R. Marchan

发表

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high‐resolution magic angle spinning 1H NMR spectroscopy

J. Rahnenführer, K. Edlund, J. Hengstler, 2018, NMR in biomedicine.

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway

J. Rahnenführer, K. Edlund, J. Hengstler, 2017, Analytical and Bioanalytical Chemistry.

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis.

A. Hierlemann, J. Kelm, J. Hengstler, 2015, Journal of biotechnology.

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.

U. Hofmann, L. Kuepfer, R. Gebhardt, 2016, Journal of hepatology.

Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Christian H. Holland, U. Hofmann, S. Dooley, 2021, Hepatology communications.

Adverse outcome pathways: opportunities, limitations and open questions

S. H. Bennekou, F. Oesch, S. Dooley, 2017, Archives of Toxicology.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Wolfgang Moritz, Wiebke Albrecht, Tim Brecklinghaus, 2019, Archives of Toxicology.

Correction: Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers

K. Ickstadt, J. Hengstler, S. Selinski, 2012, PloS one.

Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers

K. Ickstadt, J. Hengstler, S. Selinski, 2012, PloS one.

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Nils Blüthgen, Tanja Waldmann, Jan G. Hengstler, 2015, Archives of Toxicology.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

J. Rahnenführer, K. Edlund, O. Taboureau, 2018, Archives of Toxicology.

Highlight report: cytoprotective signaling in toxicology

H. Bolt, R. Marchan, 2015, Archives of Toxicology.

Recent developments in in vitro toxicology: perspectives of European research and Tox21

H. Bolt, R. Marchan, C. Thriel, 2013, Archives of Toxicology.

Pyrethroid insecticide neurotoxicity

J. Hengstler, C. van Thriel, R. Marchan, 2012, Archives of Toxicology.

Gene array screening for identification of drugs with low levels of adverse side effects

J. Hengstler, H. Bolt, R. Marchan, 2010, Archives of Toxicology.

Lung and breast cancer research: immunoglobulin Kappa C hits the headlines

R. Marchan, 2012, EXCLI journal.

Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes

J. Hengstler, J. Amin, P. Godoy, 2010, Biological chemistry.

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.

Alison J. Foster, Dominic P. Williams, J. Rahnenführer, 2021, Chemico-biological interactions.

Bile acids as colon carcinogens and coffee ingredients as antagonists

J. Hengstler, H. Bolt, R. Marchan, 2011, Archives of Toxicology.

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses

M. Nitsche, U. Nöthlings, S. Vieths, 2020, Archives of Toxicology.

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells.

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Journal of hepatology.

Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release.

N. Ballatori, R. Marchan, C. Hammond, 2008, Biochimica et biophysica acta.

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins

J. Hengstler, S. Hoehme, A. Ghallab, 2022, Archives of Toxicology.

Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.

L. Pluta, F. Gonzalez, J. Everitt, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1.

L. Pluta, F. Gonzalez, J. Everitt, 2003, Cancer research.

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading

J. Rahnenführer, J. Hengstler, E. Rempel, 2014, Cell adhesion & migration.

Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities

J. Hengstler, R. Winter, R. Marchan, 2012, Cell cycle.

GDPD5, a choline-generating enzyme and its novel role in tumor cell migration

R. Marchan, 2016, Archives of Toxicology.

Highlight report: redox—metals in toxicology

R. Marchan, 2015, Archives of Toxicology.

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red Assay.

J. Rahnenführer, K. Edlund, J. Hengstler, 2022, Toxicology letters.

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Cells.

The cytoprotective and the dark side of Nrf2

H. Bolt, R. Marchan, 2013, Archives of Toxicology.

Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes.

J. Rahnenführer, J. Hengstler, A. Ghallab, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response

J. Rahnenführer, J. Hengstler, C. Cadenas, 2014, Breast Cancer.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

J. Rahnenführer, K. Edlund, L. Kuepfer, 2019, Archives of Toxicology.

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology

J. Hengstler, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Highlights in toxicology

R. Marchan, 2011 .

Editorial: HIGHLIGHTS IN TOXICOLOGY

R. Marchan, 2011 .

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.

N. Ballatori, R. Marchan, C. Hammond, 2009, Molecular aspects of medicine.

Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study

M. Nitsche, E. Wascher, J. Hengstler, 2021, JMIR research protocols.

Dortmund Vital Study: a protocol of an interdisciplinary cross-sectional and longitudinal study to evaluate impact of biological and lifestyle factors on cognitive aging and work ability (Preprint)

M. Nitsche, E. Wascher, J. Hengstler, 2021 .

Severe arsenic poisoning: one of the largest man-made catastrophies

J. Hengstler, K. Golka, H. Bolt, 2010, Archives of Toxicology.

Key messages from Experimental and Clinical Sciences

R Marchan, R. Marchan, 2012, EXCLI journal.

Editorial: KEY MESSAGES FROM EXPERIMENTAL AND CLINICAL SCIENCES

R Marchan, Leibniz-Institut für Arbeitsforschung, R. Marchan, 2012 .

Key messages of recent publications in the field of toxicology

R. Marchan, C. Cadenas, P. Godoy, 2012, EXCLI journal.

Current developments in toxicology

J. D. Stewart, R. Marchan, R. Marchan, 2012, EXCLI journal.

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

Jan Böttger, Jan G. Hengstler, Raymond Reif, 2014, Archives of Toxicology.

Contribution to the ongoing discussion on fluoride toxicity

M. Nitsche, U. Nöthlings, S. Vieths, 2021, Archives of Toxicology.

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

J. Rahnenführer, Marcus Schmidt, J. Hengstler, 2012, BMC Cancer.

Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

C. Lindskog, J. Rahnenführer, K. Edlund, 2023, Journal of Experimental & Clinical Cancer Research.

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

J. Rahnenführer, K. Edlund, J. Hengstler, 2017, Cancer research.

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

Herbert Waldmann, Gerd Schmitz, Jan G Hengstler, 2012, Proceedings of the National Academy of Sciences.

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

J. Hengstler, H. Ellinger-Ziegelbauer, T. Heise, 2013, Archives of Toxicology.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Hedi Peterson, Daniel Gerhard, Raivo Kolde, 2012, Archives of Toxicology.

Standard compounds for establishment of in vitro test systems

J. Hengstler, H. Bolt, R. Marchan, 2014, Archives of Toxicology.

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

J. Rahnenführer, K. Edlund, Marcus Schmidt, 2016, PloS one.

Metabolic Profiling of Thymic Epithelial Tumors Hints to a Strong Warburg Effect, Glutaminolysis and Precarious Redox Homeostasis as Potential Therapeutic Targets

G. Ott, S. Schölch, C. Sticht, 2022, Cancers.

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.

L. Holmberg, J. Rahnenführer, F. Pontén, 2013, Cancer letters.

Mechanisms of telomere maintenance and attrition: linking cancer and ageing

J. Hengstler, H. Bolt, R. Marchan, 2009, Archives of Toxicology.

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

J. Rahnenführer, K. Edlund, Marcus Schmidt, 2014, Cell cycle.

A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

L. Holmberg, J. Rahnenführer, K. Edlund, 2012, Clinical Cancer Research.

Glutathione Export during Apoptosis Requires Functional Multidrug Resistance-associated Proteins*

N. Ballatori, R. Marchan, C. Hammond, 2007, Journal of Biological Chemistry.

Genetic variants in urinary bladder cancer: collective power of the “wimp SNPs”

K. Ickstadt, J. Hengstler, S. Selinski, 2011, Archives of Toxicology.

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity

J. Hengstler, S. Hoehme, A. Ghallab, 2022, Archives of Toxicology.

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression

Christian H. Holland, T. Luedde, U. Hofmann, 2021, Cells.

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.

E. Salido, P. Boor, A. Schriewer, 2021, Cell reports.

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

R. Vadigepalli, J. Hoek, K. Edlund, 2020, Archives of Toxicology.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Nils Blüthgen, Reinhard Guthke, Jan G. Hengstler, 2016, Archives of Toxicology.

Highlight report: redox—metals in toxicology

R. Marchan, 2015, Archives of Toxicology.

Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins.

N. Ballatori, R. Marchan, C. Hammond, 2005, Toxicology and applied pharmacology.

Marker in Human Solid Tumors C as a Compatible Prognostic κ Identifies Stromal Immunoglobulin A Comprehensive Analysis of Human Gene Expression Profiles

L. Holmberg, K. Edlund, H. Bojar, 2012 .

Immunoglobulin Kappa C Predicts Overall Survival in Node-Negative Breast Cancer

Marcus Schmidt, J. Hengstler, M. Gehrmann, 2012, PloS one.

Polymorphisms hit the headlines

R. Marchan, J. Stewart, 2012, Archives of Toxicology.

Cancer research: from prognostic genes to therapeutic targets

R. Marchan, 2014, EXCLI journal.

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A

J. Hengstler, S. Hoehme, A. Ghallab, 2022, Archives of Toxicology.

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

T. Luedde, J. Rahnenführer, A. Canbay, 2022, Journal of hepatology.

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

R. Vadigepalli, J. Hoek, K. Edlund, 2020, Archives of Toxicology.

Recent developments in in vitro toxicology: perspectives of European research and Tox21

H. Bolt, R. Marchan, C. Thriel, 2013, Archives of Toxicology.

Glycerophospholipid profile in oncogene-induced senescence.

J. Rahnenführer, Z. Török, J. Hengstler, 2012, Biochimica et biophysica acta.

Toxicology of magnetic nanoparticles: disturbed body iron homeostasis?

J. Hengstler, R. Marchan, R. Reif, 2012, Archives of Toxicology.

Selenium: an element with two faces

J. Hengstler, H. Bolt, R. Marchan, 2011, Archives of Toxicology.

The human bitumen study hits the headlines

C. van Thriel, R. Marchan, 2012, Archives of Toxicology.

Zinc as a multipurpose trace element

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Iron dysregulation: an important aspect in toxicology

H. Bolt, R. Marchan, 2010, Archives of Toxicology.

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses

M. Nitsche, U. Nöthlings, S. Vieths, 2020, Archives of Toxicology.

Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

J. Rahnenführer, K. Edlund, S. Loibl, 2021, Clinical Cancer Research.

A special issue on nanotoxicology

R. Marchan, 2012, EXCLI journal.

Research on plant extracts and phytochemicals: criteria for evaluation

S. Hammad, H. Bolt, R. Marchan, 2013, Archives of Toxicology.

The nanotoxicology revolution

J. Hengstler, R. Marchan, T. Gebel, 2013, Archives of Toxicology.

Toxicology of magnetic nanoparticles: disturbed body iron homeostasis?

R. Marchan, R. Reif, J. Hengstler, 2012, Archives of Toxicology.

Recent developments in nanotoxicology

R. Marchan, J. Hengstler, H. Bolt, 2012, Archives of Toxicology.

Editorial: A SPECIAL ISSUE ON NANOTOXICOLOGY

R. Marchan, 2012 .

Highlight report: cytoprotective signaling in toxicology

H. Bolt, R. Marchan, 2015, Archives of Toxicology.

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Chemical research in toxicology.

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Wolfgang Moritz, Wiebke Albrecht, Tim Brecklinghaus, 2018, Archives of Toxicology.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

J. Rahnenführer, K. Edlund, O. Taboureau, 2018, Archives of Toxicology.

EDI3, a key enzyme of choline metabolism controls tumour cell migration

R. Marchan, J. Stewart, Michaela S. Lesjak, 2012, EXCLI journal.

LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer

A. Schriewer, J. Rahnenführer, F. Pontén, 2019, International journal of cancer.

Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.

Jan G Hengstler, Jörg Rahnenführer, Karolina Edlund, 2015, Anticancer research.

Progress in ‘body-on-a-chip’ research

J. Kelm, R. Marchan, 2014, Archives of Toxicology.

Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

J. Hengstler, M. Leist, R. Marchan, 2011, Archives of Toxicology.

Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

Jan G. Hengstler, Marcel Leist, J. Hengstler, 2011, Archives of Toxicology.

Cutting-edge topics in research on animal sciences

J. Hengstler, S. Hammad, R. Marchan, 2013 .

Highlight report: Validation of prognostic genes in lung cancer

R. Marchan, 2014, EXCLI journal.

Progress in gene expression profiling by the introduction of metagenes

H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Zinc as a multipurpose trace element

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Imatinib: the controversial discussion on cardiotoxicity induced by endoplasmic reticulum (ER) stress

H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Role of heat shock proteins in stress response and carcinogenesis

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Carcinogenesis and genotoxicity

R. Marchan, 2010 .

Low-dose extrapolation in toxicology: an old controversy revisited

Jan G. Hengstler, J. Hengstler, H. Bolt, 2009, Archives of Toxicology.

Can drinking tea prevent cancer?

J. Hengstler, H. Bolt, R. Marchan, 2008, Archives of Toxicology.

Recent developments in nanotoxicology

J. Hengstler, H. Bolt, R. Marchan, 2013, Archives of Toxicology.

Buckyballs (fullerenes): free radical sponges or inflammatory agents?

J. Hengstler, C. Cadenas, R. Marchan, 2012, Archives of Toxicology.

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation

J. Hengstler, A. Ghallab, A. Mally, 2023, Archives of Toxicology.

' s response to reviews Title : Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

J. Hengstler, M. Gehrmann, C. Solbach, 2012 .

Risk assessment of parabens in a transcriptomics-based in vitro test.

J. Rahnenführer, J. Hengstler, A. Sachinidis, 2023, Chemico-biological interactions.

Pyrethroid insecticide neurotoxicity

J. Hengstler, R. Marchan, C. Thriel, 2012, Archives of Toxicology.

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Oxidative stress research

R. Marchan, 2011 .

Editorial: OXIDATIVE STRESS RESEARCH

R. Marchan, 2011 .

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

J. Rahnenführer, K. Edlund, J. Hengstler, 2018, Archives of Toxicology.

Standard compounds for establishment of in vitro test systems

J. Hengstler, H. Bolt, R. Marchan, 2014, Archives of Toxicology.

A user-friendly guide on how to obtain and accurately interpret information from metabolic databases

R. Marchan, C. Cadenas, C. Cadenas, 2011, Archives of Toxicology.

Progress in ‘body-on-a-chip’ research

J. Kelm, R. Marchan, 2014, Archives of Toxicology.

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Jan G. Hengstler, Regina Stöber, Raymond Reif, 2012, Archives of Toxicology.

1 2 3 D Spherical Microtissues and Microfluidic Technology 3 for Multi-tissue Experiments and Analysis 4 5

A. Hierlemann, J. Kelm, J. Hengstler, 2014 .

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology

R. Marchan, J. G. Hengstler, R. Marchan, 2012, Archives of Toxicology.

The cytoprotective and the dark side of Nrf2

H. Bolt, R. Marchan, 2013, Archives of Toxicology.

Systems biology meets toxicology

R. Marchan, J. G. Hengstler, J. Hengstler, 2012, Archives of Toxicology.