H. Nakai

发表

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

H. Itazaki, K. Nagashima, K. Sugita, 1990, The Journal of antibiotics.

Two chromosomal locations for human ornithine decarboxylase gene sequences and elevated expression in colorectal neoplasia.

R. Eddy, T. Shows, C. Porter, 1990, Cancer research.

Fourier transform infrared spectrometric study of tautomeric (enol-keto) and dimeric equilibria in 2-hydroxypyridines and 1,3-cyclohexanediones in CHCl3 and/or CCl4 solutions

H. Nakai, Takashi Saito, M. Takasuka, 1996 .

Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{N-[(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

T. Sugawara, H. Nakai, T. Yoshikawa, 2018, ACS omega.

ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis.

H. Nakai, R. Kruklitis, D. Welty, 1996, The EMBO journal.

Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms.

H. Nakai, J. M. Jones, D. Welty, 1997, Journal of molecular biology.

Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. I. Isolation, structure elucidation and biological activities.

T. Fujiwara, Y. Kawamura, H. Nakai, 2002, The Journal of antibiotics.

Stereoselective synthesis of the C-24 and C-25 stereoisomeric pairs of 24-ethyl-26-hydroxy- and 24-ethyl-[26-2H]sterols and their Δ22-derivatives: reassignment of 13C n.m.r. signals of the pro-R and the pro-S methyl groups at C-25 of 24-ethylsterols

S. Takatsuto, Tomohiro Sato, H. Nakai, 1989 .

Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in Rats (1): Blood and Plasma Levels, Distribution, Metabolism and Excretion after a Single Intravenous Administration

H. Nakai, K. Nakai, S. Iida, 1996 .

The Surveillance for Contents of Pharmacogenomics Information in Package Inserts and Interview Forms

F. Komada, H. Nakai, 2016 .

Crystal data for some halogenated steroids.

H. Nakai, H. Koyama, 1967, Acta crystallographica.

Cloning of a Phosphate-Regulated Hemolysin Gene (Phospholipase C) from Pseudomonas aeruginosa

R. Berka, M. Vasil, H. Nakai, 1982, Journal of bacteriology.

Versatile Action of Escherichia coli ClpXP as Protease or Molecular Chaperone for Bacteriophage Mu Transposition*

H. Nakai, Jessica M Jones, D. Welty, 1998, The Journal of Biological Chemistry.

A case of 21q-syndrome with normal SOD-1 activity

Yoshifumi Yamamoto, Y. Kuroki, H. Nakai, 1979, Human Genetics.

Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola.

M. Matsumoto, K. Sugita, H. Yoshida, 1992, The Journal of antibiotics.

Asparenomycins A, B and C, new carbapenem antibiotics. III. Structures.

T. Kato, K. Nagashima, H. Nakai, 1982, The Journal of antibiotics.

Derepression of bacteriophage mu transposition functions by truncated forms of the immunity repressor.

H. Nakai, D. O'handley, 2002, Journal of molecular biology.

Cinatrins, a novel family of phospholipase A2 inhibitors. I. Taxonomy and fermentation of the producing culture; isolation and structures of cinatrins.

H. Itazaki, K. Nagashima, Y. Kawamura, 1992, The Journal of antibiotics.

Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.

A. C. Webb, R. Eddy, T. Shows, 1986, Lymphokine research.

Primary structure and gene localization of human prolidase.

K. Titani, F. Endo, Y. Indo, 1989, The Journal of biological chemistry.

Fine Assignment of 3-Hexosaminidase A ar-Subunit on 15823-q 24 by High Resolution In Situ Hybridization

T. Shows, K. Tada, H. Nakai, 2006 .

Fine assignment of beta-hexosaminidase A alpha-subunit on 15q23-q24 by high resolution in situ hybridization.

T. Shows, K. Tada, R. Myerowitz, 1990, The Tohoku journal of experimental medicine.

Sequential expression in the nervous system of C-MYB andVIP genes, located in human chromosomal region 6q24

T. Shows, I. Gozes, H. Nakai, 1987, Somatic cell and molecular genetics.

Host DNA replication forks are not preferred targets for bacteriophage Mu transposition

H. Nakai, A. L. Taylor, 1985, Journal of bacteriology.

trans-Targeting of the Phage Mu Repressor Is Promoted by Conformational Changes That Expose Its ClpX Recognition Determinant*

H. Nakai, Kimberly R. Marshall-Batty, K. Marshall-Batty, 2003, The Journal of Biological Chemistry.

No evidence for AT2R gene derangement in human urinary tract anomalies.

H. Tsukahara, H. Nakai, M. Hiraoka, 2001, Kidney international.

Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in Dogs: Blood or Plasma Levels, Metabolism and Excretion after a Single Intravenous Administration

H. Nakai, S. Iida, T. Komatsu, 1996 .

Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in Rats (3): Feto-Placental Transfer and Excretio n into Milk

H. Nakai, S. Iida, T. Komatsu, 1996 .

Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in Rats (2): Blood and Plasma Levels, Distribution, Metabolism, Excretion and Accumulation during and after Repeated Intravenous Administration

H. Nakai, K. Nakai, S. Iida, 1996 .

Participation of the bacteriophage Mu A protein and host factors in the initiation of Mu DNA synthesis in vitro.

H. Nakai, R. Kruklitis, 1994, The Journal of biological chemistry.

Mapping of the human gene for inducible heme oxygenase to chromosome 22q12.

S. Shibahara, A. Kuwano, H. Nakai, 1994, The Tohoku journal of experimental medicine.

Disassembly of the Bacteriophage Mu Transposase for the Initiation of Mu DNA Replication (*)

H. Nakai, R. Kruklitis, 1995, The Journal of Biological Chemistry.

Dysferlin mutations in Japanese Miyoshi myopathy

Y. Itoyama, I. Nonaka, Kayoko Saito, 2003, Neurology.

Novel S-alkylation products from isolated thiamin ylide via thiaminium neothiaminthiolate ion pair

Tomohiro Sato, H. Sugimoto, H. Nakai, 1990 .

Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species.

H. Nakai, J. Shoji, R. Sakazaki, 1988, The Journal of antibiotics.

Isolation, characterization and structures of PA-46101 A and B.

M. Matsumoto, Y. Kawamura, H. Nakai, 1990, The Journal of antibiotics.

Salfredins, new aldose reductase inhibitors produced by Crucibulum sp. RF-3817. I. Fermentation, isolation and structures of salfredins.

H. Itazaki, K. Nagashima, Y. Kawamura, 1995, The Journal of antibiotics.

Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.

T. Watanabe, H. Nakai, S. Yuki, 1997, The Journal of pharmacology and experimental therapeutics.

Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis

Tomohiro Sato, A. Numata, H. Nakai, 1995 .

INTRAMOLECULAR CYCLIZATION USING PALLADIUM-CATALYZED ARYLATION TOWARD FORMYL AND NITRO GROUPS

H. Nakai, H. Muratake, 1999 .

Micacocidin A, B and C, novel antimycoplasma agents from Pseudomonas sp. II. Structure elucidation.

H. Nakai, Y. Hayase, S. Kobayashi, 1998, The Journal of antibiotics.

Terprenins, novel immunosuppressants produced by Aspergillus candidus.

K. Nagashima, Y. Kawamura, Y. Yasuda, 1998, The Journal of antibiotics.

Preparation of azocarbaboranes: oxidation of 1-amino-o-carbaborane anion in liquid ammonia

H. Nakai, M. Shiro, K. Aono, 1980 .

The crystal and molecular structures of p-nitrobenzylidene-p-dimethylaminoaniline and p-dimethylaminobenzylidene-p-nitroaniline

H. Nakai, M. Shiro, T. Kubota, 1976 .

Effects of various saccharides on cycloinulo-oligosaccharide fructanotransferase reaction: production of β-inulotriosyl-α-d-mannopyranoside and 1-O-β-inulotriosyl-α-l-sorbopyranose

H. Nakai, T. Uchiyama, M. Kawamura, 1999 .

Synthesis of methyl 6-O-β-inulotriosyl-α-d-glucopyranoside by intermolecular transglycosylation reaction of cycloinulo-oligosaccharide fructanotransferase

H. Nakai, M. Sawada, Y. Takai, 1997 .

Reactions of (η6-diphenylacetylene) chromiumtricarbonyl complexes with polynuclear carbonyls I. Synthesis of Cr(CO)3(η6-diphenylacetylene) complex and its reaction with Co2(CO)8. Crystal and molecular structure of Cr(CO)3(η6:η2-diphenylacetylene)Co2(CO)6

Tomohiro Sato, S. Tunik, H. Nakai, 1994 .

IR and Raman spectral and X-ray structural studies of polymorphic forms of sulfamethoxazole

H. Nakai, M. Takasuka, 2001 .

X-Ray and infrared spectral studies of the ionic structure of trimethoprim–sulfamethoxazole 1 : 1 molecular complex

H. Nakai, M. Shiro, M. Takasuka, 1984 .

Crystal structure of 2?,3?-epithio-5?-androstan-17?-ol (R)-S-oxide

H. Nakai, Hirozo Koyama, Hiroshi Nakai, 1977 .

Novel antitumor sesquiterpenoids in Achillea millefolium.

H. Ishii, H. Nakai, N. Uchida, 1994, Chemical & pharmaceutical bulletin.

Cytotoxic hydroxypolygodials. X-Ray molecular structure of (1R,3S,5aS,-9aS,9bR)-1,3,5,5a,6,7,8,9,9a,9b-decahydro-1,3-dimethoxy-6,6,9a-trimethylnaphtho[1,2-c]furan

H. Nakai, H. Tada, T. Tozyo, 1992 .

Novel antitumor sesquiterpenoids in Achillea millefolium.

H. Ishii, H. Nakai, N. Uchida, 1994, Chemical & pharmaceutical bulletin.

Structure of a bryonolic acid derivative, 3β-hydroxy-D:C-friedoolean-8-en-29-oic acid methyl ester

H. Nakai, M. Shiro, C. Honda, 1987 .

Structure of a bryonolic acid derivative, D:C‐friedoolean‐8‐ene‐3β,29‐diol diacetate, C34H54O4

H. Nakai, M. Shiro, W. Kamisako, 1984 .

Conformations of bryonolic acid and its derivatives in CDCl3 solution by 1H and 13C NMR spectroscopy

H. Nakai, K. Machida, M. Shiro, 1987 .

Binuclear platinum(II) complexes bridged by pyridine-2-thiolate and related ligands. Synthesis and crystal structure

Keiji Matsumoto, H. Nakai, M. Shiro, 1989 .

X-Ray determination of the structure of the polyether antibiotic K-41

K. Nagashima, H. Nakai, M. Shiro, 1978 .

Synthesis and structure-activity relationships of 7-(3'-amino-4'-methoxypyrrolidin-1'-yl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxoquinoline-3-carboxylic acids.

H. Satō, H. Nakai, T. Okada, 1993, Chemical & pharmaceutical bulletin.

Partial trisomy of 11 and 22 due to familial translocation t(11;22) (q23;q11), inherited in three generations

Yoshifumi Yamamoto, Y. Kuroki, H. Nakai, 1979, Human Genetics.

Bisabosquals, novel squalene synthase inhibitors. II. Physico-chemical properties and structure elucidation.

Y. Kawamura, H. Nakai, K. Minagawa, 2001, The Journal of antibiotics.

I . Isolation , Structure Elucidation and Biological Activities

T. Fujiwara, Y. Kawamura, H. Nakai, 2008 .

Bisabosquals, Novel Squalene Synthase Inhibitors. Part 2. Physicochemical Properties and Structure Elucidation.

Y. Kawamura, H. Nakai, K. Minagawa, 2002 .

Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization.

R. Eddy, R. Pease, T. Innerarity, 1985, Science.

Stringent response processes suppress DNA damage sensitivity caused by deficiency in full‐length translation initiation factor 2 or PriA helicase

H. Nakai, S. Kirtland Turner, S. North, 2014, Molecular microbiology.

A case of a female infant with simultaneous occurrence of de novo terminal deletions on chromosome 14q and 20p

A. Yajima, K. Okamura, S. Uehara, 1993, Clinical genetics.

A case of 9p- syndrome

Yoshifumi Yamamoto, Y. Kuroki, H. Nakai, 1977, Human Genetics.

A case of trisomy 3q21→qter syndrome

I. Kondo, H. Hamaguchi, H. Nakai, 1979, Human Genetics.

Palladium-catalyzed intramolecular α-arylation of aliphatic ketone, formyl, and nitro groups

H. Nakai, H. Muratake, M. Natsume, 2004 .

The gene for human carbonic anhydrase II (CA2) is located at chromosome 8q22.

T. Shows, R. Tashian, H. Nakai, 1987, Cytogenetics and cell genetics.

Human renin gene assigned to chromosome band 1q42 by in situ hybridization.

K. Tada, K. Murakami, S. Inoue, 1988, Cytogenetics and cell genetics.

The gene for human transforming growth factor alpha is on the short arm of chromosome 2.

T. Shows, G. Bell, H. Nakai, 1986, Cytogenetics and cell genetics.

Chromosome 1 localization of the human alpha-L-fucosidase structural gene with a homologous site on chromosome 2.

R. Eddy, T. Shows, H. Nakai, 1986, Cytogenetics and cell genetics.

Host factors that promote transpososome disassembly and the PriA‐PriC pathway for restart primosome assembly

H. Nakai, S. North, 2005, Molecular microbiology.

Handoff from recombinase to replisome: Insights from transposition

V. Doseeva, H. Nakai, Jessica M Jones, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Starvation‐induced Mucts62‐mediated coding sequence fusion: a role for ClpXP, Lon, RpoS and Crp

J. Shapiro, A. Toussaint, C. Ranquet, 1999, Molecular microbiology.

Handoff from recombinase tc from transposition

V. Doseeva, H. Nakai, Jessica M. Jonest, 2016 .

Interactions of the DNA polymerase and gene 4 protein of bacteriophage T7. Protein-protein and protein-DNA interactions involved in RNA-primed DNA synthesis.

C. Richardson, H. Nakai, 1986, The Journal of biological chemistry.

Single DNA marker generated by “YAC-Alu PCR” that is end-specific

H. Tashiro, Y. Murakami, E. Soeda, 1991, Japanese Journal of Human Genetics.

Site Specific Mapping of Chromosome 21 Gene Probes and the Study of Down Syndrome

T. Shows, K. Tada, P. Watkins, 1987, Acta paediatrica Japonica : Overseas edition.

A case of tetrasomy 9 p with cleft lip and palate

Kazumasa Yamada, H. Nakai, Y. Yamamoto, 1988 .

The gene for human transforming growth factor α is on the short arm of chromosome 2

T. Shows, G. Bell, H. Nakai, 1986 .

Pharmacokinetic Studies of Argipidine (MD-805) in Rats (II): Plasma level profile, distribution, metabolism and excretion after single or consecutive intravenous administration of argipidine

H. Nakai, S. Iida, M. Iwamoto, 1986 .

Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase.

M. Futai, H. Nakai, Y. Wada, 2001, Gene.

The structures of polymorphs of N-(p-dimethylaminobenzylidene)-p-nitroaniline

H. Nakai, M. Shiro, K. Ezumi, 1981 .

The φX174‐type primosome promotes replisome assembly at the site of recombination in bacteriophage Mu transposition

H. Nakai, Jessica M Jones, 1997, The EMBO journal.

Potential Mechanisms for Linking Phage Mu Transposition with Cell Physiology

H. Nakai, S. North, 2005 .

Conformational dynamics of a transposition repressor in modulating DNA binding.

H. Nakai, D. O'handley, S. S. Rai, 2001, Journal of molecular biology.

Activation of a Dormant ClpX Recognition Motif of Bacteriophage Mu Repressor by Inducing High Local Flexibility*

H. Nakai, Kimberly R. Marshall-Batty, K. Marshall-Batty, 2008, Journal of Biological Chemistry.

Trans‐targeting of protease substrates by conformationally activating a regulable ClpX‐recognition motif

H. Nakai, Kimberly R. Marshall‐Batty, K. Marshall-Batty, 2008, Molecular microbiology.

A Context-dependent ClpX Recognition Determinant Located at the C Terminus of Phage Mu Repressor*

H. Nakai, D. Defenbaugh, 2003, Journal of Biological Chemistry.

Modulation of phage Mu repressor DNA binding and degradation by distinct determinants in its C‐terminal domain

H. Nakai, Bani Mukhopadhyay, Kimberly R. Marshall-Batty, 2003, Molecular microbiology.

Translation factor IF2 at the interface of transposition and replication by the PriA‐PriC pathway

H. Nakai, S. Kirtland, S. North, 2007, Molecular microbiology.

Leading and lagging strand synthesis at the replication fork of bacteriophage T7. Distinct properties of T7 gene 4 protein as a helicase and primase.

C. Richardson, H. Nakai, 1988, The Journal of biological chemistry.

PriA and phage T4 gp59: factors that promote DNA replication on forked DNA substrates

H. Nakai, Jessica M Jones, 2000, Molecular microbiology.

A New Role for Translation Initiation Factor 2 in Maintaining Genome Integrity

H. Nakai, Mona Abdelmeguid, K. Madison, 2012, PLoS genetics.

Properties of the PriA Helicase Domain and Its Role in Binding PriA to Specific DNA Structures*

H. Nakai, S. North, Hua-Wei Chen, 2004, Journal of Biological Chemistry.

Duplex opening by primosome protein PriA for replisome assembly on a recombination intermediate.

H. Nakai, J. M. Jones, Jessica M Jones, 1999, Journal of molecular biology.

Three novel mutations responsible for Cockayne syndrome group A.

Y. Nakatsu, M. Yamaizumi, Kiyoji Tanaka, 2003, Genes & genetic systems.

Escherichia coli PriA helicase: fork binding orients the helicase to unwind the lagging strand side of arrested replication forks.

H. Nakai, J. M. Jones, 2001, Journal of molecular biology.

Gene mapping of human bilirubin UDP-glucuronosyl transferase on 1q21-q23 by a cell sorter and in situ hybridization

H. Nakai, H. Ikeda, K. Takeda, 1991, Japanese Journal of Human Genetics.

Structures of N,N,N',N'‐tetramethylbenzidine (I) and 4,4'‐methylenebis(N,N‐dimethylaniline) (II)

H. Nakai, Takashi Saito, M. Yamakawa, 1988 .

Effect of 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, on aggressive behavior and marble burying behavior in mice.

H. Nakai, K. Saito, M. Egawa, 1998, Japanese journal of pharmacology.

THE IMPORTANCE OF INTRAMOLECULAR CHARGE TRANSFER EFFECT ON THE MOLECULAR CONFIGURATION OF p-NITROBENZYLIDENE-p-DIMETHYLAMINOANILINE

K. Nishikida, H. Nakai, M. Shiro, 1974 .

Role of the φ X-type primosome in transposition Table I . PriA – Escherichia coli hosts can support Mu lysogenization but not lytic development Host straina Relevant trait Mu plating Frequency of efficiency lysogenization EL 501 PriA

H. Nakai, Jessica M Jones, 2013 .

Dissection of RNA-primed DNA synthesis catalyzed by gene 4 protein and DNA polymerase of bacteriophage T7. Coupling of RNA primer and DNA synthesis.

C. Richardson, H. Nakai, 1986, The Journal of biological chemistry.

Senecicannabine, a new pyrrolizidine alkaloid from ☆

H. Nakai, M. Shiro, T. Furuya, 1982 .

Structure of a 7α-methoxy-1-oxacephem: diphenylmethyl 7α-methoxy-3-(1-methyl-1H-tetrazol-5-ylthio)methyl-7β-phenylacetamido-1-oxa-1-dethia-3-cephem-4-carboxylate

H. Nakai, M. Shiro, M. Narisada, 1980 .

Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22----q24.1, 11p15, and 4q25----q27, respectively.

T. Shows, C. Morton, G. Bell, 1986, Cytogenetics and cell genetics.

Synthetic study of hetisine-type aconite alkaloids. Part 3: Total synthesis of (±)-nominine

H. Nakai, H. Muratake, M. Natsume, 2006 .

Structure of a 1/1 molecular complex of tylolupenol A acetate and tylolupenol B acetate, C32H52O2.C32H52O2

H. Ishii, H. Nakai, M. Shiro, 1985 .

The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein.

C. Richardson, H. Nakai, 1990, The Journal of biological chemistry.

Study of substituent effects on conformational equilibrium (E⇆Z) of 2-(4-substituted anilino)-5-nitropyridines by infrared spectra, X-ray crystallography, and CNDO/2 calculations

H. Nakai, M. Shiro, M. Takasuka, 1986 .

Relationships of the molecular structure of aldosterone derivatives with their binding affinity for mineralocorticoid receptor.

H. Nakai, M. Shiro, K. Ezumi, 1986, Molecular pharmacology.

The effect of the T7 and Escherichia coli DNA-binding proteins at the replication fork of bacteriophage T7.

C. Richardson, H. Nakai, 1988, The Journal of biological chemistry.

Lythraceous Alkaloids. XII. Circular Dichroism Studies on Lythranine-Type Alkaloids

H. Nakai, M. Shiro, E. Fujita, 1984 .

Studies on the Metabolic Fate of (±)-2-(Dimethylamino)-1-[[o-(m-methoxyphenethyl)-phenoxy]methyl]ethyl hydrogen succinate hydrochloride (MCI-9042) (II): Absorption, Distribution, Metabolism and Excretion after a Single Administration to Rats

H. Nakai, S. Iida, T. Komatsu, 1991 .

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

T. Shows, H. Nakai, M. Byers, 1986, Cytogenetics and cell genetics.

THE STRUCTURES OF OHCHINOLIDE A AND B, TWO NEW LIMONOIDS FROM MELIA AZEDARACH LINN. VAR. JAPONICA MAKINO

H. Nakai, M. Shiro, M. Ochi, 1979 .