C. Hutton

发表

A. Cuzzupe, C. Hutton, M. Lilly, 2004, Organic letters.

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

J. Gerrard, C. Hutton, M. Perugini, 2007, Mini reviews in medicinal chemistry.

Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions.

A. O’Connor, D. Heath, F. Karimi, 2018, Biomaterials.

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-linked Peptides using Ultraviolet Photodissociation Mass Spectrometry.

G. Reid, E. Kapp, R. Huguet, 2019, Analytical chemistry.

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry.

Eugene A. Kapp, C. Masters, A. Bush, 2017, Analytical chemistry.

Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity.

C. Hutton, A. G. Wedd, Tessa R. Young, 2017, Metallomics : integrated biometal science.

Potentially Macrocyclic Peptidyl Boronic Acids as Chymotrypsin Inhibitors.

D. P. Mack, P. Bartlett, C. Hutton, 1997, The Journal of organic chemistry.

Copper-free palladium-catalyzed Sonogashira and Hiyama cross-couplings using aryl imidazol-1-ylsulfonates

Spencer J. Williams, C. Hutton, S. Zammit, 2010 .

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

M. Perugini, R. Dobson, J. Gerrard, 2008, Bioorganic & medicinal chemistry letters.

One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.

Mohammad B. Haskali, R. Hicks, A. Katsifis, 2013, Journal of labelled compounds & radiopharmaceuticals.

Celogentin mimetics as inhibitors of tubulin polymerization

E. Reynolds, N. O’Brien-Simpson, C. Hutton, 2019, Journal of peptide science : an official publication of the European Peptide Society.

The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product

R. Dobson, C. Hutton, B. Boughton, 2012, Proteins.

Preparation of Cyclic Peptide Alkaloids Containing Functionalized Tryptophan Residues

C. Hutton, A. Yuen, 2006 .

Neighbouring group effects promote substitution reactions over elimination and provide a stereocontrolled route to chloramphenicol

E. Tiekink, M. Merrett, C. Easton, 1996 .

Synthesis of the Leu-Trp Component of the Celogentin Family of Cyclic Peptides Through a C-H Activation-Cross-Coupling Strategy

J. White, C. Hutton, Barbara T. Y. Li, 2010 .

Correction to: Investigation of Fluorine-18 Labelled Peptides for Binding to Cholecystokinin-2 Receptors with High Affinity

Mohammad B. Haskali, C. Hutton, Alicia Corlett, 2021, International Journal of Peptide Research and Therapeutics.

Inhibitors of lysine biosynthesis as antibacterial agents.

C. Hutton, T. Southwood, Jennifer J. Turner, 2003, Mini reviews in medicinal chemistry.

Total Synthesis of the Putative Structure of Asperipin-2a and Stereochemical Reassignment.

J. White, C. Hutton, Sadegh Shabani, 2020, Organic letters.

Progress and perspectives on directing group-assisted palladium-catalysed C-H functionalisation of amino acids and peptides.

C. Hutton, Sadegh Shabani, Yuezhou Wu, 2021, Chemical Society reviews.

Biochemical characterization of a recombinant thermoalkalophilic lipase and assessment of its substrate enantioselectivity

L. Hunter, P. Bergquist, A. Sunna, 2002 .

Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction.

C. Hutton, Quentin I. Churches, Aaron Brown, 2015, The Journal of organic chemistry.

1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase.

J. Gerrard, C. Hutton, L. Hor, 2012, Bioorganic & Medicinal Chemistry.

Enantioselective preparation of a stable boronate complex stereogenic only at boron.

J. White, C. Hutton, P. Kaiser, 2008, Journal of the American Chemical Society.

Inhibition of lysine biosynthesis: an evolving antibiotic strategy.

M. Perugini, J. Gerrard, C. Hutton, 2007, Molecular bioSystems.

Organoboron Reagents in the Preparation of Functionalized ?-Amino Acids

C. Hutton, P. Kaiser, Quentin I. Churches, 2007 .

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.

J. Baell, L. Tilley, N. Klonis, 2013, Journal of medicinal chemistry.

Factors affecting the efficiency and stereoselectivity of α-amino acid synthesis by the Petasis reaction

C. Hutton, M. Curry, T. Southwood, 2006 .

Synthesis of the β-hydroxydopa–γ-hydroxy-δ-sulfinylnorvaline component of ustiloxins A and B

L. Hunter, C. Hutton, M. McLeod, 2005 .

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

J. Baell, A. Cowman, P. Gilson, 2017, Journal of medicinal chemistry.

Depsipeptide synthesis using a late-stage Ag(I)-promoted macrolactonisation of peptide thioamides.

C. Hutton, Sadegh Shabani, 2021, Chemical communications.

Total Synthesis of Seongsanamide B.

C. Hutton, Sadegh Shabani, 2020, Organic letters.

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives.

M. Davies, C. Hutton, C. Schiesser, 2018, Chemical communications.

The asymmetric aminohydroxylation route to GABOB and homoserine derivatives

A. Willis, C. Hutton, M. McLeod, 2009 .

Introduction, Interconversion and Removal of Boron Protecting Groups

C. Hutton, Quentin I. Churches, 2016 .

Synthesis of homochiral hydroxy-α-amino acid derivatives

E. Tiekink, C. Easton, C. Hutton, 1990 .

Synthesis of the C-Terminal Macrocycle of Asperipin-2a.

J. White, C. Hutton, Sadegh Shabani, 2019, Organic letters.

The enantioselective synthesis of APTO and AETD: polyhydroxylated beta-amino acid constituents of the microsclerodermin cyclic peptides.

C. Hutton, M. McLeod, H. Duong, 2007, Organic & biomolecular chemistry.

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

R. Dobson, J. Gerrard, C. Hutton, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of Peptides by Silver-Promoted Coupling of Carboxylates and Thioamides: Mechanistic Insight from Computational Studies.

C. Hutton, Jing-Yan Shang, U. Wille, 2016, Chemistry.

A new method for peptide synthesis in the N→C direction: amide assembly through silver-promoted reaction of thioamides.

J. Cochrane, C. Hutton, Aysa Pourvali, 2014, Chemical communications.

Steric and Electronic Effects in the Synthesis and Regioselective Hydrolysis of Unsymmetrical Imides

J. Cochrane, C. Hutton, Jing-Yan Shang, 2015 .

Towards a total synthesis of ustiloxins A & B. Stereocontrolled synthesis of (2S,4S,6S)-4-hydroxy-5-phenylsulfinylnorvaline

J. White, C. Hutton, 1997 .

Total synthesis of mycocyclosin.

J. Cochrane, J. White, C. Hutton, 2012, Organic letters.

Role of 2-oxo and 2-thioxo modifications on the fragmentation reactions of the histidine radical cation.

R. O'hair, C. Hutton, A. K. Lam, 2011, Rapid communications in mass spectrometry : RCM.

Synthesis of each stereoisomer of [3-2H1]phenylalanine and evaluation of the stereochemical course of the reaction of (R)-phenylalanine with (S)-phenylalanine ammonia-lyase

C. Easton, C. Hutton, 1994 .

Deprotection of pinacolyl boronate esters by transesterification with polystyrene-boronic acid

C. Hutton, T. Pennington, Cynantya Kardiman, 2004 .

Synthesis of β,γ-dihydroxyhomotyrosines by a tandem Petasis-asymmetric dihydroxylation approach.

J. White, C. Hutton, Quentin I. Churches, 2011, Organic letters.

Substituent effects in the stereoconvergent synthesis of β-hydroxyphenylalanine derivatives

C. Hutton, 1997 .

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis*

M. Perugini, R. Dobson, C. Hutton, 2013, The Journal of Biological Chemistry.

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.

M. Perugini, R. Dobson, J. Gerrard, 2008, Bioorganic & medicinal chemistry.

Rapid, Traceless, AgI -Promoted Macrocyclization of Peptides Possessing an N-Terminal Thioamide.

C. Hutton, Varsha J. Thombare, 2019, Angewandte Chemie.

Rapid, Traceless, AgI -Promoted Macrocyclization of Peptides Possessing an N-Terminal Thioamide.

C. Hutton, Varsha J. Thombare, 2019, Angewandte Chemie.

Total Synthesis of Ustiloxin D

L. Hunter, P. Chan, C. Hutton, 2016 .

A convenient preparation of dityrosine via Miyaura borylation–Suzuki coupling of iodotyrosine derivatives

C. Hutton, Ojia Skaff, 2003 .

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.

D. Tew, M. Parker, J. Karas, 2009, Chemical communications.

Synthesis of Tryptophans by Lewis Acid Promoted Ring-Opening of Aziridine-2-carboxylates: Optimization of Protecting Group and Lewis Acid.

C. Hutton, J. Eakins, I. Tirotta, 2013 .

Deprotection of pinacolyl boronate esters via hydrolysis of intermediate potassium trifluoroborates

C. Hutton, A. Yuen, 2005 .

Synthesis of cyclic peptide hemicryptophanes: enantioselective recognition of a chiral zwitterionic guest.

J. Cochrane, C. Hutton, U. Wille, 2013, Chemical communications.

Role of 2-oxo and 2-thioxo modifications on the proton affinity of histidine and fragmentation reactions of protonated histidine.

R. O'hair, C. Hutton, A. K. Lam, 2010, Rapid communications in mass spectrometry : RCM.

Bridged bicyclic peptides: Structure and function

C. Hutton, Varsha J. Thombare, 2018 .

Antimicrobial activity of simplified mimics of celogentin C

E. Reynolds, N. O’Brien-Simpson, A. Chattopadhyay, 2017 .

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

R. Dobson, J. Gerrard, C. Hutton, 2005, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of cyclo(L-tyrosyl-L-tyrosine) derivatives binding to Mycobacterium tuberculosis CYP121: iodinated analogues promote shift to high-spin adduct.

A. Munro, C. Levy, K. J. McLean, 2019, Journal of medicinal chemistry.

LC-MS and NMR characterization of the purple chromophore formed in the o-aminobenzaldehyde assay of dihydrodipicolinate synthase.

J. Gerrard, S. Devenish, C. Hutton, 2011, Bioorganic & medicinal chemistry.

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

L. Domigan, R. Dobson, J. Gerrard, 2009, Biochimica et biophysica acta.

Conserved main‐chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

Sean R.A. Devenish, Juliet A. Gerrard, Craig A. Hutton, 2008, Protein science : a publication of the Protein Society.

Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.

J. Gerrard, C. Hutton, Jennifer J. Turner, 2005, Bioorganic & medicinal chemistry.

Selective Cleavage of Carbamate Protecting Groups from Aziridines with Otera's Catalyst

C. Hutton, I. Tirotta, Sha Sun, 2014 .

Structure of olefin-imidacloprid and gas-phase fragmentation chemistry of its protonated form.

J. White, R. O'hair, C. Hutton, 2016, Organic & biomolecular chemistry.

Effects of PPARγ ligands on TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells

J. Bourke, C. Hutton, X. Tan, 2010, Respiratory research.

Effects of PPARg ligands on TGF-b1-induced epithelial-mesenchymal transition in alveolar epithelial cells

J. Bourke, C. Hutton, X. Tan, 2010 .

Effects of PPAR g ligands on TGF-b 1-induced epithelial-mesenchymal transition in alveolar epithelial cells

J. Bourke, C. Hutton, X. Tan, 2010 .

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

N. Smargiasso, D. Baiwir, P. Delvenne, 2016, eLife.

Blood-Borne Amyloid-β Dimer Correlates with Clinical Markers of Alzheimer's Disease

C. Rowe, N. Faux, J. Bedő, 2010, The Journal of Neuroscience.

Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

R. Hicks, C. Hutton, D. Denoyer, 2019, MedChemComm.

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer.

R. Hicks, P. Thompson, C. Ang, 2021, Journal of medicinal chemistry.

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.

P. Bartlett, C. Hutton, 2007, The Journal of organic chemistry.

Effective Preparation of [18F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

L. Vivash, C. Hutton, B. Jupp, 2022, Molecules.

Biomaterials functionalized with nanoclusters of integrin- and syndecan-binding ligands improve cell adhesion and mechanosensing under shear flow conditions.

G. Qiao, A. O’Connor, D. Heath, 2020, Journal of biomedical materials research. Part A.

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

J. Bellier, V. Castronovo, J. Cochrane, 2017, Scientific Reports.

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

C. Masters, V. Villemagne, A. Rembach, 2013, Acta Neuropathologica.

Synthesis of the side chain cross-linked tyrosine oligomers dityrosine, trityrosine, and pulcherosine.

K. Jolliffe, C. Hutton, Ojia Skaff, 2005, The Journal of organic chemistry.

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

R. Cappai, G. Ciccotosto, M. Parker, 2013 .

Cu2+ Coordination of Covalently Cross-linked β-Amyloid Dimers

C. Hutton, K. Barnham, W. M. Kok, 2013, Applied Magnetic Resonance.

Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel 18F-Labeled Cyclic RGD Analogues.

R. Hicks, R. Haubner, N. Pouliot, 2017, Molecular pharmaceutics.

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

E. Winzeler, L. Tilley, L. Dick, 2018, Journal of medicinal chemistry.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.

M. Parker, M. Perugini, R. Dobson, 2009, Acta Crystallographica. Section F : Structural Biology and Crystallization Communications.

Recent developments in radiolabelled peptides for PET imaging of cancer

R. Hicks, C. Hutton, P. Roselt, 2016 .

Stereochemical and conformational consequences of the oxidation of 1,4-thiazane-3,5-dicarboxylates

J. White, G. Bacskay, C. Hutton, 2002 .

Ring expansion of thiolactams via imide intermediates: an amino acid insertion strategy.

C. Hutton, Jing-Yan Shang, U. Wille, 2020, Chemistry.

Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin B.

A. Cuzzupe, C. Hutton, M. Lilly, 2001, The Journal of organic chemistry.

Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform

David Binns, Rodney J. Hicks, Stan Poniger, 2019, EJNMMI Radiopharmacy and Chemistry.

A general method for interconversion of boronic acid protecting groups: trifluoroborates as common intermediates.

C. Hutton, Joel F. Hooper, Quentin I. Churches, 2015, The Journal of organic chemistry.

Anomalies in the Stereoselectivity of the Petasis Reaction Using Styrenyl Boronic Acids

C. Hutton, James K. Johnson, Nathan L. Fifer, 2011 .

Stereoselectivity of the Petasis reaction with various chiral amines and styrenylboronic acids

C. Hutton, P. Turner, Scott B. Cohen, 2008 .

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax*

M. Parker, M. Perugini, R. Dobson, 2009, The Journal of Biological Chemistry.

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.

M. Perugini, R. Dobson, C. Dogovski, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin-2 Receptor Positive Cancers.

P. Thompson, C. Cullinane, C. Hutton, 2023, Journal of medicinal chemistry.

A new robust kinetic assay for DAP epimerase activity.

M. Perugini, C. Hutton, L. Hor, 2013, Biochimie.

4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules

C. Hutton, P. Roselt, M. Haskali, 2020, RSC medicinal chemistry.

Investigation of Fluorine-18 Labelled Peptides for Binding to Cholecystokinin-2 Receptors with High Affinity

C. Hutton, Alicia Corlett, N. Khan, 2021, International Journal of Peptide Research and Therapeutics.

Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

L. Hunter, P. Bergquist, C. Hutton, 2004 .

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

C. Masters, V. Villemagne, A. Rembach, 2013, Acta Neuropathologica.

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax*

M. Parker, M. Perugini, R. Dobson, 2009, The Journal of Biological Chemistry.

A new robust kinetic assay for DAP epimerase activity.

M. Perugini, C. Hutton, L. Hor, 2013, Biochimie.

Lysine biosynthesis in bacteria:: an unchartered pathway for novel antibiotic design

R. Dobson, Sarah C Atkinson, C. Dogovski, 2009 .

Recent Developments in the Use of N-Phthaloyl-Amino Acid Derivatives in Synthesis

C. Easton, C. Hutton, 1998 .

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

J. Baell, A. Cowman, P. Gilson, 2017, Journal of medicinal chemistry.

Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions.

A. O’Connor, D. Heath, F. Karimi, 2018, Biomaterials.

One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.

R. Hicks, A. Katsifis, J. Karas, 2013, Journal of labelled compounds & radiopharmaceuticals.

Automated preparation of 2-[18 F]fluoropropionate labeled peptides using a flexible, multi-stage synthesis platform (iPHASE Flexlab).

R. Hicks, C. Hutton, P. Roselt, 2018, Journal of labelled compounds & radiopharmaceuticals.