A. Safdar

发表

The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men

M. Tarnopolsky, M. Hamadeh, I. Samjoo, 2013, Nutrition & Diabetes.

miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice

M. Tarnopolsky, A. Safdar, A. Abadi, 2009, PloS one.

Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small

J. Huizinga, G. Donnelly, A. Safdar, 2009 .

Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old.

M. Tarnopolsky, A. Safdar, J. Debeer, 2010, Free radical biology & medicine.

Effect of sex on the acute skeletal muscle response to sprint interval exercise

Martin J. MacInnis, M. Tarnopolsky, M. MacDonald, 2017, Experimental physiology.

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle.

D. Bishop, M. Tarnopolsky, M. Gibala, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS

M. Tarnopolsky, M. Hamadeh, A. Safdar, 2010, PloS one.

Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.

K. Khrapko, J. Tilly, D. Woods, 2016, Current opinion in genetics & development.

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.

M. Tarnopolsky, J. Kolesar, B. Kaufman, 2014, Free radical biology & medicine.

Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men.

M. Tarnopolsky, J. Crane, D. Ogborn, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

Supplementation with α-Lipoic Acid, CoQ10, and Vitamin E Augments Running Performance and Mitochondrial Function in Female Mice

M. Tarnopolsky, J. Crane, D. Ogborn, 2013, PloS one.

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis*

M. Tarnopolsky, J. Little, A. Safdar, 2011, The Journal of Biological Chemistry.

The Order of Exercise during Concurrent Training for Rehabilitation Does Not Alter Acute Genetic Expression, Mitochondrial Enzyme Activity or Improvements in Muscle Function

M. Tarnopolsky, A. Safdar, E. Glover, 2014, PloS one.

Adipose-brain crosstalk: do adipokines have a role in neuroprotection?

J. Little, A. Safdar, 2015, Neural regeneration research.

Richter : important for exercise performance ? α PGC-1

Y. Meckel, D. Bishop, M. Tarnopolsky, 2008 .

of autophagy signaling in skeletal muscle Exercise protects against doxorubicin-induced markers

S. Powers, A. Kavazis, A. Smuder, 2015 .

When man got his mtDNA deletions?

K. Khrapko, K. Popadin, Y. Kraytsberg, 2014, Aging cell.

adaptations in human skeletal muscle and exercise performance traditional endurance training: similar initial versus

M. Tarnopolsky, M. Gibala, J. Little, 2006 .

A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations

M. Tarnopolsky, J. Schwartzentruber, A. Saleem, 2017, European Journal of Human Genetics.

performance during resistance training Long-term creatine intake is beneficial to muscle

E. Achten, M. Tarnopolsky, S. Melov, 2015 .

Editorial: Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes

J. Little, A. Safdar, K. Karstoft, 2018, Front. Endocrinol..

Regular Exercise Shapes Healthy Gut Microbiome

Aisha Nazli, A. Safdar, M. Akhtar, 2016 .

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

D. Bishop, J. Little, A. Safdar, 2017, Journal of sport and health science.

The FASEB Journal express article 10.1096/fj.04-3149fje. Published online June 28, 2005. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise

M. Tarnopolsky, S. Melov, D. Mahoney, 2022 .

Exercise‐induced histone acetylation – playing tag with the genome

A. Saleem, A. Safdar, 2010, The Journal of physiology.

Hypoxic Induction of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in Muscle by Truncated Peroxisome Proliferator-activated Receptor γ Coactivator (PGC)-1α

Cholsoon Jang, A. Safdar, Z. Arany, 2014, The Journal of Biological Chemistry.

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

Gregory C Kujoth, Daniel I Ogborn, Mahmood Akhtar, 2011, Proceedings of the National Academy of Sciences.

The potential of endurance exercise-derived exosomes to treat metabolic diseases

M. Tarnopolsky, A. Saleem, A. Safdar, 2016, Nature Reviews Endocrinology.

Running Forward: New Frontiers in Endurance Exercise Biology

A. Safdar, Z. Arany, G. Rowe, 2014, Circulation.

Parkinson s disease Delays aging Counters diabetes Best current therapy for Peripheral Artery Disease Protects against atherosclerosis Improves func on in heart failure Improves muscle strength Slows muscle atrophy and prevents sarcopenia Maintains bone density and decreases osteoporosis risk Mainta

A. Safdar, Z. Arany, G. Rowe, 2014 .

How Does Muscle Reprogram in Response to Exercise ?

A. Safdar, Z. Arany, G. Rowe, 2022 .

Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle.

M. Tarnopolsky, M. Gibala, J. Little, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

A practical model of low‐volume high‐intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

M. Tarnopolsky, M. Gibala, J. Little, 2010, The Journal of physiology.

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis.

J. Little, A. Safdar, D. Wright, 2011, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise.

M. Tarnopolsky, A. Safdar, 2018, Cold Spring Harbor perspectives in medicine.

Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

M. Tarnopolsky, J. Little, G. Steinberg, 2013, PloS one.

Exercise increases mitochondrial PGC-1 α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

M. Tarnopolsky, J. Little, A. Safdar, 2011, The Journal of Biological Chemistry.

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

M. Tarnopolsky, M. Hamadeh, A. Safdar, 2010, PloS one.

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

F. Jaffer, H. Watada, N. Sawada, 2014, Cell metabolism.

creatine monohydrate supplementation in skeletal muscle of young men following short-term Global and targeted gene expression and protein content

S. Melov, R. Snow, A. Safdar, 2016 .

short-term creatine monohydrate supplementation content in skeletal muscle of young men following Global and targeted gene expression and protein

E. Ravussin, S. Melov, W. Evans, 2015 .

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

M. Tarnopolsky, S. Melov, R. Snow, 2008, Physiological genomics.

Extracellular Vesicles and Circulating miRNAs—Exercise-Induced Mitigation of Obesity and Associated Metabolic Diseases

A. Saleem, A. Safdar, Patience O. Obi, 2020, Pathophysiology of Obesity-Induced Health Complications.

Polymerase Gamma Mutator (PolG) Mice Rely on Increased Glycolytic Flux for Energy Production

M. Tarnopolsky, A. Saleem, A. Safdar, 2015, Mitochondrion.

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

T. Prolla, K. Khrapko, M. Tarnopolsky, 2015, Skeletal Muscle.

The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure.

M. Tarnopolsky, M. Hamadeh, J. Crane, 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.

M. Tarnopolsky, S. Melov, D. Mahoney, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults.

M. Tarnopolsky, A. Safdar, 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

The effects of creatine and exercise on skeletal muscle of FRG1‐transgenic mice

M. Tarnopolsky, R. Tupler, J. Crane, 2010, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance

Sandeep Raha, M. Tarnopolsky, M. Gibala, 2006, The Journal of physiology.

muscles undergoing sarcopenia Mitochondrial abnormalities are more frequent in

S. McKiernan, J. Aiken, M. Tarnopolsky, 2015 .

Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women

A. Hubbard, M. Tarnopolsky, S. Melov, 2009, PloS one.

Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity.

M. Tarnopolsky, L. Koch, S. Britton, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Eccentric Exercise Affects NRF2-mediated Oxidative Stress Response in Skeletal Muscle by Increasing Nuclear NRF2 Content: 1657

M. Tarnopolsky, S. Melov, S. Baker, 2011 .

Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

M. Tarnopolsky, T. Doherty, A. Safdar, 2007, PloS one.

Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes.

M. Tarnopolsky, Z. Punthakee, M. Gibala, 2011, Journal of applied physiology.

Friend or Foe: Can Mitochondrial Toxins Lead to Similar Benefits as Exercise?

K. Khrapko, J. Tilly, D. Woods, 2018 .

The myogenic component in distention-induced peristalsis in the guinea pig small intestine.

J. Huizinga, G. Donnelly, A. Safdar, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain

M. Tarnopolsky, D. Simon, A. Saleem, 2015, Neurobiology of Aging.

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

F. Jaffer, H. Watada, N. Sawada, 2014, Cell metabolism.

Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.

M. Tarnopolsky, A. Safdar, G. Parise, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

A practical model of low‐volume high‐intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

M. Tarnopolsky, M. Gibala, J. Little, 2010, The Journal of physiology.

capacity in patients with type 2 diabetes hyperglycemia and increases muscle mitochondrial Low-volume high-intensity interval training reduces

Eric C. Freese, Nicholas H. Gist, Rachelle M. Acitelli, 2011 .

The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults.

M. Tarnopolsky, A. Safdar, 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis*

M. Tarnopolsky, J. Little, A. Safdar, 2011, The Journal of Biological Chemistry.

Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by N-terminus Peroxisome Proliferator-Associated Receptor Gamma Coactivator (NT-PGC)-1

Cholsoon Jang, A. Safdar, Z. Arany, 2013 .