Jingya Li

发表

CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.

Mengzhu Xue, B. Xiong, Jing-kang Shen, 2012, Bioorganic & medicinal chemistry letters.

Design and Synthesis of 4‐(2,4,5‐Trifluorophenyl)butane‐1,3‐diamines as Dipeptidyl Peptidase IV Inhibitors

B. Xiong, Jing-kang Shen, Xin Wang, 2013, ChemMedChem.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla.

Yu-bo Zhou, Yi Zang, Junmin Li, 2019, Phytochemistry.

Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Jia Li, Jing-kang Shen, Q. Chai, 2010, Acta Pharmacologica Sinica.

LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

Jun-qing Du, Yu-bo Zhou, Jia Li, 2009, Acta Pharmacologica Sinica.

Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba.

Jia Li, Jingya Li, A. Hou, 2017, Fitoterapia.

New Isoprenylated Phenolic Compounds from Morus laevigata

M. Wang, Jia Li, Jingya Li, 2015, Chemistry & biodiversity.

Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Hualiang Jiang, Zeng Li, Hong Liu, 2014, European journal of medicinal chemistry.

Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase.

Jiwu Chen, Jia Li, Jingya Li, 2005, Biochimica et biophysica acta.

Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury

Jia Li, Jingya Li, A. Hou, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.

M. Gu, F. Nan, Jingya Li, 2006, Biochimica et biophysica acta.

Design, Synthesis, in vitro Antiproliferative Activity Evaluation of 2-Acylaminothiopene-3-carboxamide Derivatives

Yan-fen Fang, Jia Li, Xiongwen Zhang, 2016 .

Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes.

Hualiang Jiang, Honglin Li, Xiaofeng Liu, 2016, Journal of medicinal chemistry.

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

F. Nan, Jingya Li, Yu Xiao, 2018, Acta Pharmacologica Sinica.

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

Chuan-ming Xie, Wei Lu, Jia Li, 2006, Bioorganic & medicinal chemistry letters.

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

W. Jia, Yu-bo Zhou, L. Rui, 2014, Nature Communications.

Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Hong Liu, Jiang Wang, Jingya Li, 2019, European journal of medicinal chemistry.

BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase

Donghai Wu, Shouguang Jin, Jingya Li, 2012, PloS one.

New alkaloids from Daphniphyllum himalense

Jia Li, J. Yue, Jingya Li, 2016 .

Isoquinoline‐1,3,4‐trione and its derivatives attenuate β‐amyloid‐induced apoptosis of neuronal cells

F. Nan, Jia Li, Jingya Li, 2006, The FEBS journal.

The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling

Lihong Hu, Haowen Jiang, Jingya Li, 2020, Cell Death & Disease.

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

M. Gu, F. Nan, Jingya Li, 2018, Acta Pharmacologica Sinica.

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

F. Zhang, Ling-Ling Yang, Dong-mei Chen, 2015, Acta Pharmacologica Sinica.

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Haowen Jiang, Jingya Li, Jia Li, 2020, Acta Pharmacologica Sinica.

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.

F. Nan, Jia Li, Jingya Li, 2013, ACS medicinal chemistry letters.

Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng.

Wan-ying Wu, D. Guo, Jingya Li, 2017, Journal of natural products.

Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii

Haowen Jiang, Jingya Li, S. Jiang, 2019, Natural product research.

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Specificity for inhibitors of metal-substituted methionine aminopeptidase.

F. Nan, Jia Li, Q. Ye, 2003, Biochemical and biophysical research communications.

Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity.

Jia Li, Yiming Li, Yu-bo Zhou, 2021, European journal of medicinal chemistry.

Synthesis of pyranochalcone derivatives and their inhibitory effect on NF-κB activation.

Jingya Li, Zuo Peng Li, Dilidaer Ajiaikebaier, 2021, Bioorganic & medicinal chemistry letters.

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models.

M. Gu, Jia Li, Jingya Li, 2010, Bioorganic & medicinal chemistry.

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

M. Gu, Haowen Jiang, Jia Li, 2019, Diabetes.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis.

Ting Huang, Yi Zang, Jia Li, 2019, Phytochemistry.

The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.

J. Chen, Jia Li, Jingya Li, 2013, Bioorganic & medicinal chemistry letters.

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Jing Fang, Jingya Li, B. Song, 2019, Nature Communications.

Discovery, synthesis, and structure-activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPKα2β1γ1 activators.

Lihong Hu, P. Liu, Jia Li, 2014, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.

Lihong Hu, Jia Li, Junwei Wang, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.

Jia Li, Jingya Li, Li Zhang, 2016, Bioorganic & medicinal chemistry letters.

PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).

C. Luo, Fanwang Meng, Jia Li, 2015, Bioorganic & medicinal chemistry letters.

Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong.

J. Yue, Jingya Li, Yao-yue Fan, 2018, Organic letters.

Quinoxalinylurea Derivatives as a Novel Class of JSP‐1 Inhibitors.

B. Xiong, Jing-kang Shen, Xin Wang, 2007 .

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Jing-kang Shen, Xin Wang, Jingya Li, 2006, Molecules.

Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

Jia Li, Jian-jun Yang, Jingya Li, 2010 .

Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction.

Jingya Li, Xiaoyan Shen, Yongmei Wu, 2021, Kidney international.

Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

Weiliang Zhu, Zhijian Xu, Cheng Peng, 2021, Acta Pharmacologica Sinica.

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.

Jia Li, Jingya Li, G. Meng, 2016, European journal of medicinal chemistry.

New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis.

Jia Li, Jingya Li, A. Hou, 2019, Fitoterapia.

Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki.

Jia Li, Jingya Li, A. Hou, 2018, Fitoterapia.

Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata

Jia Li, Jingya Li, A. Hou, 2016, Natural Products and Bioprospecting.

Isoprenylated Flavonoids with PTP1B Inhibition from Ficus tikoua

Jia Li, Jingya Li, A. Hou, 2015, Natural product communications.

Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum.

Jia Li, Jingya Li, A. Hou, 2015, Organic letters.

Diels-Alder adducts with PTP1B inhibition from Morus notabilis.

Jia Li, Jingya Li, A. Hou, 2015, Phytochemistry.

Novel grayanane diterpenoids from Rhododendron principis

Jia Li, Jingya Li, A. Hou, 2014 .

SYNTHESIS AND BIOLOGICAL EVALUATION OF OLEANOLIC ACID DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B

Jia Li, Jingya Li, Jie Tang, 2012 .

Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.

Li-Hong Hu, Jingya Li, Q. Shen, 2006, Biochimica et biophysica acta.