Y. Irukayama-Tomobe

发表

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

T. Sakurai, M. Yanagisawa, Hirokazu Tanaka, 2009, Proceedings of the National Academy of Sciences.

Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002 .

A Single Nucleotide Polymorphism of the Neuropeptide B/W Receptor-1 Gene Influences the Evaluation of Facial Expressions

T. Sakurai, Noriya Watanabe, Naoki Furutani, 2012, PloS one.

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2020, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2022, Bioorganic & Medicinal Chemistry Letters.

The Peroxisome Proliferator-activated Receptor α Activator Fenofibrate Inhibits Endothelin-1-induced Cardiac Fibroblast Proliferation

I. Yamaguchi, T. Miyauchi, K. Goto, 2004, Journal of cardiovascular pharmacology.

Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans.

J. Sugawara, S. Kuno, M. Matsuda, 2001, Life sciences.

Peroxisome proliferator-activated receptor-gamma activators inhibit endothelin-1-related cardiac hypertrophy in rats.

I. Yamaguchi, T. Miyauchi, K. Goto, 2002, Clinical science.

The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations.

N. Shimojo, T. Miyauchi, Y. Irukayama-Tomobe, 2008, American journal of physiology. Heart and circulatory physiology.

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

Hiromasa Funato, Y. Nagumo, Y. Irukayama-Tomobe, 2022, PloS one.

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

K. Vogt, T. Sakurai, M. Yanagisawa, 2017, Proceedings of the National Academy of Sciences.

Pathway -terminal Kinase 2 Partly via Blockade of C-jun Nh Α Activated Receptor- − Proliferator Induced Cardiac Hypertrophy Is Inhibited by Activation of Peroxisome − Endothelin-1 Endothelin-1–induced Cardiac Hypertrophy Is Inhibited by Activation of Peroxisome Proliferator–activated Receptor-␣ Part

Y. Kasuya, I. Yamaguchi, T. Miyauchi, 2004 .

Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training.

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002, American journal of physiology. Heart and circulatory physiology.

Association of An Orexin 1 Receptor 408Val Variant with Polydipsia–Hyponatremia in Schizophrenic Subjects

T. Sakurai, Kazuo Yamada, Y. Iwayama, 2005, Biological Psychiatry.

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

T. Sakurai, M. Yanagisawa, H. Gouda, 2021, European journal of medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2019, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2019, Bioorganic & medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts.

I. Yamaguchi, T. Miyauchi, K. Goto, 2002, Clinical science.

Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat.

T. Miyauchi, K. Goto, A. Nakahara, 2001, European journal of pharmacology.

Effects of Medium-chain Triglyceride (MCT) Application to SHR on Cardiac Function, Hypertrophy and Expression of Endothelin-1 mRNA and other Genes

N. Shimojo, I. Yamaguchi, T. Miyauchi, 2004, Journal of cardiovascular pharmacology.

Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart.

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002, Clinical science.

Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity*

A. Utani, M. Karin, S. Asada, 2002, The Journal of Biological Chemistry.

Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide

Y. Irukayama-Tomobe, T. Kanbayashi, Hiromu Tanaka, 2022, Journal of sleep research.

Activation of Peroxisome Proliferator-activated Receptor-α Decreases Endothelin-1-induced p38 Mitogen-activated Protein Kinase Activation in Cardiomyocytes

Y. Kasuya, I. Yamaguchi, T. Miyauchi, 2004, Journal of cardiovascular pharmacology.