A. Yokoyama

Y. Tachimori, T. Muramatsu, A. Yokoyama, 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Short-term follow-up after endoscopic mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics.

S. Higuchi, T. Muramatsu, K. Okuyama, 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Health Risk Appraisal Models for Mass Screening for Esophageal and Pharyngeal Cancer: An Endoscopic Follow-up Study of Cancer-Free Japanese Men

T. Omori, T. Tsujinaka, M. Muto, 2009, Cancer Epidemiology Biomarkers & Prevention.

Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men.

S. Higuchi, T. Matsui, A. Yokoyama, 2013, Alcoholism, clinical and experimental research.

Aldehyde dehydrogenase-2 as a therapeutic target

S. Higuchi, A. Yokoyama, M. Kimura, 2019, Expert opinion on therapeutic targets.

Enzymatic Aspects of Alcoholism-ADH and ALDH

S. Higuchi, A. Yokoyama, S. Matsushita, 2014 .

Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase‐2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men

T. Hibi, T. Omori, S. Higuchi, 2007, Journal of gastroenterology and hepatology.

Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase‐2 genotype

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, International journal of cancer.

Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis.

H. Saito, H. Ebinuma, H. Ishii, 2004, Hepatology research : the official journal of the Japan Society of Hepatology.

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Title Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus , Head , and Neck

K. Kaneko, T. Yano, A. Ochiai, 2016 .

Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck.

K. Kaneko, T. Yano, A. Ochiai, 2016, Gastroenterology.

A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men.

A. Yokoyama, T. Yokoyama, Y. Kumagai, 2013, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long‐term endoscopic follow‐up study

T. Omori, H. Kawakubo, A. Yokoyama, 2008, Cancer science.

Risk of Squamous Cell Carcinoma of the Upper Aerodigestive Tract in Cancer-Free Alcoholic Japanese Men: An Endoscopic Follow-up Study

T. Hibi, T. Omori, S. Higuchi, 2006, Cancer Epidemiology Biomarkers & Prevention.

Pulmonary disease as a risk factor for transfusion-related acute lung injury

H. Yasunaga, K. Fushimi, H. Matsui, 2021, ERJ Open Research.

Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma.

T. Yano, I. Oda, K. Shiga, 2020, Japanese journal of clinical oncology.

Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions.

T. Yano, I. Oda, H. Ishikawa, 2020, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

Validation study of a health risk appraisal model and endoscopic screening for early esophageal cancer in men in specialized hospitals

K. Yamashita, M. Azuma, S. Tanabe, 2017, Esophagus.

Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde‐derived DNA damage in the blood of Japanese alcoholics

T. Chiba, T. Matsuda, M. Muto, 2012, Cancer Science.

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Yoichi Tanaka, T. Omori, T. Matsui, 2011, Cancer letters.

Difference between urban and rural regions in Japan in estimated risk of esophageal cancer based on a health risk appraisal model that includes an alcohol flushing questionnaire

K. Murakami, T. Fujioka, K. Soga, 2011, Esophagus.

Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.

A. Yokoyama, T. Yokoyama, Chun-Xia Yang, 2010, World journal of gastroenterology.

Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer in Japanese drinkers

T. Omori, A. Yokoyama, T. Yokoyama, 2010, Cancer science.

Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men.

A. Yokoyama, E. Tsutsumi, H. Imazeki, 2010, Alcoholism, clinical and experimental research.

Risk factors for esophageal iodine‐unstained lesions and changing trends among Japanese alcohol‐dependent men (2003‐2018)

T. Omori, A. Yokoyama, T. Yokoyama, 2020, Cancer science.

Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.

T. Omori, T. Tsujinaka, M. Muto, 2006, Alcoholism, clinical and experimental research.

A STUDY OF SMOKING AND DRINKING HABITS AS CARCINOGENS IN THE DEVELOPMENT OF ORAL CANCER

T. Shibahara, T. Muramatsu, G. Yamane, 1998 .

Alcoholics show reduced telomere length in the oesophagus

M. Fujiwara, M. Sawabe, K. Takubo, 2011, The Journal of pathology.

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T. Omori, H. Kawakubo, T. Matsui, 2009, Alcoholism, clinical and experimental research.

Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.

A. Yokoyama, E. Tsutsumi, H. Imazeki, 2008, Alcoholism, clinical and experimental research.

Increased DNA damage in ALDH2-deficient alcoholics.

S. Shibutani, R. Kanaly, T. Matsuda, 2006, Chemical research in toxicology.

Telomere Shortening in the Oral Epithelium in Relation to Alcohol Intake, Alcohol Dehydrogenase (ADH-1B) and Acetaldehyde Dehydrogenase (ALDH-2) Genotypes and Clinicopathologic Features.

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Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk.

S. Higuchi, T. Muramatsu, A. Yokoyama, 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Successful screening for early esophageal cancer in alcoholics using endoscopy and mucosa iodine staining

K. Okuyama, A. Yokoyama, T. Yokoyama, 1995, Cancer.

Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.

S. Higuchi, P. J. Brooks, T. Matsui, 2016, Alcoholism, clinical and experimental research.

Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men.

S. Higuchi, T. Matsui, A. Yokoyama, 2014, Alcohol and alcoholism.

Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes.

T. Omori, M. Asaka, Mototsugu Kato, 2007, Journal of gastroenterology and hepatology.

Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics.

S. Higuchi, T. Muramatsu, K. Okuyama, 1996, Alcoholism, clinical and experimental research.

Addiction research centres and the nurturing of creativity: the Kurihama medical and addiction centre-a profile.

S. Higuchi, A. Yokoyama, S. Matsushita, 2014, Addiction.

Alcohol and cancer.

X. D. Wang, A. Yokoyama, H. Seitz, 2001, Alcoholism, clinical and experimental research.

Risk appraisal and endoscopic screening for esophageal squamous cell carcinoma in Japanese populations

T. Omori, A. Yokoyama, T. Yokoyama, 2007, Esophagus.

Associations between headache and stress, alcohol drinking, exercise, sleep, and comorbid health conditions in a Japanese population

A. Yokoyama, T. Yokoyama, H. Hosoai, 2009, The Journal of Headache and Pain.

Alcohol and Cancer of the Aerodigestive Tract

A. Yokoyama, S. Kato, K. Maruyama, 2001 .

Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.

T. Omori, S. Higuchi, T. Muramatsu, 1999, Alcoholism, clinical and experimental research.

Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers.

A. Yokoyama, T. Yokoyama, S. Kondo, 2005, Alcoholism, clinical and experimental research.

Telomere Shortening in the Esophagus of Japanese Alcoholics: Relationships with Chromoendoscopic Findings, ALDH2 and ADH1B Genotypes and Smoking History

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Assessment of Autonomic Nervous Dysfunction by Heart Rate Variation in Alcoholic Diabetics

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Influence of Genetic Variations of Ethanol‐Metabolizing Enzymes on Phenotypes of Alcohol‐Related Disorders

Go Suzuki, S. Higuchi, H. Mochizuki, 2004, Annals of the New York Academy of Sciences.

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R. Hernández-Muñoz, C. Lieber, E. Baraona, 1991, Life sciences.

Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes.

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Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.

T. Omori, S. Higuchi, T. Muramatsu, 2003, Carcinogenesis.

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.

T. Omori, A. Yokoyama, 2003, Japanese journal of clinical oncology.

The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer.

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Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men

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Low serum amylase levels in drinking alcoholics.

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Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis

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Fatal herpes simplex hepatitis type 2 in a post-thymectomized adult

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Benign type of central pontine myelinolysis in alcoholism

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Comparison of cyanamide and disulfiram in effects on liver function.

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Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase‐1B and aldehyde dehydrogenase‐2 genotypes in Japanese men with alcohol dependence

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Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde.

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Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption

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Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.

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Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

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Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria.

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Screening by Total Colonoscopy Following Fecal Immunochemical Tests and Determinants of Colorectal Neoplasia in Japanese Men With Alcohol Dependence

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COLLAPSE‐SUBMERGENCE METHOD: SIMPLE COLONOSCOPIC TECHNIQUE COMBINING WATER INFUSION WITH COMPLETE AIR REMOVAL FROM THE RECTOSIGMOID COLON

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Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.

T. Omori, T. Tsujinaka, M. Muto, 2002, Carcinogenesis.

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T. Omori, S. Higuchi, T. Muramatsu, 2001, Carcinogenesis.

Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach

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Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men

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Mean corpuscular volume, alcohol flushing, and the predicted risk of squamous cell carcinoma of the esophagus in cancer-free Japanese men.

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Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men

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Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.

T. Omori, T. Tsujinaka, M. Muto, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.

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Health Risk Appraisal Models for Mass Screening of Esophageal Cancer in Japanese Men

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Major Anaerobic Bacteria Responsible for the Production of Carcinogenic Acetaldehyde from Ethanol in the Colon and Rectum.

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Novel narrow-band imaging magnifying endoscopic classification for early gastric cancer.

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Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers.

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Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers.

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[Alcohol and oropharyngolaryngeal and digestive tract cancer].

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Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.

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Nonsmoking after simultaneous alcohol abstinence and smoking cessation program was associated with better drinking status outcome in Japanese alcohol-dependent men: A prospective follow-up study

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Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2

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[Verification and Validation on Single Nucleotide Polymorphism Analysis of Alcohol Metabolism-Related Genes ADH1B and ALDH2, Using Dried-Saliva Samples].

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Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.

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Development of squamous neoplasia in esophageal iodine‐unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men

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Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men.

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Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.

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Impaired autonomic nervous system in alcoholics assessed by heart rate variation.

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Changing trends in cancer incidence of upper aerodigestive tract and stomach in Japanese alcohol‐dependent men (1993‐2018)

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Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma

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Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women

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Cimetidine Induces Interleukin-18 Production through H2-Agonist Activity in Monocytes

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Alcohol dependence severity determines the course of treatment-seeking patients.

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Interactions between migraine and tension-type headache and alcohol drinking, alcohol flushing, and hangover in Japanese

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Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men

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Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

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CHANGES IN THE SERUM BONE METABOLISM MARKERS OF ELDERLY ALCOHOLICS DURING ABSTINENCE

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Influence of ADHD, especially attention-deficit characteristics, on the course of alcohol-dependent individuals

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Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years

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