K. Stillmock

发表

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

D. Hazuda, S. Harper, M. Rowley, 2007, Journal of medicinal chemistry.

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.

D. Hazuda, M. Rowley, V. Summa, 2008, Journal of medicinal chemistry.

A potent and orally active HIV-1 integrase inhibitor.

Wei Xu, D. Hazuda, Michael D. Miller, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of Human Immunodeficiency Virus Type 1 Concerted Integration by Strand Transfer Inhibitors Which Recognize a Transient Structural Intermediate

D. Hazuda, Krishan Kumar Pandey, D. Grandgenett, 2007, Journal of Virology.

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.

H. M. Langford, D. Hazuda, W. Schleif, 2008, Bioorganic & medicinal chemistry letters.

Polygenic control of neuroinvasiveness in California serogroup bunyaviruses

M. Endres, S. Scherer, A. Pekosz, 1993, Journal of virology.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Linghang Zhuang, D. Hazuda, W. Schleif, 2003, Journal of medicinal chemistry.

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

H. M. Langford, D. Hazuda, W. Schleif, 2000, Journal of medicinal chemistry.

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

D. Hazuda, Jiunn H. Lin, W. Schleif, 2005, Bioorganic & medicinal chemistry letters.

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

J A Grobler, Amy S. Espeseth, D. Hazuda, 2000, Science.

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Michael Rowley, Cristina Gardelli, Marco Ferrara, 2007, Journal of medicinal chemistry.

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Amy S. Espeseth, Amy S Espeseth, D. Hazuda, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.

D. Hazuda, S. Venkatraman, J. Vacca, 2010, Bioorganic & medicinal chemistry letters.

Analysis of the intracellular transport properties of recombinant La Crosse virus glycoproteins.

K. Stillmock, F. González-Scarano, K. Bupp, 1996, Virology.

Protection from La Crosse virus encephalitis with recombinant glycoproteins: role of neutralizing anti-G1 antibodies

A. Pekosz, C. Griot, N. Nathanson, 1995, Journal of virology.

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

D. Hazuda, W. Schleif, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

Scintillation proximity assays for mechanistic and pharmacological analyses of HIV-1 integration.

D. Hazuda, K. Stillmock, J. Grobler, 2009, Methods.

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2006, Bioorganic & medicinal chemistry letters.

10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.

D. Hazuda, W. Schleif, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.

U. Koch, V. Summa, A. Petrocchi, 2007, Bioorganic & medicinal chemistry letters.

Mechanisms of Human Immunodeficiency Virus Type 1 Concerted Integration Related to Strand Transfer Inhibition and Drug Resistance

D. Hazuda, Krishan Kumar Pandey, D. Grandgenett, 2008, Antimicrobial Agents and Chemotherapy.

Replication in cultured C2C12 muscle cells correlates with the neuroinvasiveness of California serogroup bunyaviruses.

A. Pekosz, C. Griot, N. Nathanson, 1994, Virology.