A. Saija

D. Trombetta, F. Bonina, A. Saija, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Compositional Characterisation and Antioxidant Activity of Fresh Juices from Sicilian Sweet Orange (Citrus sinensis L. Osbeck) Varieties

C. Rice-Evans, A. Saija, A. Proteggente, 2003, Free radical research.

`In vitro' evaluation of the antioxidant activity and biomembrane interaction of the plant phenols oleuropein and hydroxytyrosol

D. Trombetta, F. Bonina, A. Saija, 1998 .

The almond milk: a new approach to the management of cow-milk allergy/intolerance in infants.

G. Muscolino, S. Gangemi, D. Trombetta, 2005, Minerva pediatrica.

In Vitro Protective Effects of a Standardized Extract From Cynara Cardunculus L. Leaves Against TNF-α-Induced Intestinal Inflammation

A. Speciale, F. Cimino, A. Saija, 2022, Frontiers in Pharmacology.

Increased serum levels of advanced oxidation protein products and glycation end products in subjects exposed to low-dose benzene.

S. Gangemi, G. Spatari, F. Cimino, 2012, International journal of hygiene and environmental health.

Nut Consumption Lower Cardiovascular Risk: Lights and Shadows

A. Saija, A. Tomaino, 2012 .

Alteration in synaptic junction proteins following traumatic brain injury.

F. Angileri, F. Cimino, A. Conti, 2014, Journal of neurotrauma.

Pulsed high oxygen induces a hypoxic-like response in human umbilical endothelial cells and in humans.

Costantino Balestra, A. Speciale, F. Cimino, 2012, Journal of applied physiology.

Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-induced lipotoxicity

P. Wilde, A. Speciale, F. Cimino, 2020, Archives of physiology and biochemistry.

Toxic effect of nickel in an in vitro model of human oral epithelium.

M. Cristani, F. Cimino, D. Trombetta, 2005, Toxicology letters.

Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation.

A. Speciale, F. Cimino, A. Saija, 2016, Molecular medicine reports.

Differences between coumaric and cinnamic acids in membrane permeation as evidenced by time-dependent calorimetry.

D. Trombetta, A. Saija, N. Uccella, 1999, Journal of agricultural and food chemistry.

Antiallergic and antihistaminic effect of two extracts of Capparis spinosa L. flowering buds

N. A. Santagati, C. Puglia, D. Trombetta, 2005, Phytotherapy research : PTR.

Antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H.B.K. leaves and their major flavonoids.

L. Grumetto, C. Puglia, F. Bonina, 2002, Journal of ethnopharmacology.

In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds.

C. Puglia, A. Sacchi, F. Bonina, 2002, Journal of cosmetic science.

Chemical analysis and photoprotective effect of an extract of wine from Jacquez grapes

F. Cimino, F. Bonina, A. Saija, 2002 .

In vitro antioxidant activity and in vivo photoprotective effect of a red orange extract

A. Saija, P. Rapisarda, A. Tomaino, 1998, International journal of cosmetic science.

Fractionation and characterisation of arabinoxylans from brewers' spent grain and wheat bran

A. Sancho, K. Waldron, C. Faulds, 2005 .

Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins.

A. Saija, D. Monteleone, A. Tomaino, 2010, Biochimie.

Radical-scavenging capacity of several Italian red wines

F. Cimino, D. Trombetta, A. Saija, 2007 .

Serum levels of protein oxidation products in patients with nickel allergy.

S. Gangemi, M. Cristani, G. Spatari, 2009, Allergy and asthma proceedings.

Essential Oil from Aerial Parts of Wild Algerian Rosemary: Screening of Chemical Composition, Antimicrobial and Antioxidant Activities

M. Cristani, A. Saija, G. Ginestra, 2019, Journal of Essential Oil Bearing Plants.

Chemical composition, antimicrobial and antioxidant activities of the essential oil of several populations of Algerian Origanum glandulosum Desf.

D. Biondi, G. Mandalari, A. Saija, 2006 .

Increased protein carbonyl groups in the serum of patients affected by thalassemia major

S. Gangemi, M. Cristani, F. Cimino, 2006, Annals of Hematology.

Flavonoid-biomembrane interactions: A calorimetric study on dipalmitoylphosphatidylcholine vesicles

D. Trombetta, F. Bonina, A. Saija, 1995 .

Protective effect of red orange extract supplementation against UV‐induced skin damages: photoaging and solar lentigines

C. Puglia, D. Trombetta, A. Saija, 2014, Journal of cosmetic dermatology.

Oxidative stress in oncohematologic diseases: an update

A. Allegra, S. Gangemi, C. Musolino, 2013, Expert review of hematology.

Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia.

A. Allegra, A. Alibrandi, S. Gangemi, 2011, Clinical biochemistry.

Increase in serum protein carbonyl groups is associated with more advanced stage of disease in multiple myeloma patients

A. Allegra, S. Gangemi, A. Alonci, 2011, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.

K. Waldron, C. Faulds, G. Mandalari, 2006, Journal of agricultural and food chemistry.

Experimental exposure of blue mussels (Mytilus galloprovincialis) to high levels of benzo[a]pyrene and possible implications for human health.

A. Speciale, F. Cimino, D. Trombetta, 2018, Ecotoxicology and environmental safety.

Biomolecular Characterization of Wild Sicilian Oregano: Phytochemical Screening of Essential Oils and Extracts, and Evaluation of Their Antioxidant Activities

A. Speciale, T. Tuttolomondo, C. Leto, 2013, Chemistry & biodiversity.

Phytochemical, Ecological and Antioxidant Evaluation of Wild Sicilian Thyme: Thymbra capitata (L.) Cav.

A. Speciale, T. Tuttolomondo, M. C. Gennaro, 2016, Chemistry & biodiversity.

On the In‐vitro Antimicrobial Activity of Oleuropein and Hydroxytyrosol

A. Saija, N. Uccella, G. Bisignano, 1999, The Journal of pharmacy and pharmacology.

Oxidative stress markers in patients with hereditary angioedema

S. Gangemi, G. Tartarisco, M. Cristani, 2017, Archives of medical science : AMS.

Anti-Inflammatory Activity of an In Vitro Digested Anthocyanin-Rich Extract on Intestinal Epithelial Cells Exposed to TNF-α

P. Wilde, A. Speciale, F. Cimino, 2022, Molecules.

Bitter Orange (Citrus aurantium L.) Oils

A. Speciale, F. Cimino, Nafees Ahmed, 2016 .

Release of atrial natriuretic factor induced by the A1 adenosine receptor agonist 2-chloro-N6-cyclopentyl-adenosine in the rat.

G. Cristalli, C. Polidori, M. Massi, 1992, Pharmacological research.

In vitro antibacterial activity of some aliphatic aldehydes from Olea europaea L.

D. Trombetta, A. Saija, G. Bisignano, 2001, FEMS microbiology letters.

Increased serum levels of IL‐22 in patients with nickel contact dermatitis

S. Gangemi, D. Trombetta, A. Saija, 2009, Contact dermatitis.

Interaction of melatonin with model membranes and possible implications in its photoprotective activity.

D. Trombetta, A. Saija, S. Caruso, 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds

M. Cristani, A. Saija, D. Trombetta, 2008, Phytotherapy research : PTR.

Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers.

D. Trombetta, F. Bonina, A. Saija, 1997, Journal of pharmacological and toxicological methods.

Cytotoxic effects induced in vitro by organic extracts from urban air particulate matter in human leukocytes

M. Cristani, A. Speciale, F. Cimino, 2014, Drug and chemical toxicology.

A pinitol-rich Glycyrrhiza glabra L. leaf extract as functional supplement with potential in the prevention of endothelial dysfunction through improving insulin signalling

M. Cristani, A. Speciale, F. Cimino, 2020, Archives of physiology and biochemistry.

The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms

A. Speciale, F. Cimino, A. Saija, 2022, Molecules.

Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species

M. Cristani, A. Speciale, F. Cimino, 2022, Molecules.

Rituximab for the treatment of post‐bone marrow transplantation refractory hemolytic anemia in a child with Omenn's syndrome

D. Trombetta, A. Saija, C. Salpietro, 2007, Pediatric transplantation.

Changes in advanced oxidation protein products, advanced glycation end products, and s-nitrosylated proteins, in patients affected by polycythemia vera and essential thrombocythemia.

A. Allegra, S. Gangemi, A. Alonci, 2012, Clinical biochemistry.

Wild Sicilian Rosemary: Phytochemical and Morphological Screening and Antioxidant Activity Evaluation of Extracts and Essential Oils

A. Speciale, T. Tuttolomondo, C. Leto, 2015, Chemistry & biodiversity.

Hypersensitivity to tranexamic acid: a wide spectrum of adverse reactions

S. Gangemi, S. Imbesi, A. Vacca, 2010, Pharmacy World & Science.

In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit.

A. Saija, A. Saija, G. Bisignano, 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Interaction of four monoterpenes contained in essential oils with model membranes: implications for their antibacterial activity.

Francesco Castelli, Maria Grazia Sarpietro, M. Cristani, 2007, Journal of agricultural and food chemistry.

Mechanisms of Antibacterial Action of Three Monoterpenes

Francesco Castelli, Gabriela Mazzanti, Claudia Daniele, 2005, Antimicrobial Agents and Chemotherapy.

Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-κB pathways.

A. Allegra, C. Musolino, A. Speciale, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Electron beam irradiated UHMWPE: degrading action of air and hyaluronic acid.

L. Torrisi, M. Cristani, A. Visco, 2008, Bio-medical materials and engineering.

Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats

M. Cristani, A. Speciale, F. Cimino, 2016, Natural product research.

Flavonoid profile, antioxidant and antiglycation properties of Retama sphaerocarpa fruits extracts

L. Mondello, F. Cacciola, M. Cristani, 2018, Natural product research.

Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves.

A. Saija, R. Aquino, A. Tomaino, 2001, Journal of natural products.

In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents.

D. Paolino, D. Trombetta, F. Bonina, 2000, International journal of pharmaceutics.

Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat.

C. Puglia, A. Saija, D. Trombetta, 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

In‐vitro Antioxidant and In‐vivo Photoprotective Effect of Three Lyophilized Extracts of Sedum telephium L. Leaves

C. Puglia, A. Romani, N. Mulinacci, 2000, The Journal of pharmacy and pharmacology.

Evaluation of in‐vivo topical anti‐inflammatory activity of indometacin from liposomal vesicles

C. Puglia, D. Trombetta, F. Bonina, 2004, The Journal of pharmacy and pharmacology.

In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac.

M. G. Rimoli, C. Puglia, F. Bonina, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Protective effect of glutathione on kainic acid-induced neuropathological changes in the rat brain

A. Saija, P. Princi, G. Costa, 1994 .

Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations

A. Speciale, F. Cimino, S. Giofrè, 2021, Computers in Biology and Medicine.

Circulating Advanced Oxidation Protein Products as Oxidative Stress Biomarkers and Progression Mediators in Pathological Conditions Related to Inflammation and Immune Dysregulation.

S. Gangemi, M. Cristani, A. Speciale, 2016, Current medicinal chemistry.

Design and Characterization of Liposomes Containing Long-Chain N-AcylPEs for Brain Delivery: Penetration of Liposomes Incorporating GM1 into the Rat Brain

D. Trombetta, F. Bonina, A. Saija, 2002, Pharmaceutical Research.

Transport of Alpha-Tocopherol and Its Derivatives Through Erythrocyte Membranes

L. Salerno, D. Trombetta, F. Bonina, 1996, Pharmaceutical Research.

Synthesis, stability, and pharmacological evaluation of nipecotic acid prodrugs.

D. Trombetta, F. Bonina, A. Saija, 1999, Journal of pharmaceutical sciences.

Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases.

M. Cristani, A. Speciale, F. Cimino, 2020, Current medicinal chemistry.

Oxidative stress markers in patients with hymenoptera venom allergy.

S. Gangemi, A. Saija, S. Saitta, 2015, Allergy and asthma proceedings.

Studies on antidiarrhoeal activity of an extract of wine from Jacquez grapes in mice

A. Saija, F. Vitali, B. Tita, 2005, Phytotherapy research : PTR.

Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells.

A. Speciale, F. Cimino, A. Saija, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

How gene polymorphisms can influence clinical response and toxicity following R-CHOP therapy in patients with diffuse large B cell lymphoma.

A. Allegra, S. Gangemi, C. Musolino, 2017, Blood reviews.

Exposure to Anisakis extracts can induce inflammation on in vitro cultured human colonic cells

S. Gangemi, A. Speciale, F. Cimino, 2017, Parasitology Research.

Malondialdehyde in benign prostate hypertrophy: a useful marker?

S. Gangemi, F. Salvo, A. Saija, 2003, Mediators of inflammation.

In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G.

D. Trombetta, A. Saija, F. Castelli, 2001, Life sciences.

Modification of the content of plasma protein carbonyl groups in donors after granulocyte colony stimulating factor-induced stem cell mobilization.

S. Gangemi, M. Cristani, F. Cimino, 2005, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

Oxidative stress in handball players: effect of supplementation with a red orange extract

C. Puglia, F. Cimino, D. Trombetta, 2005 .

Iron-induced Lipid Peroxidation in Human Skin-derived Cell Lines: Protection by a Red Orange Extract

F. Bonina, A. Saija, M. Ferro, 2000, Alternatives to laboratory animals : ATLA.

Glutathione Metabolism: Favorable Versus Unfavorable Effects

F. Cimino, A. Saija, 2008 .

Oxidants in biology: a question of balance

A. Lojek, H. Forman, A. Avogaro, 2008 .

Bioavailability and molecular activities of anthocyanins as modulators of endothelial function

A. Speciale, F. Cimino, A. Saija, 2014, Genes & Nutrition.

Anthocyanins in Vascular Diseases

A. Speciale, F. Cimino, A. Saija, 2014 .

Protective effects of a standardised red orange extract on air pollution-induced oxidative damage in traffic police officers

G. Frasca, C. Puglia, F. Cimino, 2008, Natural product research.

Ferulic and caffeic acids as potential protective agents against photooxidative skin damage

D. Trombetta, F. Bonina, A. Saija, 1999 .

Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-α induced endothelium dysfunction.

A. Speciale, F. Cimino, A. Saija, 2018, Archives of biochemistry and biophysics.

Cellular adaptive response to glutathione depletion modulates endothelial dysfunction triggered by TNF-α.

A. Speciale, F. Cimino, A. Saija, 2011, Toxicology letters.

Bioavailability and molecular activities of anthocyanins as modulators of endothelial function

A. Speciale, F. Cimino, A. Saija, 2014, Genes & Nutrition.

Changes in the permeability of the blood-brain barrier following sodium dodecyl sulphate administration in the rat

D. Trombetta, A. Saija, P. Princi, 1997, Experimental Brain Research.

The hypothalamic paraventricular nucleus is a site of action for the central effect of tachykinins on plasma vasopressin1

C. Polidori, M. Massi, A. Saija, 1991, Brain Research Bulletin.

Biocompatible silver nanoparticles embedded in a PEG–PLA polymeric matrix for stimulated laser light drug release

S. Spadaro, M. Santoro, F. Barreca, 2016, Journal of Nanoparticle Research.

Protective effect of Mediterranean fish oil extracts on heat‐induced denaturation of albumin

C. Puglia, M. Cristani, A. Speciale, 2006, The Journal of pharmacy and pharmacology.

Evaluation of biological response induced by molybdenum oxide nanocolloids on in vitro cultured NIH/3T3 fibroblast cells by micro-Raman spectroscopy.

S. Spadaro, F. Neri, E. Fazio, 2018, Colloids and surfaces. B, Biointerfaces.

1-ethylazacycloalkan-2-one indomethacin esters as new oral prodrugs: chemical stability, enzymatic hydrolysis, anti-inflammatory activity and gastrointestinal toxicity

D. Trombetta, F. Bonina, A. Saija, 1997 .

Genetically epilepsy-prone rodents show some changes of ion levels in the brain

D. Trombetta, A. Saija, P. Princi, 1994, Brain Research Bulletin.

Vasopressin release induced by intracranial injection of tachykinins is due to activation of central neurokinin-3 receptors

C. Polidori, M. Massi, A. Saija, 1989, Neuroscience Letters.

1-Ethyl and 1-Propylazacycloalkan-2-one Ester Prodrugs of Ketoprofen

N. A. Santagati, C. Puglia, D. Trombetta, 2002, Arzneimittelforschung.

Silibinin as potential tool against SARS‐Cov‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects

A. Speciale, F. Cimino, S. Giofrè, 2021, Phytotherapy research : PTR.

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

M. Cristani, A. Speciale, F. Cimino, 2022, Molecules.

Montelukast-Induced Generalized Urticaria

S. Gangemi, E. Ferlazzo, A. Saija, 2004, The Annals of pharmacotherapy.

Inhibition of intestinal motility and secretion by extracts of Epilobium spp. in mice.

A. Saija, F. Vitali, B. Tita, 2006, Journal of ethnopharmacology.

The effect of concussive head injury on central cholinergic neurons

Ronald L. Hayes, C. Edward Dixon, S. Robinson, 1988, Brain Research.

Exposure of sea bream (Sparus aurata) to toxic concentrations of benzo[a]pyrene: possible human health effect.

A. Speciale, F. Cimino, D. Trombetta, 2015, Ecotoxicology and environmental safety.

Raman spectroscopy differentiates between sensitive and resistant multiple myeloma cell lines.

A. Allegra, C. Musolino, F. Neri, 2017, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro.

F. Bonina, A. Saija, F. Vitali, 2006, Fitoterapia.

-SH groups and glutathione in cancer patient's blood.

A. Saija, M. Broccio, F. della Rovere, 2000, Anticancer research.

Blood-brain barrier dysfunctions following systemic injection of kainic acid in the rat.

G. Santoro, A. Saija, P. Princi, 1992, Life sciences.

Protective Effect of Buflomedil in a Rat Model of Moderate Cerebral Ischemia

D. Trombetta, A. Saija, M. Galluzzo, 2005, Arzneimittelforschung.

Effect of the 5-HT2 antagonist ketanserin on salt appetite in the rat

M. Massi, A. Saija, L. Gentili, 1991, Pharmacology Biochemistry and Behavior.

Regulation of mitotic clonal expansion and thermogenic pathway are involved in the antiadipogenic effects of cyanidin-3-O-glucoside

A. Speciale, F. Cimino, A. Saija, 2023, Frontiers in pharmacology.

Effects of a pinitol-rich Glycyrrhiza glabra L. leaf extract on insulin and inflammatory signaling pathways in palmitate-induced hypertrophic adipocytes

M. Cristani, A. Speciale, F. Cimino, 2021, Natural Product Research.

Antioxidant effectiveness as influenced by phenolic content of fresh orange juices.

A. Saija, F. Bonina, A. Saija, 1999, Journal of agricultural and food chemistry.

Flavonoids as antioxidant agents: importance of their interaction with biomembranes.

A. Saija, F. Bonina, A. Saija, 1995, Free radical biology & medicine.

[Effect of combined exposure to ethanol and tobacco smoke on lipid peroxidation in rats].

E. Ignatowicz, E. Florek, W. Piekoszewski, 2009, Przeglad lekarski.

Increased serum levels of IL‐22 in patients with nickel contact dermatitis

S. Gangemi, D. Trombetta, A. Saija, 2009, Contact dermatitis.

Interleukin-10 involvement in exposure to low dose of benzene

S. Gangemi, M. Cristani, G. Spatari, 2015, Toxicology and industrial health.

Cyanidin-3-O-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway.

A. Speciale, F. Cimino, A. Saija, 2013, Molecular nutrition & food research.

Oxidative stress in oncohematologic diseases: an update

A. Allegra, S. Gangemi, C. Musolino, 2013, Expert review of hematology.

Effect of Cd++ on germination, growth and active principles of Datura metel L.∗

A. Saija, R. Pasquale, S. Ragusa, 1989 .

Cellular adaptive response to glutathione depletion modulates endothelial dysfunction triggered by TNF-α.

A. Speciale, F. Cimino, A. Saija, 2011, Toxicology letters.

Cynara cardunculus L. inhibits adipogenic differentiation of 3T3-L1 cells via activation of AMPK signaling pathway

A. Speciale, F. Cimino, A. Saija, 2024, Journal of Functional Foods.

D-Allulose Reduces Hypertrophy and Endoplasmic Reticulum Stress Induced by Palmitic Acid in Murine 3T3-L1 Adipocytes

A. Speciale, F. Cimino, A. Saija, 2024, International journal of molecular sciences.

Intestinal epithelial differentiation and barrier function is promoted in vitro by a Cynara cardunculus L. leaf extract through AMPK pathway activation.

A. Speciale, F. Cimino, A. Saija, 2024, Natural product research.

Low concentrations of antimony impair adipogenesis and endoplasmic reticulum homeostasis during 3T3-L1 cells differentiation.

A. Speciale, F. Cimino, A. Saija, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Possible Link between History of Hypersensitivity to a Specific Non-steroidal Anti-inflammatory Drug (NSAID) and Positive Results Following Challenge Test to Alternative NSAIDs

S. Gangemi, S. Imbesi, D. Trombetta, 2009, Arzneimittelforschung.