J. Mason

发表

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.

B. Faubert, Russell G. Jones, S. Berger, 2011, Genes & development.

A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

B. Tycko, J. Licht, D. Choubey, 2008, Neoplasia.

The SH2 Inositol 5-Phosphatase Ship1 Is Recruited in an SH2-dependent Manner to the Erythropoietin Receptor*

B. Beattie, D. Barber, D. Barber, 2000, The Journal of Biological Chemistry.

Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C

J. Licht, M. A. Basson, J. Powell, 2010, Molecular biology of the cell.

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Narendra Kumar Patel, Y. Liu, T. Mak, 2016, ACS medicinal chemistry letters.

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2014, Bioorganic & medicinal chemistry.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2015 .

Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells

P. Boutros, T. Mak, A. Wakeham, 2014, Oncogene.

Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy

I. Jurisica, T. Mak, V. Lapin, 2014, Oncogenesis.

Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility.

Yiqiang Cai, J. Mason, J. Mason, 2000, The Journal of clinical endocrinology and metabolism.

Hepatocyte growth factor decreases sensitivity to chemotherapeutic agents and stimulates cell adhesion, invasion, and migration.

E. Rosen, I. Goldberg, S. Fan, 2000, Biochemical and biophysical research communications.

The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.

Y. Liu, T. Mak, P. Sampson, 2013, Journal of medicinal chemistry.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Targeting Mitosis in Cancer: Emerging Strategies.

T. Mak, K. Thu, H. Blaser, 2015, Molecular cell.

Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases*

B. Beattie, B. Zanke, D. Barber, 2002, The Journal of Biological Chemistry.

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

S. Inoue, D. Cescon, T. Mak, 2015, Cancer cell.

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.

Y. Liu, T. Mak, O. Plotnikova, 2016, Bioorganic & medicinal chemistry letters.

Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma

S. Pastorino, T. Mak, H. Pass, 2017, Oncogene.

Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

J. Licht, M. A. Basson, J. Mason, 2006, Trends in cell biology.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop.

J. Licht, M. Dimri, H. Band, 2004, Molecular biology of the cell.

Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.

D. Cescon, T. Mak, D. Awrey, 2014, Cancer cell.

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

D. Hedley, M. Pintilie, I. Lohse, 2016, Oncotarget.

The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair

T. Mak, M. Pujana, V. Stambolic, 2016, Cell Death and Differentiation.

Role of Nek 2 on centrosome duplication and aneuploidy in breast cancer cells

Bruce, T. Mak, A. Elia, 2022 .

Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins.

B. Druker, A. D’Andrea, H. Band, 1997, Blood.

Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer

T. Mak, I. Beletskaya, M. Bray, 2017, Proceedings of the National Academy of Sciences.

Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.

Narendra Kumar Patel, T. Mak, P. Sampson, 2016, Bioorganic & medicinal chemistry letters.

CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors.

Adam A. Margolin, Adam A Margolin, Benjamin Tycko, 2004, The American journal of pathology.

Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.

J. Mason, D. Budman, V. Vinciguerra, 2000, Gene.

Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210

J. Licht, M. Olsson, J. Mason, 2004, Journal of Negative Results in BioMedicine.

Nucleophilicity towards a saturated carbon atom: rate constants for the aminolysis of methyl 4-nitrobenzenesulfonate in aqueous solution. A comparison of the n and N+ parameters for amine nucleophilicity

J. Mason, J. W. Bunting, C. Heo, 1994 .

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.

M. H. Nguyen, B. Beattie, D. Barber, 2001, Blood.

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

G Melino, T. Mak, G. Melino, 2014, Oncogene.

IFI16 is a novel WT1-associated protein identified by expression profiling in syndromic versus sporadic wilms tumors

B. Tycko, J. Licht, D. Choubey, 2006 .

Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210

J. Licht, M. Olsson, J. Mason, 2004, Journal of Negative Results in BioMedicine.

implications for the docking model of STAT activation transcription-5 ( STAT 5 ) and the phosphorylated erythropoietin receptor : A common epitope is shared by activated signal transducer and activator

B. Beattie, D. Barber, D. Frank, 2001 .

Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms.

M. Minden, Steven M. Chan, A. Schimmer, 2023, Leukemia.

The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.