S. Kachler

发表

Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.

A. Sperduti, S. Moro, K. Klotz, 2009, Bioorganic & medicinal chemistry.

Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.

E. Novellino, K. Klotz, K. Jacobson, 2017, Journal of medicinal chemistry.

Synthesis and adenosine receptors binding studies of new fluorinated analogues of pyrido[2,3-d]pyrimidines and quinazolines

K. Klotz, S. Kachler, B. Chandrasekaran, 2017, Medicinal Chemistry Research.

Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold

J. N. Low, S. Vilar, K. Klotz, 2016 .

Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors

K. Klotz, S. Kachler, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Bronchospasmolytic activity and adenosine receptor binding of some newer 1,3‐dipropyl‐8‐phenyl substituted xanthine derivatives

K. Klotz, D. Yadav, Rakesh Yadav, 2020, Chemical biology & drug design.

Discovery of 2-aminoimidazole and 2-amino imidazolyl-thiazoles as non-xanthine human adenosine A3 receptor antagonists: SAR and molecular modeling studies.

S. Moro, K. Klotz, S. Kachler, 2018, MedChemComm.

Synthesis, adenosine receptor binding and molecular modelling studies of novel thieno[2,3‐d]pyrimidine derivatives

Rajwinder Kaur, K. Klotz, S. Kachler, 2018, Chemical biology & drug design.

Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.

K. Klotz, S. Kachler, Hitesh B. Jalani, 2015, Bioorganic & medicinal chemistry letters.

Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives

L. Santana, E. Uriarte, K. Klotz, 2013, The Journal of pharmacy and pharmacology.

9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities

K. Klotz, G. Cristalli, S. Vittori, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

K. Klotz, G. Cristalli, S. Vittori, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.

K. Klotz, G. Vilahur, L. Badimón, 2017, International journal of cardiology.

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.

S. Moro, K. Klotz, Davide Sabbadin, 2013, European journal of medicinal chemistry.

A Versatile Synthetic Affinity Probe Reveals Inhibitory Synapse Ultrastructure and Brain Connectivity

O. Schueler‐Furman, C. Specht, P. Tovote, 2022, Angewandte Chemie.

Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors

K. Klotz, S. Kachler, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

A New Series Of 1,3-Dimethylxanthine Based Adenosine A2a Receptor Antagonists As A Non-Dopaminergic Treatment Of Parkinson's Disease.

K. Klotz, S. Kachler, Suman Rohilla, 2020, Current drug discovery technologies.

Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors

S. Vilar, L. Santana, E. Uriarte, 2014, ChemMedChem.

Chalcone‐based derivatives as new scaffolds for hA3 adenosine receptor antagonists

L. Santana, E. Uriarte, K. Klotz, 2013, The Journal of pharmacy and pharmacology.

Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.

S. Vilar, L. Santana, E. Uriarte, 2015, Bioorganic chemistry.

Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists.

K. Klotz, A. Lavecchia, R. Petrelli, 2018, Journal of medicinal chemistry.

N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

K. Klotz, A. Lavecchia, R. Petrelli, 2009, Journal of medicinal chemistry.

New substituted 9-propyladenine derivatives as A2Aadenosine receptor antagonists

K. Klotz, G. Marucci, M. Buccioni, 2015 .

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

S. Moro, K. Klotz, S. Federico, 2011, Bioorganic & medicinal chemistry.

The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

M. Sturlese, S. Moro, K. Klotz, 2015, PloS one.

Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists.

S. Moro, G. Spalluto, G. Pastorin, 2005, Farmaco.

Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists.

S. Moro, K. Klotz, G. Spalluto, 2005, Farmaco.

New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

K. Klotz, G. Marucci, M. Buccioni, 2019, Bioorganic chemistry.

Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors

K. Klotz, M. Kirstein, S. Kachler, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

7‐Amino‐2‐aryl/hetero‐aryl‐5‐oxo‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles: Synthesis and adenosine receptor binding studies

K. Klotz, S. Kachler, Khasim Shaik, 2019, Chemical biology & drug design.

[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype.

S. Moro, K. Klotz, S. Federico, 2018, European journal of medicinal chemistry.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

K. Klotz, G. Marucci, M. Buccioni, 2018, European journal of medicinal chemistry.

Synthesis and Evaluation of a New Series of 8‐(2‐Nitroaryl)Xanthines as Adenosine Receptor Ligands

K. Klotz, L. Young, S. Kachler, 2016, Drug development research.

Structure-based optimization of coumarin hA3 adenosine receptor antagonists.

S. Vilar, L. Santana, E. Uriarte, 2019, Journal of medicinal chemistry.

Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core

S. Vilar, L. Santana, E. Uriarte, 2016 .

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

K. Klotz, G. Marucci, M. Buccioni, 2014, Biochemical pharmacology.

[3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor.

K. Klotz, G. Cristalli, S. Vittori, 2007, European journal of pharmacology.

The Length and Flexibility of the 2‐Substituent of 9‐Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

K. Klotz, G. Marucci, M. Buccioni, 2016, ChemMedChem.

Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A2A AR ligands with in vivo efficacy against animal model of Parkinson's disease.

K. Klotz, S. Kachler, Suman Rohilla, 2019, Bioorganic chemistry.

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.

S. Moro, K. Klotz, S. Federico, 2010, Journal of medicinal chemistry.

5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.

Riccardo Petrelli, Ettore Novellino, Antonio Lavecchia, 2015, Journal of medicinal chemistry.

Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands

S. Vilar, E. Uriarte, K. Klotz, 2015 .

Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties.

S. Moro, K. Klotz, S. Federico, 2021, RSC medicinal chemistry.

Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs

S. Vilar, E. Uriarte, K. Klotz, 2020, Molecules.

Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor

M. Prato, M. Sturlese, S. Moro, 2020, ChemMedChem.

Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.

K. Klotz, S. Bharate, Sonali S. Bharate, 2016, Journal of medicinal chemistry.

Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.

K. Klotz, S. Kachler, Suman Rohilla, 2016, Bioorganic chemistry.

Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity.

K. Klotz, S. Kachler, R. Bansal, 2014, European journal of medicinal chemistry.

Synthesis and adenosine receptors binding affinities of a series of 3‐arylcoumarins

L. Santana, E. Uriarte, K. Klotz, 2013, The Journal of pharmacy and pharmacology.

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold.

E. Uriarte, S. Moro, K. Klotz, 2012, Biochemical pharmacology.

Adenosine Receptor with Antinociceptive Effects in Mice

K. Klotz, A. Lavecchia, R. Petrelli, 2009 .

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example.

S. Moro, K. Klotz, S. Federico, 2019, MedChemComm.

Coumarins and adenosine receptors: New perceptions in structure–affinity relationships

S. Vilar, E. Uriarte, K. Klotz, 2018, Chemical biology & drug design.

Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.

K. Klotz, S. Bharate, Sonali S. Bharate, 2016, Journal of medicinal chemistry.

Synthesis and adenosine receptors binding affinities of a series of 3‐arylcoumarins

L. Santana, E. Uriarte, K. Klotz, 2013, The Journal of pharmacy and pharmacology.

S. Moro, K. Klotz, G. Spalluto, 2005, Farmaco.

Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors

K. Klotz, S. Federico, G. Spalluto, 2023, Biomolecules.

Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors

K. Klotz, M. Kirstein, S. Kachler, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.