K. Nagasawa

J. Gallagher, M. Uesugi, M. Konrad, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.

Y. Hashimoto, K. Wakabayashi, H. Miyachi, 2005, Bioorganic & medicinal chemistry letters.

Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.

A. Phan, B. Heddi, K. Nagasawa, 2013, Journal of the American Chemical Society.

Targeting STUB1–tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

Mostafa E. Belghasem, E. Edelman, V. Kolachalama, 2017, Science Translational Medicine.

Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex.

Yue Ma, H. Mao, K. Nagasawa, 2022, Analytical biochemistry.

Novel Specific Puromycin‐Sensitive Aminopeptidase Inhibitors: 3‐(2,6‐Diethylphenyl)‐2,4(1H,3H)‐quinazolinedione and N‐(2,6‐Diethylphenyl)‐2‐amino‐4H‐3,1‐benzoxazin‐4‐one.

Y. Koiso, Y. Hashimoto, K. Nagasawa, 2001 .

Novel Specific Puromycin-sensitive Aminopeptidase Inhibitors: 3-(2,6-Diethylphenyl)-2,4(1H,3H)quinazolinedione and N-(2,6-Diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one

Y. Koiso, Y. Hashimoto, K. Nagasawa, 2001 .

(S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.

K. Shin‐ya, T. Doi, Masahito Yoshida, 2011, Organic & biomolecular chemistry.

A Novel Glucosylation Reaction on Anthocyanins Catalyzed by Acyl-Glucose–Dependent Glucosyltransferase in the Petals of Carnation and Delphinium[C][W]

Y. Ozeki, H. Matsuoka, H. Funabashi, 2010, Plant Cell.

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.

M. Uesugi, Shin-ichi Sato, K. Nagasawa, 2017, Cell chemical biology.

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists.

M. Sodeoka, D. Hashizume, H. Osada, 2019, Chemistry.

Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.

Y. Hashimoto, K. Nagasawa, T. Ishioka, 2003, Bioorganic & medicinal chemistry letters.

Agrocybynes A–E from the culture broth of Agrocybe praecox

Hirofumi Hirai, D. Hashizume, S. Tokuyama, 2012 .

Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.

K. Noguchi, M. Yohda, H. Nakayama, 2015, Angewandte Chemie.

Synthesis of Deuterium-Labeled Vitamin D Metabolites as Internal Standards for LC-MS Analysis

Y. Kikutani, S. Fukuzawa, K. Nagasawa, 2022, Molecules.

Organocatalytic asymmetric nitroaldol reaction: cooperative effects of guanidine and thiourea functional groups.

K. Nagasawa, K. Takada, Y. Sohtome, 2007, Chemistry, an Asian journal.

Targeting STUB 1-tissue factor axis normalizes the hyperthrombotic uremic phenotype without increasing the bleeding risk

Mostafa E. Belghasem, E. Edelman, V. Kolachalama, 2017 .

Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

K. Shin‐ya, H. Seimiya, K. Nagasawa, 2021, The Journal of Antibiotics.

Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.

Yue Ma, K. Ikebukuro, K. Nagasawa, 2019, Bioorganic & medicinal chemistry.

Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization.

Yue Ma, H. Seimiya, Young‐Tae Chang, 2020, Chemical communications.

Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine-Urea Bifunctional Organocatalyst.

K. Nagasawa, M. Yamanaka, Minami Odagi, 2018, Organic letters.

Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety.

A. Itai, Y. Koiso, Y. Hashimoto, 2002, Bioorganic & medicinal chemistry.

A-Ring Synthons of 19-Nor Type Vitamin D Derivatives

K. Nagasawa, Yusuke Akagi, K. Yasui, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Total synthesis of (-)- and (+)-decarbamoyloxysaxitoxin and (+)-saxitoxin.

K. Nagasawa, O. Iwamoto, Ryoko Shinohara, 2009, Chemistry, an Asian journal.

Intramolecular 1,3-dipolar cycloaddition-mediated stereoselective synthesis of disubstituted cyclopentane: a simple model for the cyclopentane ring system of polycyclic oroidine alkaloids.

K. Nagasawa, Takuya Imaoka, O. Iwamoto, 2013, Chemistry, an Asian journal.

Ligand-induced conformational changes with cation ejection upon binding to human telomeric DNA G-quadruplexes.

Yue Ma, M. Teulade‐Fichou, K. Nagasawa, 2015, Journal of the American Chemical Society.

Macrocyclic polyoxazoles as G-quadruplex ligands.

K. Nagasawa, Keisuke Iida, 2013, Chemical record.

A Caged Ligand for a Telomeric G‐Quadruplex

K. Shin‐ya, H. Seimiya, K. Nagasawa, 2012, Chembiochem : a European journal of chemical biology.

Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand

I. Karube, T. Kawai, K. Ikebukuro, 2018, Scientific Reports.

Synthesis of 24,24-Difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 Derivatives and Evaluation of Their Vitamin D Receptor-Binding Affinity.

M. Uesugi, K. Nagasawa, I. Shimizu, 2016, Biological & pharmaceutical bulletin.

Synthesis of Diastereomers of 1,3-cis-25-Dihydroxy-19-norvitamin D3.

M. Uesugi, Takuya Yamaguchi, K. Nagasawa, 2016, Chemical & pharmaceutical bulletin.

Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.

Yue Ma, K. Nagasawa, S. Sasaki, 2021, Chemical communications.

A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions

H. Balci, Yue Ma, K. Nagasawa, 2016, Nucleic Acids Research.

Fluorescent-ligand-mediated screening of G-quadruplex structures using a DNA microarray.

K. Ikebukuro, K. Hata, K. Nakabayashi, 2013, Angewandte Chemie.

Novel synthesis of 1α,25-dihydroxy-19-norvitamin D from 25-hydroxyvitamin D.

Y. Moriguchi, K. Nagasawa, T. Tsuchida, 2009 .

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Y. Hashimoto, G. Roodman, N. Kurihara, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam

Y. Hashimoto, K. Nagasawa, Y. Kato, 2003, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry.

Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

H. Seimiya, K. Nagasawa, Takahiro Nakamura, 2013, Molecules.

Asymmetric Organocatalytic Nitroaldol Reaction of α-Ketoesters: Stereoselective Construction of Chiral Tertiary Alcohols at Subzero Temperature.

K. Nagasawa, K. Takada, Y. Sohtome, 2008 .

Activated basic alumina promotes a mild, clean and high-yield racemization-free synthesis of t-butyl esters from chiral acid bromides and t-butyl alcohol

K. Nagasawa, Keiichi Ito, Keiko Ohhashi, 1994 .

Conversion of Ca2+ salt of an organic compound to its Li+ salt to simplify the fast atom bombardment mass spectrum.

N. Morisaki, Y. Hashimoto, M. Sodeoka, 2003, Chemical & pharmaceutical bulletin.

Chemical Synthesis of Side‐Chain‐Hydroxylated Vitamin D3 Derivatives and Their Metabolism by CYP27B1

K. Yasuda, R. Sakamoto, T. Sakaki, 2021, Chembiochem : a European journal of chemical biology.

Detection of 1-O-malylglucose: pelargonidin 3-O-glucose-6''-O-malyltransferase activity in carnation (Dianthus caryophyllus).

Y. Ozeki, Nobuhiro Sasaki, K. Nagasawa, 2008, Biochemical and biophysical research communications.

Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine‐Thiourea Bifunctional Organocatalyst

Y. Hashimoto, K. Nagasawa, Y. Sohtome, 2006 .

6.6 Henry and aza-Henry Reactions

K. Nagasawa, Y. Sohtome, 2012 .

Guanidine‐Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction

Y. Hashimoto, K. Nagasawa, Y. Sohtome, 2005 .

Synthetic Chemical Probes That Dissect Vitamin D Activities.

M. Uesugi, K. Nagasawa, K. Kotake, 2019, ACS chemical biology.

Enantioselective Epoxidation of 2,3-Disubstituted Naphthoquinones by a Side Chain Truncated Guanidine-Urea Bifunctional Organocatalyst.

K. Nagasawa, M. Yamanaka, Minami Odagi, 2020, The Journal of organic chemistry.

Recent Advances in Natural Products Synthesis Using Bifunctional Organocatalysts Bearing a Hydrogen‐Bonding Donor Moiety

K. Nagasawa, Minami Odagi, 2019, Asian Journal of Organic Chemistry.

FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

Yue Ma, J. Jiricny, Matteo Berti, 2017, Nature Communications.

Random formation of G-quadruplexes in human telomere overhangs leads to a kinetic folding pattern with targetable vacant G-tracts

Jibin Abraham Punnoose, Yue Ma, H. Mao, 2019 .

Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts.

M. E. Hoque, Yue Ma, H. Mao, 2018, Biochemistry.

Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides.

K. Nagasawa, K. Yasui, Takanari Kato, 2015, Chemical communications.

An efficient asymmetric synthesis of 1α,25-(OH)2 vitamin D3 A-ring synthon

K. Nagasawa, Yoshiro Zako, H. Ishihara, 1993 .

Stereoselective synthesis of cyclopentanones by reductive cleavage of 6-oxonorbornane-2-carboxylates and its application to the synthesis of 1α,25-dihydroxyvitamin D3 CD ring

K. Nagasawa, Yoshiro Zako, I. Shimizu, 1993 .

Synthesis of vitamin D3 D ring synthons by reductive cleavage of norbornan-6-one-2-carboxylates

K. Nagasawa, Yoshiro Zako, I. Shimizu, 1990 .

Synthesis of Macrocyclic Dimer of Cyclic Hexaoxazole and Examination of Its Interaction with Telomeric Oligonucleotide

K. Nagasawa, Takahiro Nakamura, Keisuke Iida, 2014 .

Asymmetric α-hydroxylation of a lactone with vinylogous pyridone by using a guanidine-urea bifunctional organocatalyst: catalytic enantioselective synthesis of a key intermediate for (20S)-camptothecin analogues.

K. Nagasawa, Minami Odagi, Tatsuya Watanabe, 2014, Chemistry.

A humpback whale, Megaptera novaeangliae (Borowski, 1781), from the Pleistocene Kioroshi Formation of Inba-mura, Chiba Prefecture, central Japan

K. Nagasawa, Yutaka Mitani, 2004 .

Design of the Chiral Environment for Asymmetric Acid-Base Catalysis

M. Sodeoka, K. Nagasawa, Y. Sohtome, 2018 .

Guanidine-Urea BifunctionalOrganocatalyst for Asymmetric Epoxidation of 1,3-Diarylenones withHydrogen Peroxide

Shinji Tanaka, K. Nagasawa, 2009 .

Synthesis of marine guanidine alkaloids and their application as chemical/biological tools.

Y. Hashimoto, K. Nagasawa, 2003, Chemical record.

Total synthesis of crambescidin 359.

Y. Hashimoto, H. Koshino, T. Nakata, 2002, Organic letters.

Practical and Stereoselective Synthesis of a Pentacyclic Guanidine System: Synthetic Studies toward Ptilomycalin A and Related Compounds

T. Nakata, K. Nagasawa, A. Georgieva, 2000 .

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

Y. Hashimoto, K. Nagasawa, H. Kakuta, 2003, Chemical & pharmaceutical bulletin.

Sequential enantiodivergent organocatalysis: reversibility in enantioswitching controlled by a conformationally flexible guanidine/bisthiourea organocatalyst.

Shinji Tanaka, K. Nagasawa, Y. Sohtome, 2013, Organic & biomolecular chemistry.

Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts.

K. Nagasawa, Y. Sohtome, 2012, Chemical communications.

Solvent-dependent enantiodivergent Mannich-type reaction: utilizing a conformationally flexible guanidine/bisthiourea organocatalyst.

Shinji Tanaka, K. Nagasawa, K. Takada, 2010, Angewandte Chemie.

Enantioselective Total Synthesis of Cepharatines via Bioinspired Ring Reconstruction.

K. Nagasawa, Minami Odagi, Taisei Matoba, 2021, The Journal of organic chemistry.

Nontoxic Enantiomeric Reference Materials for Saxitoxins.

Ryuichi Watanabe, M. Ozawa, H. Uchida, 2022, Analytical chemistry.

Synthesis of Paralytic Shellfish Toxins: Saxitoxins

K. Nagasawa, Hayate Ishizuka, 2020 .

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

K. Nagasawa, Minami Odagi, Kanna Adachi, 2019, Marine drugs.

Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels.

M. Yotsu-Yamashita, K. Nagasawa, Chao Wang, 2016, Angewandte Chemie.

Total synthesis of (-)-decarbamoyloxysaxitoxin.

D. Hashizume, H. Koshino, K. Nagasawa, 2007, Angewandte Chemie.

Regioselective oxidation of isoxazolidines to ketonitrones

H. Koshino, K. Nagasawa, O. Iwamoto, 2006 .

Conversion of androstenolone to pregnenolone.

S. Danishefsky, K. Nagasawa, N. Wang, 1975, The Journal of organic chemistry.

Thiourea-catalyzed Morita–Baylis–Hillman reaction

Y. Hashimoto, K. Nagasawa, Y. Sohtome, 2008 .

Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction

Y. Hashimoto, K. Nagasawa, A. Tanatani, 2004 .

Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11C23 segment

T. Nakata, K. Nagasawa, I. Shimizu, 1996 .

Entropy-Driven 1,2-Type Friedel-Crafts Reaction of Phenols with N-tert-Butoxycarbonyl Aldimines.

Masaru Kato, Makoto Sato, K. Nagasawa, 2015, Chemistry.

Linking conformational flexibility and kinetics: catalytic 1,4-type Friedel-Crafts reactions of phenols utilizing 1,3-diamine-tethered guanidine/bisthiourea organocatalysts.

K. Noguchi, K. Nagasawa, Y. Sohtome, 2011, Chemistry, an Asian journal.

Organocatalytic Asymmetric Synthesis of N,N-Bis(dihydrofuranyl)hydroxyamines: A Cascade Reaction Involving Friedel–Crafts Alkylation, Internal Redox Reaction, and Umpolung

K. Nagasawa, Y. Sohtome, B. Shin, 2011 .

Entropy-controlled catalytic asymmetric 1,4-type Friedel-Crafts reaction of phenols using conformationally flexible guanidine/bisthiourea organocatalyst.

K. Noguchi, K. Nagasawa, Y. Sohtome, 2010, Angewandte Chemie.

Development of novel chiral urea catalysts for the hetero-Michael reaction.

Y. Hashimoto, K. Nagasawa, A. Tanatani, 2004, Chemical & pharmaceutical bulletin.

Enantioselective total synthesis of batzelladine A.

Y. Hashimoto, K. Nagasawa, A. Tanatani, 2004, Angewandte Chemie.

Acceleration of hetero-Michael reaction by symmetrical pentacyclic guanidines

T. Nakata, K. Nagasawa, A. Georgieva, 2001 .

Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.

Y. Koiso, Y. Hashimoto, K. Nagasawa, 2003, Bioorganic & medicinal chemistry letters.

A novel and efficient synthesis of 5-substituted and 5,6-disubstituted 4-methylcoumarins using organocerium(III) reagents☆

K. Nagasawa, Keiichi Ito, Hajime Kanbara, 1985 .

Mechanistic insights into entropy-driven 1,2-type Friedel-Crafts reaction with conformationally flexible guanidine-bisthiourea bifunctional organocatalysts

K. Nagasawa, M. Yamanaka, Minami Odagi, 2021, Tetrahedron.

Sequential stereodivergent organocatalysis and programmed organocascades.

K. Nagasawa, Y. Sohtome, 2014, Organic & biomolecular chemistry.

Enantioselective Phospha‐Michael Reaction of Diphenyl Phosphonate with Nitroolefins Utilizing Conformationally Flexible Guanidinium/Bisthiourea Organocatalyst: Assembly‐State Tunability in Asymmetric Organocatalysis

K. Nagasawa, Y. Sohtome, Rika Takagi, 2011 .

Guanidine‐Urea Bifunctional Organocatalyst for Asymmetric Epoxidation of 1,3‐Diarylenones with Hydrogen Peroxide.

Shinji Tanaka, K. Nagasawa, 2009 .

Synthesis of saxitoxins

K. Nagasawa, O. Iwamoto, Takafumi Akimoto, 2012 .

Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3.

K. Nagasawa, O. Iwamoto, 2010, Organic letters.

Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.

Y. Hashimoto, H. Koshino, T. Nakata, 2005, Chemistry.

[Total synthesis of marine cyclic guanidine compounds and development of novel guanidine type asymmetric organocatalysts].

K. Nagasawa, 2003, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Synthesis of (+)-batzelladine K

K. Nagasawa, O. Iwamoto, Y. Iijima, 2010 .

Synthesis and biological activities on batzelladine derivatives

Y. Hashimoto, K. Nagasawa, Haruo Tanaka, 2007 .

Stereoselective synthesis of tricyclic guanidine, the key component of the batzelladine alkaloids

Y. Hashimoto, T. Nakata, K. Nagasawa, 2002 .

Total synthesis of batzelladine D.

Y. Hashimoto, H. Koshino, T. Nakata, 2002, Organic letters.

Synthesis of Marine Guanidine Alkaloids and Their Application as Chemical/Biological Tools

Y. Hashimoto, K. Nagasawa, 2004 .

C(2)-symmetric chiral pentacyclic guanidine: a phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate Schiff base.

Y. Hashimoto, T. Nakata, K. Nagasawa, 2002, Angewandte Chemie.

Stereoselective synthesis of tricyclic guanidine systems: confirmation of the stereochemistry of batzelladine F left-hand tricyclic guanidine portion

H. Koshino, T. Nakata, K. Nagasawa, 2001 .

Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.

Y. Hashimoto, H. Koshino, T. Nakata, 2005, Chemistry.

Enantioselective total synthesis of batzelladine A.

Y. Hashimoto, K. Nagasawa, A. Tanatani, 2004, Angewandte Chemie.

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

K. Shin‐ya, I. Nakano, Yue Ma, 2017, Scientific Reports.

New Aureothin Derivative, Alloaureothin, from Streptomyces sp. MM23

J. Hashimoto, K. Shin‐ya, S. Harayama, 2007, The Journal of Antibiotics.

Asymmetric Michael Reaction of Nitroolefins with β‐Dicarbonyl Compounds Catalysed by 1,3‐Diamine‐Tethered Guanidine‐Thiourea Bifunctional Organocatalysts

K. Nagasawa, K. Yasui, Y. Sohtome, 2014 .

Origin of stereocontrol in guanidine-bisurea bifunctional organocatalyst that promotes α-hydroxylation of tetralone-derived β-ketoesters: asymmetric synthesis of β- and γ-substituted tetralone derivatives via organocatalytic oxidative kinetic resolution.

Yoshiharu Yamamoto, Makoto Sato, K. Nagasawa, 2015, Journal of the American Chemical Society.

Stereodivergent Synthesis of 1,3-Dienes via Protodeboronation of Homoallenylboronic Esters.

R. Sakamoto, K. Nagasawa, Minami Odagi, 2022, The Journal of organic chemistry.

Total Synthesis of (+)-Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of Its Absolute Configuration.

Yoshiharu Yamamoto, K. Nagasawa, Minami Odagi, 2018, Angewandte Chemie.

Brønsted base and acid catalysts, and additional topics

T. Hashimoto, P. Schreiner, M. Klussmann, 2012 .

Enantioselective Oxidative Enolate Coupling of Oxindoles Catalyzed by Chiral Guanidinium Hypoiodite

K. Nagasawa, Minami Odagi, Kota Sugimoto, 2023, ACS Catalysis.

Guanidinium Hypoiodite-Catalyzed Intramolecular Oxidative Coupling Reaction of Oxindoles with β-Dicarbonyls.

Choon‐Hong Tan, K. Nagasawa, Minami Odagi, 2023, The Journal of organic chemistry.

Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of β–Ketoamides with Oxindoles

K. Nagasawa, Minami Odagi, K. Yasui, 2017 .

Synthesis of a Quaternary N,N′‐Aminal‐Containing A–E Ring System of Palau′amine via an Enamide‐Type Overman Rearrangement Reaction

K. Nagasawa, M. Iwata, Takuya Imaoka, 2018 .

Asymmetric α-hydroxylation of tetralone-derived β-ketoesters by using a guanidine-urea bifunctional organocatalyst in the presence of cumene hydroperoxide.

K. Nagasawa, Minami Odagi, Tatsuya Watanabe, 2013, Chemistry.

Synthesis of (+)‐Batzelladine K (I).

K. Nagasawa, O. Iwamoto, Y. Iijima, 2010 .

Conformationally Flexible Guanidine–(Thio)Urea Bifunctional Organocatalysts

Masaru Kato, K. Nagasawa, Minami Odagi, 2015 .

t-Butyl lithioacetate on ortho-hydroxyphenones providing 2-methylchromones. An easy access to khellin

K. Nagasawa, Keiichi Ito, Hajime Kanbara, 1988 .

Synthesis of Hydrocarbazole Derivatives by Oxidative Dearomative Cyclization of Diarylamines using a Hypervalent Iodine Reagent.

Keita Iida, K. Nagasawa, Minami Odagi, 2020, The Journal of organic chemistry.

Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical l-Leu-based peptides

Masakazu Tanaka, K. Nagasawa, H. Okuda, 2011 .

Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of ( E )-chalcone

Masakazu Tanaka, K. Nagasawa, H. Okuda, 2011 .

Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligand

H. Seimiya, K. Nagasawa, Takahiro Nakamura, 2013 .

DESIGN AND SYNTHESIS OF G-QUADRUPLEX LIGANDS BEARING MACROCYCLIC HEXAOXAZOLES WITH FOUR-WAY SIDE CHAINS (Dedicated to Dr. Albert Padwa on his 75th birthday)

K. Shin‐ya, K. Nagasawa, Keisuke Iida, 2012 .

Design and Synthesis of Telomestatin Derivatives Containing Methyl Oxazole and Their G-Quadruplex Stabilizing Activities.

K. Shin‐ya, K. Nagasawa, Keisuke Iida, 2011 .

Synthesis of a Potent G‐Quadruplex‐Binding Macrocyclic Heptaoxazole

K. Shin‐ya, T. Doi, M. Takagi, 2009, Chembiochem : a European journal of chemical biology.

Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders.

K. Shin‐ya, M. Takagi, M. Suganuma, 2008, Angewandte Chemie.

Design and synthesis of telomestatin derivatives and their inhibitory activity of telomerase

K. Shin‐ya, T. Doi, M. Takagi, 2006 .

G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer.

K. Shin‐ya, T. Hirokawa, K. Nagasawa, 2009, Chemical communications.

Novel Chiral Derivatizing Agents for 1H NMR Determination of Enantiomeric Purities of Carboxylic Acids

H. Yamashita, K. Nagasawa, K. Wada, 2017 .

Guanidine organocatalysis for enantioselective carbon-heteroatom bond-forming reactions

K. Nagasawa, Minami Odagi, Keisuke Hosoya, 2017 .

Application of Organosuperbases to Total Synthesis

K. Nagasawa, 2009 .

Direct quantification of loop interaction and π-π stacking for G-quadruplex stability at the submolecular level.

H. Sugiyama, H. Mao, K. Nagasawa, 2014, Journal of the American Chemical Society.

Osteoclast-forming suppressing compounds, gargalols A, B, and C, from the edible mushroom Grifola gargal

K. Noguchi, Hirofumi Hirai, H. Kawagishi, 2011 .

Antibacterial flavonoids from Desmos chinensis

M. Rashid, H. Koshino, M. M. Rahman, 1996 .

Synthesis of 19‐Nor‐Vitamin D A‐Ring Synthons via Ring‐Closing Olefin Metathesis

K. Nagasawa, Keisuke Iida, Hazuki Nagai, 2014 .

Development of Macrocyclic Polyoxazoles and Evaluation of Their G-Quadruplex Stabilizing Activities

K. Shin‐ya, K. Nagasawa, Keisuke Iida, 2011 .

G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors

K. Shin‐ya, T. Shalaby, M. Grotzer, 2013, Molecules.

Organosulfur Chemistry. II. Use of Dimethyl Sulfoxide ; a Facile Synthesis of Cyclic Sulfides

K. Nagasawa, A. Yoneta, 1985 .

Synthesis of an Advanced Model of Zetekitoxin AB Focusing on the N-Acylisoxazolidine Amide Structure Corresponding to C13–C17

H. Koshino, K. Nagasawa, Chao Wang, 2014 .

Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transforming Growth Factor-β Signaling via Estrogen Receptor α

J. Yanagisawa, Y. Nakajima, H. Hiyoshi, 2014, Journal of Cancer.

Guanidinium iodide/urea hydrogen peroxide-catalyzed azidation of β-dicarbonyl compounds with trimethylsilyl azide

Masaru Kato, K. Nagasawa, Minami Odagi, 2016 .

Analysis of Interactions between Telomeric i‐Motif DNA and a Cyclic Tetraoxazole Compound

A. Phan, Yue Ma, M. Katahira, 2018, Chembiochem : a European journal of chemical biology.

Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA.

T. Hirokawa, Yue Ma, K. Nagasawa, 2016, Organic & biomolecular chemistry.

Thalidomide and its analogues as cyclooxygenase inhibitors.

Kazuo Nagasawa, Yuichi Hashimoto, Y. Hashimoto, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity.

T. Hirokawa, K. Nagasawa, C. Miyaura, 2012, Organic & biomolecular chemistry.

Cyclooxygenase inhibitors derived from thalidomide.

Y. Hashimoto, H. Kagechika, K. Nagasawa, 2003, Chemical & pharmaceutical bulletin.

Total Synthesis of Rishirilide B by Organocatalytic Oxidative Kinetic Resolution: Revision of Absolute Configuration of (+)-Rishirilide B.

K. Noguchi, K. Nagasawa, Minami Odagi, 2017, Angewandte Chemie.

Conformation of ligands bound to the muscarinic acetylcholine receptor.

Shigeyuki Yokoyama, Kazuo Nagasawa, Hiroshi Hirota, 2002, Molecular pharmacology.

Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands

Yue Ma, K. Ikebukuro, S. Numata, 2021, International journal of molecular sciences.

Development of G-quadruplex ligands for selective induction of a parallel-type topology.

T. Hirokawa, Yue Ma, H. Seimiya, 2018, Organic & biomolecular chemistry.

Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

K. Shin‐ya, I. Jelesarov, A. Arcaro, 2010, Molecular Cancer Therapeutics.

Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties

K. Shin‐ya, T. Hirokawa, K. Nagasawa, 2010, Journal of nucleic acids.

Design and Synthesis of Telomestatin Derivatives and Their Inhibitory Activity of Telomerase.

K. Shin‐ya, T. Doi, M. Takagi, 2007 .

Esterification of PQQ Enhances Blood-Brain Barrier Permeability and Inhibitory Activity against Amyloidogenic Protein Fibril Formation.

K. Ikebukuro, K. Sode, K. Nagasawa, 2018, ACS chemical neuroscience.

Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo.

M. Uesugi, Hayato Nakagawa, S. Kawamura, 2021, Journal of medicinal chemistry.

Structure-Dependent Binding of hnRNPA1 to Telomere RNA.

Yan Xu, Danzhou Yang, Takumi Ishizuka, 2017, Journal of the American Chemical Society.

Detection of DNA Methylation of G-Quadruplex and i-Motif-Forming Sequences by Measuring the Initial Elongation Efficiency of Polymerase Chain Reaction.

I. Karube, K. Ikebukuro, K. Nagasawa, 2016, Analytical chemistry.

942. TROPICAL MOLLUSCAN ASSOCIATION IN THE MIDDLE MIOCENE MARGINAL SEA OF THE JAPANESE ISLASDS : AN EXAMPLE OF MOLLUSCS FROM THE OYAMA FORMATION, TSURUOKA CITY, NORTHEAST HONSHU, JAPAN

K. Nagasawa, K. Ogasawara, 1992 .

Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage-gated sodium channels.

T. Hirokawa, Masafumi Hidaka, M. Yotsu-Yamashita, 2019, Chemistry.

A new skull of an early diverging rorqual (Balaenopteridae, Mysticeti, Cetacea) from the late Miocene to early Pliocene of Yamagata, northeastern Japan

K. Nagasawa, oshihiro Tanaka, Y. Taketani, 2020 .

An Efficient Asymmetric Synthesis of 1α,25‐(OH)2 Vitamin D3 A‐ Ring Synthon (I).

K. Nagasawa, Yoshiro Zako, H. Ishihara, 1993 .

Synthesis of 1 α‐ and 1 β‐amino‐25‐hydroxyvitamin D3

M. Uesugi, K. Nagasawa, Yusuke Akagi, 2016 .

Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.

Yue Ma, S. Mandal, H. Mao, 2017, Journal of the American Chemical Society.

A nonclassical vitamin D receptor pathway suppresses renal fibrosis.

Toshiyuki Shimizu, J. Yanagisawa, A. Murayama, 2013, The Journal of clinical investigation.

A force sensor that converts fluorescence signal into force measurement utilizing short looped DNA.

H. Balci, S. Basu, Yue Ma, 2018, Biosensors & bioelectronics.

Total synthesis of preswinholide A. 2. completion of the synthesis

T. Nakata, K. Nagasawa, I. Shimizu, 1996 .

Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities

Yue Ma, N. Kakusho, H. Masai, 2019, Scientific Reports.

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains

A. Phan, T. Hirokawa, Yue Ma, 2019, Molecules.

A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription

Yue Ma, F. Toyoshima, K. Nagasawa, 2016, Scientific Reports.

Binding of a Telomestatin Derivative Changes the Mechanical Anisotropy of a Human Telomeric G-Quadruplex.

H. Sugiyama, S. Jonchhe, H. Mao, 2018, Angewandte Chemie.

Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands

I. Karube, K. Ikebukuro, F. Lisdat, 2017, BMC Molecular Biology.

Rif1 binds to G quadruplexes and suppresses replication over long distances

Nobuaki Kono, Kazuo Nagasawa, Katsuhiko Shirahige, 2015, Nature Structural &Molecular Biology.

Development of Guanidine-Bisurea Bifunctional Organocatalyst Bearing Chirality at the Inner and Outer Sides of the Urea Groups, and Application to Enantioselective α-Hydroxylation of Pyranoindolizine Intermediate for Camptothecin Synthesis

Tatsuya Watanabe, Kazuo Nagasawa, Minami Odagi, 2015, Symmetry.

EFFICIENT SYNTHESIS OF 2,3-TRANS-TETRAHYDROPYRANS AND OXEPANES : REARRANGEMENT-RING EXPANSION OF CYCLIC ETHERS HAVING A CHLOROMETHANESULFONATE

Takeshi Shimizu, T. Nakata, K. Nagasawa, 1999 .

A tandem Friedel-Crafts based method for the construction of a tricyclic pyrroloquinoline skeleton and its application in the synthesis of ammosamide B.

K. Nagasawa, Tatsuya Yamada, Yohei Takayama, 2013, Chemical communications.

A Tandem Friedel—Crafts Based Method for the Construction of a Tricyclic Pyrroloquinoline Skeleton and Its Application in the Synthesis of Ammosamide B.

K. Nagasawa, Tatsuya Yamada, Yohei Takayama, 2013 .

Author Correction: FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

Kazuo Nagasawa, Antonio Porro, Matteo Berti, 2017, Nature Communications.

Oxidative Kinetic Resolution of cis-Fused Tricyclic 1-Tetralone Derivatives by Guanidine–Bisurea Bifunctional Organocatalyst

Yoshiharu Yamamoto, K. Nagasawa, Minami Odagi, 2017, Synlett.

Molecular architecture of G-quadruplex structures generated on duplex Rif1-binding sequences

Yue Ma, N. Kakusho, H. Masai, 2018, The Journal of Biological Chemistry.

Antispasmodic action of quaternary compounds administered orally

K. Nagasawa, K. Takagi, I. Takayanagi, 1974, The Journal of pharmacy and pharmacology.

Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy.

C. Nakamura, K. Ikebukuro, Yosuke Amemiya, 2011, Chemical communications.

Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole.

K. Shin‐ya, K. Ikebukuro, H. Seimiya, 2010, Organic & biomolecular chemistry.

Regulation of the vitamin D receptor by vitamin D lactam derivatives

Toshiyuki Shimizu, J. Yanagisawa, Tsuyoshi Waku, 2016, FEBS letters.

Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3 　

K. Yasuda, M. Uesugi, T. Sakaki, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

i-Motif-Binding Ligands and Their Effects on the Structure and Biological Functions of i-Motif.

K. Nagasawa, Shadi Sedghi Masoud, 2018, Chemical & pharmaceutical bulletin.

[Coumarin-containing chiral discriminating agents. VII. New crystalline 1H-NMR enantiomeric excess determination reagent for alcohols and amines, (R)-(-)- and (S)-(+)-O-coumarinylmandelic acids].

K. Nagasawa, K. Ito, N. Seto, 1997, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

K. Shin‐ya, I. Nakano, H. Seimiya, 2017, Scientific Reports.

Synthesis of 2,6,7-Trisubstituted Prenylated indole.

K. Nagasawa, M. Yamanaka, Minami Odagi, 2018, The Journal of organic chemistry.

Ophiura sarsii sarsii (Echinodermata, Ophiuroidea) from the Late Miocene to Early Pliocene formations of Yamagata Prefecture, northern Japan

K. Nagasawa, Y. Ishida, H. Tokairin, 1999 .

Structure-activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist.

K. Nagasawa, S. Ishizuka, K. Takenouchi, 2008, Bioorganic & medicinal chemistry letters.

Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation.

M. Makishima, Y. Hashimoto, K. Wakabayashi, 2006, Bioorganic & medicinal chemistry.

Dynamic enantiodivergent organocatalysis: merging molecular motors with bifunctional organocatalysts.

K. Nagasawa, Y. Sohtome, 2011, Chemphyschem : a European journal of chemical physics and physical chemistry.

Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent

K. Nagasawa, Minami Odagi, Kanna Adachi, 2020 .

Dynamic Enantiodivergent Organocatalysis: Merging Molecular Motors with Bifunctional Organocatalysts

K. Nagasawa, Y. Sohtome, 2012 .

Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25.

M. Uesugi, K. Nagasawa, M. Yamanaka, 2019, The Journal of organic chemistry.

Synthetic studies of (23S,25R)-1α,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives

K. Nagasawa, Minami Odagi, A. Nagata, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.

M. Uesugi, Hayato Nakagawa, R. Sakamoto, 2021, Cell chemical biology.

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites

K. Yasuda, T. Hirokawa, T. Sakaki, 2023, Biomolecules.

Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-Lactams (DLAMs), a Novel Series of 1α,25-Dihydroxyvitamin D3 Antagonist.

Y. Hashimoto, H. Koshino, Hisayoshi Kobayashi, 2004 .

Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

K. Nagasawa, M. Iwata, Takuya Imaoka, 2013 .

Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii

H. Nagai, K. Nagasawa, A. Yanagihara, 2020, Molecules.

Stereoselective synthesis of tricyclic guanidine systems: confirmation of the stereochemistry of batzelladine F left-hand tricyclic guanidine portion

H. Koshino, T. Nakata, K. Nagasawa, 2001 .

Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers.

Yue Ma, K. Ikebukuro, K. Sode, 2016, Chemical communications.

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.

M. Makishima, Y. Hashimoto, K. Wakabayashi, 2006, Bioorganic & medicinal chemistry letters.

Total Synthesis of Pinnatoxin A

K. Nagasawa, 2000 .

Development of a novel biosensing system based on the structural change of a polymerized guanine-quadruplex DNA nanostructure.

Koji Sode, Kazunori Ikebukuro, Kazuo Nagasawa, 2011, Biosensors & bioelectronics.

Development of G-quadruplex ligands for selective induction of a parallel-type topology.

T. Hirokawa, Yue Ma, H. Seimiya, 2018, Organic & biomolecular chemistry.

Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.

A. Phan, B. Heddi, K. Nagasawa, 2013, Journal of the American Chemical Society.

Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.

Y. Hashimoto, K. Nagasawa, Y. Kato, 2006, Journal of medicinal chemistry.

K. Nagasawa, Minami Odagi, Tatsuya Watanabe, 2014, Chemistry.

Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis.

M. Yotsu-Yamashita, K. Nagasawa, Minami Odagi, 2023, The Journal of organic chemistry.

Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine‐Thiourea Bifunctional Organocatalyst

Y. Hashimoto, K. Nagasawa, Y. Sohtome, 2006 .

Total synthesis of (+)-dibromophakellin.

K. Noguchi, K. Nagasawa, Takuya Imaoka, 2009, Angewandte Chemie.

Exploring Guanidinium Organocatalysts for Hypoiodite‐Mediated Reactions

K. Nagasawa, Miami Odagi, 2023, Chemical record.

Synthesis of 1α,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1α,25-dihydroxyvitamin D3 antagonist

Y. Hashimoto, H. Koshino, Hisayoshi Kobayashi, 2004 .

Synthesis of Isoxazolidines by Intramolecular Hydroamination of N-Alkoxyamides in the Presence of a Visible-Light Photoredox Catalyst

K. Nagasawa, Minami Odagi, Kanna Adachi, 2019, Bulletin of the Chemical Society of Japan.

The Design of Chiral Double Hydrogen Bonding Networks and Their Applications to Catalytic Asymmetric Carbon―Carbon and Carbon―Oxygen Bond-Forming Reactions

K. Nagasawa, Y. Sohtome, 2010 .