J. M. Hutzler

发表

Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes.

G. Siuzdak, Zhouxin Shen, R. Steenwyk, 2006, Rapid communications in mass spectrometry : RCM.

A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry

J. M. Hutzler, R. D. Crouch, J. Daniels, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Aldehyde Oxidase Activity in Donor-Matched Fresh and Cryopreserved Human Hepatocytes and Assessment of Variability in 75 Donors

S. Heyward, T. Moeller, J. M. Hutzler, 2014, Drug Metabolism and Disposition.

Characterization of Aldehyde Oxidase Enzyme Activity in Cryopreserved Human Hepatocytes

Daniel R. Albaugh, J. M. Hutzler, M. Fisher, 2012, Drug Metabolism and Disposition.

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.

H. Cai, S. Strom, T. Tracy, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Atypical kinetic profiles in drug metabolism reactions.

T. Tracy, J. M. Hutzler, J. Hutzler, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382

J. M. Hutzler, Diane F Wong, Young-Sun Yang, 2014, Drug Metabolism and Disposition.

Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?

N. Renaud, J. M. Hutzler, Collette D. Linder, 2009, Drug Metabolism and Disposition.

Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species.

L. Wienkers, J. M. Hutzler, M. Wynalda, 2003, Archives of biochemistry and biophysics.

Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements.

T. Tracy, M. Hummel, J. M. Hutzler, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Influence of Fluorescent Probe Size and Cytochrome b5 on Drug-Drug Interactions in CYP2C9

D. Rock, T. Tracy, M. Hummel, 2006, Journal of biomolecular screening.

Microsoft Word-29061966-file00

J. M. Hutzler, Collette D. Linder, R. Melton, 2010 .

Non-Specific Cytochrome P450 Inactivator?

N. Renaud, J. M. Hutzler, Collette D. Linder, 2008 .

Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone.

R. Branch, K. Korzekwa, T. Tracy, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Discovery and optimization of oxadiazole-based FLAP inhibitors.

Asitha Abeywardane, J. M. Hutzler, A. Bartolozzi, 2017, Bioorganic & medicinal chemistry letters.

Single Dose Pharmacokinetics of Syrup of Ipecac

T. Tracy, J. M. Hutzler, E. Scharman, 2000, Therapeutic drug monitoring.

Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite.

D. Thompson, L. Wienkers, D. Rock, 2008, Chemical research in toxicology.

Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.

G. S. Walker, L. Wienkers, J. M. Hutzler, 2003, Chemical research in toxicology.

Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs

J. M. Hutzler, Sherri Smith, M. Huskin, 2018, The AAPS Journal.

Visible Spectra of Type II Cytochrome P450-Drug Complexes: Evidence that “Incomplete” Heme Coordination Is Common

Timothy S Tracy, T. Tracy, J. M. Hutzler, 2007, Drug Metabolism and Disposition.

Visible spectra of type-II P450-drug complexes: evidence that “incomplete” heme coordination is common

T. Tracy, J. M. Hutzler, C. Locuson, 2007 .

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

P. Potter, P. Marathe, J. M. Hutzler, 2016, The AAPS Journal.

Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma.

T. Tracy, R. Frye, J. M. Hutzler, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Drug–Drug Interactions: Designing Development Programs and Appropriate Product Labeling

J. M. Hutzler, J. Fleishaker, J. Cook, 2011 .

Drug–Drug Interactions: Designing Development Programs and Appropriate Product Labeling

J. M. Hutzler, J. Fleishaker, J. Cook, 2011 .

Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model

J. M. Hutzler, Xiaochun Zhu, S. Anderson, 2018, Drug Metabolism and Disposition.

Special Section – New Models in Drug Metabolism and Transport Assessment of the Biotransformation of Low-Turnover Drugs in the H m REL Human Hepatocyte Coculture Model s

J. M. Hutzler, Xiaochun Zhu, S. Anderson, 2018 .

Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).

M. Hao, Asitha Abeywardane, T. Morwick, 2015, Journal of medicinal chemistry.

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

Deepak Dalvie, R. Obach, D. Dalvie, 2013, Expert opinion on drug metabolism & toxicology.

Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection

Michael Zientek, Timothy S Tracy, T. Tracy, 2009, Drug Metabolism and Disposition.

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.

Leslie J Dickmann, Timothy S Tracy, A. Rettie, 2002, Drug metabolism and disposition: the biological fate of chemicals.

In vitro metabolism of clindamycin in human liver and intestinal microsomes.

L. Wienkers, J. M. Hutzler, J Matthew Hutzler, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model.

T. Tracy, J. M. Hutzler, J M Hutzler, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems

Daniel R. Albaugh, J. M. Hutzler, M. Fisher, 2012, Drug Metabolism and Disposition.

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.

Timothy S Tracy, Timothy J Carlson, L. Wienkers, 2003, Archives of biochemistry and biophysics.

Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity.

L. Wienkers, J. M. Hutzler, M. Schrag, 2005, Archives of biochemistry and biophysics.