cancer research : CR.

In vitro and in vivo characterization of stem‐like cells from canine osteosarcoma and assessment of drug sensitivity

A. Ratto, Roberto Würth, S. Thellung, 2018, Experimental cell research.

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

A. Pagano, Roberto Würth, S. Thellung, 2016, Oncotarget.

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

F. Mattioli, A. Pagano, A. Ratto, 2015, BMC Cancer.

Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm

Roberto Würth, S. Thellung, A. Bajetto, 2013, International journal of peptides.

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

F. Mattioli, A. Pagano, A. Ratto, 2015, BMC Cancer.

Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential.

M. Cilli, A. Ratto, S. Thellung, 2012, Experimental cell research.

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

Claudio Russo, A. Pagano, S. Thellung, 2012, Journal of toxicology.

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System

Roberto Würth, S. Thellung, T. Florio, 2014, International journal of endocrinology.

Role of Prion Protein Aggregation in Neurotoxicity

S. Thellung, T. Florio, M. Nizzari, 2012, International journal of molecular sciences.

Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms

S. Thellung, T. Florio, F. Barbieri, 2019, International journal of molecular sciences.

Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes.

G. Schettini, S. Thellung, T. Florio, 1999, Life sciences.

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

D. Noonan, A. Albini, M. Culler, 2003, Endocrinology.

Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants

H. Kretzschmar, A. Aceto, S. Thellung, 2007, Journal of neurochemistry.

Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells †

M. Mazzanti, S. Thellung, T. Florio, 2019, Cells.

Release‐Regulating Serotonin 5‐HT1D Autoreceptors in Human Cerebral Cortex

M. Raiteri, G. Maura, S. Thellung, 1993, Journal of neurochemistry.

Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma

Roberto Würth, S. Thellung, A. Bajetto, 2016, Expert opinion on drug discovery.

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

K. Cortese, C. Tacchetti, M. Gagliani, 2018, Cell Death & Disease.

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

M. Robello, S. Thellung, T. Florio, 2017, Neurotoxicity Research.

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.

M. Robello, F. Novelli, S. Thellung, 2016, Pharmacological research.

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

F. Novelli, S. Thellung, T. Florio, 2014, Molecular Neurobiology.

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

F. Novelli, S. Thellung, T. Florio, 2014, Molecular Neurobiology.

Intracellular accumulation of a mild‐denatured monomer of the human PrP fragment 90–231, as possible mechanism of its neurotoxic effects

A. Aceto, A. Perico, S. Thellung, 2007, Journal of neurochemistry.

Conformation Dependent Pro-Apoptotic Activity of the Recombinant Human Prion Protein Fragment 90-231

A. Aceto, P. Ballerini, G. Schettini, 2006, International Journal of Immunopathology and Pharmacology.

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Roberto Würth, S. Thellung, T. Florio, 2016, Current drug targets.

Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation

C. Ciniglia, F. Volpicelli, S. Thellung, 2015, PloS one.

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

M. Robello, S. Thellung, T. Florio, 2017, Neurotoxicity Research.

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein.

A. Aceto, T. Bucciarelli, S. Thellung, 2011, The international journal of biochemistry & cell biology.

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

S. Thellung, T. Florio, F. Barbieri, 2019, International journal of molecular sciences.

Identification of a Conserved N-Capping Box Important for the Structural Autonomy of the Prion α3-Helix: The Disease Associated D202N Mutation Destabilizes the Helical Conformation

G. Damonte, A. Aceto, M. Paci, 2005, International journal of immunopathology and pharmacology.

Efficacy of Novel Acridine Derivatives in the Inhibition of hPrP90-231 Prion Protein Fragment Toxicity

A. Sparatore, A. Aceto, F. Novelli, 2011, Neurotoxicity Research.

Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

A. Aceto, A. Simi, S. Thellung, 2009, Neurotoxicity Research.

Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

G. Forloni, F. Tagliavini, M. Salmona, 2000, Neurobiology of Disease.

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106–126

G. Forloni, F. Tagliavini, M. Salmona, 2000, International Journal of Developmental Neuroscience.

NITRIC OXIDE AND GABAA RECEPTOR FUNCTION THE RAT CEREBRAL CORTEX AND CEREBELLAR GRANULE CELLS

A. Cupello, M. Robello, S. Thellung, 1996, Neuroscience.

Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization.

A. Ratto, S. Thellung, A. Bajetto, 2016, The Japanese journal of veterinary research.

Serotonergic inhibition of the mossy fibre—granule cell glutamate transmission in rat cerebellar slices

M. Raiteri, G. Maura, S. Thellung, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment

M. Vassalli, M. Robello, S. Thellung, 2012, Neurotoxicity Research.

ERK1/2 and p38 MAP kinases control prion protein fragment 90–231‐induced astrocyte proliferation and microglia activation

A. Aceto, M. Robello, S. Thellung, 2007, Glia.

Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro

G. Schettini, S. Thellung, T. Florio, 2005 .

Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation

G. Damonte, A. Aceto, E. Millo, 2003, Annals of the New York Academy of Sciences.

A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.

G. Schettini, S. Thellung, T. Florio, 1999, Journal of molecular endocrinology.

Prolonged treatment with α-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats

R. Bonavia, S. Arena, G. Schettini, 1999, Aging.

TGF‐β1 prevents gp120‐induced impairment of Ca2+ homeostasis and rescues cortical neurons from apoptotic death

G. Schettini, S. Thellung, T. Florio, 1997, Journal of neuroscience research.

The Chemokine SDF1/CXCL12: A Novel Autocrine/Paracrine Factor Involved In Pituitary Adenoma Development

Roberto Würth, S. Thellung, A. Bajetto, 2011 .

The Activation of the Phosphotyrosine Phosphatase (cid:1) (r-PTP (cid:1) ) Is Responsible for the Somatostatin Inhibition of PC Cl3 Thyroid Cell Proliferation

A. Fusco, F. Trapasso, S. Arena, 2001 .

Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment

M. Vassalli, M. Robello, S. Thellung, 2013, Neurotoxicity Research.

DEVELOPMENT AND VALIDATION OF A GC-MS METHOD FOR DETERMINATION OF METFORMIN IN NORMAL BRAIN AND IN GLIOBLASTOMA TISSUES

M. Mazzanti, S. Thellung, T. Florio, 2023, Journal of Pharmaceutical and Biomedical Analysis.

Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization.

R. Vitale, P. Amodeo, E. Ioannou, 2020, Bioorganic chemistry.

The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation.

A. Fusco, F. Trapasso, S. Arena, 2001, Molecular endocrinology.

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein

G. Damonte, F. Tagliavini, A. Aceto, 2002, Neurochemistry International.

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

A. Aceto, G. Schettini, S. Thellung, 2006, Annals of the New York Academy of Sciences.

M. Robello, V. Leuzzi, S. Thellung, 2012, BMC Neuroscience.

Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure

A. Aceto, T. Bucciarelli, B. Maras, 2012, PloS one.

Characterization of two central AMPA-preferring receptors having distinct location, function and pharmacology

M. Raiteri, A. Pittaluga, G. Maura, 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

Chemokine Stromal Cell-Derived Factor 1α Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals

M. Robello, S. Arena, G. Schettini, 2006, Molecular Pharmacology.

Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity.

M. Dono, P. Fiaschi, D. De Pietri Tonelli, 2023, Neuro-oncology.

Effect of Nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes

A. Cupello, M. Robello, S. Thellung, 1997, Neurochemical Research.