J. Kushner

发表

Elevated Methionine-tRNA Synthetase Activity in Human Colon Cancer 1

J. Kushner, D. Boll, J. Quagliana, 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Thyroid disease in hemochromatosis. Increased incidence in homozygous men.

J. Kushner, T. M. Kelly, C. Edwards, 1983, Archives of internal medicine.

Hypogonadism in hemochromatosis: reversal with iron depletion.

A. Meikle, J. Kushner, T. M. Kelly, 1984, Annals of internal medicine.

Hereditary hemochromatosis. Analysis of laboratory expression of the disease by genotype in 18 pedigrees.

M. Skolnick, D. Bishop, J. Kushner, 1982, American journal of clinical pathology.

Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin‐D and mithramycin

J. Kushner, S. Hammar, V. L. Hansen, 1975, Cancer.

Homogeneous multiplex genotyping of hemochromatosis mutations with fluorescent hybridization probes.

P. Bernard, C. Wittwer, J. Kushner, 1998, The American journal of pathology.

A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda

J. Phillips, C. Reilly, J. Kushner, 2007, Proceedings of the National Academy of Sciences.

An inherited enzymatic defect in porphyria cutanea tarda: decreased uroporphyrinogen decarboxylase activity.

A. Barbuto, J. Kushner, G. R. Lee, 1976, The Journal of clinical investigation.

Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis

D. McClain, J. Kushner, J. Rogers, 2006, Diabetologia.

Fast track to the porphyrias

J. Phillips, J. Kushner, 2005, Nature Medicine.

Comparison of stainable liver iron between symptomatic and asymptomatic hemochromatosis homozygotes and their homozygous relatives.

J. Kushner, C. Edwards, L. Griffen, 1991, The American journal of the medical sciences.

L. Jorde, L. Jorde, B. LaSalle, 2000, The New England journal of medicine.

The morbidity of hemochromatosis among clinically unselected homozygotes: preliminary report.

J. Kushner, C. Edwards, L. Griffen, 1994, Advances in experimental medicine and biology.

Hemochromatosis: Hemochromatosis: a genetic definition

J. Kushner, C. Edwards, R. Ajioka, 2000 .

Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.

R. Cooksey, Deborah L Jones, D. McClain, 2004, Endocrinology.

Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.

J. Phillips, J. Kushner, M. Franklin, 1997, Toxicology and applied pharmacology.

Blood lead concentrations in hereditary hemochromatosis.

R. Leggett, M. Patton, J. Barton, 1994, The Journal of laboratory and clinical medicine.

Increased Glucose Disposal and AMP-dependent Kinase Signaling in a Mouse Model of Hemochromatosis*

L. Boros, Bai Luo, R. Cooksey, 2007, Journal of Biological Chemistry.

Regulation of HeLa cell transferrin receptors.

J. Kushner, J. Kaplan, J. H. Ward, 1982, The Journal of biological chemistry.

Steady-state levels of uroporphyrinogen decarboxylase mRNA in lymphoblastoid cell lines from patients with familial porphyria cutanea tarda and their relatives.

J. Kushner, J. Hansen, M. Pryor, 1988, American journal of human genetics.

Clostridial species in the pathogenesis of necrotizing enterocolitis in patients with neutropenia

J. Kushner, D. G. Hopkins, 1983, American journal of hematology.

Hereditary hemochromatosis.

J. Kushner, R. Ajioka, 2002, Seminars in hematology.

Screening for hemochromatosis: phenotype versus genotype.

J. Kushner, C. Edwards, R. Ajioka, 1998, Seminars in hematology.

Identification of a novel mutation (C321X) in HJV.

N. Andrews, M. Fleming, I. Rubio-Aliaga, 2004, Blood.

Regulation of iron absorption in Hfe mutant mice.

N. Andrews, J. Kushner, J. Levy, 2002, Blood.

Reconstitution of normal hepcidin expression in Hfe-deficient mice after liver transplantation: a new role of HFE in Kupffer cells?

J. Kushner, I. De Domenico, 2010, Gastroenterology.

Coincidental hemochromatosis and viral hepatitis.

J. Kushner, C. Edwards, L. Griffen, 1991, The American journal of the medical sciences.

High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis

D. McClain, J. Kushner, J. Rogers, 2006, Diabetologia.

Preserving the national blood supply.

G. Brittenham, H. Klein, J. Kushner, 2001, Hematology. American Society of Hematology. Education Program.

Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda.

J. Phillips, J. Kushner, C. Edwards, 2000, Blood.

Clinical consequences of iron overload in hemochromatosis homozygotes.

J. Kushner, R. Ajioka, 2003, Blood.

Secondary iron overload.

N. Olivieri, J. Kushner, J. Porter, 2001, Hematology. American Society of Hematology. Education Program.

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

Dean Y. Li, R. Daynes, J. Kushner, 2010, The Journal of clinical investigation.

Increased frequency of HLA-A3 in subjects with sporadic porphyria cutanea tarda.

J. Kushner, C. Edwards, L. Griffen, 1988, Tissue antigens.

Hepatic siderosis and porphyria cutanea tarda: relation of iron excess to the metabolic defect.

J. Kushner, B. Felsher, 1977, Seminars in hematology.

Disorders of excess iron.

J. Kushner, C. Edwards, L. Griffen, 1991, Hospital practice.

Sporadic Porphyria Cutanea Tarda in Individuals with HLA‐linked Hemochromatosis Allele(s)

M. Skolnick, J. Kushner, C. Edwards, 1988, Annals of the New York Academy of Sciences.

Iron overload in hereditary spherocytosis: Association with hla‐linked hemochromatosis

M. Skolnick, J. Kushner, C. Edwards, 1982, American journal of hematology.

Hereditary hemochromatosis: contributions of genetic analyses.

M. Skolnick, J. Kushner, C. Edwards, 1981, Progress in hematology.

Iron absorption in hypotransferrinemic mice.

S. Buys, J. Kushner, J. Kaplan, 1991, Blood.

Recombinations defining centromeric and telomeric borders for the hereditary haemochromatosis locus.

P. Yu, J. Gruen, J. Kushner, 1997, Journal of medical genetics.

Prevalence of hemochromatosis among 11,065 presumably healthy blood donors.

M. Skolnick, D. Goldgar, J. Kushner, 1988, The New England journal of medicine.

Rebuttal to Beutler

J. Kushner, R. Ajioka, 2003 .

Screening for hemochromatosis.

J. Kushner, 1995, Gastroenterology.

Mapping the locus for hereditary hemochromatosis: localization between HLA-B and HLA-A.

M. Skolnick, J. Kushner, C. Edwards, 1986, American journal of human genetics.

Mining the genome for iron

J. Kushner, J. Kaplan, 2000, Nature.

Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis.

W. Hofmann, H. Koeffler, J. Kushner, 2002, Blood.

CXCR 4 expression is associated with survival in familial chronic lymphocytic leukemia , but CD 38 expression

W. Hofmann, H. Koeffler, J. Kushner, 2002 .

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations.

J. Kushner, J. Kaplan, I. De Domenico, 2007, Blood.

Analysis of uroporphyrinogen decarboxylase complementary DNAs in sporadic porphyria cutanea tarda.

D. Brown, J. Garey, J. Kushner, 1993, Gastroenterology.

Clinical and biochemical abnormalities in people heterozygous for hemochromatosis.

L. Jorde, L. Jorde, J. Kushner, 1996, The New England journal of medicine.

Transdermal estrogen replacement therapy in postmenopausal women previously treated for porphyria cutanea tarda.

J. Phillips, J. Kushner, K. Miller, 2000, The Journal of laboratory and clinical medicine.

Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains.

L. Amon, R. Leboeuf, J. Kushner, 2007, Blood cells, molecules & diseases.

Thermostable erythrocyte rosette-forming lymphocytes in hereditary hemochromatosis. I. Identification in peripheral blood

M. Skolnick, J. Kushner, C. Bryan, 1984, Journal of Clinical Immunology.

The enzymatic defect in porphyria cutanea tarda.

J. Kushner, 1982, The New England journal of medicine.

Neonatal hemochromatosis. Genetic analysis of transferrin-receptor, H-apoferritin, and L-apoferritin loci and of the human leukocyte antigen class I region.

J. Kushner, A. Knisely, J. Hansen, 1990, The American journal of pathology.

Idiopathic refractory sideroblastic anemia Incidence and risk factors for leukemic transformation

J. Kushner, D. S. Cheng, M. Wintrobe, 1979, Cancer.

The HLA class I locus: analysis of RFLPs in hereditary hemochromatosis.

J. Kushner, J. Hansen, 1989, Cytogenetics and cell genetics.

Transferrin receptor function in hereditary hemochromatosis.

J. Kushner, J. Kaplan, J. H. Ward, 1984, The Journal of laboratory and clinical medicine.

Biosynthesis of porphyrins and heme from gamma, delta-dioxovalerate by intact hepatocytes.

K. Morton, J. Kushner, W. Horton, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase.

J. G. Straka, J. Kushner, 1983, Biochemistry.

Anti-Obesity and Pro-Diabetic Effects of Hemochromatosis

D. McClain, J. Kushner, D. Abraham, 2014, Obesity.

Characterization and crystallization of human uroporphyrinogen decarboxylase

C. Hill, J. Phillips, F. Whitby, 1997, Protein science : a publication of the Protein Society.

High-performance liquid chromatography of porphyrin esters. Identification of mixed esters generated in sample preparation.

J. G. Straka, J. Kushner, B. Burnham, 1981, Analytical biochemistry.

Identification of a novel mutation in the L‐ferritin IRE leading to hereditary hyperferritinemia‐cataract syndrome

J. Phillips, J. Kushner, C. Warby, 2005, American journal of medical genetics. Part A.

Crystal structure of the oxygen-dependent coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae

P. Labbé, J. Pflugrath, C. Hill, 2004 .

Internalization and subcellular localization of transferrin and transferrin receptors in HeLa cells.

J. Kushner, J. Kaplan, J. Lamb, 1983, The Journal of biological chemistry.

Porphyria cutanea tarda associated with disinfectant misuse.

R. Lynch, J. Kushner, G. R. Lee, 1975, Archives of internal medicine.

The Role of Iron in the Pathogenesis of Porphyria Cutanea Tarda

J. Kushner, G. R. Lee, D. Steinmuller, 2013 .

Fulminant amebic meningoencephalitis due to Acanthamoeba

J. Kushner, M. Grunnet, G. Cannon, 1981, Neurology.

Laboratory diagnosis of the porphyrias.

J. Kushner, 1991, The New England journal of medicine.

Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation.

J. Kushner, J. Kaplan, J. H. Ward, 1982, The Biochemical journal.

Congenital Erythropoietic Porphyria, β-Thalassemia Intermedia and Thrombocytopenia Due to a GATA1 Mutation.

D. Steensma, J. Phillips, G. Spangrude, 2005 .

Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles.

J. Garey, T. Zoladek, J. Kushner, 1992, The Biochemical journal.

Prevalence of heterozygotes for hemochromatosis in the white population of the United States.

V. Hasselblad, C. McLaren, G. Brittenham, 1995, Blood.

Reduction of porphyrins to porphyrinogens with palladium on carbon.

J. Phillips, J. Kushner, H. Bergonia, 2009, Analytical biochemistry.

Biosynthesis of heme in mammals.

J. Phillips, J. Kushner, Richard S Ajioka, 2006, Biochimica et biophysica acta.

Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae*

P. Labbé, Cheng Yang, J. Pflugrath, 2004, Journal of Biological Chemistry.

Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase

C. Hill, J. Phillips, F. Whitby, 2003, The EMBO journal.

Porphyria cutanea tarda in three generations of a single family.

J. S. Taylor, J. Kushner, A. Benedetto, 1978, The New England journal of medicine.

Heme regulation of HeLa cell transferrin receptor number.

J. Kushner, J. Kaplan, J. H. Ward, 1984, The Journal of biological chemistry.

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

C. Kablitz, J. Ward, J. Kushner, 1992, The Journal of clinical investigation.

Recommendations for the Diagnosis and Treatment of the Acute Porphyrias

H. Bonkovsky, R. Desnick, K. Anderson, 2005, Annals of Internal Medicine.

The role of iron in the pathogenesis of porphyria cutanea tarda. An in vitro model.

J. Kushner, G. R. Lee, S. Nacht, 1972, The Journal of clinical investigation.

Congenital erythropoietic porphyria, diminished activity of uroporphyrinogen decarboxylase and dyserythropoiesis.

J. Kushner, N. Pimstone, C. Kjeldsberg, 1982, Blood.

Prevalence of the 281 (Gly→Glu) mutation in hepatoerythropoietic porphyria and porphyria cutanea tarda

B. Grandchamp, G. Elder, Y. Nordmann, 2004, Human Genetics.

Biosynthesis of 5-aminolevulinic acid and heme from 4,5-dioxovalerate in the rat.

J. G. Straka, K. Morton, J. Kushner, 1983, The Journal of clinical investigation.

A method for determining δ-aminolevulinic acid synthase activity in homogenized cells and tissues.

J. Phillips, J. Kushner, H. Bergonia, 2015, Clinical biochemistry.

The Role of Iron in the Pathogenesis

J. Kushner, G. R. Lee, S. Nacht, 1972 .

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis.

C. Craven, J. Kushner, J. Kaplan, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Monoblastic transformation in chronic myelogenous leukemia: Presentation with massive hepatic involvement

J. Kushner, R. Fineman, C. Kjeldsberg, 1981, Cancer.

Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria.

D. Steensma, J. Phillips, M. Pulsipher, 2007, Blood.

Measurement of Uroporphyrinogen Decarboxylase Activity

J. Phillips, J. Kushner, 1999, Current protocols in toxicology.

A mouse model of familial porphyria cutanea tarda.

N. Andrews, J. Phillips, K. Thomas, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Allelic association under map error and recombinational heterogeneity: a tale of two sites.

N. Morton, L. Jorde, L. Jorde, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A method for detecting recent selection in the human genome from allele age estimates.

L. Jorde, M. Kreitman, C. Toomajian, 2003, Genetics.

Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes.

L. Jorde, L. Jorde, E. Radisky, 1997, American journal of human genetics.

Crystal structure of human uroporphyrinogen decarboxylase

C. Hill, J. Phillips, F. Whitby, 1998, The EMBO journal.

Mutational analysis of human uroporphyrinogen decarboxylase.

J. Phillips, E. Wyckoff, J. Kushner, 1996, Biochimica et biophysica acta.

Uroporphyrinogen decarboxylase in Saccharomyces cerevisiae. HEM12 gene sequence and evidence for two conserved glycines essential for enzymatic activity.

P. Labbé, J. Garey, J. Kushner, 1992, European journal of biochemistry.

Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda.

E. Radisky, J. Garey, J. Kushner, 1990, The Journal of clinical investigation.

The hepcidin-binding site on ferroportin is evolutionarily conserved.

T. Ganz, J. Phillips, E. Nemeth, 2008, Cell metabolism.

Coincidental nontransfusional iron overload and thalassemia minor: association with HLA-linked hemochromatosis.

M. Skolnick, J. Kushner, C. Edwards, 1981, Blood.

Molecular cloning and nucleotide sequence of a complete human uroporphyrinogen decarboxylase cDNA.

P. Romeo, D. Beaupain, M. Goossens, 1986, The Journal of biological chemistry.

Regulation of the Distribution of Tissue Iron

C. Craven, J. Lamb, J. Kushner, 1988, Annals of the New York Academy of Sciences.

Attenuation of polychlorinated biphenyl induced uroporphyria by iron deprivation.

J. Phillips, J. Kushner, M. Franklin, 2005, Environmental toxicology and pharmacology.

Uroporphyria in the uroporphyrinogen decarboxylase‐deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure

J. Phillips, J. Kushner, M. Franklin, 2002, Hepatology.

Accelerated development of uroporphyria in mice heterozygous for a deletion at the uroporphyrinogen decarboxylase locus

J. Phillips, J. Kushner, M. Franklin, 2001, Journal of biochemical and molecular toxicology.

CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda.

J. Phillips, J. Kushner, M. Franklin, 2000, Biochemical pharmacology.

HLA-linked hemochromatosis alleles in sporadic porphyria cutanea tarda.

M. Skolnick, D. Goldgar, J. Kushner, 1989, Gastroenterology.

Heterozygosity for HLA-linked hemochromatosis as a likely cause of the hepatic siderosis associated with sporadic porphyria cutanea tarda.

M. Skolnick, J. Kushner, C. Edwards, 1985, Gastroenterology.

Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP).

C. Hill, J. Phillips, F. Whitby, 2007, Translational research : the journal of laboratory and clinical medicine.

A point mutation in the coding region of uroporphyrinogen decarboxylase associated with familial porphyria cutanea tarda.

J. Garey, J. Kushner, J. Hansen, 1989, Blood.

Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi.

L. Bockenstedt, J. Kushner, J. Kaplan, 2009, Blood.

Screening for hemochromatosis.

J. Kushner, C. Edwards, James P. Kushner, 1993, The New England journal of medicine.

Acquired myeloperoxidase deficiency and recurrent infections in a patient with acute myelomonocytic leukemia

J. Kushner, M. Kitahara, 1979, Cancer.

Cellular Distribution of Porphyrins In Porphyria Cutanea Tarda

J. Phillips, J. Kushner, H. Bergonia, 2010 .

Hemochromatosis: The iron phenotype of hemochromatosis heterozygotes

J. Kushner, C. Edwards, R. Ajioka, 2000 .

Down-regulation of hepcidin in porphyria cutanea tarda.

M. Katze, S. Proll, R. Weiss, 2008, Blood.

Another link in the chain

J. Kushner, Richard S. Ajioka, James P. Kushner, 2004 .

Maintaining iron balance in women blood donors of childbearing age: summary of a workshop

G. Brittenham, V. Gordeuk, J. Kushner, 2002, Transfusion.

Uroporphyria in the Cyp1a2-/- mouse.

J. Phillips, J. Kushner, H. Bergonia, 2011, Blood cells, molecules & diseases.

Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients.

M. Katze, K. Walters, S. Proll, 2006, Gastroenterology.

Biosynthesis of porphyrin precursors. Purification and characterization of mammalian L-alanine:gamma,delta-dioxovaleric acid aminotransferase.

L. Varticovski, J. Kushner, B. Burnham, 1980, The Journal of biological chemistry.

The effect of glyoxalase I on the metabolism of 4,5-dioxovaleric acid.

D. Stafforini, J. Kushner, B. Burnham, 1985, Biochimica et biophysica acta.

Phase I trial of low-dose oral Clofarabine in myelodysplastic syndromes patients who have failed frontline therapy.

K. Boucher, J. Kushner, P. Shami, 2015, Leukemia research.

2 out of 3 isn't bad.

J. Kushner, 2010, Blood.

Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.

C. Hill, J. Phillips, F. Whitby, 2009, Cellular and molecular biology.

Hemochromatosis: Estimate of the frequency of morbid complications of hemochromatosis

J. Kushner, Richard S. Ajioka, James P. Kushner, 2000 .

Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.

C. Hill, J. Phillips, F. Whitby, 2009, Journal of molecular biology.

Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.

Tiffany L. Parker, C. Hill, J. Phillips, 2001, Blood.

Successful treatment of a cardiac angiosarcoma with combined modality therapy.

D. Renlund, J. Kushner, J. Kushner, 1994, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Assignment of uroporphyrinogen decarboxylase (UROD) to the pter----p21 region of human chromosome 1.

R. Eddy, T. Shows, J. Kushner, 1985, Cytogenetics and cell genetics.

Uroporphyrinogen decarboxylase. A method for measuring enzyme activity.

J. G. Straka, J. Kushner, M. Pryor, 1982, Enzyme.

Iron Chelation by Deferoxamine Induces Autophagy

J. Kushner, J. Kaplan, D. Ward, 2008 .

Cytologic diagnosis and monitoring of Hodgkin's disease in cerebrospinal fluid: A case report

J. Kushner, G. Schumann, Uma A. Shenoy, 1987, Diagnostic cytopathology.

Uroporphyria in the Cyp1a2-/- mouse.

J. Phillips, J. Kushner, H. Bergonia, 2011, Blood cells, molecules & diseases.

Clinical consequences of iron overload in hemochromatosis homozygotes.

J. Kushner, R. Ajioka, 2003, Blood.

Screening for Hemochromatosis in Healthy Blood Donors

M. Skolnick, J. Kushner, C. Edwards, 1988 .

Increased Incidence in Homozygous Men

J. Kushner, T. M. Kelly, C. Edwards, 2016 .

Mapping recombinant events with molecular markers in hemochromatosis pedigrees.

E. Radisky, J. Kushner, C. Edwards, 1994, Cytogenetics and cell genetics.