K. Isono

发表

Absolute configuration of reveromycin A, an inhibitor of the signal transduction of epidermal growth factor

M. Ubukata, H. Koshino, H. Osada, 1994 .

Absolute Configuration of Reveromycin A, an Inhibitor of the Signal Transduction of Epidermal Growth Factor.

M. Ubukata, H. Koshino, H. Osada, 1995 .

Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties.

Hidetoshi Takahashi, H. Koshino, H. Osada, 1992, The Journal of antibiotics.

Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization.

H. Osada, K. Isono, T. Sonoda, 1989, The Journal of antibiotics.

Actiketal, a new member of the glutarimide antibiotics.

H. Osada, K. Isono, T. Sonoda, 1991, The Journal of antibiotics.

Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor.

H. Koshino, H. Osada, K. Isono, 1991, The Journal of antibiotics.

Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rous sarcoma virus.

H. Osada, K. Isono, T. Sonoda, 1992, Bioscience, biotechnology, and biochemistry.

Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

The structure of liposidomycin B, an inhibitor of bacterial peptidoglycan synthesis

M. Ubukata, J. McCloskey, K. Isono, 1988 .

Structure elucidation of liposidomycins, a class of complex lipid nucleoside antibiotics

J. M. Gregson, M. Ubukata, J. McCloskey, 1992 .

Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.

K. Shin‐ya, J. McCloskey, M. Uramoto, 1991, The Journal of antibiotics.

Current progress on nucleoside antibiotics.

K. Isono, 1991, Pharmacology & therapeutics.

Nucleoside antibiotics: structure, biological activity, and biosynthesis.

K. Isono, 1988, The Journal of antibiotics.

Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules.

M. Yamasaki, J. Magae, K. Nagai, 1992, The Journal of antibiotics.

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.

H. Koshino, H. Osada, T. Kudo, 1992, The Journal of antibiotics.

A new biological role of sangivamycin; inhibition of protein kinases.

H. Osada, K. Isono, T. Sonoda, 1989, The Journal of antibiotics.

Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system.

M. Yamasaki, J. Magae, K. Nagai, 1989, The Journal of antibiotics.

A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

A new indolocarbazole antibiotic, RK-286D.

M. Satake, H. Koshino, H. Osada, 1992, The Journal of antibiotics.

Studies on differentiation inducing substances of animal cells. I. Differenol A, a differentiation inducing substance against mouse leukemia cells.

K. Isono, H. Kusakabe, K. Asahi, 1981, The Journal of antibiotics.

Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation.

H. Osada, M. Uramoto, K. Isono, 1989, The Journal of antibiotics.

Cytovaricin, a novel antibiotic.

K. Isono, H. Kusakabe, T. Kihara, 1981, The Journal of antibiotics.

A pharmacophore model of tautomycin, an inhibitor of protein phosphatases 1 and 2A.

M. Ubukata, H. Koshino, K. Isono, 1997, The Journal of antibiotics.

Bisulfite-catalyzed facile decarboxylation reaction of 5-carboxyuracil derivatives and transformation of polyoxins

K. Isono, Mutsuo Tanaka, Saburô Suzuki, 1970 .

Polyoxins and Related Nucleosides

K. Isono, 1995 .

Structural identity and stereochemical revision of polyoximic acid

S. Hanessian, K. Isono, Jian-min Fu, 1993 .

A new antifungal antibiotic, cystargin: fermentation, isolation, and characterization.

K. Shin‐ya, M. Uramoto, K. Isono, 1988, The Journal of antibiotics.

Chemistry of the neopolyoxins, pyrimidine and imidazoline nucleoside peptide antibiotics

J. McCloskey, M. Uramoto, K. Isono, 1982 .

Structures of neopolyoxins A, B, and C

J. McCloskey, M. Uramoto, K. Isono, 1980 .

Biosynthesis of octosyl acid A: Incorporation of C-13 labeled glucose

K. Isono, J. Uzawa, K. Hirasawa, 1979 .

Origin of nitrogen in the biosynthesis of carbamoylpolyoxamic acid.

P. Crain, J. McCloskey, K. Isono, 1978, Biomedical mass spectrometry.

Biosynthesis of the polyoxins, nucleoside peptide antibiotics: biosynthetic pathway for 5-O-carbamoyl-2-amino-2-deoxy-L-xylonic acid (carbamoylpolyoxamic acid).

K. Isono, S. Funayama, 1977, Biochemistry.

Biosynthesis of the Polyoxins, Nucleoside Peptide Antibiotics: Formation of 5-Carboxyuracil Nucleosides by Streptomyces cacaoi

K. Isono, S. Funayama, 1976 .

The biosynthesis of natural and unnatural polyoxins by Streptomyces cacaoi.

K. Isono, R. Suhadolnik, 1976, Archives of biochemistry and biophysics.

Biosynthesis of the polyoxins, nucleoside peptide antibiotics: glutamate as an origin of 2-amino-2-deoxy-L-xylonic acid (polyoxamic acid).

K. Isono, S. Funayama, 1975, Biochemistry.

Biosynthesis of the polyoxins, nucleoside peptide antibiotics: a new metabolic role for L-isoleucine as a precursor for 3-ethylidene-L-azetidine-2-carboxylic acid (polyoximic acid).

K. Isono, S. Funayama, R. Suhadolnik, 1975, Biochemistry.

Recently, we isolated epiderstatin1 '2) which inhibits the mitogenic activity induced by epidermal growth factor (EGF) in the culture fluid of Streptomyces pulveraceus subsp. epiderstagenes. Actiketal, a new member

H. Osada, K. Isono, T. Sonoda, 2006 .

Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus.

M. Ubukata, H. Osada, K. Isono, 1992, The Journal of antibiotics.

Synthesis of (±)-Epiderstatin

M. Ubukata, K. Isono, T. Sonoda, 1992 .

Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

H. Kakeya, H. Osada, K. Isono, 1995, The Journal of antibiotics.

Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor

M. Ubukata, K. Isono, M. Isobe, 1996 .

Morphological changes and reorganization of actinfilaments in human myeloid leukemia cells induced by a novel protein phosphatase inhibitor, tautomycin.

M. Yamasaki, J. Magae, T. Yoshida, 1993, Cell structure and function.

Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins.

H. Osada, K. Isono, M. Yoshihama, 1998, The Journal of antibiotics.

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). II. Isolation, physico-chemical properties and structure.

H. Osada, M. Uramoto, K. Isono, 1990, The Journal of antibiotics.

Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.

J. Magae, H. Osada, K. Isono, 1988, The Journal of antibiotics.

Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin

M. Ubukata, J. Magae, H. Osada, 1988 .

Synthesis of guanine 7-oxide, an antitumor antibiotic from streptomyces species

M. Ubukata, K. Isono, T. Fujii, 1987 .

Structure and Biological Activity of Neopeptins A, B and C, Inhibitors of Fungal Cell Wall Glycan Synthesis

M. Ubukata, K. Isono, J. Uzawa, 1986 .

Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase, in mammalian cell membranes and susceptibility to ascamycin.

H. Osada, K. Isono, 1986, The Journal of antibiotics.

Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri.

H. Osada, K. Isono, 1986, The Biochemical journal.

Antiviral activity and its mechanism of guanine 7-N-oxide on DNA and RNA viruses derived from salmonid.

K. Isono, M. Saneyoshi, M. Hasobe, 1985, The Journal of antibiotics.

Liposidomycins: novel nucleoside antibiotics which inhibit bacterial peptidoglycan synthesis.

J. McCloskey, M. Uramoto, K. Isono, 1985, The Journal of antibiotics.

A new antitumor antibiotic, guanine 7-N-oxide produced by Streptomyces sp.

J. McCloskey, K. Isono, H. Kusakabe, 1985, The Journal of antibiotics.

A new antifungal antibiotic, phosphazomycin A.

M. Uramoto, K. Isono, H. Kusakabe, 1985, The Journal of antibiotics.

Chemistry of the neopolyoxins, pyrimidine and imidazoline nucleoside peptide antibiotics

J. McCloskey, M. Uramoto, K. Isono, 1982 .

Neopolyoxins A, B, and C, New Chitin Synthetase Inhibitors

M. Uramoto, K. Isono, H. Kusakabe, 1980 .

A new antibiotic, lipopeptin A.

K. Isono, S. Suzuki, T. Kihara, 1980, The Journal of antibiotics.

Studies on Polyoxins, Antifungal Antibiotics

K. Isono, Saburô Suzuki, J. Nagatsu, 1966 .

Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach

A. Komori, H. Fujiki, M. Suganuma, 2005, Journal of Cancer Research and Clinical Oncology.

Taxonomic studies on Kitasatosporia cystarginea sp. nov., which produces a new antifungal antibiotic cystargin.

K. Isono, H. Kusakabe, 1988, The Journal of antibiotics.

Respiratory burst induced by phorbol ester in the presence of tautomycin, a novel inhibitor of protein phosphatases.

J. Magae, K. Nagai, K. Isono, 1992, The Journal of antibiotics.

Biosynthesis of the C-nucleoside, minimycin: asymmetric incorporation of glutamate and acetate into the oxazine ring.

K. Isono, R. Suhadolnik, 1977, The Journal of antibiotics.

Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment.

M. Ubukata, H. Kakeya, H. Osada, 1996, The Journal of antibiotics.

Studies on a New Antibiotic, Laurusin

K. Isono, N. Ōtake, H. Yonehara, 1965 .

The structure of neopeptins, inhibitors of fungal cell wall biosynthesis

M. Ubukata, M. Uramoto, K. Isono, 1984 .

Biosynthesis of the 5-fluoropolyoxins, aberrant nucleoside antibiotics.

P. Crain, J. McCloskey, K. Isono, 1973, Journal of the American Chemical Society.

Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.

M. Ubukata, H. Kakeya, H. Osada, 1995, The Journal of antibiotics.

A new antibiotic, antlermicin A.

M. Uramoto, K. Isono, K. Kobinata, 1980, The Journal of antibiotics.

Formation of 8-azaguanine from guanine by Streptomyces albus.

K. Isono, K. Hirasawa, 1978, The Journal of antibiotics.

Isoxazole-4-carboxylic Acid as a Metabolite of Streptomyces sp. and Its Herbicidal Activity

M. Ubukata, S. Sekido, I. Yamaguchi, 1991 .

Isolation of structure of octosyl acids. Anhydrooctose uronic acid nucleosides

P. Crain, J. McCloskey, K. Isono, 1975 .

Absolute configuration of tautomycin, a protein phosphatase inhibitor from a streptomycete

M. Ubukata, K. Isono, M. Isobe, 1993 .

A new cyclic lipopeptide antibiotic, enamidonin.

H. Koshino, H. Osada, K. Isono, 1995, The Journal of antibiotics.

RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.

M. Ubukata, H. Osada, T. Kudo, 1995, The Journal of antibiotics.

Isolation and characterization of a new antibiotic, malolactomycin A.

H. Koshino, H. Osada, K. Isono, 1993, The Journal of antibiotics.

Synthetic studies on tautomycin synthesis of Segment B

M. Ubukata, K. Isono, M. Isobe, 1997 .

Isolation and structure of phosphazomycin C.

M. Uramoto, K. Isono, T. Tomiya, 1990, The Journal of antibiotics.

Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.

M. Ubukata, H. Kakeya, H. Osada, 1995, The Journal of antibiotics.

Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment

M. Ubukata, H. Kakeya, H. Osada, 1996 .

The structure of enopeptins A and B, novel depsipeptide antibiotics

H. Koshino, H. Osada, K. Isono, 1991 .

Studies on Polyoxins, Antifungal Antibiotics:Part I. Isolation and Characterization of Polyoxins A and B

Saburo Suzuki, K. Isono, Yoshitsugu Kawashima, 1965 .

Structure of malolactomycins A and B, novel 40-membered macrolide antibiotics

H. Koshino, H. Osada, M. Uramoto, 1993 .

Isolation and Characterization of Polyoxins J, K and L, New Components of Polyoxin Complex

K. Isono, K. Kobinata, Saburô Suzuki, 1968 .

13C‐NMR evidence for the biosynthetic incorporation of acetate into minimycin and compounds related to krebs cycle

K. Isono, J. Uzawa, 1977, FEBS letters.

Morphological Changes of Human Myeloid Leukemia K562 Cells by a Protein Phosphatase Inhibitor, Tautomycin

M. Yamasaki, J. Magae, K. Nagai, 1990 .

A new species of Actinomadura producing a polyether antibiotic, cationomycin.

K. Isono, G. Nakamura, 1983, The Journal of antibiotics.

The mechanism of protein synthesis-initiation, elongation and termination in translation of genetic messeges.

D. Richter, K. Isono, 1977, Current topics in microbiology and immunology.

Liposidolide A, a new antifungal macrolide antibiotic.

H. Koshino, K. Isono, T. Kihara, 1995, The Journal of antibiotics.

Antlermicins B and C, new members of the antlermicin family.

M. Uramoto, K. Isono, K. Kobinata, 1980, The Journal of antibiotics.

Respinomycins A1, A2 B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities.

M. Ubukata, H. Osada, T. Kudo, 1993, The Journal of antibiotics.

Aromatic side chain analogs of cationomycin and their biological activities

M. Ubukata, K. Isono, T. Akama, 1988 .

Chemical Modification of Cationomycin and Its Structure-Activity Relationship

M. Ubukata, K. Isono, Y. Hamazaki, 1986 .

Biosynthesis of cationomycin: direct and indirect incorporation of 13C-acetate and application of homoscalar correlated 2-D carbon-13 NMR and double quantum coherence

M. Ubukata, K. Isono, J. Uzawa, 1984 .

N-Acetylglycine Side Chain is Critical for the Antimicrobial Activity of Xanthostatin

M. Ubukata, K. Isono, Si-Kwan Kim, 2003 .

Xanthostatin, a new antibiotic

Yinchu Shen, I. Yamaguchi, K. Isono, 1987 .

Chemical transglycosylation of octosyl acid

P. Crain, J. McCloskey, K. Isono, 1976 .

Formation and Characterization of 5'-Deoxy-5', 6-epimino-5, 6-dihydro-2', 3'-O-isopropylideneuridine

K. Isono, T. Azuma, 1972 .

Transnucleosidation : An Improved Method for Transglycosylation from Pyrimidines to Purines

K. Isono, T. Azuma, 1977 .

BIOSYNTHESIS OF THE 5-FLUOROPOLYOXIMS, ABERRANT NUCLEOSIDE ANTIBIOTICS

P. Crain, J. McCloskey, K. Isono, 1973 .

THE BIOSYNTHESIS OF THE NUCLEOSIDE ANTIBIOTICS: MINIMYCIN FORMATION BY STREPTOMYCES HYGROSCOPICUS *

K. Isono, R. Suhadolnik, 1975, Annals of the New York Academy of Sciences.

The absolute configuration of cytovaricin: isolation of methyl beta-D-cymaroside by methanolysis.

K. Isono, T. Kihara, 1983, The Journal of antibiotics.

TRANSNUCLEOSIDATION- AN IMPROVED METHOD FOR TRANSGLYCOSYLATION FROM PYRIMIDINES TO PURINES

K. Isono, T. Azuma, 1978 .

The synergism of nucleoside antibiotics combined with guanine 7-N-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV).

K. Isono, M. Saneyoshi, M. Hasobe, 1986, The Journal of antibiotics.

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a

M. Yoshida, T. Beppu, H. Osada, 1991, The Journal of cell biology.

Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic

H. Osada, K. Isono, 1985, Antimicrobial Agents and Chemotherapy.

Studies on the Mode of Action of Antlermicin a on Bacillus subtilis

K. Isono, K. Izaki, H. Takahashi, 1984 .

Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp.

M. Ubukata, J. McCloskey, M. Uramoto, 1984, The Journal of antibiotics.

New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.

H. Osada, K. Isono, H. Takahashi, 1998, The Journal of antibiotics.

Biosynthesis of the nucleoside skeleton of polyoxins

K. Isono, K. Hirasawa, S. Funayama, 1978 .

New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.

M. Ubukata, H. Osada, K. Isono, 1998, The Journal of antibiotics.

Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia coli Y-10

Y. Kamio, K. Isono, G. Kawanishi, 1989 .

A new antibiotic, grisamine.

K. Isono, S. Suzuki, G. Nakamura, 1955, The Journal of antibiotics.

Biosynthesis and 13C NMR assignment of cytovaricin, a neutral macrolide antibiotic.

M. Ubukata, K. Isono, J. Uzawa, 1989, The Journal of antibiotics.

Biosynthesis of the dialkylmaleic anhydride-containing antibiotics, tautomycin and tautomycetin

M. Ubukata, K. Isono, J. Uzawa, 1995 .

Structure of cytovaricin–acetonitrile (1:1), C47H80O16.C2H3N

K. Isono, T. Kihara, T. Sakurai, 1983 .

New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties.

H. Osada, K. Isono, T. Yano, 1990, Agricultural and biological chemistry.

Biosynthesis of the Dialkylmaleic Anhydride Containing Antibiotics, Tautomycin and Tautomycetin.

M. Ubukata, K. Isono, J. Uzawa, 1996 .

Rapid screening method for inhibitors of protein kinase C.

H Osada, J. Magae, H. Osada, 1988, The Journal of antibiotics.

Differentiation Inducing Phosphatidyl Choline(s) from the Embryos of Rainbow Trout (Salmo gairdneri): Isolation and Structural Elucidation 1

Motofumi Suzuki, N. Takahashi, A. Sakurai, 1992, Development, growth & differentiation.

Specific binding of chartreusin, an antitumor antibiotic, to DNA

M. Uramoto, K. Isono, T. Ando, 1983, FEBS letters.

Structure of the antifungal nucleotide antibiotic phosmidosine

J. McCloskey, D. R. Phillips, M. Uramoto, 1993 .

Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity.

H. Koshino, H. Osada, K. Isono, 1991, The Journal of antibiotics.

Studies on Polyoxins, Antifungal Antibiotics:Part V. Isolation and Characterization of Polyoxins C, D, E, F, G, H and I

K. Isono, K. Sasaki, K. Kobinata, 1967 .

New aspect in research and development of agricultural antibiotics.

K. Isono, 1989 .

THE POLYOXINS: PYRIMIDINE NUCLEOSIDE PEPTIDE ANTIBIOTICS INHIBITING FUNGAL CELL WALL BIOSYNTHESIS

K. Isono, Saburô Suzuki, 1979 .

Studies on Polyoxins, Antifungal Antibiotics

K. Isono, Saburô Suzuki, J. Nagatsu, 1966 .

Chemical studies on malformin—II. : Synthesis of cyclic pentapeptides related to malformin A☆

R. W. Curtis, K. Isono, 1964 .

Stereospecificity of the enzymatic dehydrogenation in the biosynthesis of 3-ethylidene-L-azetidine-2-carboxylic acid from isoleucine by Streptomyces cacaoi.

K. Isono, R. K. Hill, D. Crout, 1981, Biochemistry.

Polyoxin Analogs. I. Synthesis of Aminoacyl Derivatives of 5'-Amino-5'-deoxyuridine

K. Isono, Saburô Suzuki, T. Azuma, 1971 .

The structure of tautomycin, a regulator of eukaryotic cell growth

M. Ubukata, K. Isono, Xing-Chun Cheng, 1990 .

The structure of lipopeptin a

J. McCloskey, K. Isono, T. Miyazawa, 1981 .

The structure of polyoxin C

K. Isono, Saburô Suzuki, 1968 .

Polyoxin N, a New Member of the Polyoxin Family

J. Liehr, J. McCloskey, M. Uramoto, 1981 .

Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.

Hidetoshi Takahashi, H. Koshino, H. Osada, 1992, Journal of antibiotics (Tokyo. 1968).

Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

H. Kakeya, H. Osada, K. Isono, 1995, The Journal of antibiotics.