J. Wyke

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Mitogenesis induced by pp60v-src is not accompanied by increased expression of immediate early response genes.

A. Wyke, M. Welham, J. Wyke, 1990, Oncogene.

Regulation of both apoptosis and cell survival by the v-Src oncoprotein

W. Earnshaw, D. Johnson, M. Frame, 2000, Cell Death and Differentiation.

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.

M. Frame, J. Wyke, V. Fincham, 1995, Oncogene.

The pathogenesis of oncogenic avian retroviruses.

J. Wyke, P. Enrietto, 1983, Advances in cancer research.

The second Bagshawe lecture. Matching basic research to the management of cancer: the view from the other side of the fence.

J. Wyke, 1990, British Journal of Cancer.

Overview--burgeoning promise in metastasis research.

J. Wyke, 2000, European journal of cancer.

Strategies of viral oncogenesis

J. Wyke, 1981, Nature.

Genetic analysis of the form and function of the viral src oncogene product.

J. Wyke, A. Stoker, 1987, Biochimica et biophysica acta.

The mechanism of cell cycle regulation by v-Src

N. Carragher, M. Frame, D. Riley, 2001, Oncogene.

Temperature sensitive mutants of avian sarcoma viruses.

J. Wyke, 1975, Biochimica et biophysica acta.

Effect of transformation by Rous sarcoma virus on the character and distribution of actin in Rat-1 fibroblasts: a biochemical and microscopical study.

T. Holme, S. Kellie, J. Wyke, 1986, British Journal of Cancer.

Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus

S. Kellie, J. Wyke, A. Stoker, 1986, Journal of virology.

Functional domains of the pp60v-src protein as revealed by analysis of temperature-sensitive Rous sarcoma virus mutants

J. Wyke, A. Stoker, P. Enrietto, 1984, Molecular and cellular biology.

The use of Rous sarcoma virus transformation mutants with differing tyrosine kinase activities to study the relationships between vinculin phosphorylation, pp60v-src location and adhesion plaque integrity.

S. Kellie, D. Critchley, J. Wyke, 1986, Experimental cell research.

Active viral genes in transformed cells lie close to the nuclear cage.

A. Hayday, P. Cook, L. Lania, 1982, The EMBO journal.

Expression of the ASV src gene in hybrids between normal and virally transformed cells: Specific suppression occurs in some hybrids but not others

P. J. Dyson, J. Wyke, K. Quade, 1982, Cell.

Molecular mechanisms involved in morphological variation of avian sarcoma virus-infected rat cells.

D. Chiswell, J. Wyke, P. Enrietto, 1982, Virology.

Mapping of nonconditional and conditional mutants in the src gene of Prague strain Rous sarcoma virus.

D. Chiswell, J. Wyke, V. Fincham, 1982, Virology.

Fusion of rous‐sarcoma‐virus‐transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site

A. Green, S. Povey, J. Wyke, 1990, International journal of cancer.

Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.

L. Aaltonen, W. Bodmer, A. de la Chapelle, 1998, Journal of medical genetics.

Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus.

R. Hynes, J. Wyke, 1975, Virology.

Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene

J. Wyke, V. Fincham, 1986, Journal of virology.

Effects of inhibitors of lipid synthesis on the replication of Rous sarcoma virus. A specific effect of cerulenin on the processing of major non-glycosylated viral structural proteins.

J. Harley, H. Goldfine, J. Wyke, 1978, Biochimica et biophysica acta.

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence

D. Johnson, M. Frame, J. Wyke, 1998, Oncogene.

Analysis of the pathogenicity of transformation defective partial deletion mutants of avian sarcoma virus: characterization of recovered viruses which encode novel src specific proteins.

L. N. Payne, J. Wyke, P. Enrietto, 1983, Virology.

Altered pathogenicity of avian myelocytomatosis (MC29) viruses with mutations in the v-myc gene.

M. Hayman, L. N. Payne, J. Wyke, 1983, Virology.

Fourteen temperature-sensitive replication mutants of Rous sarcoma virus.

W. Mason, J. Wyke, J. Bosch, 1979, Virology.

The selective isolation of temperature-sensitive mutants of Rous sarcoma virus.

J. Wyke, 1973, Virology.

Gene Expression during Normal and Malignant Differentiation

J. Wyke, 1986 .

Infection of rat cells by avian sarcoma virus: factors affecting transformation and subsequent reversion.

J. Wyke, K. Quade, 1980, Virology.

sarcoma virus. temperature-sensitive mutants of Rous pp60v-src proteins expressed by two distinct Intracellular localization and processing of

S. Kellie, J. Wyke, A. Stoker, 2013 .

Methods PATIENTS STUDY 1 : FIBRONECTIN CONCENTRATIONS IN PATIENTS WITH CROHN ' S DISEASE Fresh blood specimens

D. Scott, J. Wyke, R. Allan, 2006 .

Plasma fibronectin in Crohn's disease.

D. Scott, J. Wyke, R. Allan, 1989, Gut.

Comparison of the relative importance of tyrosine-specific vinculin phosphorylation and the loss of surface-associated fibronectin in the morphology of cells transformed by Rous sarcoma virus.

S. Kellie, D. Critchley, J. Wyke, 1986, Journal of cell science.

Restriction of replication of Rous sarcoma virus mediated by the src region of the genome: analysis of the formation and integration of viral DNA and the effects of conditional and nonconditional mutations in src.

P. Neiman, J. Wyke, V. Fincham, 1981, Virology.

8 Pathogenesis of Retrovirus-induced Disease

T. Mak, A. Bernstein, J. Wyke, 1982 .

Phenotypic variation and its control in polyoma-transformed BHK21 cells.

J. Wyke, 1971, Experimental cell research.

The case for high-dose adjuvant chemotherapy in breast cancer: (II) clinical experience

V. Brunton, J. Wyke, J. Pitts, 2002 .

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins

V. Brunton, M. Frame, J. Wyke, 1996, The Journal of cell biology.

The genetics of C-type RNA tumor viruses.

J. Wyke, 1974, International review of cytology.

Evolution of oncogenes: From c-src to v-src

J. Wyke, 1983, Nature.

Selection, screening, and isolation of temperature-sensitive mutants of avian sarcoma viruses.

J. Wyke, 1976, Methods in cell biology.

Complementation of transforming functions by temperature-sensitive mutants of avian sarcoma virus.

J. Wyke, 1973, Virology.

Temperature-sensitive avian sarcoma viruses: a physiological comparison of twenty mutants.

M. Linial, J. Wyke, J. A. Wyke, 1973, Virology.

A mutant of Rous sarcoma virus with a thermolabile defect in the virus envelope.

J. Wyke, J. Beamand, F. Tató, 1978, Virology.

Expression of tumor-specific surface antigens on cells infected with temperature-sensitive mutants of avian sarcoma virus.

R. Kurth, J. Wyke, R. Friis, 1975, Virology.

Glycolipids of chick embryo fibroblasts infected with temperature-sensitive mutants of avian sarcoma viruses.

S. Hakomori, P. Vogt, J. Wyke, 1977, Virology.

Alternation in malignancy of rat spontaneous tumour cells after in vitro supertransformation by ASV.

V. Křen, P. Veselý, J. Wyke, 1982, Folia biologica.

Cell surface and metabolic labelling of the proteins of normal and transformed chicken cells.

R. Hynes, D. Critchley, J. Wyke, 1976, Biochimica et biophysica acta.

Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells

Siâ Searle, D.A.F. Gillespie, David John Chiswell, 1984, Nucleic Acids Res..

v-SRC'S hold over actin and cell adhesions

N. Carragher, M. Frame, J. Wyke, 2002, Nature Reviews Molecular Cell Biology.

Genetic recombination in Rous sarcoma virus: the genesis of recombinants and lack of evidence for linkage between pol, env and src genes in three factor crosses.

J. Wyke, J. Beamand, 1979, The Journal of general virology.

Genetic recombination among temperature-sensitive mutnats of Rous sarcoma virus.

J. Wyke, J. Beamand, J. G. Bell, 1975, Cold Spring Harbor symposia on quantitative biology.

Revertants of an ASV-transformed rat cell line have lost the complete provius or sustained mutations in src.

H. Varmus, J. Wyke, N. Quintrell, 1981, Virology.

Isolation of a murine retrovirus with a temperature-sensitive src gene.

E. Rands, J. Wyke, V. Fincham, 1987, Virology.

Factors affecting phenotypic reversion of rat cells transformed by avian sarcoma virus.

H. Varmus, J. Wyke, J. Beamand, 1980, Cold Spring Harbor symposia on quantitative biology.

Proviral position effects: possible probes for genes that suppress transcription.

A. Green, D. Gillespie, J. Wyke, 1989, Ciba Foundation symposium.

Control of expression of an integrated Rous sarcoma provirus in rat cells: role of 5' genomic duplications reveals unexpected patterns of gene transcription and its regulation

M. Bissell, D. Gillespie, J. Wyke, 1986, Journal of virology.

Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene

T. Dexter, J. Wyke, E. Spooncer, 1986, Molecular and cellular biology.

Rearrangements of viral and cellular DNA are often associated with expression of Rous sarcoma virus in rat cells

D. Gillespie, J. Wyke, K. Hart, 1985, Cell.

Novel nonconditional mutants in the src gene of Rous sarcoma virus: isolation and preliminary characterization.

P. Neiman, J. Wyke, V. Fincham, 1980, Virology.

A method of isolating cells incapable of multiplication in suspension culture.

J. Wyke, 1971, Experimental cell research.

Suppression of the Neoplastic Phenotype

A. Green, J. Wyke, 1986 .

ANTI-ONCOGENES A Subset of Regulatory Genes Involved in Carcinogenesis?

A. Green, J. Wyke, 1985, The Lancet.

On the structure, genesis and significance of DNA duplications at the Rous sarcoma proviral insertion sites in Rat-1 cells.

J. Wyke, V. Fincham, 1992, The Journal of general virology.

Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation

M. Frame, A. Catling, J. Wyke, 1994, Journal of virology.

Retroviruses and human pathology

J. Wyke, 1986 .

Differences between cellular integration sites of transcribed and nontranscribed Rous sarcoma proviruses

J. Wyke, V. Fincham, 1991, Journal of virology.

The nuclease sensitivity of active genes.

P. Cockerill, G. Goodwin, J. Wyke, 1983, Nucleic acids research.

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.

D. Gillespie, M. Frame, A. Wyke, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Plasma Fibronectin in Crohn's Disease

J. Wyke, R. Allan, A. Allan, 1987 .

Mitogenesis by v-Src: a need for active oncoprotein both in leaving G0 and in completing G1 phases of the cell cycle.

A. Wyke, J. Wyke, W. Cushley, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Prevalence of sexually transmitted disease among male patients presenting with proctitis.

J. Wyke, M. Lane, R. Allan, 1988, Gut.

Factors influencing physiological variations in the activity of the Rous sarcoma virus long terminal repeat.

J. Wyke, V. Fincham, A. Lang, 1993, Virology.

Transformation by a temperature sensitive mutant of Rous sarcoma virus in the absence of serum.

J. Wyke, J. G. Bell, I. Macpherson, 1975, The Journal of general virology.

A single point mutation has pleiotropic effects on pp60v-src function

M. Welham, J. Wyke, J. A. Wyke, 1988, Journal of virology.

Functions of the v‐SRC protein tyrosine kinase

M. Frame, A. Wyke, J. Wyke, 1994, Cell biology international.

A Catalogue of Tools for Watch and Clock Makers

Alan Smith, John Wyke, J. Wyke, 1978 .

Michael George Parke Stoker

J. Wyke, 2013 .

Plasma fibronectin inCrohn's disease

J. Wyke, R. Allan, A. Allan, 1989 .