M. D. Di Francesco

发表

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

D. Hazuda, S. Harper, M. Rowley, 2007, Journal of medicinal chemistry.

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

T. Schirmeister, M. D. Di Francesco, E. Nizi, 2008, Journal of medicinal chemistry.

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Michael L. Wang, Shaojun Zhang, Guangchun Han, 2019, Science Translational Medicine.

Novel P2-P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategy.

U. Koch, V. Summa, P. Pace, 2010, Bioorganic & medicinal chemistry letters.

The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.

S. Harper, U. Koch, V. Matassa, 2004, Journal of medicinal chemistry.

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

C. Rudin, Jason P. Burke, C. Bristow, 2020, Journal of medicinal chemistry.

High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege

K. Rajapakshe, C. Coarfa, Akash Boda, 2021, Journal for ImmunoTherapy of Cancer.

Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.

P. Mandal, Jason P. Burke, F. Mseeh, 2021, Journal of medicinal chemistry.

Time-dependent release of extracellular vesicle subpopulations in tumor CABA I cells.

V. Bollati, S. D'Ascenzo, V. Dolo, 2015, Oncology reports.

Toward the synthesis of peloruside a: fragment synthesis and coupling studies.

M. D. Di Francesco, I. Paterson, T. Kuehn, 2003, Organic letters.

Platelet Concentration in Platelet-Rich Plasma Affects Tenocyte Behavior In Vitro

S. D'Ascenzo, V. Dolo, M. D. Di Francesco, 2014, BioMed research international.

Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.

M. Rowley, V. Summa, S. Avolio, 2012, Bioorganic & medicinal chemistry.

Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy.

Philip Jones, C. Ager, M. D. Di Francesco, 2019, Bioorganic & medicinal chemistry letters.

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Justin K. Huang, P. Mandal, Jason P. Burke, 2020, Cancer Research.

Novel macrocyclic inhibitors of hepatitis C NS3/4A protease featuring a 2-amino-1,3-thiazole as a P4 carbamate replacement.

U. Koch, M. Rowley, V. Summa, 2009, Journal of medicinal chemistry.

SF2312 is a natural phosphonate inhibitor of Enolase

R. DePinho, F. Muller, Y. A. Wang, 2016, Nature chemical biology.

Tumor-Derived Extracellular Vesicles Activate Normal Human Fibroblasts to a Cancer-Associated Fibroblast-Like Phenotype, Sustaining a Pro-Tumorigenic Microenvironment

S. D'Ascenzo, V. Dolo, M. D. Di Francesco, 2022, Frontiers in Oncology.

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

M. Protopopova, R. DePinho, M. Konopleva, 2018, Nature Medicine.

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Parantu K. Shah, Nora S. Sanchez, L. Chin, 2016, Cell reports.

From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis

P. Sanità, S. D'Ascenzo, V. Dolo, 2016, Tumor Biology.

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Darryl J. Pappin, Navdeep S. Chandel, D. Pappin, 2018, Cell reports.

A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma

R. Deberardinis, Jian Wang, J. McQuade, 2019, Clinical Cancer Research.

The human ovarian cancer cell line CABA I: A peculiar genetic evolution

S. D'Ascenzo, V. Dolo, M. D. Di Francesco, 2016, International journal of molecular medicine.

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

J. Hirst, J. Marszalek, M. D. Di Francesco, 2021, Science Advances.

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo

M. Dewhirst, O. Mawlawi, J. D. de Groot, 2019, Cells.

Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior

S. D'Ascenzo, V. Dolo, M. D. Di Francesco, 2018, Cancer Biology & Therapy.

Leukocyte depletion does not affect the in vitro healing ability of platelet rich plasma.

S. D'Ascenzo, V. Dolo, M. D. Di Francesco, 2018, Experimental and therapeutic medicine.

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, M. D. Di Francesco, 2009, Journal of medicinal chemistry.

Extracellular Vesicles in Glioblastoma: Role in Biological Processes and in Therapeutic Applications.

V. Dolo, M. D. Di Francesco, I. Giusti, 2017, Current cancer drug targets.

Case report: Interdisciplinary treatment of complex C1/C2 fractures in a patient with concomitant three-vessel coronary artery disease requiring bypass surgery

M. Tatagiba, M. D. Di Francesco, H. Magunia, 2023, Frontiers in Surgery.

Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.

M. Rowley, V. Summa, P. Pace, 2008, Bioorganic & Medicinal Chemistry Letters.